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Volumn 24, Issue 6, 2008, Pages 279-284

Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIMALARIAL AGENT; ATOVAQUONE; AZITHROMYCIN; CHLOROQUINE; CIPROFLOXACIN; CLINDAMYCIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXYCYCLINE; ERYTHROMYCIN; FATTY ACID; FOSMIDOMYCIN; GUANOSINE TRIPHOSPHATASE; GYRASE INHIBITOR; LINCOSAMIDE; MACROLIDE; PENICILLIN DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RHODAMINE 123; RIBOSOME RNA; RIFAMPICIN; RNA POLYMERASE; TETRACYCLINE; THIOSTREPTON; TRANSFER RNA;

EID: 43949134849     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2008.03.007     Document Type: Review
Times cited : (129)

References (69)
  • 1
    • 43949086269 scopus 로고
    • The use of antibiotics in the treatment of malaria
    • Coatney G.R., and Greenberg J. The use of antibiotics in the treatment of malaria. Ann. N. Y. Acad. Sci. 55 (1952) 1075-1081
    • (1952) Ann. N. Y. Acad. Sci. , vol.55 , pp. 1075-1081
    • Coatney, G.R.1    Greenberg, J.2
  • 2
    • 0035991701 scopus 로고    scopus 로고
    • Clindamycin as an antimalarial drug: review of clinical trials
    • Lell B., and Kremsner P.G. Clindamycin as an antimalarial drug: review of clinical trials. Antimicrob. Agents Chemother. 46 (2002) 2315-2320
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2315-2320
    • Lell, B.1    Kremsner, P.G.2
  • 3
    • 0020686105 scopus 로고
    • Falciparum malaria: the urgent need for safe and effective drugs
    • Rieckmann K.H. Falciparum malaria: the urgent need for safe and effective drugs. Annu. Rev. Med. 34 (1983) 321-335
    • (1983) Annu. Rev. Med. , vol.34 , pp. 321-335
    • Rieckmann, K.H.1
  • 4
    • 33748755472 scopus 로고    scopus 로고
    • The past, present and future of antifolates in the treatment of Plasmodium falciparum infection
    • Nzila A. The past, present and future of antifolates in the treatment of Plasmodium falciparum infection. J. Antimicrob. Chemother. 57 (2006) 1043-1054
    • (2006) J. Antimicrob. Chemother. , vol.57 , pp. 1043-1054
    • Nzila, A.1
  • 5
    • 33845987535 scopus 로고    scopus 로고
    • Fatty acid biosynthesis as a drug target in apicomplexan parasites
    • Goodman C.D., and McFadden G.I. Fatty acid biosynthesis as a drug target in apicomplexan parasites. Curr. Drug Targets 8 (2007) 15-30
    • (2007) Curr. Drug Targets , vol.8 , pp. 15-30
    • Goodman, C.D.1    McFadden, G.I.2
  • 6
    • 0020560766 scopus 로고
    • Effects of antibiotics on Plasmodium falciparum in vitro
    • Geary T.G., and Jensen J.B. Effects of antibiotics on Plasmodium falciparum in vitro. Am. J. Trop. Med. Hyg. 32 (1983) 221-225
    • (1983) Am. J. Trop. Med. Hyg. , vol.32 , pp. 221-225
    • Geary, T.G.1    Jensen, J.B.2
  • 7
    • 0024544052 scopus 로고
    • Mitochondria as the site of action of tetracycline on Plasmodium falciparum
    • Kiatfuengfoo R., et al. Mitochondria as the site of action of tetracycline on Plasmodium falciparum. Mol. Biochem. Parasitol. 34 (1989) 109-115
    • (1989) Mol. Biochem. Parasitol. , vol.34 , pp. 109-115
    • Kiatfuengfoo, R.1
  • 8
    • 0023930175 scopus 로고
    • Depression of Plasmodium falciparum dihydroorotate dehydrogenase activity in in vitro culture by tetracycline
    • Prapunwattana P., et al. Depression of Plasmodium falciparum dihydroorotate dehydrogenase activity in in vitro culture by tetracycline. Mol. Biochem. Parasitol. 27 (1988) 119-124
    • (1988) Mol. Biochem. Parasitol. , vol.27 , pp. 119-124
    • Prapunwattana, P.1
  • 9
    • 0028013554 scopus 로고
    • Comparison of mutants of Toxoplasma gondii selected for resistance to azithromycin, spiramycin, or clindamycin
    • Pfefferkorn E.R., and Borotz S.E. Comparison of mutants of Toxoplasma gondii selected for resistance to azithromycin, spiramycin, or clindamycin. Antimicrob. Agents Chemother. 38 (1994) 31-37
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 31-37
    • Pfefferkorn, E.R.1    Borotz, S.E.2
  • 10
    • 0029044369 scopus 로고
