메뉴 건너뛰기




Volumn 29, Issue 2, 2010, Pages 143-152

DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures

Author keywords

Artemisinin; DMSO; Elicitation; ROS

Indexed keywords

ARTEMISININ; ARTEMISININ DERIVATIVE; ASCORBIC ACID; DIHYDROARTEMISINIC ACID; DIMETHYL SULFOXIDE; MESSENGER RNA; PLANT RNA; REACTIVE OXYGEN METABOLITE;

EID: 77949268296     PISSN: 07217714     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00299-009-0807-y     Document Type: Article
Times cited : (67)

References (52)
  • 1
    • 3242715114 scopus 로고    scopus 로고
    • Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
    • Apel K, Hirt H (2004) Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol 55: 373-399.
    • (2004) Annu Rev Plant Biol , vol.55 , pp. 373-399
    • Apel, K.1    Hirt, H.2
  • 2
    • 58149386641 scopus 로고    scopus 로고
    • Recent advances in artemisinin production through heterologous expression
    • Arsenault PR, Wobbe KK, Weathers PJ (2008) Recent advances in artemisinin production through heterologous expression. Curr Med Chem 15: 2886-2896.
    • (2008) Curr Med Chem , vol.15 , pp. 2886-2896
    • Arsenault, P.R.1    Wobbe, K.K.2    Weathers, P.J.3
  • 3
    • 36448992454 scopus 로고
    • 65 uptake, respiration, and RNA and protein metabolism in bean (Phaseolus vulgaris) tissues
    • 65 uptake, respiration, and RNA and protein metabolism in bean (Phaseolus vulgaris) tissues. Am J Bot 57: 794-799.
    • (1970) Am J Bot , vol.57 , pp. 794-799
    • Bajaj, Y.P.S.1    Rathore, V.S.2    Wittwer, S.H.3    Adams, M.W.4
  • 4
    • 41849126781 scopus 로고    scopus 로고
    • Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua
    • Baldi A, Dixit VK (2008) Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. Bioresour Tech 99: 4609-4614.
    • (2008) Bioresour Tech , vol.99 , pp. 4609-4614
    • Baldi, A.1    Dixit, V.K.2
  • 5
    • 0032422745 scopus 로고    scopus 로고
    • Alkaloid repartition and DMSO effects on alkaloid accumulation in Catharanthus seedlings
    • Bozom MP, Gargadennec A, Andary C, Roussel JL, Gueiffier A (1998) Alkaloid repartition and DMSO effects on alkaloid accumulation in Catharanthus seedlings. J Plant Physiol 153: 534-538.
    • (1998) J Plant Physiol , vol.153 , pp. 534-538
    • Bozom, M.P.1    Gargadennec, A.2    Andary, C.3    Roussel, J.L.4    Gueiffier, A.5
  • 6
    • 0346964232 scopus 로고    scopus 로고
    • In vivo transformations of dihydroartemisinic acid in Artemisia annua plants
    • Brown GD, Sy LK (2004) In vivo transformations of dihydroartemisinic acid in Artemisia annua plants. Tetrahedron 60: 1139-1159.
    • (2004) Tetrahedron , vol.60 , pp. 1139-1159
    • Brown, G.D.1    Sy, L.K.2
  • 7
    • 34547699424 scopus 로고    scopus 로고
    • In vivo transformations of artemisinic acid in Artemisia annua plants
    • Brown GD, Sy LK (2007) In vivo transformations of artemisinic acid in Artemisia annua plants. Tetrahedron 63: 9548-9566.
    • (2007) Tetrahedron , vol.63 , pp. 9548-9566
    • Brown, G.D.1    Sy, L.K.2
  • 8
    • 0000844023 scopus 로고
    • O-acetyl-salicylic acid promotes colony formation from protoplasts of an elite maize inbred
    • Carswell GK, Johnson CM, Shillito RD, Harms CT (1989) O-acetyl-salicylic acid promotes colony formation from protoplasts of an elite maize inbred. Plant Cell Rep 8: 282-284.
    • (1989) Plant Cell Rep , vol.8 , pp. 282-284
    • Carswell, G.K.1    Johnson, C.M.2    Shillito, R.D.3    Harms, C.T.4
  • 9
    • 20744444589 scopus 로고    scopus 로고
    • Dimethyl sulfoxide targets phage RNA polymerases to promote transcription
    • Chen Z, Zhang Y (2005) Dimethyl sulfoxide targets phage RNA polymerases to promote transcription. Biochem Biophys Res Comm 333: 664-670.
