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Volumn 4, Issue 4, 2009, Pages 441-455

Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria

Author keywords

Digestive vacuole; Hemozoln; Multidrug resistance; Plasmodium falciparum chloroquine resistance transporter

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMODIAQUINE; ARTEMISIN; ARTEMISININ DERIVATIVE; CHLOROQUINE; CYCLOGUANIL; ENDOPEROXIDE; FOLIC ACID ANTAGONIST; MEFLOQUINE; MICROORGANISM PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN CG2; PROTEIN CRT; PYRIMETHAMINE; QUINIDINE; QUININE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; QUINOLINE; QUINOLINE DERIVATIVE;

EID: 66949146530     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/fmb.09.15     Document Type: Review
Times cited : (49)

References (100)
  • 1
    • 0022930404 scopus 로고
    • Uptake of (3H)chloroquine by drug sensitive and resistant strains of the human malaria parasite Plasmodium falciparum
    • Geary TG, Jensen JB, Ginsburg H: Uptake of (3H)chloroquine by drug sensitive and resistant strains of the human malaria parasite Plasmodium falciparum. Biochem. Pharmacol. 35, 3805-3812 (1986).
    • (1986) Biochem. Pharmacol , vol.35 , pp. 3805-3812
    • Geary, T.G.1    Jensen, J.B.2    Ginsburg, H.3
  • 2
    • 0030451452 scopus 로고    scopus 로고
    • Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum
    • Bray PG, Hawley SR, Mungthin M, Ward SA: Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum. Mol. Pharmacol. 50, 1559-1566 (1996).
    • (1996) Mol. Pharmacol , vol.50 , pp. 1559-1566
    • Bray, P.G.1    Hawley, S.R.2    Mungthin, M.3    Ward, S.A.4
  • 4
    • 0023105195 scopus 로고
    • The basis of antimalarial action: Non-weak base effects of chloroquine on acid vesicle pH
    • Krogstad DJ, Schlesinger PH: The basis of antimalarial action: non-weak base effects of chloroquine on acid vesicle pH. J. Trop. Med. Hygiene 36, 213-220 (1987).
    • (1987) J. Trop. Med. Hygiene , vol.36 , pp. 213-220
    • Krogstad, D.J.1    Schlesinger, P.H.2
  • 5
    • 33646474569 scopus 로고    scopus 로고
    • Interactions of quinoline antimalarials with hematin in solution
    • Egan TJ: Interactions of quinoline antimalarials with hematin in solution. J. Inorg. Biochem. 100(5-6), 916-926 (2006).
    • (2006) J. Inorg. Biochem , vol.100 , Issue.5-6 , pp. 916-926
    • Egan, T.J.1
  • 6
    • 0036720312 scopus 로고    scopus 로고
    • Recent progress in elucidating the molecular mechanism of resistance to the antimalarial drug chloroquine
    • Ursos LMB, Roepe PD: Recent progress in elucidating the molecular mechanism of resistance to the antimalarial drug chloroquine. Med. Res. Rev. 22(5), 465-491 (2002).
    • (2002) Med. Res. Rev , vol.22 , Issue.5 , pp. 465-491
    • Ursos, L.M.B.1    Roepe, P.D.2
  • 8
    • 0031964307 scopus 로고    scopus 로고
    • A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum
    • Bray PG, Ward SA: A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum. Pharmacol. Ther. 77, 1-28 (1998).
    • (1998) Pharmacol. Ther , vol.77 , pp. 1-28
    • Bray, P.G.1    Ward, S.A.2
  • 9
  • 10
    • 0242408771 scopus 로고    scopus 로고
    • Inhibition of heme crystal growth by antimalarials and other compounds: Implications for drug discovery
    • Chong CR, Sullivan DJ Jr: Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery. Biochem. Pharmacol. 66(11), 2201-2212 (2003).
    • (2003) Biochem. Pharmacol , vol.66 , Issue.11 , pp. 2201-2212
    • Chong, C.R.1    Sullivan Jr, D.J.2
  • 11
    • 0000884823 scopus 로고
    • Complex formation between chloroquine and ferrihaemic acid in vitro, and its effect on the antimalarial action of chloroquine
    • Cohen SN, Phifer KO, Yielding KL: Complex formation between chloroquine and ferrihaemic acid in vitro, and its effect on the antimalarial action of chloroquine. Nature 202, 805-806 (1964).
    • (1964) Nature , vol.202 , pp. 805-806
    • Cohen, S.N.1    Phifer, K.O.2    Yielding, K.L.3
  • 12
    • 0014650528 scopus 로고
    • Chloroquine resistance in malaria: A deficiency of chloroquine binding
    • Fitch CD: Chloroquine resistance in malaria: a deficiency of chloroquine binding. Proc. Natl Acad. Sci. USA 64(4), 1181-1187 (1969).
