-
1
-
-
26444556822
-
Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania
-
Martensson A, Strömberg J, Sisowath C, et al. Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania. Clin Infect Dis 2005; 41:1079-86.
-
(2005)
Clin Infect Dis
, vol.41
, pp. 1079-1086
-
-
Martensson, A.1
Strömberg, J.2
Sisowath, C.3
-
2
-
-
33846817519
-
Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania
-
Martensson A, Ngasala B, Ursing J, et al. Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania. J Infect Dis 2007; 195:597-601.
-
(2007)
J Infect Dis
, vol.195
, pp. 597-601
-
-
Martensson, A.1
Ngasala, B.2
Ursing, J.3
-
3
-
-
38449087076
-
Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso
-
Zongo I, Dorsey G, Rouamba N, et al. Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis 2007; 45:1453-61.
-
(2007)
Clin Infect Dis
, vol.45
, pp. 1453-1461
-
-
Zongo, I.1
Dorsey, G.2
Rouamba, N.3
-
4
-
-
0034708162
-
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
-
Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 2000; 403:906-9.
-
(2000)
Nature
, vol.403
, pp. 906-909
-
-
Reed, M.B.1
Saliba, K.J.2
Caruana, S.R.3
Kirk, K.4
Cowman, A.F.5
-
5
-
-
23744435838
-
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
-
Sidhu AB, Valderramos SG, Fidock DA. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol Microbiol 2005; 57:913-26.
-
(2005)
Mol Microbiol
, vol.57
, pp. 913-926
-
-
Sidhu, A.B.1
Valderramos, S.G.2
Fidock, D.A.3
-
6
-
-
19544366088
-
Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
-
Anderson TJ, Nair S, Qin H, et al. Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance? Antimicrob Agents Chemother 2005; 49:2180-8.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 2180-2188
-
-
Anderson, T.J.1
Nair, S.2
Qin, H.3
-
7
-
-
0034732666
-
The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin
-
Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol 2000; 108:13-23.
-
(2000)
Mol Biochem Parasitol
, vol.108
, pp. 13-23
-
-
Duraisingh, M.T.1
Jones, P.2
Sambou, I.3
von Seidlein, L.4
Pinder, M.5
Warhurst, D.C.6
-
8
-
-
33646736568
-
Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
-
Price RN, Uhlemann AC, van Vugt M, et al. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin Infect Dis 2006; 42:1570-7.
-
(2006)
Clin Infect Dis
, vol.42
, pp. 1570-1577
-
-
Price, R.N.1
Uhlemann, A.C.2
van Vugt, M.3
-
9
-
-
2142769136
-
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
-
Price RN, Uhlemann AC, Brockman A, et al. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 2004; 364:438-47.
-
(2004)
Lancet
, vol.364
, pp. 438-447
-
-
Price, R.N.1
Uhlemann, A.C.2
Brockman, A.3
-
10
-
-
27744555673
-
Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon
-
Uhlemann AC, Ramharter M, Lell B, Kremsner PG, Krishna S. Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon. J Infect Dis 2005; 192:1830-5.
-
(2005)
J Infect Dis
, vol.192
, pp. 1830-1835
-
-
Uhlemann, A.C.1
Ramharter, M.2
Lell, B.3
Kremsner, P.G.4
Krishna, S.5
-
11
-
-
14844327986
-
In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemetherlumefantrine (Coartem)
-
Sisowath C, Strömberg J, Mårtensson A, et al. In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemetherlumefantrine (Coartem). J Infect Dis 2005; 191:1014-7.
-
(2005)
J Infect Dis
, vol.191
, pp. 1014-1017
-
-
Sisowath, C.1
Strömberg, J.2
Mårtensson, A.3
-
12
-
-
34249883577
-
The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa
-
Sisowath C, Ferreira PE, Bustamante LY, et al. The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa. Trop Med Int Health 2007; 12:736-42.
-
(2007)
Trop Med Int Health
, vol.12
, pp. 736-742
-
-
Sisowath, C.1
Ferreira, P.E.2
Bustamante, L.Y.3
-
13
-
-
33646450674
-
Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
-
Dokomajilar C, Nsobya SL, Greenhouse B, Rosenthal PJ, Dorsey G. Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother 2006; 50:1893-5.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1893-1895
-
-
Dokomajilar, C.1
Nsobya, S.L.2
Greenhouse, B.3
Rosenthal, P.J.4
Dorsey, G.5
-
14
-
-
33847655633
-
Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria
-
Humphreys GS, Merinopoulos I, Ahmed J, et al. Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria. Antimicrob Agents Chemother 2007; 51:991-7.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 991-997
-
-
Humphreys, G.S.1
Merinopoulos, I.2
Ahmed, J.3
-
15
-
-
25444481378
-
-
Hastings IM, Ward SA. Coartem (artemether-lumefantrine) in Africa: the beginning of the end? J Infect Dis 2005; 192:1303- 4; author reply, 1304-5.