    • (2005) Biochem Biophys Res Comm , vol.333 , pp. 664-670
    • Chen, Z.1    Zhang, Y.2
  • 10
    • 0033757122 scopus 로고    scopus 로고
    • Enhanced production of microbial metabolites in the presence of dimethyl sulfoxide
    • Chen G, Wand GY, Li X, Waters B, Davies J (2000) Enhanced production of microbial metabolites in the presence of dimethyl sulfoxide. J Antibiotics 53: 1145-1153.
    • (2000) J Antibiotics , vol.53 , pp. 1145-1153
    • Chen, G.1    Wand, G.Y.2    Li, X.3    Waters, B.4    Davies, J.5
  • 11
    • 39049152539 scopus 로고    scopus 로고
    • Relative quantification of mRNA: Comparison of methods currently used for real-time PCR data analysis
    • Cikos S, Bukovska A, Koppel J (2007) Relative quantification of mRNA: comparison of methods currently used for real-time PCR data analysis. BMC Mol Biol 8: 113-123.
    • (2007) BMC Mol Biol , vol.8 , pp. 113-123
    • Cikos, S.1    Bukovska, A.2    Koppel, J.3
  • 12
    • 0029843392 scopus 로고    scopus 로고
    • Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria
    • de Vries PJ, Dien TK (1996) Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs 52: 818-836.
    • (1996) Drugs , vol.52 , pp. 818-836
    • de Vries, P.J.1    Dien, T.K.2
  • 13
    • 0001036253 scopus 로고
    • Development and fine structure of the glandular trichomes of Artemisia annua L
    • Duke S, Paul RN (1993) Development and fine structure of the glandular trichomes of Artemisia annua L. Int J Plant Sci 154: 107-118.
    • (1993) Int J Plant Sci , vol.154 , pp. 107-118
    • Duke, S.1    Paul, R.N.2
  • 14
    • 34250344275 scopus 로고    scopus 로고
    • Willmar Schwabe Award 2006: Antiplasmodial and antitumor activity of artemisinin-from bench to bedside
    • Efferth T (2007) Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin-from bench to bedside. Planta Med 73: 299-309.
    • (2007) Planta Med , vol.73 , pp. 299-309
    • Efferth, T.1
  • 15
    • 0029201602 scopus 로고
    • Floral morphology of Artemisia annua with special reference to trichomes
    • Ferreira JFS, Janick J (1995) Floral morphology of Artemisia annua with special reference to trichomes. Int J Plant Sci 156: 807-815.
    • (1995) Int J Plant Sci , vol.156 , pp. 807-815
    • Ferreira, J.F.S.1    Janick, J.2
  • 16
    • 0029808207 scopus 로고    scopus 로고
    • Roots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua
    • Ferreira JFS, Janick J (1996) Roots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua. Plant Cell Tiss Organ Cult 44: 211-217.
    • (1996) Plant Cell Tiss Organ Cult , vol.44 , pp. 211-217
    • Ferreira, J.F.S.1    Janick, J.2
  • 17
    • 0042127968 scopus 로고
    • Dimethyl sulfoxide can initiate cell divisions of arrested callus protoplasts by promoting cortical microtubule assembly
    • Hahne G, Hoffmann F (1984) Dimethyl sulfoxide can initiate cell divisions of arrested callus protoplasts by promoting cortical microtubule assembly. Proc Natl Acad Sci USA 81: 5449-5453.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 5449-5453
    • Hahne, G.1    Hoffmann, F.2
  • 18
    • 29144516319 scopus 로고    scopus 로고
    • Effects of elicitor and copper sulfate on grindelic acid production in submerged cultures of Grindelia pulchella
    • Hernandez XE, Orden AA, Giordano OS, Kurina M (2005) Effects of elicitor and copper sulfate on grindelic acid production in submerged cultures of Grindelia pulchella. Eur J Biotechnol 8: 276-283.
    • (2005) Eur J Biotechnol , vol.8 , pp. 276-283
    • Hernandez, X.E.1    Orden, A.A.2    Giordano, O.S.3    Kurina, M.4
  • 20
    • 0011596217 scopus 로고
    • Chloroperoxidase generation of singlet Δ molecular oxygen observed directly by spectroscopy in the 1- to 1. 6-μm region
    • Khan AU, Gebauer P, Hager LP (1983) Chloroperoxidase generation of singlet Δ molecular oxygen observed directly by spectroscopy in the 1- to 1. 6-μm region. PNAS 17: 5195-5197.