    • (1969) Proc. Natl Acad. Sci. USA , vol.64 , Issue.4 , pp. 1181-1187
    • Fitch, C.D.1
  • 15
    • 33750088680 scopus 로고    scopus 로고
    • Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites, 1. Quantification of hemozoin development for drug sensitive versus resistant malaria
    • Gligorijevic B, McAllister R, Urbach JS, Roepe PD: Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites, 1. Quantification of hemozoin development for drug sensitive versus resistant malaria. Biochemistry 45(41), 12400-12410 (2006).
    • (2006) Biochemistry , vol.45 , Issue.41 , pp. 12400-12410
    • Gligorijevic, B.1    McAllister, R.2    Urbach, J.S.3    Roepe, P.D.4
  • 16
    • 0028947372 scopus 로고
    • Malarial hemazoin/ β-hematin supports heme polymerization in the absence of protein
    • Dorn A, Stoffel R, Matile H, Bubendorf A, Ridley RG: Malarial hemazoin/ β-hematin supports heme polymerization in the absence of protein. Nature 374, 269-271 (1995).
    • (1995) Nature , vol.374 , pp. 269-271
    • Dorn, A.1    Stoffel, R.2    Matile, H.3    Bubendorf, A.4    Ridley, R.G.5
  • 19
    • 10044257575 scopus 로고    scopus 로고
    • Structure of the amodiaquine - FPIX μ oxo dimer solution complex at atomic resolution
    • de Dios AC, Casabianca LB, Kosar A, Roepe PD: Structure of the amodiaquine - FPIX μ oxo dimer solution complex at atomic resolution. Inorg. Chem. 43(25), 8078-8084 (2004).
    • (2004) Inorg. Chem , vol.43 , Issue.25 , pp. 8078-8084
    • de Dios, A.C.1    Casabianca, L.B.2    Kosar, A.3    Roepe, P.D.4
  • 21
    • 0345528107 scopus 로고    scopus 로고
    • Acidic digestive vacuolar pH of drug resistant Plasmodium falciparum
    • Bennett TN, Kosar AD, Ursos LMB et al.: Acidic digestive vacuolar pH of drug resistant Plasmodium falciparum. Mol. Biochem. Parasitol. 133, 99-114 (2004).
    • (2004) Mol. Biochem. Parasitol , vol.133 , pp. 99-114
    • Bennett, T.N.1    Kosar, A.D.2    Ursos, L.M.B.3
  • 22
    • 33750090345 scopus 로고    scopus 로고
    • Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria
    • Gligorijevic B, Bennett T, McAllister R, Urbach JS, Roepe PD: Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria. Biochemistry 45(41), 12411-12423 (2006).
    • (2006) Biochemistry , vol.45 , Issue.41 , pp. 12411-12423
    • Gligorijevic, B.1    Bennett, T.2    McAllister, R.3    Urbach, J.S.4    Roepe, P.D.5
  • 23
    • 0033082759 scopus 로고    scopus 로고
    • Are ion exchange processes central to understanding drug resistance phenomena?
    • Roepe PD, Martiney JA: Are ion exchange processes central to understanding drug resistance phenomena? Trends Pharmacol. Sci. 20, 62-65 (1998).
    • (1998) Trends Pharmacol. Sci , vol.20 , pp. 62-65
    • Roepe, P.D.1    Martiney, J.A.2
  • 24
    • 33846945465 scopus 로고    scopus 로고
    • The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization
    • Pisciotta JM, Coppens I, Tripathi AK et al.: The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization. Biochem. J. 402(1), 197-204 (2007).
    • (2007) Biochem. J , vol.402 , Issue.1 , pp. 197-204
    • Pisciotta, J.M.1    Coppens, I.2    Tripathi, A.K.3
  • 25
    • 4744364660 scopus 로고    scopus 로고
    • Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum
    • Jackson KE, Klonis N, Ferguson DJ, Adisa A, Dogovski C, Tilley L: Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum. Mol. Microbiol. 54(1), 109-122 (2004).
    • (2004) Mol. Microbiol , vol.54 , Issue.1 , pp. 109-122
    • Jackson, K.E.1    Klonis, N.2    Ferguson, D.J.3    Adisa, A.4    Dogovski, C.5    Tilley, L.6
  • 26
    • 47949119710 scopus 로고    scopus 로고
    • Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium
    • Casabianca LB, An D, Natarajan JK et al.: Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium. Inorg. Chem. 47(13), 6077-6081 (2008).
    • (2008) Inorg. Chem , vol.47 , Issue.13 , pp. 6077-6081
    • Casabianca, L.B.1    An, D.2    Natarajan, J.K.3
  • 28
    • 41549115882 scopus 로고    scopus 로고
    • Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy
    • Gligorijevic B, Purdy K, Elliott DA, Cooper RA, Roepe PD: Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy. Mol. Biochem. Parasitol. 159 (1), 7-23 (2008).
    • (2008) Mol. Biochem. Parasitol , vol.159 , Issue.1 , pp. 7-23
    • Gligorijevic, B.1    Purdy, K.2    Elliott, D.A.3    Cooper, R.A.4    Roepe, P.D.5
  • 29
    • 40649122026 scopus 로고    scopus 로고
    • Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum
    • Elliott DA, McIntosh MT, Hosgood HD et al.: Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum. Proc. Natl Acad. Sci. USA 105(7), 2463-2468 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.7 , pp. 2463-2468
    • Elliott, D.A.1    McIntosh, M.T.2    Hosgood, H.D.3
  • 30
    • 0030879653 scopus 로고    scopus 로고
    • Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
    • Francis SE, Sullivan DJ Jr, Goldberg DE: Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annu. Rev. Microbiol. 51, 97-123 (1997).
