메뉴 건너뛰기




Volumn 52, Issue 12, 2008, Pages 4374-4380

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; HYDROGEN;

EID: 57049091831     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00666-08     Document Type: Article
Times cited : (46)

References (47)
  • 1
    • 12344265141 scopus 로고    scopus 로고
    • Plasmodium falciparum strain GC-03 exhibits hyper-gametocytogenesis in partially hemoglobin depleted red blood cells
    • Bennett, T. N., A. D. Kosar, and P. D. Roepe. 2005. Plasmodium falciparum strain GC-03 exhibits hyper-gametocytogenesis in partially hemoglobin depleted red blood cells. Mol. Biochem. Parasitol. 139:261-265.
    • (2005) Mol. Biochem. Parasitol , vol.139 , pp. 261-265
    • Bennett, T.N.1    Kosar, A.D.2    Roepe, P.D.3
  • 2
    • 17144422120 scopus 로고    scopus 로고
    • Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
    • Bray, P. G., R. E. Martin, L. Tilley, S. A. Ward, K. Kirk, and D. A. Fidock. 2005. Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance. Mol. Microbiol. 56:323-333.
    • (2005) Mol. Microbiol , vol.56 , pp. 323-333
    • Bray, P.G.1    Martin, R.E.2    Tilley, L.3    Ward, S.A.4    Kirk, K.5    Fidock, D.A.6
  • 4
    • 0036155237 scopus 로고    scopus 로고
    • Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH
    • Bray, P. G., K. J. Saliba, J. D. Davies, D. G. Spiller, M. R. White, K. Kirk, and S. A. Ward. 2002. Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH. Mol. Biochem. Parasitol. 119:301-304.
    • (2002) Mol. Biochem. Parasitol , vol.119 , pp. 301-304
    • Bray, P.G.1    Saliba, K.J.2    Davies, J.D.3    Spiller, D.G.4    White, M.R.5    Kirk, K.6    Ward, S.A.7
  • 5
    • 0242290995 scopus 로고    scopus 로고
    • pfcrt allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines
    • Chen, N., D. E. Kyle, C. Pasay, E. V. Fowler, J. Baker, J. M. Peters, and Q. Cheng. 2003. pfcrt allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines. Antimicrob. Agents Chemother. 47:3500-3505.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 3500-3505
    • Chen, N.1    Kyle, D.E.2    Pasay, C.3    Fowler, E.V.4    Baker, J.5    Peters, J.M.6    Cheng, Q.7
  • 6
    • 18244396971 scopus 로고    scopus 로고
    • Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum
    • Cooper, R. A., M. T. Ferdig, X. Z. Su, L. M. B. Ursos, J. Mu, T. Nomura, H. Fujioka, D. A. Fidock, P. D. Roepe, and T. E. Wellems. 2002. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol. Pharmacol. 61:35-42.
    • (2002) Mol. Pharmacol , vol.61 , pp. 35-42
    • Cooper, R.A.1    Ferdig, M.T.2    Su, X.Z.3    Ursos, L.M.B.4    Mu, J.5    Nomura, T.6    Fujioka, H.7    Fidock, D.A.8    Roepe, P.D.9    Wellems, T.E.10
  • 8
    • 1142297431 scopus 로고    scopus 로고
    • Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs
    • Fitch, C. D. 2004. Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 74:1957-1972.
    • (2004) Life Sci , vol.74 , pp. 1957-1972
    • Fitch, C.D.1
  • 9
    • 0014952885 scopus 로고
    • Plasmodium falciparum in owl monkeys: Drug resistance and chloroquine binding capacity
    • Fitch, C. D. 1970. Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity. Science 169:289-290.
    • (1970) Science , vol.169 , pp. 289-290
    • Fitch, C.D.1
  • 10
    • 0030879653 scopus 로고    scopus 로고
    • Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
    • Francis, S. E., D. J. Sullivan, Jr., and D. E. Goldberg. 1997. Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu. Rev. Microbiol. 51:97-123.
    • (1997) Annu. Rev. Microbiol , vol.51 , pp. 97-123
    • Francis, S.E.1    Sullivan Jr., D.J.2    Goldberg, D.E.3
  • 11
    • 33750090345 scopus 로고    scopus 로고
    • Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria
    • Gligorijevic, B., T. Bennett, R. McAllister, J. S. Urbach, and P. D. Roepe. 2006. Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria. Biochemistry 45:12411-12423.