    • (1983) PNAS , vol.17 , pp. 5195-5197
    • Khan, A.U.1    Gebauer, P.2    Hager, L.P.3
  • 21
    • 0020645529 scopus 로고
    • Structural basis for biological activities of dimethyl sulfoxide
    • Kharasch N, Thyagarajan BS (1983) Structural basis for biological activities of dimethyl sulfoxide. Annal NY Acad Sci 411: 391-402.
    • (1983) Annal NY Acad Sci , vol.411 , pp. 391-402
    • Kharasch, N.1    Thyagarajan, B.S.2
  • 22
    • 0033898254 scopus 로고    scopus 로고
    • Enhancement of tessaric acid production in Tessaria absinthioides cell suspension cultures
    • Kurina-Sanz M, Hernandez XE, Tonn CE, Guerreiro E (2000) Enhancement of tessaric acid production in Tessaria absinthioides cell suspension cultures. Plant Cell Rep 19: 821-824.
    • (2000) Plant Cell Rep , vol.19 , pp. 821-824
    • Kurina-Sanz, M.1    Hernandez, X.E.2    Tonn, C.E.3    Guerreiro, E.4
  • 23
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 24
    • 40849086415 scopus 로고    scopus 로고
    • Abiotic stress induced expression of artemisinin biosynthesis genes in Artemisia annua L
    • Lulu Y, Chang Z, Ying H, Ruiyi Y, Qingping Z (2008) Abiotic stress induced expression of artemisinin biosynthesis genes in Artemisia annua L. Chin J Appl Environ Biol 14: 1-5.
    • (2008) Chin J Appl Environ Biol , vol.14 , pp. 1-5
    • Lulu, Y.1    Chang, Z.2    Ying, H.3    Ruiyi, Y.4    Qingping, Z.5
  • 25
    • 33846122993 scopus 로고    scopus 로고
    • Dimethyl sulfoxide to vorinostat: Development of this histone inhibitor an anticancer drug
    • Marks PA, Breslow R (2007) Dimethyl sulfoxide to vorinostat: development of this histone inhibitor an anticancer drug. Nat Biotechnol 25: 84-90.
    • (2007) Nat Biotechnol , vol.25 , pp. 84-90
    • Marks, P.A.1    Breslow, R.2
  • 26
    • 0025904817 scopus 로고
    • Susceptibility of Pneumocystis carinii to artemisinin in vitro
    • Merali S, Meshnick SR (1991) Susceptibility of Pneumocystis carinii to artemisinin in vitro. Antimicrob Agents Chemother 35: 1225-1227.
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 1225-1227
    • Merali, S.1    Meshnick, S.R.2
  • 27
    • 84982358134 scopus 로고
    • A revised medium for rapid growth and bioassays with tobacco tissue cultures
    • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473-497.
    • (1962) Physiol Plant , vol.15 , pp. 473-497
    • Murashige, T.1    Skoog, F.2
  • 28
    • 34247255872 scopus 로고    scopus 로고
    • Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells
    • Nam W, Tak J, Ryu JK, Jung M, Yook JI, Kim HJ, Cha IH (2007) Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells. Head Neck 29: 335-340.
    • (2007) Head Neck , vol.29 , pp. 335-340
    • Nam, W.1    Tak, J.2    Ryu, J.K.3    Jung, M.4    Yook, J.I.5    Kim, H.J.6    Cha, I.H.7
  • 29
    • 0031735647 scopus 로고    scopus 로고
    • Ascorbate and glutathione: Keeping active oxygen under control
    • Noctor G, Foyer CH (1998) Ascorbate and glutathione: keeping active oxygen under control. Ann Rev Plant Physiol 49: 249-279.
    • (1998) Ann Rev Plant Physiol , vol.49 , pp. 249-279
    • Noctor, G.1    Foyer, C.H.2
  • 30
    • 27644565158 scopus 로고    scopus 로고
    • Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system
    • Romero MR, Efferth T, Serrano MA, Castano B, Macias RI, Briz O, Marin JJ (2005) Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res 68: 75-83.
    • (2005) Antiviral Res , vol.68 , pp. 75-83
    • Romero, M.R.1    Efferth, T.2    Serrano, M.A.3    Castano, B.4    Macias, R.I.5    Briz, O.6    Marin, J.J.7
  • 31
    • 0027144868 scopus 로고
    • Biotransformation of arteannuic acid into arteannuin-B and artemisinin in Artemisia annua
    • Sangwan RS, Agarwal K, Luthra R, Thakur RS, Singh-Sangwan N (1993) Biotransformation of arteannuic acid into arteannuin-B and artemisinin in Artemisia annua. Phytochemistry 34: 1301-1302.