    • (1997) Annu. Rev. Microbiol , vol.51 , pp. 97-123
    • Francis, S.E.1    Sullivan Jr, D.J.2    Goldberg, D.E.3
  • 31
    • 57749099137 scopus 로고    scopus 로고
    • Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium. Evidence of artemisinin-resistant malaria in western Cambodia
    • Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM: Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium. Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 359(24), 2619-2620 (2008).
    • (2008) N. Engl. J. Med , vol.359 , Issue.24 , pp. 2619-2620
    • Noedl, H.1    Se, Y.2    Schaecher, K.3    Smith, B.L.4    Socheat, D.5    Fukuda, M.M.6
  • 32
    • 0030448652 scopus 로고    scopus 로고
    • 4-aminoquinoline resistance of Plasmodium falciparum: Insights from the study of amodiaquine uptake
    • Bray PG, Hawley SR, Ward SA: 4-aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake. Mol. Pharmacol. 50, 1551-1558 (1996).
    • (1996) Mol. Pharmacol , vol.50 , pp. 1551-1558
    • Bray, P.G.1    Hawley, S.R.2    Ward, S.A.3
  • 33
    • 0029087801 scopus 로고
    • Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect
    • Martiney JA, Cerami A, Slater AFG: Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. J. Biol. Chem. 270, 22393-22398 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 22393-22398
    • Martiney, J.A.1    Cerami, A.2    Slater, A.F.G.3
  • 34
    • 33847188819 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells
    • Vargas RC, Garcia-Salcedo R, Tenreiro S et al.: Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells. Eukaryot. Cell 6(2), 134-142 (2007).
    • (2007) Eukaryot. Cell , vol.6 , Issue.2 , pp. 134-142
    • Vargas, R.C.1    Garcia-Salcedo, R.2    Tenreiro, S.3
  • 35
    • 0033827908 scopus 로고    scopus 로고
    • Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chioroquine
    • Dzekunov S, Ursos L, Roepe PD: Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chioroquine. Mol. Biochem. Parasitol. 110, 107-124 (2000).
    • (2000) Mol. Biochem. Parasitol , vol.110 , pp. 107-124
    • Dzekunov, S.1    Ursos, L.2    Roepe, P.D.3
  • 36
    • 0030885534 scopus 로고    scopus 로고
    • Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression
    • Hoffman MM, Roepe PD: Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression. Biochemistry 36, 11153-11168 (1997).
    • (1997) Biochemistry , vol.36 , pp. 11153-11168
    • Hoffman, M.M.1    Roepe, P.D.2
  • 37
    • 0027960657 scopus 로고
    • + antiporter that is physiologically important at elevated pH
    • + antiporter that is physiologically important at elevated pH. J. Biol. Chem. 269, 27365-27371 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 27365-27371
    • Cheng, J.1    Guffanti, A.A.2    Krulwich, T.A.3
  • 38
    • 0024356582 scopus 로고
    • Amplification of a gene related to mammalian. mdr genes in drug-resistant Plasmodium falciparum
    • Wilson CM, Serrano AE, Wasley A, Bogenschutz MP, Shankar AH, Wirth DF: Amplification of a gene related to mammalian. mdr genes in drug-resistant Plasmodium falciparum. Science 244, 1184-1186 (1989).
    • (1989) Science , vol.244 , pp. 1184-1186
    • Wilson, C.M.1    Serrano, A.E.2    Wasley, A.3    Bogenschutz, M.P.4    Shankar, A.H.5    Wirth, D.F.6
  • 39
    • 0024338609 scopus 로고
    • Amplification of the mulidrug resistance gene in some chloroquine-resistant isolates of P. falciparum
    • Foote SJ, Thompson JK, Cowman AF, Kemp DJ: Amplification of the mulidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell 57, 921-930 (1989).
    • (1989) Cell , vol.57 , pp. 921-930
    • Foote, S.J.1    Thompson, J.K.2    Cowman, A.F.3    Kemp, D.J.4
  • 40
    • 0025305350 scopus 로고
    • Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
    • Wellems TE, Panton LJ, Gluzman IY et al.: Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature 345, 253-255 (1990).
    • (1990) Nature , vol.345 , pp. 253-255
    • Wellems, T.E.1    Panton, L.J.2    Gluzman, I.Y.3
  • 41
    • 0026645269 scopus 로고
    • Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum
    • Barnes DA, Foote SJ, Galatis D, Kemp DJ, Cowman AF: Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO J. 11, 3067-3075 (1992).