    • (2006) Biochemistry , vol.45 , pp. 12411-12423
    • Gligorijevic, B.1    Bennett, T.2    McAllister, R.3    Urbach, J.S.4    Roepe, P.D.5
  • 12
    • 14544293532 scopus 로고    scopus 로고
    • pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum
    • Hayward, R., K. J. Saliba, and K. Kirk. 2005. pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum. Mol. Microbiol. 55:1285-1295.
    • (2005) Mol. Microbiol , vol.55 , pp. 1285-1295
    • Hayward, R.1    Saliba, K.J.2    Kirk, K.3
  • 13
    • 33645751112 scopus 로고    scopus 로고
    • The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance
    • Hayward, R., K. J. Saliba, and K. Kirk. 2006. The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance. J. Cell Sci. 119:1016-1025.
    • (2006) J. Cell Sci , vol.119 , pp. 1016-1025
    • Hayward, R.1    Saliba, K.J.2    Kirk, K.3
  • 14
    • 49649107709 scopus 로고    scopus 로고
    • Genome-wide compensatory changes accompany drug-selected mutations in the Plasmodium falciparum crt gene
    • Jiang, H., J. J. Patel, M. Yi, J. Mu, J. Ding, R. Stephens, R. A. Cooper, M. T. Ferdig, and X. Z. Su. 2008. Genome-wide compensatory changes accompany drug-selected mutations in the Plasmodium falciparum crt gene. PLoS ONE 3:e2484.
    • (2008) PLoS ONE , vol.3
    • Jiang, H.1    Patel, J.J.2    Yi, M.3    Mu, J.4    Ding, J.5    Stephens, R.6    Cooper, R.A.7    Ferdig, M.T.8    Su, X.Z.9
  • 15
    • 35748956775 scopus 로고    scopus 로고
    • Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum
    • Klonis, N., O. Tan, K. Jackson, D. Goldberg, M. Klemba, and L. Tilley. 2007. Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum. Biochem. J. 407:343-354.
    • (2007) Biochem. J , vol.407 , pp. 343-354
    • Klonis, N.1    Tan, O.2    Jackson, K.3    Goldberg, D.4    Klemba, M.5    Tilley, L.6
  • 17
    • 0022347074 scopus 로고
    • Antimalarials increase vesicle pH in Plasmodium falciparum
    • Krogstad, D. J., P. H. Schlesinger, and I. Y. Gluzman. 1985. Antimalarials increase vesicle pH in Plasmodium falciparum. J. Cell Biol. 101:2302-2309.
    • (1985) J. Cell Biol , vol.101 , pp. 2302-2309
    • Krogstad, D.J.1    Schlesinger, P.H.2    Gluzman, I.Y.3
  • 19
    • 33947125517 scopus 로고    scopus 로고
    • Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin
    • Kuhn, Y., P. Rohrbach, and M. Lanzer. 2007. Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin. Cell. Microbiol. 9:1004-1013.
    • (2007) Cell. Microbiol , vol.9 , pp. 1004-1013
    • Kuhn, Y.1    Rohrbach, P.2    Lanzer, M.3
  • 21
    • 46249086673 scopus 로고    scopus 로고
    • + leak from the digestive vacuole in chloroquine-resistant malaria parasites
    • + leak from the digestive vacuole in chloroquine-resistant malaria parasites. J. Cell Sci. 121:1624-1632.
    • (2008) J. Cell Sci , vol.121 , pp. 1624-1632
    • Lehane, A.M.1    Hayward, R.2    Saliba, K.J.3    Kirk, K.4
  • 22
    • 4944253804 scopus 로고    scopus 로고
    • The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily
    • Martin, R. E., and K. Kirk. 2004. The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily. Mol. Biol. Evol. 21:1938-1949.
    • (2004) Mol. Biol. Evol , vol.21 , pp. 1938-1949
    • Martin, R.E.1    Kirk, K.2
  • 23
    • 0023137728 scopus 로고
    • Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
    • Martin, S. K., A. M. Oduola, and W. K. Milhous. 1987. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. Science 235:899-901.