    • In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii
    • Fichera M.E., et al. In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii. Antimicrob. Agents Chemother. 39 (1995) 1530-1537
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1530-1537
    • Fichera, M.E.1
  • 11
    • 0025743648 scopus 로고
    • Organisation and expression of small subunit ribosomal RNA genes encoded by a 35-kilobase circular DNA in Plasmodium falciparum
    • Gardner M.J., et al. Organisation and expression of small subunit ribosomal RNA genes encoded by a 35-kilobase circular DNA in Plasmodium falciparum. Mol. Biochem. Parasitol. 48 (1991) 77-88
    • (1991) Mol. Biochem. Parasitol. , vol.48 , pp. 77-88
    • Gardner, M.J.1
  • 12
    • 0030590259 scopus 로고    scopus 로고
    • Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum
    • Wilson R.J., et al. Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum. J. Mol. Biol. 261 (1996) 155-172
    • (1996) J. Mol. Biol. , vol.261 , pp. 155-172
    • Wilson, R.J.1
  • 13
    • 0026538116 scopus 로고
    • The 6-kb element of Plasmodium falciparum encodes mitochondrial cytochrome genes
    • Feagin J.E. The 6-kb element of Plasmodium falciparum encodes mitochondrial cytochrome genes. Mol. Biochem. Parasitol. 52 (1992) 145-148
    • (1992) Mol. Biochem. Parasitol. , vol.52 , pp. 145-148
    • Feagin, J.E.1
  • 14
    • 0024402191 scopus 로고
    • Sequences similar to genes for two mitochondrial proteins and portions of ribosomal RNA in tandemly arrayed 6-kilobase-pair DNA of a malarial parasite
    • Vaidya A.B., et al. Sequences similar to genes for two mitochondrial proteins and portions of ribosomal RNA in tandemly arrayed 6-kilobase-pair DNA of a malarial parasite. Mol. Biochem. Parasitol. 35 (1989) 97-107
    • (1989) Mol. Biochem. Parasitol. , vol.35 , pp. 97-107
    • Vaidya, A.B.1
  • 15
    • 15844369205 scopus 로고    scopus 로고
    • Plastid in human parasites
    • McFadden G.I., et al. Plastid in human parasites. Nature 381 (1996) 482
    • (1996) Nature , vol.381 , pp. 482
    • McFadden, G.I.1
  • 16
    • 0028220332 scopus 로고
    • The evolutionary origin of the 35 kb circular DNA of Plasmodium falciparum: new evidence supports a possible rhodophyte ancestry
    • Williamson D.H., et al. The evolutionary origin of the 35 kb circular DNA of Plasmodium falciparum: new evidence supports a possible rhodophyte ancestry. Mol. Gen. Genet. 243 (1994) 249-252
    • (1994) Mol. Gen. Genet. , vol.243 , pp. 249-252
    • Williamson, D.H.1
  • 17
    • 0040982083 scopus 로고    scopus 로고
    • A plastid of probable green algal origin in apicomplexan parasites
    • Kohler S., et al. A plastid of probable green algal origin in apicomplexan parasites. Science 275 (1997) 1485-1489
    • (1997) Science , vol.275 , pp. 1485-1489
    • Kohler, S.1
  • 18
    • 3142738371 scopus 로고    scopus 로고
    • Evolution: red algal genome affirms a common origin of all plastids
    • McFadden G.I., and van Dooren G.G. Evolution: red algal genome affirms a common origin of all plastids. Curr. Biol. 14 (2004) R514-R516
    • (2004) Curr. Biol. , vol.14
    • McFadden, G.I.1    van Dooren, G.G.2
  • 19
    • 0031444101 scopus 로고    scopus 로고
    • A plastid organelle as a drug target in apicomplexan parasites
    • Fichera M.E., and Roos D.S. A plastid organelle as a drug target in apicomplexan parasites. Nature 390 (1997) 407-409
    • (1997) Nature , vol.390 , pp. 407-409
    • Fichera, M.E.1    Roos, D.S.2
  • 20
    • 0035253864 scopus 로고    scopus 로고
    • A plastid segregation defect in the protozoan parasite Toxoplasma gondii
    • He C.Y., et al. A plastid segregation defect in the protozoan parasite Toxoplasma gondii. EMBO J. 20 (2001) 330-339
    • (2001) EMBO J. , vol.20 , pp. 330-339
    • He, C.Y.1
  • 21
    • 33748707031 scopus 로고    scopus 로고
    • Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum
    • Dahl E.L., et al. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob. Agents Chemother. 50 (2006) 3124-3131
