Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system

Journal of Biological Chemistry

Volumn 280, Issue 29, 2005, Pages 27458-27465

  Mather, Michael W ^a   Darrouzet, Elisabeth ^b,c   Valkova Valchanova, Maria ^b,d   Cooley, Jason W ^b   McIntosht, Michael T ^a,e   Daldal, Fevzi ^b   Vaidya, Akhil B ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CEA Marcoule   (France)

^d MEDAREX INC   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELL MEMBRANES; CELLS; IRON; MALARIA CONTROL; MUTAGENESIS; PROTEINS; SULFUR;

ANTIPARASITIC DRUGS; ATOVAQUONE; CYTOCHROMES; MITOCHONDRIAL MEMBRANES;

DRUG PRODUCTS;

ANTIMALARIAL AGENT; ATOVAQUONE; CYTOCHROME B; CYTOCHROME C; MYXOTHIAZOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; STIGMATELLIN; UBIQUINOL CYTOCHROME C REDUCTASE;

ANTIMALARIAL ACTIVITY; ARTICLE; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME INHIBITION; ESCHERICHIA COLI; GENE MUTATION; MALARIA; MITOCHONDRIAL MEMBRANE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ANTIMALARIALS; ATOVAQUONE; BACTERIAL PROTEINS; CYTOCHROMES B; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; NAPHTHOQUINONES; OXIDATION-REDUCTION;

MAMMALIA;

EID: 22844435982     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502319200     Document Type: Article

References (43)

