Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 17142-17148

  Kessl, Jacques J ^a   Ha, Kevin H ^a   Merritt, Anne K ^a   Lange, Benjamin B ^a   Hill, Philip ^b   Meunier, Brigitte ^b   Meshnick, Steven R ^c   Trumpower, Bernard L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; ENZYMES; LIVING SYSTEMS STUDIES; YEAST;

ANTI-MALARIAL AGENTS; CYTOCHROME; PARASITE RESPIRATION; POINT MUTATION;

ALCOHOLS;

ATOVAQUONE; CYTOCHROME B; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIMALARIAL AGENT; DRUG DERIVATIVE; NAPHTHOQUINONE; UBIQUINOL; UBIQUINONE;

ANTIMALARIAL ACTIVITY; ARTICLE; COMPLEX FORMATION; DRUG RESISTANCE; DRUG TARGETING; GENE MUTATION; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; QUANTITATIVE ANALYSIS; SACCHAROMYCES CEREVISIAE; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETICS; IC 50; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; OXYGEN CONSUMPTION; PROTEIN BINDING; SEQUENCE HOMOLOGY; TIME;

PLASMODIUM FALCIPARUM; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; ATOVAQUONE; CYTOCHROMES B; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX III; INHIBITORY CONCENTRATION 50; KINETICS; MALARIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NAPHTHOQUINONES; OXYGEN CONSUMPTION; PLASMODIUM FALCIPARUM; POINT MUTATION; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; UBIQUINONE;

EID: 20444504719     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500388200     Document Type: Article

References (33)

1. Breman, J. G. (2001) Am. J. Trop. Med. Hyg. 64, 1-11
2. Fry, M., and Pudney, M. (1992) Biochem. Pharmacol. 43, 1545-1553
3. Araujo, F. G., Huskinson, J., and Remington, J. S. (1991) Antimicrob. Agents Chemother. 35, 293-299
4. Hughes, W. T., and Oz, H. S. (1995) J. Infect. Dis. 172, 1042-1046
5. Hughes, W. T., Gray, V. L., Gutteridge, W. E., Latter, V. S., and Pudney, M. (1990) Antimicrob. Agents Chemother. 34, 225-228
6. Kessl, J. J., Lange, B. B., Merbitz-Zahradnick, T., Zwicker, K, Hill, P., Meunier, B., Palsdottir, H., Hunte, C., Meshnick, S., and Trumpower, B. L. (2003) J. Biol. Chem. 278, 31312-31318
7. Camus, D., Djossou, F., Schilthuis, H. J., Hogh, B., Dutoit, E., Malvy, D., Roskell, N. S., Hedgley, C., De Soever, E. H., and Miller, G. B. (2004) Clin. Infect. Dis. 38, 1716-1723
8. Petersen, E. (2003) J. Travel Med. 10, S13-S15
9. Srivastava, I. K., Morrisey, J. M., Darrouzet, E., Daldal, F., and Vaidya, A. B. (1999) Mol. Microbiol. 33, 704-711
10. Suswam, E., Kyle, D., and Lang-Unnasch, N. (2001) Exp. Parasitol. 98, 180-187
11. Fivelman, Q. L., Butcher, G. A., Adagu, I. S., Warhurst, D. C., and Pasvol, G. (2002) Malar. J. 1, 1
12. Korsinczky, M., Chen, N., Kotecka, B., Saul, A., Rieckmann, K., and Cheng, Q. (2000) Antimicrob. Agents Chemother. 44, 2100-2108
13. Farnert, A., Lindberg, J., Gil, P., Swedberg, G., Berqvist, Y., Thapar, M. M., Lindegardh, N., Berezcky, S., and Bjorkman, A. (2003) Br. Med. J. 326, 628-629
14. Schwobel, B., Alifrangis, M., Salanti, A., and Jelinek, T. (2003) Malar. J. 2, 5
15. David, K. P., Alifrangis, M., Salanti, A., Vestergaard, L. S., Ronn, A., and Bygbjerg, I. (2003) Scand. J. Infect. Dis. 35, 897-898
16. Schwartz, E., Bujanover, S., and Kain, K. C. (2003) Clin. Infect. Dis. 37, 450-451
17. Gil, J. P., Nogueiria, F., Stromberg-Norklit, J., Lindberg, J., Carrolo, M., Casimiro, C., Lopes, D., Ares, A. P., Cravo, P. V., and Rosario, V. E. (2003) Mol. Cell. Probes 17, 85-89
18. Wichmann, O., Muehlberger, N., Jelinek, T., Alifrangis, M., Peyerl-Hoffmann, G., Muhlen, M., Grobusch, M. P., Gascon, J., Matteelli, A., Laferl, H., Bisoffi, Z., Ehrhardt, S., Cuadros, J., Hatz, C., Gjorup, I., McWhinney, P., Beran, J., da Cunha, S., Schulze, M., Kollaritsch, H., Kern, P., Fry, G., and Richter, J. (2004) J. Infect. Dis. 190, 1541-1546
19. Hill, P., Kessl, J., Fisher, N., Meshnick, S., Trumpower, B. L., and Meunier, B. (2003) Antimicrob. Agents Chemother. 47, 2725-2731
20. Kessl, J. J., Hill, P., Lange, B. B., Meshnick, S. R., Meunier, B., and Trumpower, B. L. (2004) J. Biol. Chem. 279, 2817-2824
21. Snyder, C. H., and Trumpower, B. L. (1999) J. Biol. Chem. 274, 31209-31216
22. Ljungdahl, P. O., Pennoyer, J. D., Robertson, D., and Trumpower, B. L. (1987) Biochim. Biophys. Acta 891, 227-242
23. Atlante, A., Calissano, P., Bobba, A., Azzariti, A., Marra, E., and Passarella, S. (2000) J. Biol. Chem. 275, 37159-37166
24. Palsdottir, H., Lojero, C. G., Trumpower, B. L., and Hunte, C., (2003) J. Biol. Chem. 278, 31303-31311
25. Syafruddin, D., Siregar, J. E., and Marzuki, S. (1999) Mol. Biochem. Parasitol. 104, 185-194
26. Hudson, A. T. (1993) Parasitol. Today 9, 66-68
27. Gao, X., Wen, X., Yu, C. A., Esser, L., Tsao, S., Quinn, B., Zhang, L., Yu, L., and Xia, D. (2002) Biochemistry 41, 11692-11702
28. Crofts, A. R., Guergova, K., Kuras, R., Ugulava, N., Li, J., and Hong, S. (2000) Biochim. Biophys. Acta 1459, 456-466
29. Fisher, N., Castleden, K., Bourges, I., Brasseur, G., Dujardin, G., and Meunier, B. (2004) J. Biol. Chem. 279, 12951-12958
30. Wibrand, F., Ravn, K., Schwartz, M., Rosenberg, T., Horn, N., and Vissing, J. (2001) Ann. Neurol. 50, 540-543
31. Peters, J. M., Chen, N., Gatton, M., Korsinczky, M., Fowler, E. V., Manzetti, S., Saul, A., and Cheng, Q. (2002) Antimicrob. Agents Chemother. 46, 2435-2441
32. Billington, O. J., McHugh, T. D., and Gillespie, S. H. (1999) Antimicrob. Agents Chemother. 43, 1866-1869
33. Devereux, H. L., Emery, H. L., Johnson, M. A., and Loveday, C. (2001) J. Med. Virol. 65, 218-224