    • (1992) EMBO J , vol.11 , pp. 3067-3075
    • Barnes, D.A.1    Foote, S.J.2    Galatis, D.3    Kemp, D.J.4    Cowman, A.F.5
  • 42
    • 0027452387 scopus 로고
    • Lower electrical membrane potential and altered pHi homeostasis in multidrug resistant cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein
    • Roepe PD, Wei L-Y, Cruz J, Carlson D: Lower electrical membrane potential and altered pHi homeostasis in multidrug resistant cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein. Biochemistry 32, 11042-11056 (1993).
    • (1993) Biochemistry , vol.32 , pp. 11042-11056
    • Roepe, P.D.1    Wei, L.-Y.2    Cruz, J.3    Carlson, D.4
  • 43
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74(6), 957-967 (1993).
    • (1993) Cell , vol.74 , Issue.6 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 44
    • 0032521241 scopus 로고    scopus 로고
    • Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia
    • den Boer ML, Pieters R, Kazemier KM et al.: Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. Blood 91(6), 2092-2098 (1998).
    • (1998) Blood , vol.91 , Issue.6 , pp. 2092-2098
    • den Boer, M.L.1    Pieters, R.2    Kazemier, K.M.3
  • 45
    • 0031589733 scopus 로고    scopus 로고
    • Complex polymorphisms in an 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
    • Su X, Kirkman LA, Fujioka H, Wellems TE: Complex polymorphisms in an 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell 91, 593-603 (1997).
    • (1997) Cell , vol.91 , pp. 593-603
    • Su, X.1    Kirkman, L.A.2    Fujioka, H.3    Wellems, T.E.4
  • 46
    • 0026328231 scopus 로고
    • Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7
    • Wellems TE, Walker-Jonah A, Panton LJ: Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proc. Natl Acad. Sci. USA 88(8), 3382-3386 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , Issue.8 , pp. 3382-3386
    • Wellems, T.E.1    Walker-Jonah, A.2    Panton, L.J.3
  • 49
    • 0032493905 scopus 로고    scopus 로고
    • + exchangers. Cell 94, 285-286 (1998).
    • + exchangers. Cell 94, 285-286 (1998).
  • 50
    • 27644450245 scopus 로고    scopus 로고
    • PfCG2, a Plasmodium falciparum protein peripherally associated with the parasitophorous vacuolar membrane, is expressed in the period of maximum hemoglobin uptake and digestion by trophozoites
    • Cooper RA, Papakrivos J, Lane KD, Fujioka H, Lingelbach K, Wellems TE: PfCG2, a Plasmodium falciparum protein peripherally associated with the parasitophorous vacuolar membrane, is expressed in the period of maximum hemoglobin uptake and digestion by trophozoites. Mol. Biochem. Parasitol. 144(2), 167-176 (2005).
    • (2005) Mol. Biochem. Parasitol , vol.144 , Issue.2 , pp. 167-176
    • Cooper, R.A.1    Papakrivos, J.2    Lane, K.D.3    Fujioka, H.4    Lingelbach, K.5    Wellems, T.E.6
  • 51
    • 0344867895 scopus 로고    scopus 로고
    • Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum
    • Bray PG, Janneh O, Raynes KJ, Mungthin M, Ginsburg H, Ward SA: Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum. J. Cell Biol. 145, 363-376 (1999).
    • (1999) J. Cell Biol , vol.145 , pp. 363-376
    • Bray, P.G.1    Janneh, O.2    Raynes, K.J.3    Mungthin, M.4    Ginsburg, H.5    Ward, S.A.6
  • 53
    • 0033827905 scopus 로고    scopus 로고
    • Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum
    • Fidock DA, Nomura T, Cooper RA, Su X, Talley AK, Wellems TE: Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum. Mol. Biochem. Parasitol. 110(1), 1-10 (2000).
    • (2000) Mol. Biochem. Parasitol , vol.110 , Issue.1 , pp. 1-10
    • Fidock, D.A.1    Nomura, T.2    Cooper, R.A.3    Su, X.4    Talley, A.K.5    Wellems, T.E.6
  • 54
    • 0000191574 scopus 로고    scopus 로고
    • Chloroquine uptake, altered partitioning and the basis of drug resistance: Evidence for a role of chloride-dependent ionic regulation
    • Wiley, Winchester, UK
    • Martiney JA, Ferrey AS, Cerami A, Dzekuhov S, Roepe PD: Chloroquine uptake, altered partitioning and the basis of drug resistance: evidence for a role of chloride-dependent ionic regulation. In: Transport and trafficking in the malaria infected erythrocyte. Wiley, Winchester, UK, 265-281 (1999).
    • (1999) Transport and trafficking in the malaria infected erythrocyte , pp. 265-281
    • Martiney, J.A.1    Ferrey, A.S.2    Cerami, A.3    Dzekuhov, S.4    Roepe, P.D.5
  • 55
    • 0033636607 scopus 로고    scopus 로고
    • Mutations in the digestive vacuole transmembrane proteins pfcrt and evidence for their role in chloroquine resistance
    • Fidock DA, Nomura T, Talley AK et al.: Mutations in the digestive vacuole transmembrane proteins pfcrt and evidence for their role in chloroquine resistance. Mol. Cell. 6, 861-871 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 861-871
    • Fidock, D.A.1    Nomura, T.2    Talley, A.K.3
  • 56
    • 0037020024 scopus 로고    scopus 로고
    • Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
    • Sidhu AB, Verdier-Pinard D, Fidock DA: Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 298, 210-213 (2002).