-
Hastings IM, Ward SA. Coartem (artemether-lumefantrine) in Africa: the beginning of the end? J Infect Dis 2005; 192:1303- 4; author reply, 1304-5.
-
-
-
-
16
-
-
14544293532
-
pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum
-
Hayward R, Saliba KJ, Kirk K. pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum. Mol Microbiol 2005; 55:1285-95.
-
(2005)
Mol Microbiol
, vol.55
, pp. 1285-1295
-
-
Hayward, R.1
Saliba, K.J.2
Kirk, K.3
-
17
-
-
0033636607
-
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
-
Fidock DA, Nomura T, Talley AK, et al. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 2000; 6:861-71.
-
(2000)
Mol Cell
, vol.6
, pp. 861-871
-
-
Fidock, D.A.1
Nomura, T.2
Talley, A.K.3
-
18
-
-
0035945682
-
A molecular marker for chloroquine-resistant falciparum malaria
-
Djimdé A, Doumbo OK, Cortese JF, et al. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 2001; 344:257-63.
-
(2001)
N Engl J Med
, vol.344
, pp. 257-263
-
-
Djimdé, A.1
Doumbo, O.K.2
Cortese, J.F.3
-
19
-
-
0037020024
-
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
-
Sidhu AB, Verdier-Pinard D, Fidock DA. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 2002; 298:210-3.
-
(2002)
Science
, vol.298
, pp. 210-213
-
-
Sidhu, A.B.1
Verdier-Pinard, D.2
Fidock, D.A.3
-
20
-
-
22744447610
-
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance
-
Lakshmanan V, Bray PG, Verdier-Pinard D, et al. A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. EMBO J 2005; 24:2294-305.
-
(2005)
EMBO J
, vol.24
, pp. 2294-2305
-
-
Lakshmanan, V.1
Bray, P.G.2
Verdier-Pinard, D.3
-
21
-
-
18244396971
-
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum
-
Cooper RA, Ferdig MT, Su XZ, et al. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol Pharmacol 2002; 61:35-42.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 35-42
-
-
Cooper, R.A.1
Ferdig, M.T.2
Su, X.Z.3
-
22
-
-
4644251136
-
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents
-
Johnson DJ, Fidock DA, Mungthin M, et al. Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Mol Cell 2004; 15:867-77.
-
(2004)
Mol Cell
, vol.15
, pp. 867-877
-
-
Johnson, D.J.1
Fidock, D.A.2
Mungthin, M.3
-
23
-
-
33644774433
-
Multiplex PCR-RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum
-
Veiga MI, Ferreira PE, Björkman A, Gil JP. Multiplex PCR-RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum. Mol Cell Probes 2006; 20:100-4.
-
(2006)
Mol Cell Probes
, vol.20
, pp. 100-104
-
-
Veiga, M.I.1
Ferreira, P.E.2
Björkman, A.3
Gil, J.P.4
-
24
-
-
0032407858
-
Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase
-
Fidock DA, Nomura T, Wellems TE. Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase. Mol Pharmacol 1998; 54:1140-7.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 1140-1147
-
-
Fidock, D.A.1
Nomura, T.2
Wellems, T.E.3
-
25
-
-
33749989605
-
Transporters involved in resistance to antimalarial drugs
-
Valderramos SG, Fidock DA. Transporters involved in resistance to antimalarial drugs. Trends Pharmacol Sci 2006; 27:594-601.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 594-601
-
-
Valderramos, S.G.1
Fidock, D.A.2
-
26
-
-
0025305350
-
Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
-
Wellems TE, Panton LJ, Gluzman IY, et al. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature 1990; 345:253-5.
-
(1990)
Nature
, vol.345
, pp. 253-255
-
-
Wellems, T.E.1
Panton, L.J.2
Gluzman, I.Y.3
-
27
-
-
61849176322
-
-
Available at:, Accessed 20 May 2008
-
World Health Organization. Treatment policies. Available at: http://www.who.int/malaria/treatmentpolicies.html. Accessed 20 May 2008.
-
Treatment policies
-
-
-
28
-
-
33746289507
-
Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum
-
Rohrbach P, Sanchez CP, Hayton K, et al. Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. EMBO J 2006; 25:3000-11.
