Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones

Journal of Biological Chemistry

Volumn 276, Issue 43, 2001, Pages 39713-39720

  García Piñeres, Alfonso J ^a   Castro, Víctor ^b   Mora, Gerardo ^b   Schmidt, Thomas J ^c   Strunck, Elisabeth ^d   Pahl, Heike L ^d   Merfort, Irmgard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DEGRADATION; ENZYME INHIBITION;

TRANSCRIPTION FACTOR;

DNA;

CYSTEINE; DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PARTHENOLIDE; SERINE; SESQUITERPENE LACTONE; SYNAPTOTAGMIN; DNA BINDING PROTEIN; I KAPPA B; LACTONE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NONSTEROID ANTIINFLAMMATORY AGENT; PLENOLIN; PROTEIN SUBUNIT; QUERCETIN; SESQUITERPENE; TRANSCRIPTION FACTOR RELA;

ALKYLATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; DRUG ANTAGONISM; DRUG DESIGN; METABOLISM; PROTEIN BINDING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYSTEINE; DNA-BINDING PROTEINS; DRUG DESIGN; I-KAPPA B PROTEINS; LACTONES; NF-KAPPA B; PROTEIN BINDING; PROTEIN SUBUNITS; QUERCETIN; SESQUITERPENES; TRANSCRIPTION FACTOR RELA;

EID: 0035955729     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101985200     Document Type: Article

References (46)