    • (2002) Science , vol.298 , pp. 210-213
    • Sidhu, A.B.1    Verdier-Pinard, D.2    Fidock, D.A.3
  • 57
    • 18244396971 scopus 로고    scopus 로고
    • Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT produce chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum
    • Cooper RA, Ferdig MT, Su X et al.: Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT produce chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol. Pharmacol. 61, 1-8 (2002).
    • (2002) Mol. Pharmacol , vol.61 , pp. 1-8
    • Cooper, R.A.1    Ferdig, M.T.2    Su, X.3
  • 58
    • 0034708162 scopus 로고    scopus 로고
    • Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    • Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF: Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403, 906-909 (2000).
    • (2000) Nature , vol.403 , pp. 906-909
    • Reed, M.B.1    Saliba, K.J.2    Caruana, S.R.3    Kirk, K.4    Cowman, A.F.5
  • 59
    • 23744435838 scopus 로고    scopus 로고
    • pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
    • Sidhu AB, Valderramos SG, Fidock DA: pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol. Microbiol. 57(4), 913-926 (2005).
    • (2005) Mol. Microbiol , vol.57 , Issue.4 , pp. 913-926
    • Sidhu, A.B.1    Valderramos, S.G.2    Fidock, D.A.3
  • 60
    • 3142772962 scopus 로고    scopus 로고
    • Dissecting the loci of low-level quinine resistance in malaria parasites
    • Ferdig MT, Cooper RA, Mu J et al.: Dissecting the loci of low-level quinine resistance in malaria parasites. Mol. Microbiol. 52(4), 985-997 (2004).
    • (2004) Mol. Microbiol , vol.52 , Issue.4 , pp. 985-997
    • Ferdig, M.T.1    Cooper, R.A.2    Mu, J.3
  • 61
    • 0023666563 scopus 로고
    • Efflux of chloroquine from Plasmodium falciparum: Mechanism of chloroquine resistance
    • Krogstad DJ, Gluzman IY, Kyle DE et al.: Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science 238, 1283-1285 (1987).
    • (1987) Science , vol.238 , pp. 1283-1285
    • Krogstad, D.J.1    Gluzman, I.Y.2    Kyle, D.E.3
  • 62
    • 0026645269 scopus 로고
    • Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum
    • Barnes DA, Foote SJ, Galatis D, Kemp DJ, Cowman AF: Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO J. 11, 3067-3075 (1992).
    • (1992) EMBO J , vol.11 , pp. 3067-3075
    • Barnes, D.A.1    Foote, S.J.2    Galatis, D.3    Kemp, D.J.4    Cowman, A.F.5
  • 63
    • 0025269612 scopus 로고
    • Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
    • Foote SJ, Kyle DE, Martin RK et al.: Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature 345, 255-258 (1990).
    • (1990) Nature , vol.345 , pp. 255-258
    • Foote, S.J.1    Kyle, D.E.2    Martin, R.K.3
  • 64
    • 0035940425 scopus 로고    scopus 로고
    • Evolution of new Plasmodium falciparum chloroquine resistance phenotype in association with pfcrt polymorphisms in Papua New Guinea and South America
    • Mehlotra RV, Fujioka H, Roepe PD et al.: Evolution of new Plasmodium falciparum chloroquine resistance phenotype in association with pfcrt polymorphisms in Papua New Guinea and South America. Proc. Natl Acad. Sci. USA 98(22), 12689-12694 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , Issue.22 , pp. 12689-12694
    • Mehlotra, R.V.1    Fujioka, H.2    Roepe, P.D.3
  • 65
    • 0242290995 scopus 로고    scopus 로고
    • Pfcrt allelic types with two novel amino-acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Phillipines
    • Chen N, Kyle DE, Pasay C et al.: Pfcrt allelic types with two novel amino-acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Phillipines. Antimicrob. Agents Chemother. 47(11), 3500-3505 (2003).
    • (2003) Antimicrob. Agents Chemother , vol.47 , Issue.11 , pp. 3500-3505
    • Chen, N.1    Kyle, D.E.2    Pasay, C.3
  • 66
    • 12244269105 scopus 로고    scopus 로고
    • Pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia
    • Lim P, Chy S, Ariey F et al.: Pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia. Antimicrob. Agents Chemother. 47(11), 87-94 (2003).
    • (2003) Antimicrob. Agents Chemother , vol.47 , Issue.11 , pp. 87-94
    • Lim, P.1    Chy, S.2    Ariey, F.3
  • 67
    • 0028014644 scopus 로고
    • Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine
    • Cowman AF, Galatis D, Thompson JK: Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proc. Natl Acad. Sci. USA 91, 1143-1147 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 1143-1147
    • Cowman, A.F.1    Galatis, D.2    Thompson, J.K.3
  • 68
    • 0030566669 scopus 로고    scopus 로고
    • In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1
    • Ritchie GY, Mungthin M, Green JE, Bray PG, Hawley SR, Ward SA: In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1. Mol. Biochem. Parasitol. 83, 35-46 (1996).
