Plasmodium falciparum Na+/H+ exchanger 1 transporter is involved in reduced susceptibility to quinine

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 5, 2009, Pages 1926-1930

  Henry, Maud ^a   Briolant, Sébastien ^a   Zettor, Agnès ^a   Pelleau, Stéphane ^a   Baragatti, Meili ^a   Baret, Eric ^a   Mosnier, Joel ^a   Amalvict, Rémy ^a   Fusai, Thierry ^a   Rogier, Christophe ^a   Pradines, Bruno ^a,b  

^a SERVICE DE SANTÉ DES ARMÉES   (France)

^b Centre National de Reference du Paludisme   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; QUININE; SODIUM PROTON EXCHANGE PROTEIN 1;

ANTIMALARIAL DRUG RESISTANCE; ARTICLE; DNA EXTRACTION; DRUG SENSITIVITY; GENETIC POLYMORPHISM; GENOTYPE; GEOGRAPHIC ORIGIN; IC 50; MUTATIONAL ANALYSIS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS;

ANIMALS; ANTIMALARIALS; DRUG RESISTANCE; HUMANS; MALARIA, FALCIPARUM; MICROSATELLITE REPEATS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PROTOZOAN PROTEINS; QUININE; SODIUM-HYDROGEN ANTIPORTER;

EID: 66149137552     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01243-08     Document Type: Article

References (35)