    • (1993) Phytochemistry , vol.34 , pp. 1301-1302
    • Sangwan, R.S.1    Agarwal, K.2    Luthra, R.3    Thakur, R.S.4    Singh-Sangwan, N.5
  • 32
    • 0037379110 scopus 로고    scopus 로고
    • Multidisciplinary utilization of dimethyl sulfoxide: Pharmacological, cellular, and molecule aspects
    • Santos NC, Figueira-Coelho J, Martins-Silva J, Saldanha C (2003) Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecule aspects. Biochem Pharmacol 65: 1035-1041.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1035-1041
    • Santos, N.C.1    Figueira-Coelho, J.2    Martins-Silva, J.3    Saldanha, C.4
  • 33
    • 77949261918 scopus 로고
    • On the effects of DMSO in cation transport by excised barley roots
    • Schmid WE (1968) On the effects of DMSO in cation transport by excised barley roots. Am J Bot 55: 757-761.
    • (1968) Am J Bot , vol.55 , pp. 757-761
    • Schmid, W.E.1
  • 35
    • 27744502061 scopus 로고    scopus 로고
    • Evaluation of different strategies for real-time RT-PCR expression analysis of corticotropin-releasing hormone and related proteins in human gestational tissues
    • Sehringer B, Zahradnik HP, Deppert WR, Simon M, Noethling C, Schaefer WR (2005) Evaluation of different strategies for real-time RT-PCR expression analysis of corticotropin-releasing hormone and related proteins in human gestational tissues. Anal Bioanal Chem 383: 768-775.
    • (2005) Anal Bioanal Chem , vol.383 , pp. 768-775
    • Sehringer, B.1    Zahradnik, H.P.2    Deppert, W.R.3    Simon, M.4    Noethling, C.5    Schaefer, W.R.6
  • 36
    • 0034683588 scopus 로고    scopus 로고
    • Biological turnover of DMS, DMSP, and DMSO in contrasting open-sea waters
    • Simó R, Pedrós-Alió C, Malin G, Gimalt JO (2000) Biological turnover of DMS, DMSP, and DMSO in contrasting open-sea waters. Mar Ecol Prog Ser 203: 1-11.
    • (2000) Mar Ecol Prog Ser , vol.203 , pp. 1-11
    • Simó, R.1    Pedrós-Alió, C.2    Malin, G.3    Gimalt, J.O.4
  • 37
    • 4444261942 scopus 로고    scopus 로고
    • Artemisinin induces apoptosis in human cancer cells
    • Singh NP, Lai HC (2004) Artemisinin induces apoptosis in human cancer cells. Anticancer Res 24: 2277-2280.
    • (2004) Anticancer Res , vol.24 , pp. 2277-2280
    • Singh, N.P.1    Lai, H.C.2
  • 38
    • 0031420771 scopus 로고    scopus 로고
    • Effects of gibberellic acid on hairy root cultures of Artemisia annua: Growth and artemisinin production
    • Smith TC, Weathers PJ, Cheetham RD (1997) Effects of gibberellic acid on hairy root cultures of Artemisia annua: growth and artemisinin production. In Vitro Cell Dev Biol Plant 33: 75-79.
    • (1997) In Vitro Cell Dev Biol Plant , vol.33 , pp. 75-79
    • Smith, T.C.1    Weathers, P.J.2    Cheetham, R.D.3
  • 39
    • 0037185534 scopus 로고    scopus 로고
    • The mechanism of the spontaneous autoxidation of dihydroartemisinic acid
    • Sy L-K, Brown GD (2002) The mechanism of the spontaneous autoxidation of dihydroartemisinic acid. Tetrahedron 58: 897-908.
    • (2002) Tetrahedron , vol.58 , pp. 897-908
    • Sy, L.-K.1    Brown, G.D.2
  • 40
    • 32344437343 scopus 로고    scopus 로고
    • Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin
    • Teoh KH, Polichuk DR, Reed DW, Nowak G, Covello PS (2006) Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. FEBS Lett 580: 1411-1416.
    • (2006) FEBS Lett , vol.580 , pp. 1411-1416
    • Teoh, K.H.1    Polichuk, D.R.2    Reed, D.W.3    Nowak, G.4    Covello, P.S.5
  • 41
    • 68149089486 scopus 로고    scopus 로고
    • Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua
    • Teoh KH, Polichuk DR, Reed DW, Covello PS (2009) Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua. Botany 87: 635-642.