    • (1996) Mol. Biochem. Parasitol , vol.83 , pp. 35-46
    • Ritchie, G.Y.1    Mungthin, M.2    Green, J.E.3    Bray, P.G.4    Hawley, S.R.5    Ward, S.A.6
  • 69
    • 0035341936 scopus 로고    scopus 로고
    • Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr1 genes and clinical response to chloroquine in Kampala, Uganda
    • Dorsey G, Kamya MR, Singh A, Rosenthal PJ: Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr1 genes and clinical response to chloroquine in Kampala, Uganda, J. Infec. Dis. 183, 1417-1420 (2001).
    • (2001) J. Infec. Dis , vol.183 , pp. 1417-1420
    • Dorsey, G.1    Kamya, M.R.2    Singh, A.3    Rosenthal, P.J.4
  • 70
    • 2142769136 scopus 로고    scopus 로고
    • Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    • Price RN, Uhlemann AC, Brockman A et al.: Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 364 (5432), 438-447 (2004).
    • (2004) Lancet , vol.364 , Issue.5432 , pp. 438-447
    • Price, R.N.1    Uhlemann, A.C.2    Brockman, A.3
  • 71
    • 0033824184 scopus 로고    scopus 로고
    • The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine
    • Ursos L, Dzekunov S, Roepe PD: The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine. Mol. Biochem. Parasitol. 110, 125-134 (2000).
    • (2000) Mol. Biochem. Parasitol , vol.110 , pp. 125-134
    • Ursos, L.1    Dzekunov, S.2    Roepe, P.D.3
  • 72
    • 0037147244 scopus 로고    scopus 로고
    • Analysis of the antimalarial drug resistance protein PfCRT expressed in yeast
    • Zhang H, Howard EM, Roepe PD: Analysis of the antimalarial drug resistance protein PfCRT expressed in yeast. J. Biol. Chem. 277, 49767-49775 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 49767-49775
    • Zhang, H.1    Howard, E.M.2    Roepe, P.D.3
  • 73
    • 3142618432 scopus 로고    scopus 로고
    • The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine
    • Zhang H, Paguio M, Roepe PD: The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine. Biochemistry 43(26), 8290-8296 (2004).
    • (2004) Biochemistry , vol.43 , Issue.26 , pp. 8290-8296
    • Zhang, H.1    Paguio, M.2    Roepe, P.D.3
  • 74
    • 21844437088 scopus 로고    scopus 로고
    • Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT
    • Naude B, Brzostowski JA, Kimmel AR, Wellems TE: Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT. J. Biol. Chem. 280 (27), 25596-25603 (2005).
    • (2005) J. Biol. Chem , vol.280 , Issue.27 , pp. 25596-25603
    • Naude, B.1    Brzostowski, J.A.2    Kimmel, A.R.3    Wellems, T.E.4
  • 75
    • 4644251136 scopus 로고    scopus 로고
    • Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents
    • Johnson DJ, Fidock DA, Mungthin M et al.: Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Mol. Cell. 15(6), 867-877 (2004).
    • (2004) Mol. Cell , vol.15 , Issue.6 , pp. 867-877
    • Johnson, D.J.1    Fidock, D.A.2    Mungthin, M.3
  • 76
    • 33750617003 scopus 로고    scopus 로고
    • Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms
    • Reeves DC, Liebelt DA, Lakshmanan V, Roepe PD, Fidock DA, Akabas MH: Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. Mol. Biochem. Parasitol. 150(2), 288-299 (2006).
    • (2006) Mol. Biochem. Parasitol , vol.150 , Issue.2 , pp. 288-299
    • Reeves, D.C.1    Liebelt, D.A.2    Lakshmanan, V.3    Roepe, P.D.4    Fidock, D.A.5    Akabas, M.H.6
  • 79
    • 64549141583 scopus 로고    scopus 로고
    • + exchanger (PfNHE) hxnctxon and quinine resistance (QNR). Mol. Biochem. Parasitol. 166, 1-2 (2009).
    • + exchanger (PfNHE) hxnctxon and quinine resistance (QNR). Mol. Biochem. Parasitol. 166, 1-2 (2009).
  • 80
    • 0028070308 scopus 로고
    • Cloning and characterization of the vacuolar ATPase B subunit from Plasmodium falciparum
    • Karcz SR, Herrmann VR, Trottein F, Cowman AF: Cloning and characterization of the vacuolar ATPase B subunit from Plasmodium falciparum. Mol. Biochem. Parasitol. 65(1), 123-133 (1984).
    • (1984) Mol. Biochem. Parasitol , vol.65 , Issue.1 , pp. 123-133
    • Karcz, S.R.1    Herrmann, V.R.2    Trottein, F.3    Cowman, A.F.4
  • 81
    • 33645751112 scopus 로고    scopus 로고
    • The pH of the digestive vacuole of Plasmodium falciparum is not associated with-chloroquine resistance
    • Hayward R, Saliba KJ, Kirk K: The pH of the digestive vacuole of Plasmodium falciparum is not associated with-chloroquine resistance. J. Cell Sci. 119(Pt 6), 1016-1025 (2006).
