Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

Biochemical Pharmacology

Volumn 77, Issue 3, 2009, Pages 322-336

  Hartwig, Carmony L ^a   Rosenthal, Andrew S ^b   D'Angelo, John ^b   Griffin, Carol E ^a   Posner, Gary H ^b   Cooper, Roland A ^a  

^a OLD DOMINION UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Digestive vacuole; Free radicals; Heme; Lipid peroxidation; Reactive oxygen species

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; ARTEMISININ DERIVATIVE; CHOLESTEROL ESTER; DEFEROXAMINE; ENDOPEROXIDE; FATTY ACID; FLUORESCENT DYE; HEME; HEMOZOIN; IRON; LIPID; PEROXY RADICAL; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CELL VACUOLE; CELLULAR DISTRIBUTION; CYTOPLASM; DRUG ACCUMULATION; DRUG DISTRIBUTION; ERYTHROCYTE; IRON CHELATION; MALARIA FALCIPARUM; MEMBRANE; MEMBRANE DAMAGE; MEROZOITE; MICROSCOPY; NONHUMAN; OXIDATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHIZONT; TROPHOZOITE;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CHROMATOGRAPHY, THIN LAYER; LIPID METABOLISM; LIPID PEROXIDATION; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; PEROXIDES; PLASMODIUM FALCIPARUM;

EID: 58249143778     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.10.015     Document Type: Article

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