    • (1987) Science , vol.235 , pp. 899-901
    • Martin, S.K.1    Oduola, A.M.2    Milhous, W.K.3
  • 24
    • 1942501812 scopus 로고    scopus 로고
    • Site-directed mutation of arginine 282 to glutamate uncouples the movement of peptides and protons by the rabbit proton-peptide cotransporter PepT1
    • Meredith, D. 2004. Site-directed mutation of arginine 282 to glutamate uncouples the movement of peptides and protons by the rabbit proton-peptide cotransporter PepT1. J. Biol. Chem. 279:15795-15798.
    • (2004) J. Biol. Chem , vol.279 , pp. 15795-15798
    • Meredith, D.1
  • 25
    • 0042808413 scopus 로고    scopus 로고
    • Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi
    • Mita, T., A. Kaneko, J. K. Lum, B. Bwijo, M. Takechi, I. L. Zungu, T. Tsukahara, K. Tanabe, T. Kobayakawa, and A. Bjorkman. 2003. Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi. Am. J. Trop. Med. Hyg. 68:413-415.
    • (2003) Am. J. Trop. Med. Hyg , vol.68 , pp. 413-415
    • Mita, T.1    Kaneko, A.2    Lum, J.K.3    Bwijo, B.4    Takechi, M.5    Zungu, I.L.6    Tsukahara, T.7    Tanabe, K.8    Kobayakawa, T.9    Bjorkman, A.10
  • 26
    • 0028011015 scopus 로고
    • Hemoglobin catabolism and the killing of intraerythrocytic Plasmodium falciparum by chloroquine
    • Orjih, A. U., J. S. Ryerse, and C. D. Fitch. 1994. Hemoglobin catabolism and the killing of intraerythrocytic Plasmodium falciparum by chloroquine. Experientia 50:34-39.
    • (1994) Experientia , vol.50 , pp. 34-39
    • Orjih, A.U.1    Ryerse, J.S.2    Fitch, C.D.3
  • 29
    • 0031713287 scopus 로고    scopus 로고
    • Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance
    • Saliba, K. J., P. I. Folb, and P. J. Smith. 1998. Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance. Biochem. Pharmacol. 56:313-320.
    • (1998) Biochem. Pharmacol , vol.56 , pp. 313-320
    • Saliba, K.J.1    Folb, P.I.2    Smith, P.J.3
  • 30
    • 22744436592 scopus 로고    scopus 로고
    • Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum
    • Sanchez, C. P., J. E. McLean, P. Rohrbach, D. A. Fidock, W. D. Stein, and M. Lanzer. 2005. Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum. Biochemistry 44:9862-9870.
    • (2005) Biochemistry , vol.44 , pp. 9862-9870
    • Sanchez, C.P.1    McLean, J.E.2    Rohrbach, P.3    Fidock, D.A.4    Stein, W.D.5    Lanzer, M.6
  • 31
    • 11144279334 scopus 로고    scopus 로고
    • Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains
    • Sanchez, C. P., J. E. McLean, W. Stein, and M. Lanzer. 2004. Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains. Biochemistry 43:16365-16373.
    • (2004) Biochemistry , vol.43 , pp. 16365-16373
    • Sanchez, C.P.1    McLean, J.E.2    Stein, W.3    Lanzer, M.4
  • 32
    • 34247364130 scopus 로고    scopus 로고
    • Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum
    • Sanchez, C. P., P. Rohrbach, J. E. McLean, D. A. Fidock, W. D. Stein, and M. Lanzer. 2007. Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum. Mol. Microbiol. 64:407-420.
    • (2007) Mol. Microbiol , vol.64 , pp. 407-420
    • Sanchez, C.P.1    Rohrbach, P.2    McLean, J.E.3    Fidock, D.A.4    Stein, W.D.5    Lanzer, M.6
  • 33
    • 0042573722 scopus 로고    scopus 로고
    • Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum
    • Sanchez, C. P., W. Stein, and M. Lanzer. 2003. Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum. Biochemistry 42:9383-9394.
    • (2003) Biochemistry , vol.42 , pp. 9383-9394
    • Sanchez, C.P.1    Stein, W.2    Lanzer, M.3
  • 34
    • 0037020024 scopus 로고    scopus 로고
    • Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
    • Sidhu, A. B., D. Verdier-Pinard, and D. A. Fidock. 2002. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 298:210-213.
    • (2002) Science , vol.298 , pp. 210-213
    • Sidhu, A.B.1    Verdier-Pinard, D.2    Fidock, D.A.3
  • 36
    • 0031589733 scopus 로고    scopus 로고
    • Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
    • Su, X., L. A. Kirkman, H. Fujioka, and T. E. Wellems. 1997. Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell 91:593-603.