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3124-3131
    • Dahl, E.L.1
  • 22
    • 33847266418 scopus 로고    scopus 로고
    • The effects of anti-bacterials on the malaria parasite Plasmodium falciparum
    • Goodman C.D., et al. The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol. Biochem. Parasitol. 152 (2007) 181-191
    • (2007) Mol. Biochem. Parasitol. , vol.152 , pp. 181-191
    • Goodman, C.D.1
  • 23
    • 33846026771 scopus 로고    scopus 로고
    • Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum
    • Ramya T.N., et al. Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum. Antimicrob. Agents Chemother. 51 (2007) 307-316
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 307-316
    • Ramya, T.N.1
  • 24
    • 34047255258 scopus 로고    scopus 로고
    • In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin
    • Sidhu A.B., et al. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. J. Biol. Chem. 282 (2007) 2494-2504
    • (2007) J. Biol. Chem. , vol.282 , pp. 2494-2504
    • Sidhu, A.B.1
  • 25
    • 34948847580 scopus 로고    scopus 로고
    • Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast
    • Dahl E.L., and Rosenthal P.J. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob. Agents Chemother. 51 (2007) 3485-3490
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 3485-3490
    • Dahl, E.L.1    Rosenthal, P.J.2
  • 26
    • 0037474121 scopus 로고    scopus 로고
    • Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum
    • Foth B.J., et al. Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science 299 (2003) 705-708
    • (2003) Science , vol.299 , pp. 705-708
    • Foth, B.J.1
  • 27
    • 2342520626 scopus 로고    scopus 로고
    • Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
    • Ralph S.A., et al. Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. Nat. Rev. Microbiol. 2 (2004) 203-216
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 203-216
    • Ralph, S.A.1
  • 28
    • 0035986717 scopus 로고    scopus 로고
    • Antibiotics targeting ribosomes: crystallographic studies
    • Auerbach T., et al. Antibiotics targeting ribosomes: crystallographic studies. Curr. Drug Targets Infect. Disord. 2 (2002) 169-186
    • (2002) Curr. Drug Targets Infect. Disord. , vol.2 , pp. 169-186
    • Auerbach, T.1
  • 29
    • 33847770014 scopus 로고    scopus 로고
    • The structure of free L11 and functional dynamics of L11 in free, L11-rRNA(58 nt) binary and L11-rRNA(58 nt)-thiostrepton ternary complexes
    • Lee D., et al. The structure of free L11 and functional dynamics of L11 in free, L11-rRNA(58 nt) binary and L11-rRNA(58 nt)-thiostrepton ternary complexes. J. Mol. Biol. 367 (2007) 1007-1022
    • (2007) J. Mol. Biol. , vol.367 , pp. 1007-1022
    • Lee, D.1
  • 30
    • 0031040480 scopus 로고    scopus 로고
    • The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitors
    • Budimulja A.S., et al. The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitors. Mol. Biochem. Parasitol. 84 (1997) 137-141
    • (1997) Mol. Biochem. Parasitol. , vol.84 , pp. 137-141
    • Budimulja, A.S.1
  • 31
    • 0031030313 scopus 로고    scopus 로고
    • Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton
    • McConkey G.A., et al. Inhibition of Plasmodium falciparum protein synthesis. Targeting the plastid-like organelle with thiostrepton. J. Biol. Chem. 272 (1997) 2046-2049
    • (1997) J. Biol. Chem. , vol.272 , pp. 2046-2049
    • McConkey, G.A.1
  • 32
    • 13444301270 scopus 로고    scopus 로고
    • Parasite plastids: approaching the endgame
    • Wilson R.J. Parasite plastids: approaching the endgame. Biol. Rev. Camb. Philos. Soc. 80 (2005) 129-153
    • (2005) Biol. Rev. Camb. Philos. Soc. , vol.80 , pp. 129-153
    • Wilson, R.J.1
  • 33
    • 0037246674 scopus 로고    scopus 로고
    • PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data
    • Bahl A., et al. PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data. Nucleic Acids Res. 31 (2003) 212-215
    • (2003) Nucleic Acids Res. , vol.31 , pp. 212-215
    • Bahl, A.1
  • 34
