Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe

Biochemistry

Volumn 48, Issue 40, 2009, Pages 9471-9481

  Cabrera, Mynthia ^a   Natarajan, Jayakumar ^a   Paguio, Michelle F ^a   Wolf, Christian ^a   Urbach, Jeffrey S ^a   Roepe, Paul D ^a,b  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ANTIMALARIAL DRUG; CHLOROQUINE RESISTANCE; DRUG TRANSPORT; HEXANOIC ACIDS; HIGH RESOLUTION; INITIAL RATE; KINETIC ANALYSIS; KINETIC RESOLUTION; MALARIAL PARASITES; PHYSIOLOGIC CONDITIONS; PLASMODIUM FALCIPARUM; PROTEOLIPOSOMES; TRACER METHODS; TRANSPORT DATA;

ACID RESISTANCE; AMIDES; AMINATION; AMINES; AMINO ACIDS; FATTY ACIDS; FLUORESCENCE; ORGANIC ACIDS; PROBES;

RATE CONSTANTS;

6 [N (7 NITROBENZ 2 OXA 1,3 DIAZOL 4 YL)AMINO]HEXANOIC [2 [[4 (7 CHLOROQUINOLIN 4 YLAMINO)PENTYL]ETHYLAMINO]ETHYL]AMIDE; CHLOROQUINE; FLUORESCENT DYE; TRACER; TRITIUM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG TRANSPORT; FILTRATION; FLUORESCENCE; FLUORESCENCE ANALYSIS; HUMAN; KINETICS; MUTATION; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEOLIPOSOME; TROPHOZOITE;

4-CHLORO-7-NITROBENZOFURAZAN; ANIMALS; ANTIMALARIALS; BIOLOGICAL TRANSPORT, ACTIVE; CHLOROQUINE; DRUG RESISTANCE; FLUORESCENT DYES; HUMANS; KINETICS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 70350050569     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901034r     Document Type: Article

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