    • (1997) Cell , vol.91 , pp. 593-603
    • Su, X.1    Kirkman, L.A.2    Fujioka, H.3    Wellems, T.E.4
  • 37
    • 1642473952 scopus 로고    scopus 로고
    • Tran, C. V., and M. H. Saier, Jr. 2004. The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology 150:1-3.
    • Tran, C. V., and M. H. Saier, Jr. 2004. The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology 150:1-3.
  • 38
    • 0034978186 scopus 로고    scopus 로고
    • The public health impact of chloroquine resistance in Africa
    • Trape, J. F. 2001. The public health impact of chloroquine resistance in Africa. Am. J. Trop. Med. Hyg. 64:12-17.
    • (2001) Am. J. Trop. Med. Hyg , vol.64 , pp. 12-17
    • Trape, J.F.1
  • 39
    • 33751211212 scopus 로고    scopus 로고
    • Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum
    • van Schalkwyk, D. A., and T. J. Egan. 2006. Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum. Drug Resist. Updates 9:211-226.
    • (2006) Drug Resist. Updates , vol.9 , pp. 211-226
    • van Schalkwyk, D.A.1    Egan, T.J.2
  • 40
    • 18944368638 scopus 로고    scopus 로고
    • Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China
    • Wang, X., J. Mu, G. Li, P. Chen, X. Guo, L. Fu, L. Chen, X. Su, and T. E. Wellems. 2005. Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China. Am. J. Trop. Med. Hyg. 72:410-414.
    • (2005) Am. J. Trop. Med. Hyg , vol.72 , pp. 410-414
    • Wang, X.1    Mu, J.2    Li, G.3    Chen, P.4    Guo, X.5    Fu, L.6    Chen, L.7    Su, X.8    Wellems, T.E.9
  • 41
    • 0037121251 scopus 로고    scopus 로고
    • Lysosomes and drug resistance in malaria
    • Warhurst, D. C., J. C. Craig, and I. S. Adagu. 2002. Lysosomes and drug resistance in malaria. Lancet 360:1527-1529.
    • (2002) Lancet , vol.360 , pp. 1527-1529
    • Warhurst, D.C.1    Craig, J.C.2    Adagu, I.S.3
  • 43
    • 0026328231 scopus 로고
    • Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7
    • Wellems, T. E., A. Walker-Jonah, and L. J. Panton. 1991. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proc. Natl. Acad. Sci. USA 88:3382-3386.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3382-3386
    • Wellems, T.E.1    Walker-Jonah, A.2    Panton, L.J.3
  • 44
    • 0037020172 scopus 로고    scopus 로고
    • Illumination of the malaria parasite Plasmodium falciparum alters intracellular pH. Implications for live cell imaging
    • Wissing, F., C. P. Sanchez, P. Rohrbach, S. Ricken, and M. Lanzer. 2002. Illumination of the malaria parasite Plasmodium falciparum alters intracellular pH. Implications for live cell imaging. J. Biol. Chem. 277:37747-37755.
    • (2002) J. Biol. Chem , vol.277 , pp. 37747-37755
    • Wissing, F.1    Sanchez, C.P.2    Rohrbach, P.3    Ricken, S.4    Lanzer, M.5
  • 45
    • 0022211396 scopus 로고
    • The antimalarial mode of action of chloroquine
    • Yayon, A. 1985. The antimalarial mode of action of chloroquine. Rev. Clin. Basic Pharm. 5:99-139.
    • (1985) Rev. Clin. Basic Pharm , vol.5 , pp. 99-139
    • Yayon, A.1
  • 46
    • 0345652158 scopus 로고
    • Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine
    • Yayon, A., Z. I. Cabantchik, and H. Ginsburg. 1984. Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. EMBO J. 3:2695-2700.
    • (1984) EMBO J , vol.3 , pp. 2695-2700
    • Yayon, A.1    Cabantchik, Z.I.2    Ginsburg, H.3
  • 47
    • 0007740769 scopus 로고
    • Susceptibility of human malaria parasites to chloroquine is pH dependent
    • Yayon, A., Z. I. Cabantchik, and H. Ginsburg. 1985. Susceptibility of human malaria parasites to chloroquine is pH dependent. Proc. Natl. Acad. Sci. USA 82:2784-2788.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 2784-2788
    • Yayon, A.1    Cabantchik, Z.I.2    Ginsburg, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.