1. Baeuerle, P. A., and Henkel, T. (1994) Annu. Rev. Immunol. 12, 141-179
2. Pahl, H. L. (1999) Oncogene 18, 6853-6866
3. Cho, J. Y., Park, J. S., Yoo, E. S., Baik, K. U., Jung, J. H., Lee, J. S., and Park, M. H. (1998) Planta Med. 64, 594-597
4. Barnes, P. J., and Karin, M. (1997) N. Engl. J. Med. 336, 1066-1071
5. Lyss, G., Knorre, A., Schmidt, T. J., Pahl, H. L., and Merfort, I. (1998) J. Biol. Chem. 273, 33508-33516
6. Lyss, G., Schmidt, T. J., Merfort, I., and Pahl, H. L. (1997) Biol. Chem. 378, 951-961
7. Rüngeler, P., Lyss, G., Castro, V., Mora, G., Pahl, H. L., and Merfort, I. (1998) Planta Med. 64, 588-593
8. Rüngeler, P., Castro, V., Mora, G., Gören, N., Vichnewski, W., Pahl, H. L., Merfort, I., and Schmidt, T. J. (1999) Bioorg. Med. Chem. 7, 2343-2352
9. Schmidt, T. J. (1997) Bioorg. Med. Chem. 5, 645-653
10. Dupuis, G., Mitchell, J. C., and Towers, G. H. N. (1974) Can. J. Biochem. 52, 575-581
11. Picman, A. K., Rodríguez, E., and Towers, G. H. N. (1979) Chem. Biol. Interact. 28, 83-89
12. Chen, Y.-Q., Ghosh, S., and Ghosh, G. (1998) Nat. Struct. Biol. 5, 67-73
13. Hehner, S. P., Hofmann, T. G., Dröge, W., and Schmitz, M. L. (1999) J. Immunol. 163, 5617-5623
14. Hehner, S. P., Heinrich, M., Bork, P. M., Vogt, M., Ratter, F., Lehmann, V., Schulze-Östhoff, K., Dröge, W., and Schmitz, M. L. (1998) J. Biol. Chem. 273, 1288-1297
15. Willuhn, G., Kresken, J., and Leven, W. (1990) Planta Med. 56, 111-114
16. Castro, V., Rüngeler, P., Murillo, R., Hernandez, E., Mora, G., Pahl, H. L., and Merfort, I. (2000) Phytochemistry 53, 257-263
17. Merfort, I. (1985) Planta Med. 51, 136-138
18. Kieran, M., Blank, V., Logeat, F., Vandekerekhove, J., Lottspeich, F., Le Bail, O., Urban, M. R. K. P., Baeuerle, P. A., and Israel, A. (1990) Cell 62, 1007-1018
19. Ruben, S. M., Dillon, P. J., Schreek, R., Henkel, T., Chen, C.-H., Maher, M., Baeuerle, P. A., and Rosen, C. A. (1991) Science 251, 1490-1493
20. Schmitz, M. L., and Baeuerle, P. A. (1991) EMBO J. 10, 3805-3817
21. Baeuerle, P. A., and Baltimore, D. (1988) Cell 53, 211-217
22. Tsai, S.-H., Liang, Y.-C., Lin-Shiau, S.-Y., and Lin, J. (1999) J. Cell. Biochem. 74, 606-615
23. Peet, G. W., and Li, J. (1999) J. Biol. Chem. 274, 32655-32661
24. Urban, M. B., and Baeuerle, P. A. (1991) New. Biol. 3, 279-288
25. Henkel, T., Machleidt, T., Alkalay, I., Krönke, M., Ben-Neriah, Y., and Baeuerle, P. A. (1993) Nature 365, 182-185
26. Li, X., Fang, Y., Zhao, X., Jiang, X., Duong, T., and Kain, S. R. (1999) J. Biol. Chem. 274, 21244-21250
27. Tzen, C.-Y., Cox, R. L., and Scott, R. E. (1994) Exp. Cell Res. 211, 12-16
28. Lofquist, A. K., Mondal, K., Morris, J. S., and Haskill, J. S. (1995) Mol. Cell. Biol. 15, 1737-1746
29. Schinella, G. R., Giner, R. M., Recio, M. D., De Buschiazzo, P. M., Rios, J. L., and Manez, S. (1998) J. Pharm. Pharmacol. 50, 1069-1074
30. Willuhn, G. (2000) in Herbal Medicinal Products for the Treatment of Pain (Chrubasik, S., and Roufogalis, B. D., eds) pp. 105-115, Southern Cross University Press, Lismore, New South Wales, Australia
31. Knight, D. W. (1995) Nat. Prod. Rep. 12, 271-276
32. Merfort, I. (1990) in Hagers Handbuch der Pharmazeutischen Praxis (Hänsel, R., Keller, K., and Rimpler, H., eds) pp. 342-357, Springer-Verlag, Berlin
33. Hall, I. H., Lee, K.-H., Starnes, C. O., Sumida, Y., Wu, R. Y., Wadell, T. G., Cochran, J. W., and Gerhart, K. G. (1979) J. Pharmacol. Sci. 68, 537-541
34. Hall, I. H., Starnes, C. O., Lee, K.-H., and Wadell, T. G. (1980) J. Pharmacol. Sci. 69, 537-543
35. Schröder, H., Lösche, Strobach, Leven, W., Willuhn, G., Till, U., and Schrör, K. (1990) Thromb. Res. 57, 839-845
36. Castro, V., Murillo, R., Klaas, C. A., Meunier, C., Mora, G., Pahl, H. L., and Merfort, I. (2000) Planta Med. 66, 591-595
37. Kumar, S., Rabson, A. B., and Gélinas, C. (1992) Mol. Cell. Biol. 12, 3094-3106
38. Wong, H. R., and Menéndez, I. Y. (1999) Biochem. Biophys. Res. Commun. 262, 375-380
39. Mazor, R. L., Menéndez, I. Y., Ryan, M. A., Fiedler, M. A., and Wong, H. R. (1999) Cytokine 12, 239-245
40. Kapahi, P., Takahashi, T., Natoli, G., Adams, S. R., Chen, Y., Tsien, R. Y., and Karin, M. (2000) J. Biol. Chem. 275, 36062-36066
41. Rossi, A., Kapahi, P., Natoli, G., Takahashi, T., Chen, Y., Karin, M., and Santoro, G. (2000) Nature 403, 103-108
42. Béraud, C., Henzel, W. J., and Baeuerle, P. A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 429-434
43. Baeuerle, P. A., and Baichwal, V. R. (1997) Adv. Immunol. 65, 111-137
44. Zidorn, C., Dirsch, V. M., Rungeler, P., Sosa, S., Della, L., Merfort, I., Pahl, H. L., Vollmar, A. M., and Stuppner, H. (1999) Planta Med. 65, 704-708
45. Lee, H. J., Kim, N. Y., Jang, M. K., Son, H. J., Kim, K. M., Sohn, D. H., Lee, S. H., and Ryu, J. H. (1999) Planta Med. 65, 104-108
46. Koch, E., Klaas, C. A., Rüngeler, P., Castro, V., Mora, G., Vichnewski, W., and Merfort, I. (2001) Biochem. Pharmacol. 62, 795-801