    • (2009) Botany , vol.87 , pp. 635-642
    • Teoh, K.H.1    Polichuk, D.R.2    Reed, D.W.3    Covello, P.S.4
  • 42
    • 0030748530 scopus 로고    scopus 로고
    • 2 accumulation in papillae and hypersensitive response during the barley-powdery mildew interaction
    • 2 accumulation in papillae and hypersensitive response during the barley-powdery mildew interaction. Plant J 11: 1187-1194.
    • (1997) Plant J , vol.11 , pp. 1187-1194
    • Thordal-Christensen, H.1    Zhang, Z.2    Wei, Y.3    Collinge, D.B.4
  • 43
    • 36448939464 scopus 로고    scopus 로고
    • Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways
    • Towler MJ, Weathers PJ (2007) Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. Plant Cell Rep 26: 2129-2136.
    • (2007) Plant Cell Rep , vol.26 , pp. 2129-2136
    • Towler, M.J.1    Weathers, P.J.2
  • 45
    • 0032944335 scopus 로고    scopus 로고
    • Isolation and identification of dihydroartemisinic acid from Artemisia annua and its possible role in the biosynthesis of artemisinin
    • Wallaart TE, van Uden W, Lubberink HGM, Woerdenbag HJ, Pras N, Quax WJ (1999) Isolation and identification of dihydroartemisinic acid from Artemisia annua and its possible role in the biosynthesis of artemisinin. J Nat Prod 62: 430-433.
    • (1999) J Nat Prod , vol.62 , pp. 430-433
    • Wallaart, T.E.1    van Uden, W.2    Lubberink, H.G.M.3    Woerdenbag, H.J.4    Pras, N.5    Quax, W.J.6
  • 46
    • 0033983929 scopus 로고    scopus 로고
    • Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: Proof for the existence of chemotypes
    • Wallaart TE, Pras N, Beekman AC, Quax WJ (2000) Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes. Planta Med 66: 57-62.
    • (2000) Planta Med , vol.66 , pp. 57-62
    • Wallaart, T.E.1    Pras, N.2    Beekman, A.C.3    Quax, W.J.4
  • 47
    • 0035129779 scopus 로고    scopus 로고
    • Amorpha-4,11-diene synthase: Cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
    • Wallaart TE, Bouwmeester HJ, Hille J, Popping L, Maijers NC (2001) Amorpha-4, 11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin. Planta 212: 460-465.
    • (2001) Planta , vol.212 , pp. 460-465
    • Wallaart, T.E.1    Bouwmeester, H.J.2    Hille, J.3    Popping, L.4    Maijers, N.C.5
  • 49
    • 0028673929 scopus 로고
    • Dimethyl sulfoxide: A review of its applications in cell biology
    • Yu ZW, Quinn PJ (1994) Dimethyl sulfoxide: a review of its applications in cell biology. Biosci Rep 14: 259-281.
    • (1994) Biosci Rep , vol.14 , pp. 259-281
    • Yu, Z.W.1    Quinn, P.J.2
  • 50
    • 33846541098 scopus 로고    scopus 로고
    • Effect of horseradish peroxidase on the biosynthesis of artemisinin in Artemisiaannua in vitro
    • Zhang Y, Ye H, Li G (2003) Effect of horseradish peroxidase on the biosynthesis of artemisinin in Artemisiaannua in vitro. Chin J Appl Environ Biol 9: 616-618.
    • (2003) Chin J Appl Environ Biol , vol.9 , pp. 616-618
    • Zhang, Y.1    Ye, H.2    Li, G.3
  • 51
    • 15044344414 scopus 로고    scopus 로고
    • 3 and flowering induce the conversion of artemisinic acid to artemisinin in Artemisia annua plants
    • 3 and flowering induce the conversion of artemisinic acid to artemisinin in Artemisia annua plants. Russ J Plant Physiol 52: 68-73.
    • (2005) Russ J Plant Physiol , vol.52 , pp. 68-73
    • Zhang, Y.S.1    Ye, H.C.2    Liu, B.Y.3    Wang, H.4    Li, G.F.5
  • 52
    • 52049090608 scopus 로고    scopus 로고
    • The molecular cloning of artemisinic aldehyde {increment}11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua
    • Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJH, Ross ARS, Covello PS (2008) The molecular cloning of artemisinic aldehyde {increment}11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem 283: 21501-21508.
    • (2008) J Biol Chem , vol.283 , pp. 21501-21508
    • Zhang, Y.1    Teoh, K.H.2    Reed, D.W.3    Maes, L.4    Goossens, A.5    Olson, D.J.H.6    Ross, A.R.S.7    Covello, P.S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.