Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins

Molecular and Biochemical Parasitology

Volumn 89, Issue 2, 1997, Pages 161-177

  Wang, Ping ^a   Lee, Chung Shinn ^a   Bayoumi, Riad ^b   Djimde, Abdoulaye ^c   Doumbo, Ogobara ^c   Swedberg, Göte ^d   Dao, Le Duc ^e   Mshinda, Hassan ^f   Tanner, Marcel ^g   Watkins, William M ^h   Sims, Paul F G ^a   Hyde, John E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^c UNIVERSITY OF BAMAKO   (Mali)

^d UPPSALA UNIVERSITY   (Sweden)

^e Inst Malariology   (Viet Nam)

^f IFAKARA HEALTH INSTITUTE   (Tanzania)

^g SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^h KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

Author keywords

Dihydrofolate reductase; Dihydropteroate synthetase; Fansidar resistance; Plasmodium falciparum; Pyrimethamine; Sulfadoxine

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; PYRIMETHAMINE; SULFADOXINE;

AFRICA; ALLELE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG RESISTANCE; MALARIA; MIDDLE EAST; MUTATION; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AFRICA; ALLELES; ANIMALS; ANTIMALARIALS; DIHYDROPTEROATE SYNTHASE; DNA MUTATIONAL ANALYSIS; DRUG COMBINATIONS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; GENES, PROTOZOAN; HUMANS; MALARIA, FALCIPARUM; MIDDLE EAST; PLASMODIUM FALCIPARUM; POINT MUTATION; PYRIMETHAMINE; SULFADOXINE; TETRAHYDROFOLATE DEHYDROGENASE; VIETNAM;

EID: 0030801206     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00114-X     Document Type: Article

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