    • (2006) J. Cell Sci , vol.119 , Issue.PART 6 , pp. 1016-1025
    • Hayward, R.1    Saliba, K.J.2    Kirk, K.3
  • 82
    • 0033827908 scopus 로고    scopus 로고
    • Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine
    • Dzekunov S, Ursos L, Roepe PD: Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine. Mol. Biochem. Parasitol. 110, 107-124 (2000).
    • (2000) Mol. Biochem. Parasitol , vol.110 , pp. 107-124
    • Dzekunov, S.1    Ursos, L.2    Roepe, P.D.3
  • 83
    • 4544262279 scopus 로고    scopus 로고
    • Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the Plasmodium falciparum chloroquine resistance transporter, PfCRT
    • Nessler S, Friedrich O, Bakouh N et al.: Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the Plasmodium falciparum chloroquine resistance transporter, PfCRT. J. Biol. Chem. 279(38), 39438-39446 (2004).
    • (2004) J. Biol. Chem , vol.279 , Issue.38 , pp. 39438-39446
    • Nessler, S.1    Friedrich, O.2    Bakouh, N.3
  • 84
    • 35748956775 scopus 로고    scopus 로고
    • Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum
    • Klonis N, Tan O, Jackson K, Goldberg D, Klemba M, Tilley L: Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum. Biochem. J. 407(3), 343-354. (2007).
    • (2007) Biochem. J , vol.407 , Issue.3 , pp. 343-354
    • Klonis, N.1    Tan, O.2    Jackson, K.3    Goldberg, D.4    Klemba, M.5    Tilley, L.6
  • 85
    • 0033557228 scopus 로고    scopus 로고
    • Vaccine candidate MSP-1 from Plasmodium falciparum: A redesigned 4917 bp polynucleotide enables synthesis and isolation of full-length protein from Escherichia coli and mammalian cells
    • Pan W, Ravot E, Tolle R et al.: Vaccine candidate MSP-1 from Plasmodium falciparum: a redesigned 4917 bp polynucleotide enables synthesis and isolation of full-length protein from Escherichia coli and mammalian cells. Nucleic Acids Res. 27(4), 1094-1103 (1999).
    • (1999) Nucleic Acids Res , vol.27 , Issue.4 , pp. 1094-1103
    • Pan, W.1    Ravot, E.2    Tolle, R.3
  • 86
    • 22744436592 scopus 로고    scopus 로고
    • Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum
    • Sanchez CP, McLean JE, Rohrbach P, Fidock DA, Stein WD, Lanzer M: Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum. Biochemistry 44(29), 9862-9870 (2005).
    • (2005) Biochemistry , vol.44 , Issue.29 , pp. 9862-9870
    • Sanchez, C.P.1    McLean, J.E.2    Rohrbach, P.3    Fidock, D.A.4    Stein, W.D.5    Lanzer, M.6
  • 87
    • 34247364130 scopus 로고    scopus 로고
    • Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum
    • Sanchez CP, Rohrbach P, McLean JE, Fidock DA, Stein WD, Lanzer M: Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum. Mol. Microbiol. 64(2), 407-420 (2007).
    • (2007) Mol. Microbiol , vol.64 , Issue.2 , pp. 407-420
    • Sanchez, C.P.1    Rohrbach, P.2    McLean, J.E.3    Fidock, D.A.4    Stein, W.D.5    Lanzer, M.6
  • 88
    • 34249051612 scopus 로고    scopus 로고
    • Heterologous expression and ATPase activity of mutant versus wild type PfMDR1 protein
    • Amoah LE, Lekostaj JK, Roepe PD: Heterologous expression and ATPase activity of mutant versus wild type PfMDR1 protein. Biochemistry 46(20), 6060-6073 (2007).
    • (2007) Biochemistry , vol.46 , Issue.20 , pp. 6060-6073
    • Amoah, L.E.1    Lekostaj, J.K.2    Roepe, P.D.3
  • 89
    • 36448955049 scopus 로고    scopus 로고
    • A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform
    • Lekostaj JK, Amoah LE, Roepe PD: A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform. Mol. Biochem. Parasitol. 157(1), 107-111 (2008).
    • (2008) Mol. Biochem. Parasitol , vol.157 , Issue.1 , pp. 107-111
    • Lekostaj, J.K.1    Amoah, L.E.2    Roepe, P.D.3
  • 90
    • 52949104808 scopus 로고    scopus 로고
    • Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine
    • Lekostaj JK, Natarajan JK, Paguio MF, WolfC, Roepe PD: Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine. Biochemistry 47(39), 10394-10406 (2008).
    • (2008) Biochemistry , vol.47 , Issue.39 , pp. 10394-10406
    • Lekostaj, J.K.1    Natarajan, J.K.2    Paguio, M.F.3    Wolf, C.4    Roepe, P.D.5
  • 91
    • 57649155530 scopus 로고    scopus 로고
    • Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas
    • Ekoue-Kovi K, Yearick K, Iwaniuk DP et al.: Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas. Bioorg. Med. Chem. 17(1), 270-283 (2009).