    • 0028791643 scopus 로고
    • tRNA genes transcribed from the plastid-like DNA of Plasmodium falciparum
    • Preiser P., et al. tRNA genes transcribed from the plastid-like DNA of Plasmodium falciparum. Nucleic Acids Res. 23 (1995) 4329-4336
    • (1995) Nucleic Acids Res. , vol.23 , pp. 4329-4336
    • Preiser, P.1
  • 35
    • 0033180232 scopus 로고    scopus 로고
    • Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum
    • Clough B., et al. Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum. Protist 150 (1999) 189-195
    • (1999) Protist , vol.150 , pp. 189-195
    • Clough, B.1
  • 36
    • 0030915683 scopus 로고    scopus 로고
    • Thiostrepton binds to malarial plastid rRNA
    • Clough B., et al. Thiostrepton binds to malarial plastid rRNA. FEBS Lett. 406 (1997) 123-125
    • (1997) FEBS Lett. , vol.406 , pp. 123-125
    • Clough, B.1
  • 37
    • 0030791711 scopus 로고    scopus 로고
    • Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite
    • Rogers M.J., et al. Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite. RNA 3 (1997) 815-820
    • (1997) RNA , vol.3 , pp. 815-820
    • Rogers, M.J.1
  • 38
    • 0036227773 scopus 로고    scopus 로고
    • An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii
    • Camps M., et al. An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii. Mol. Microbiol. 43 (2002) 1309-1318
    • (2002) Mol. Microbiol. , vol.43 , pp. 1309-1318
    • Camps, M.1
  • 39
    • 16244385594 scopus 로고    scopus 로고
    • The apicoplast of Plasmodium falciparum is translationally active
    • Chaubey S., et al. The apicoplast of Plasmodium falciparum is translationally active. Mol. Microbiol. 56 (2005) 81-89
    • (2005) Mol. Microbiol. , vol.56 , pp. 81-89
    • Chaubey, S.1
  • 40
    • 34250356847 scopus 로고    scopus 로고
    • 15-Deoxyspergualin primarily targets the trafficking of apicoplast proteins in Plasmodium falciparum
    • Ramya T.N., et al. 15-Deoxyspergualin primarily targets the trafficking of apicoplast proteins in Plasmodium falciparum. J. Biol. Chem. 282 (2007) 6388-6397
    • (2007) J. Biol. Chem. , vol.282 , pp. 6388-6397
    • Ramya, T.N.1
  • 41
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    • Altschul S.F., et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25 (1997) 3389-3402
    • (1997) Nucleic Acids Res. , vol.25 , pp. 3389-3402
    • Altschul, S.F.1
  • 42
    • 33947514521 scopus 로고    scopus 로고
    • The little genome of apicomplexan plastids: its raison d'etre and a possible explanation for the 'delayed death' phenomenon
    • Howe C.J., and Purton S. The little genome of apicomplexan plastids: its raison d'etre and a possible explanation for the 'delayed death' phenomenon. Protist 158 (2007) 121-133
    • (2007) Protist , vol.158 , pp. 121-133
    • Howe, C.J.1    Purton, S.2
  • 43
    • 27744569528 scopus 로고    scopus 로고
    • Antibiotic susceptibility of mammalian mitochondrial translation
    • Zhang L., et al. Antibiotic susceptibility of mammalian mitochondrial translation. FEBS Lett. 579 (2005) 6423-6427
    • (2005) FEBS Lett. , vol.579 , pp. 6423-6427
    • Zhang, L.1
  • 44
    • 1342303735 scopus 로고    scopus 로고
    • Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray
    • Bozdech Z., et al. Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol. 4 (2003) R9
    • (2003) Genome Biol. , vol.4
    • Bozdech, Z.1
  • 46
    • 4243071596 scopus 로고    scopus 로고
    • The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum
    • 10.1371/journal.pbio.0000005
    • Bozdech Z., et al. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 1 (2003) e5. http://biology.plosjournals.org 10.1371/journal.pbio.0000005
    • (2003) PLoS Biol. , vol.1
    • Bozdech, Z.1
  • 47
    • 0036065460 scopus 로고    scopus 로고
    • The plastid DNA of the malaria parasite Plasmodium falciparum is replicated by two mechanisms
    • Williamson D.H., et al. The plastid DNA of the malaria parasite Plasmodium falciparum is replicated by two mechanisms. Mol. Microbiol. 45 (2002) 533-542