1. Sachs, J., and Malaney, P. (2002) Nature 415, 680-685
2. Snow, R. W., Guerra, C. A., Noor, A. M., Myint, H. Y., and Hay, S. I. (2005) Nature 434, 214-217
3. Chiodini, P. L., Conlon, C. P., Hutchinson, D. B., Farquhar, J. A., Hall, A. P., Peto, T. E., Birley, H., and Warrell, D. A. (1995) J. Antimicrob. Chemother. 36, 1073-1078
4. Looareesuwan, S., Viravan, C., Webster, H. K., Kyle, D. E., Hutchinson, D. B., and Canfield, C. J. (1996) Am. J. Trop. Med. Hyg. 54, 62-66
5. Looareesuwan, S., Chulay, J. D., Canfield, C. J., and Hutchinson, D. B. (1999) Am. J. Trop. Med. Hyg. 60, 533-541
6. Ling, J., Baird, J. K., Fryauff, D. J., Sismadi, P., Bangs, M. J., Lacy, M., Barcus, M. J., Gramzinski, R., Maguire, J. D., Kumusumangsih, M., Miller, G. B., Jones, T. R., Chulay, J. D., and Hoffman, S. L. (2002) Clin. Infect. Dis. 35, 825-833
7. Lacy, M. D., Maguire, J. D., Barcus, M. J., Ling, J., Bangs, M. J., Gramzinski, R., Basri, H., Sismadi, P., Miller, G. B., Chulay, J. D., Fryauff, D. J., Hoffman, S. L., and Baird, J. K. (2002) Clin. Infect. Dis. 35, e92-e95
8. Fivelman, Q. L., Adagu, I. S., and Warhurst, D. C. (2004) Antimicrob. Agents Chemother. 48, 4097-4102
9. Srivastava, I. K., Morrisey, J. M., Darrouzet, E., Daldal, F., and Vaidya, A. B. (1999) Mol. Microbiol. 33, 704-711
10. Fry, M., and Pudney, M. (1992) Biochem. Pharmacol. 43, 1545-1553
11. Srivastava, I. K., Rottenberg, H., and Vaidya, A. B. (1997) J. Biol. Chem. 272, 3961-3966
12. Srivastava, I. K., and Vaidya, A. B. (1999) Antimicrob. Agents Chemother. 43, 1334-1339
13. Fivelman, Q. L., Butcher, G. A., Adagu, I. S., Warhurst, D. C., and Pasvol, G. (2002) Malar. J. 1, 1
14. Korsinczky, M., Chen, N., Kotecka, B., Saul, A., Rieckmann, K., and Cheng, Q. (2000) Antimicrob. Agents Chemother. 44, 2100-2108
15. Syafruddin, D., Siregar, J. E., and Marzuki, S. (1999) Mol. Biochem. Parasitol. 104, 185-194
16. Zhang, Z., Huang, L., Shulmeister, V. M., Chi, Y. I., Kim, K. K., Hung, L. W., Crofts, A. R., Berry, E. A., and Kim, S. H. (1998) Nature 392, 677-684
17. Kim, H., Xia, D., Yu, C. A., Xia, J. Z., Kachurin, A. M., Zhang, L., Yu, L., and Deisenhofer, J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8026-8033
18. Hunte, C., Koepke, J., Lange, C., Rossmanith, T., and Michel, H. (2000) Structure Fold. Des. 8, 669-684
19. Berry, E. A., Huang, L.-S., Saechao, L. K., Pon, N. G., Valkova-Valchanova, M., and Daldal, F. (2004) Photosynth. Res. 81, 251-275
20. Trumpower, B. L., and Gennis, R. B. (1994) Annu. Rev. Biochem. 63, 675-716
21. Schutz, M., Brugna, M., Lebrun, E., Baymann, F., Huber, R., Stetter, K. O., Hauska, G., Toci, R., Lemesle-Meunier, D., Tron, P., Schmidt, C., and Nitschke, W. (2000) J. Mol. Biol. 300, 663-675
22. Darrouzet, E., Cooley, J. W., and Daldal, F. (2004) Photosynth. Res. 79, 25-44
23. Berry, E. A., Guergova-Kuras, M., Huang, L. S., and Crofts, A. R. (2000) Annu. Rev. Biochem. 69, 1005-1075
24. Darrouzet, E., Valkova-Valchanova, M., Moser, C. C., Dutton, P. L., and Daldal, F. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4567-4572
25. Valkova-Valchanova, M., Darrouzet, E., Moomaw, C. R., Slaughter, C. A., and Daldal, F. (2000) Biochemistry 39, 15484-15492
26. Xiao, K., Yu, L., and Yu, C. A. (2000) J. Biol. Chem. 275, 38597-38604
27. Atta-Asafo-Adjei, E., and Daldal, F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 492-496
28. Beatty, J. T., and Gest, H. (1981) Arch. Microbiol. 129, 335-340
29. Gray, K. A., Dutton, P. L., and Daldal, F. (1994) Biochemistry 33, 723-733
30. Myllykallio, H., Zannoni, D., and Daldal, F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4348-4353
31. Saribas, A. S., Valkova-Valchanova, M., Tokito, M. K., Zhang, Z., Berry, E. A., and Daldal, F. (1998) Biochemistry 37, 8105-8114
32. Zannoni, D., Venturoli, G., and Daldal, F. (1992) Arch. Microbiol. 157, 367-374
33. Daldal, F., Tokito, M. K., Davidson, E., and Faham, M. (1989) EMBO J. 8, 3951-3961
34. Esser, L., Quinn, B., Li, Y. F., Zhang, M., Elberry, M., Yu, L., Yu, C. A., and Xia, D. (2004) J. Mol. Biol. 341, 281-302
35. Ding, H., Robertson, D. E., Daldal, F., and Dutton, P. L. (1992) Biochemistry 31, 3144-3158
36. Ding, H., Moser, C. C., Robertson, D. E., Tokito, M. K., Daldal, F., and Dutton, P. L. (1995) Biochemistry 34, 15979-15996
37. Darrouzet, E., Moser, C. C., Dutton, P. L., and Daldal, F. (2001) Trends Biochem. Sci 26, 445-451
38. Kessl, J. J., Hill, P., Lange, B. B., Meshnick, S. R., Meunier, B., and Trumpower, B. L. (2004) J. Biol. Chem. 279, 2817-2824
39. Kessl, J. J., Lange, B. B., Merbitz-Zahradnik, T., Zwicker, K., Hill, P., Meunier, B., Palsdottir, H., Hunte, C., Meshnick, S., and Trumpower, B. L. (2003) J. Biol. Chem. 278, 31312-31318
40. Crofts, A. R., Guergova-Kuras, M., Kuras, R., Ugulava, N., Li, J., and Hong, S. (2000) Biochim. Biophys. Acta 1459, 456-466
41. Wibrand, F., Ravn, K., Schwartz, M., Rosenberg, T., Horn, N., and Vissing, J. (2001) Ann. Neurol. 50, 540-543
42. Peters, J. M., Chen, N., Gatton, M., Korsinczky, M., Fowler, E. V., Manzetti, S., Saul, A., and Cheng, Q. (2002) Antimicrob. Agents Chemother. 46, 2435-2441
43. Kublin, J. G., Cortese, J. F., Njunju, E. M., Mukadam, R. A., Wirima, J. J., Kazembe, P. N., Djimde, A. A., Kouriba, B., Taylor, T. E., and Plowe, C. V. (2003) J. Infect. Dis. 187, 1870-1875