-
(2006)
EMBO J
, vol.25
, pp. 3000-3011
-
-
Rohrbach, P.1
Sanchez, C.P.2
Hayton, K.3
-
29
-
-
0029047328
-
Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum
-
Volkman SK, Cowman AF, Wirth DF. Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum. Proc Natl Acad Sci USA 1995; 92:8921-5.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8921-8925
-
-
Volkman, S.K.1
Cowman, A.F.2
Wirth, D.F.3
-
30
-
-
0027546252
-
STE6, the yeast α-factor transporter
-
Michaelis S. STE6, the yeast α-factor transporter. Semin Cell Biol 1993; 4:17-27.
-
(1993)
Semin Cell Biol
, vol.4
, pp. 17-27
-
-
Michaelis, S.1
-
31
-
-
19344377032
-
Contribution of the pfmdr1 gene to antimalarial drug-resistance
-
Duraisingh MT, Cowman AF. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop 2005; 94:181-90.
-
(2005)
Acta Trop
, vol.94
, pp. 181-190
-
-
Duraisingh, M.T.1
Cowman, A.F.2
-
32
-
-
0027406890
-
Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum
-
Karcz SR, Galatis D, Cowman AF. Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum. Mol Biochem Parasitol 1993; 58:269-76.
-
(1993)
Mol Biochem Parasitol
, vol.58
, pp. 269-276
-
-
Karcz, S.R.1
Galatis, D.2
Cowman, A.F.3
-
33
-
-
0026645269
-
Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum
-
Barnes DA, Foote SJ, Galatis D, Kemp DJ, Cowman AF. Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO J 1992; 11:3067-75.
-
(1992)
EMBO J
, vol.11
, pp. 3067-3075
-
-
Barnes, D.A.1
Foote, S.J.2
Galatis, D.3
Kemp, D.J.4
Cowman, A.F.5
-
34
-
-
0032804039
-
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand
-
Price RN, Cassar C, Brockman A, et al. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother 1999; 43:2943-9.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 2943-2949
-
-
Price, R.N.1
Cassar, C.2
Brockman, A.3
-
35
-
-
0042769406
-
Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1
-
Pickard AL, Wongsrichanalai C, Purfield A, et al. Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1. Antimicrob Agents Chemother 2003; 47:2418-23.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 2418-2423
-
-
Pickard, A.L.1
Wongsrichanalai, C.2
Purfield, A.3
-
36
-
-
42349104331
-
(artemisinin): The price of success
-
White NJ. Qinghaosu (artemisinin): the price of success. Science 2008; 320:330-4.
-
(2008)
Science
, vol.320
, pp. 330-334
-
-
Qinghaosu, W.N.J.1
-
37
-
-
45249099771
-
Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border
-
Wongsrichanalai C, Meshnick SR. Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border. Emerg Infect Dis 2008; 14:716-9.
-
(2008)
Emerg Infect Dis
, vol.14
, pp. 716-719
-
-
Wongsrichanalai, C.1
Meshnick, S.R.2
-
38
-
-
0038239207
-
Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
-
Kublin JG, Cortese JF, Njunju EM, et al. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. J Infect Dis 2003; 187:1870-5.
-
(2003)
J Infect Dis
, vol.187
, pp. 1870-1875
-
-
Kublin, J.G.1
Cortese, J.F.2
Njunju, E.M.3
-
39
-
-
0042808413
-
Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi
-
Mita T, Kaneko A, Lum JK, et al. Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi. Am J Trop Med Hyg 2003; 68:413-5.
-
(2003)
Am J Trop Med Hyg
, vol.68
, pp. 413-415
-
-
Mita, T.1
Kaneko, A.2
Lum, J.K.3
-
40
-
-
1842662623
-
Expansion of wild type allele rather than back mutation in pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi
-
Mita T, Kaneko A, Lum JK, et al. Expansion of wild type allele rather than back mutation in pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi. Mol Biochem Parasitol 2004; 135:159-63.
-
(2004)
Mol Biochem Parasitol
, vol.135
, pp. 159-163
-
-
Mita, T.1
Kaneko, A.2
Lum, J.K.3
-
41
-
-
33750730913
-
Return of chloroquine antimalarial efficacy in Malawi
-
Laufer MK, Thesing PC, Eddington ND, et al. Return of chloroquine antimalarial efficacy in Malawi. N Engl J Med 2006; 355:1959-66.
-
(2006)
N Engl J Med
, vol.355
, pp. 1959-1966
-
-
Laufer, M.K.1
Thesing, P.C.2
Eddington, N.D.3
|