Artemisinins target the SERCA of Plasmodium falciparum

Nature

Volumn 424, Issue 6951, 2003, Pages 957-961

  Eckstein Ludwig, U ^a   Webb, R J ^a   Van Goethem, I D A ^b   East, J M ^b   Lee, A G ^b   Kimura, M ^c   O'Neill, P M ^d   Bray, P G ^e   Ward, S A ^e   Krishna, S ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; IRON; MACROMOLECULES; MALARIA CONTROL; PROTEINS;

ANTIPARASITIC ACTIVITY;

DRUG PRODUCTS;

ADENOSINE TRIPHOSPHATASE (CALCIUM); ANTIMALARIAL AGENT; ARTEFLENE; ARTEMISIN; ARTEMISIN DERIVATIVE; CHELATING AGENT; CHLOROQUINE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; DEFEROXAMINE; DIHYDROARTEMISININ; GLUCOSE TRANSPORTER; MP 118; QUININE; THAPSIGARGIN; UNCLASSIFIED DRUG;

MALARIA; MEDICINE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG STRUCTURE; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENZYME ASSAY; GENE; GENE EXPRESSION; GLUCOSE TRANSPORT; MALARIA; NONHUMAN; OOCYTE; PARASITE; PFATP6 GENE; PLASMODIUM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RABBIT; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; XENOPUS LAEVIS;

ANIMALS; ARTEMISININS; CALCIUM-TRANSPORTING ATPASES; DEFEROXAMINE; GLUCOSE; IRON; IRON CHELATING AGENTS; OOCYTES; PLASMODIUM FALCIPARUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; THAPSIGARGIN; XENOPUS LAEVIS;

ARTEMISIA; ARTEMISIA ANNUA; CINCHONA PUBESCENS; ORYCTOLAGUS CUNICULUS; PLASMODIUM FALCIPARUM; XENOPUS LAEVIS;

EID: 0042860063     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01813     Document Type: Article

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