    • (2002) Mol. Microbiol. , vol.45 , pp. 533-542
    • Williamson, D.H.1
  • 48
    • 22144494182 scopus 로고    scopus 로고
    • Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum
    • van Dooren G.G., et al. Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. Mol. Microbiol. 57 (2005) 405-419
    • (2005) Mol. Microbiol. , vol.57 , pp. 405-419
    • van Dooren, G.G.1
  • 49
    • 0026069346 scopus 로고
    • A circular DNA in malaria parasites encodes an RNA polymerase like that of prokaryotes and chloroplasts
    • Gardner M.J., et al. A circular DNA in malaria parasites encodes an RNA polymerase like that of prokaryotes and chloroplasts. Mol. Biochem. Parasitol. 44 (1991) 115-123
    • (1991) Mol. Biochem. Parasitol. , vol.44 , pp. 115-123
    • Gardner, M.J.1
  • 50
    • 0029934521 scopus 로고    scopus 로고
    • Deletion of rpoB reveals a second distinct transcription system in plastids of higher plants
    • Allison L.A., et al. Deletion of rpoB reveals a second distinct transcription system in plastids of higher plants. EMBO J. 15 (1996) 2802-2809
    • (1996) EMBO J. , vol.15 , pp. 2802-2809
    • Allison, L.A.1
  • 51
    • 0031011722 scopus 로고    scopus 로고
    • The two RNA polymerases encoded by the nuclear and the plastid compartments transcribe distinct groups of genes in tobacco plastids
    • Hajdukiewicz P.T., et al. The two RNA polymerases encoded by the nuclear and the plastid compartments transcribe distinct groups of genes in tobacco plastids. EMBO J. 16 (1997) 4041-4048
    • (1997) EMBO J. , vol.16 , pp. 4041-4048
    • Hajdukiewicz, P.T.1
  • 52
    • 0035815328 scopus 로고    scopus 로고
    • Identification and characterization of a Plasmodium falciparum RNA polymerase gene with similarity to mitochondrial RNA polymerases
    • Li J., et al. Identification and characterization of a Plasmodium falciparum RNA polymerase gene with similarity to mitochondrial RNA polymerases. Mol. Biochem. Parasitol. 113 (2001) 261-269
    • (2001) Mol. Biochem. Parasitol. , vol.113 , pp. 261-269
    • Li, J.1
  • 53
    • 0242361265 scopus 로고    scopus 로고
    • Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum
    • Bender A., et al. Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum. Mol. Biochem. Parasitol. 132 (2003) 59-66
    • (2003) Mol. Biochem. Parasitol. , vol.132 , pp. 59-66
    • Bender, A.1
  • 54
    • 0035666657 scopus 로고    scopus 로고
    • Deciphering apicoplast targeting signals-feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins
    • Zuegge J., et al. Deciphering apicoplast targeting signals-feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins. Gene 280 (2001) 19-26
    • (2001) Gene , vol.280 , pp. 19-26
    • Zuegge, J.1
  • 55
    • 11144344532 scopus 로고    scopus 로고
    • Multiple replication origins within the inverted repeat region of the Plasmodium falciparum apicoplast genome are differentially activated
    • Singh D., et al. Multiple replication origins within the inverted repeat region of the Plasmodium falciparum apicoplast genome are differentially activated. Mol. Biochem. Parasitol. 139 (2005) 99-106
    • (2005) Mol. Biochem. Parasitol. , vol.139 , pp. 99-106
    • Singh, D.1
  • 56
    • 17844368368 scopus 로고    scopus 로고
    • The plastidic DNA replication enzyme complex of Plasmodium falciparum
    • Seow F., et al. The plastidic DNA replication enzyme complex of Plasmodium falciparum. Mol. Biochem. Parasitol. 141 (2005) 145-153
    • (2005) Mol. Biochem. Parasitol. , vol.141 , pp. 145-153
    • Seow, F.1
  • 57
    • 34249986680 scopus 로고    scopus 로고
    • Nuclear gyrB encodes a functional subunit of the Plasmodium falciparum gyrase that is involved in apicoplast DNA replication
    • Raghu Ram E.V., et al. Nuclear gyrB encodes a functional subunit of the Plasmodium falciparum gyrase that is involved in apicoplast DNA replication. Mol. Biochem. Parasitol. 154 (2007) 30-39
    • (2007) Mol. Biochem. Parasitol. , vol.154 , pp. 30-39
    • Raghu Ram, E.V.1
  • 58
    • 33947638347 scopus 로고    scopus 로고