    • (2009) Bioorg. Med. Chem , vol.17 , Issue.1 , pp. 270-283
    • Ekoue-Kovi, K.1    Yearick, K.2    Iwaniuk, D.P.3
  • 92
    • 67149102908 scopus 로고    scopus 로고
    • Chloroquine transport in chloroquine resistant Plasmodium falciparum: Influx and efflux kinetics using a fluorescent chloroquine probe
    • Presented at:, Philadelphia, PA, USA, 4-8 November
    • Cabrera M, Paguio M, Natarajan JK, Wolf C, Roepe PD: Chloroquine transport in chloroquine resistant Plasmodium falciparum: influx and efflux kinetics using a fluorescent chloroquine probe. Presented at: American Society of Tropical Medicine, Hygiene Annual Meeting. Philadelphia, PA, USA, 4-8 November 2007.
    • (2007) American Society of Tropical Medicine, Hygiene Annual Meeting
    • Cabrera, M.1    Paguio, M.2    Natarajan, J.K.3    Wolf, C.4    Roepe, P.D.5
  • 93
    • 46349109273 scopus 로고    scopus 로고
    • Certain LK, Briceño M, Kiara SM, Nzila AM, Watkins WM, Sibley CH: Characteristics of Plasmodium falciparum dbfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006. J. Infect. Dis. 197(12), 1743-1751 (2008).
    • Certain LK, Briceño M, Kiara SM, Nzila AM, Watkins WM, Sibley CH: Characteristics of Plasmodium falciparum dbfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006. J. Infect. Dis. 197(12), 1743-1751 (2008).
  • 94
    • 45749094225 scopus 로고    scopus 로고
    • 4-N-, 4-S-, and 4-O-chloroquine analogues: Influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria
    • Natarajan JK, Alumasa JN, Yearick K et al.: 4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria. J. Med. Chem. 51(12), 3466-3479 (2008).
    • (2008) J. Med. Chem , vol.51 , Issue.12 , pp. 3466-3479
    • Natarajan, J.K.1    Alumasa, J.N.2    Yearick, K.3
  • 95
    • 41849132118 scopus 로고    scopus 로고
    • Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines
    • Yearick K, Ekoue-Kovi K, Iwaniuk DP et al.: Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines J. Med. Chem. 51(7), 1995-1998 (2008).
    • (2008) J. Med. Chem , vol.51 , Issue.7 , pp. 1995-1998
    • Yearick, K.1    Ekoue-Kovi, K.2    Iwaniuk, D.P.3
  • 96
    • 39249085321 scopus 로고    scopus 로고
    • Antimalarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo
    • Vivas L, Rattray L, Stewart L et al.: Antimalarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 105(3), 222-228 (2008).
    • (2008) Acta Trop , vol.105 , Issue.3 , pp. 222-228
    • Vivas, L.1    Rattray, L.2    Stewart, L.3
  • 97
    • 65649153380 scopus 로고    scopus 로고
    • Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro
    • Muangnoicharoen S, Johnson DJ, Looareesuwan S, Krudsood S, Ward SA: Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro. Antimicrob. Agents Chemother. 53(4), 1362-1366 (2009).
    • (2009) Antimicrob. Agents Chemother , vol.53 , Issue.4 , pp. 1362-1366
    • Muangnoicharoen, S.1    Johnson, D.J.2    Looareesuwan, S.3    Krudsood, S.4    Ward, S.A.5
  • 98
    • 58149213965 scopus 로고    scopus 로고
    • Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline antimalarials
    • Davis CB, Bambal R, Moorthy GS et al.: Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline antimalarials. J. Pharm. Sci. 98(1), 362-377 (2009).
    • (2009) J. Pharm. Sci , vol.98 , Issue.1 , pp. 362-377
    • Davis, C.B.1    Bambal, R.2    Moorthy, G.S.3
  • 99
    • 0036135320 scopus 로고    scopus 로고
    • Optimization of xanthones for antimalarial activity: The 3,6-bis-ω-diethylaminoalkoxyxanthone series
    • Kelly JX, Winter R, Peyton DH, Hinrichs DJ, Riscoe M: Optimization of xanthones for antimalarial activity: the 3,6-bis-ω-diethylaminoalkoxyxanthone series. Antimicrob. Agents Chemother. 46(1), 144-150 (2002).
    • (2002) Antimicrob. Agents Chemother , vol.46 , Issue.1 , pp. 144-150
    • Kelly, J.X.1    Winter, R.2    Peyton, D.H.3    Hinrichs, D.J.4    Riscoe, M.5
  • 100
    • 62249160684 scopus 로고    scopus 로고
    • Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE
    • Nkrumah LJ, Riegelhaupt PM, Moura P et al.: Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol. Biochem. Parasitol. 165, 122-131 (2009).
    • (2009) Mol. Biochem. Parasitol , vol.165 , pp. 122-131
    • Nkrumah, L.J.1    Riegelhaupt, P.M.2    Moura, P.3


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