1. Abdi, A. 2007. Bonferroni and Sidak corrections for multiple comparisons, p. 1-9. In N. J. Salkind (ed.), Encyclopedia of measurement and statistics. Sage, Thousand Oaks, CA.
2. Anderson, T. J., S. Nair, H. Qin, S. Singlam, A. Brockman, L. Paiphun, and F. Nosten. 2005. Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance? Antimicrob. Agents Chemother. 49:2180-2188.
3. Bennett, T. N., J. Patel, M. T. Ferdig, and P. D. Roepe. 2007. Plasmodium falciparum Na(+)/H(+) exchanger activity and quinine resistance. Mol. Biochem. Parasitol. 153:48-58.
4. Bjorkman, A., and P. A. Phillips-Howard. 1990. The epidemiology of drug-resistant malaria. Trans. R. Soc. Trop. Med. Hyg. 84:177-180. (Pubitemid 20171996)
5. Brasseur, P., J. Kouamouo, R. Moyou-Somo, and P. Druilhe. 1992. Multidrug resistant falciparum malaria in Cameroon in 1987-1988. I. Stable figures of prevalence of chloroquine- and quinine-resistant isolates in the original foci. Am. J. Trop. Med. Hyg. 46:1-7.
6. Cooper, R. A., M. T. Ferdig, X. Z. Su, L. M. Ursos, J. Mu, T. Nomura, H. Fujioka, D. A. Fidock, P. D. Roepe, and T. E. Wellems. 2002. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol. Pharmacol. 61:35-42. (Pubitemid 34049510)
7. Cooper, R. A., K. D. Lane, B. Deng, J. Mu, J. J. Patel, T. E. Wellems, X. Su, and M. T. Ferdig. 2007. Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine. Mol. Microbiol. 63:270-282.
8. Duarte, E. C., C. J. Fontes, T. W. Gyorkos, and M. Abrahamowicz. 1996. Randomized controlled trial of artesunate plus tetracycline versus standard treatment (quinine plus tetracycline) for uncomplicated Plasmodium falciparum malaria in Brazil. Am. J. Trop. Med. Hyg. 54:197-202.
9. Durrand, V., A. Berry, R. Sem, P. Glaziou, J. Beaudou, and T. Fandeur. 2004. Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro. Mol. Biochem. Parasitol. 136:273-285.
10. Ekland, E. H., and D. A. Fidock. 2007. Advances in understanding the genetic basis of antimalarial drug. Curr. Opin. Microbiol. 10:363-370. (Pubitemid 47404958)
11. Ferdig, M. T., R. A. Cooper, J. Mu, B. Deng, D. A. Joy, X. Z. Su, and T. E. Wellems. 2004. Dissecting the loci of low-level quinine resistance in malaria parasites. Mol. Microbiol. 52:985-997. (Pubitemid 38916169)
12. Giboda, M., and M. B. Denis. 1988. Response of Kampuchean strains of Plasmodium falciparum to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline; multiple drug resistance in vitro. J. Trop. Med. Hyg. 91:205-211.
13. Harinasuta, T., D. Bunnag, and R. Lasserre. 1990. Quinine resistant falciparum malaria treated with mefloquine. Southeast Asian J. Trop. Med. Public Health 21:552-557.
14. Jambou, R., E. Legrand, M. Niang, N. Khim, P. Lim, M. T. Ekala, C. Bouchier, P. Esterre, T. Fandeur, and O. Mercereau-Puijalon. 2005. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 366:1960-1963.
15. Jelinek, T., P. Schelbert, T. Löscher, and D. Eichenlaub. 1995. Quinine resistant falciparum acquired in east Africa. Trop. Med. Parasitol. 46:38-40.
16. Kremsner, P. G. 1990. Clindamycin in malaria treatment. J. Antimicrob. Chemother. 25:9-14. (Pubitemid 20042484)
17. Lambros, C., and J. P. Vanderberg. 1979. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 65:418-420.
18. Looareesuwan, S., P. Wilairatana, S. Vanijanonta, D. Kyle, and K. Webster. 1992. Efficacy of quinine-tetracycline for acute uncomplicated falciparum malaria in Thailand. Lancet 339:369.
19. Molinier, S., P. Imbert, D. Verrot, M. Morillon, D. Parzy, and J. E. Touze. 1994. Plasmodium falciparum malaria: type R1 quinine resistance in East Africa. Presse Med. 23:1494.
20. Mu, J., M. T. Ferdig, X. Feng, D. A. Joy, J. Duan, T. Furuya, G. Subramanian, L. Aravind, R. A. Cooper, J. C. Wootton, M. Xiong, and X. Z. Su. 2003. Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol. Microbiol. 49:977-989.
21. Noedl, H., Y. Se, K. Schaecher, B. L. Smith, D. Socheat, and M. M. Fukuda. 2008. Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 359:2619-2620.
22. Palmieri, F., N. Petrosillo, M. G. Paglia, A. Conte, D. Goletti, L. P. Pucillo, M. Menegon, A. Sannella, C. Severini, and G. Majori. 2004. Genetic confirmation of quinine-resistant Plasmodium falciparum malaria followed by postmalaria neurological syndrome in a traveler from Mozambique. J. Clin. Microbiol. 42:5424-5426.
23. Plowe, C. V., C. Rooper, J. W. Barnwell, C. T. Happi, H. H. Joshi, W. Mbacham, S. R. Meshnick, K. Mugittu, I. Naidoo, R. N. Price, R. W. Shafer, C. H. Sibley, C. J. Sutherland, P. A. Zimmerman, and P. J. Rosenthal. 2007. World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar. J. 6:121.
24. Pradines, B., C. Rogier, T. Fusai, A. Tall, F. F. Trape, and J. C. Doury. 1996. Sensibilité in vitro de 85 isolats de Plasmodium falciparum dans la region de Fatick, Sénégal. Med. Trop. 56:141-146.
25. Ralaimazava, P., R. Durand, N. Godineau, Z. Jezic, B. Pradines, O. Bouchaud, and J. Le Bras. 2002. Profile and evolution of the chemosusceptibility of falciparum malaria imported into France in 2000. Euro Surveill. 7:113-118.
26. Reed, M. B., K. J. Saliba, S. R. Caruana, K. Kirk, and A. F. Cowman. 2000. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403:906-909.
27. Rohrbach, P., C. P. Sanchez, K. Hayton, O. Friedrich, J. Patel, A. B. Sidhu, M. T. Ferdig, D. A. Fidock, and M. Lanzer. 2006. Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. EMBO J. 25:3000-3011.
28. Sanchez, P. C., A. Rotmann, W. D. Stein, and M. Lanzer. 2008. Polymorphisms within PfMDR1 alter the substrate specificity for antimalarial drugs in Plasmodium falciparum. Mol. Microbiol. 70:786-798.
29. Sanchez, P. C., W. D. Stein, and M. Lanzer. 2008. Dissecting the components of quinine accumulation in Plasmodium falciparum. Mol. Microbiol. 67:1081-1093.
30. Sibley, C. H., K. I. Barnes, and C. V. Plowe. 2007. The rationale and plan for creating a World Antimalarial Resistance Network (WARN). Malar. J. 6:118.
31. Sibley, C. H., K. I. Barnes, W. M. Watkins, and C. V. Plowe. 2008. A network to monitor antimalarial drug resistance: a plan for moving forward. Trends Parasitol. 24:43-48.
32. Sidhu, A. B., A. C. Uhlemann, S. G. Valderramos, J. C. Valderramos, S. Krishna, and D. A. Fidock. 2006. Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J. Infect. Dis. 194:528-535.
33. Tish, K. N., and P. I. Pillans. 1997. Recrudescence of Plasmodium falciparum malaria contracted in Lombok, Indonesia after quinine/doxycycline and mefloquine: case report. N. Z. Med. J. 110:255-256.
34. + exchanger 1 transporter protein implicated in quinine resistance. Antimicrob. Agents Chemother. 51:4508-4511.
35. Weaver, J. L., G. Szabo, P. S. Pine, M. M. Gottesman, S. Goldenberg, and A. Aszalos. 1993. The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter. Int. J. Cancer 54:456-461. (Pubitemid 23169685)