    • Molecular cloning of apicoplast-targeted Plasmodium falciparum DNA gyrase genes: unique intrinsic ATPase activity and ATP-independent dimerization of PfGyrB subunit
    • Dar M.A., et al. Molecular cloning of apicoplast-targeted Plasmodium falciparum DNA gyrase genes: unique intrinsic ATPase activity and ATP-independent dimerization of PfGyrB subunit. Eukaryot. Cell 6 (2007) 398-412
    • (2007) Eukaryot. Cell , vol.6 , pp. 398-412
    • Dar, M.A.1
  • 59
    • 0023927675 scopus 로고
    • Ciprofloxacin and malaria
    • Krishna S., et al. Ciprofloxacin and malaria. Lancet 1 (1988) 1231-1232
    • (1988) Lancet , vol.1 , pp. 1231-1232
    • Krishna, S.1
  • 60
    • 0031431683 scopus 로고    scopus 로고
    • Topoisomerase II inhibitors induce cleavage of nuclear and 35-kb plastid DNAs in the malarial parasite Plasmodium falciparum
    • Weissig V., et al. Topoisomerase II inhibitors induce cleavage of nuclear and 35-kb plastid DNAs in the malarial parasite Plasmodium falciparum. DNA Cell Biol. 16 (1997) 1483-1492
    • (1997) DNA Cell Biol. , vol.16 , pp. 1483-1492
    • Weissig, V.1
  • 61
    • 0038778553 scopus 로고    scopus 로고
    • Mechanisms of quinolone action and microbial response
    • Hawkey P.M. Mechanisms of quinolone action and microbial response. J. Antimicrob. Chemother. 51 Suppl 1 (2003) 29-35
    • (2003) J. Antimicrob. Chemother. , vol.51 , Issue.SUPPL. 1 , pp. 29-35
    • Hawkey, P.M.1
  • 62
    • 0037228888 scopus 로고    scopus 로고
    • A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum
    • Waller R.F., et al. A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrob. Agents Chemother. 47 (2003) 297-301
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 297-301
    • Waller, R.F.1
  • 63
    • 0033520336 scopus 로고    scopus 로고
    • Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    • Jomaa H., et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285 (1999) 1573-1576
    • (1999) Science , vol.285 , pp. 1573-1576
    • Jomaa, H.1
  • 64
    • 0031052025 scopus 로고    scopus 로고
    • Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite
    • Srivastava I.K., et al. Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J. Biol. Chem. 272 (1997) 3961-3966
    • (1997) J. Biol. Chem. , vol.272 , pp. 3961-3966
    • Srivastava, I.K.1
  • 65
    • 0035008795 scopus 로고    scopus 로고
    • In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron
    • Pradines B., et al. In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron. Antimicrob. Agents Chemother. 45 (2001) 1746-1750
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1746-1750
    • Pradines, B.1
  • 66
    • 0028933049 scopus 로고
    • Increased antimalarial activity of azithromycin during prolonged exposure of Plasmodium falciparum in vitro
    • Yeo A.E., and Rieckmann K.H. Increased antimalarial activity of azithromycin during prolonged exposure of Plasmodium falciparum in vitro. Int. J. Parasitol. 25 (1995) 531-532
    • (1995) Int. J. Parasitol. , vol.25 , pp. 531-532
    • Yeo, A.E.1    Rieckmann, K.H.2
  • 67
    • 0021946977 scopus 로고
    • Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture
    • Divo A.A., et al. Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture. Antimicrob. Agents Chemother. 27 (1985) 21-27
    • (1985) Antimicrob. Agents Chemother. , vol.27 , pp. 21-27
    • Divo, A.A.1
  • 68
    • 0031917769 scopus 로고    scopus 로고
    • The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite
    • Rogers M.J., et al. The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite. Antimicrob. Agents Chemother. 42 (1998) 715-716
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 715-716
    • Rogers, M.J.1
  • 69
    • 0023686315 scopus 로고
    • Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro
    • Divo A.A., et al. Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 32 (1988) 1182-1186
    • (1988) Antimicrob. Agents Chemother. , vol.32 , pp. 1182-1186
    • Divo, A.A.1


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