-
2
-
-
0035066332
-
Alzheimer's disease: Genes, proteins and therapy
-
Selkoe D (2001) Alzheimer's disease: genes, proteins and therapy. Physiol Rev 81, 741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.1
-
4
-
-
40949105521
-
Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease
-
Patterson C, Feightner JW, Garcia A, Hsiung GY, MacKnight C, Sadovnick AD (2008) Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ 178, 548-556.
-
(2008)
CMAJ
, vol.178
, pp. 548-556
-
-
Patterson, C.1
Feightner, J.W.2
Garcia, A.3
Hsiung, G.Y.4
MacKnight, C.5
Sadovnick, A.D.6
-
5
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama H Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, StreitW, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B,Wenk G,Wyss-Coray T (2000) Inflammation and Alzheimer's disease. Neurobiol Aging 21, 383-421.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
Cooper, N.R.7
Eikelenboom, P.8
Emmerling, M.9
Fiebich, B.L.10
Finch, C.E.11
Frautschy, S.12
Griffin, W.S.13
Hampel, H.14
Hull, M.15
Landreth, G.16
Lue, L.17
Mrak, R.18
MacKenzie, I.R.19
McGeer, P.L.20
O'Banion, M.K.21
Pachter, J.22
Pasinetti, G.23
Plata-Salaman, C.24
Rogers, J.25
Rydel, R.26
Shen, Y.27
Streit, W.28
Strohmeyer, R.29
Tooyoma, I.30
Van Muiswinkel, F.L.31
Veerhuis, R.32
Walker, D.33
Webster, S.34
Wegrzyniak, B.35
Wenk, G.36
Wyss-Coray, T.37
more..
-
6
-
-
67650458720
-
Evaluation of aging vs dementia by means of neurosonology
-
Demarin V, Kes VB, Morovi S, Zavoreo I (2009) Evaluation of aging vs dementia by means of neurosonology. J Neurol Sci 283, 9-12.
-
(2009)
J Neurol Sci
, vol.283
, pp. 9-12
-
-
Demarin, V.1
Kes, V.B.2
Morovi, S.3
Zavoreo, I.4
-
7
-
-
57449097620
-
Prevention of common neurodegenerative disorders in the elderly
-
Fratiglioni L, Qiu C (2009) Prevention of common neurodegenerative disorders in the elderly. Exp Gerontol 44, 46-50.
-
(2009)
Exp Gerontol
, vol.44
, pp. 46-50
-
-
Fratiglioni, L.1
Qiu, C.2
-
8
-
-
34249784822
-
Inflammatory markers and the risk of Alzheimer disease: The Framingham Study
-
Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S (2007) Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology 68, 1902-1908.
-
(2007)
Neurology
, vol.68
, pp. 1902-1908
-
-
Tan, Z.S.1
Beiser, A.S.2
Vasan, R.S.3
Roubenoff, R.4
Dinarello, C.A.5
Harris, T.B.6
Benjamin, E.J.7
Au, R.8
Kiel, D.P.9
Wolf, P.A.10
Seshadri, S.11
-
9
-
-
0035369189
-
Immunohistochemical localization of neprilysin in the human cerebral cortex: Inverse association with vulnerability to amyloid beta-protein (Abeta) deposition
-
Akiyama H, Kondo H, Ikeda K, Kato M, McGeer PL (2001) Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition. Brain Res 902, 277-281.
-
(2001)
Brain Res
, vol.902
, pp. 277-281
-
-
Akiyama, H.1
Kondo, H.2
Ikeda, K.3
Kato, M.4
McGeer, P.L.5
-
10
-
-
13644266898
-
Age-and region-dependent alterations in Abetadegrading enzymes: Implications for Abeta-induced disorders
-
Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM (2005) Age-and region-dependent alterations in Abetadegrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging 26, 645-654.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 645-654
-
-
Caccamo, A.1
Oddo, S.2
Sugarman, M.C.3
Akbari, Y.4
La Ferla, F.M.5
-
11
-
-
0027490614
-
Staging of Alzheimerrelated cortical destruction
-
Braak H, Braak E, Bohl J (1993) Staging of Alzheimerrelated cortical destruction. Eur Neurol 33, 403-408.
-
(1993)
Eur Neurol
, vol.33
, pp. 403-408
-
-
Braak, H.1
Braak, E.2
Bohl, J.3
-
12
-
-
0031796883
-
Neurofibrillary Pathology of Alzheimer's Disease and other taupathies
-
Van Leeuwen FW, Salehi A, Giger RJ, Holtmaat AJGD, Verhagen J, eds. Elsevier, Amsterdam
-
Goedert M (1998) Neurofibrillary Pathology of Alzheimer's Disease and other taupathies. In Progress in Brain Research, Van Leeuwen FW, Salehi A, Giger RJ, Holtmaat AJGD, Verhagen J, eds. Elsevier, Amsterdam, vol 117, pp. 287-306.
-
(1998)
Progress in Brain Research
, vol.117
, pp. 287-306
-
-
Goedert, M.1
-
13
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
14
-
-
50649114611
-
Amyloidbeta dynamics correlate with neurological status in the injured human brain
-
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM (2008) Amyloidbeta dynamics correlate with neurological status in the injured human brain. Science 321, 1221-1224.
-
(2008)
Science
, vol.321
, pp. 1221-1224
-
-
Brody, D.L.1
Magnoni, S.2
Schwetye, K.E.3
Spinner, M.L.4
Esparza, T.J.5
Stocchetti, N.6
Zipfel, G.J.7
Holtzman, D.M.8
-
16
-
-
3042857903
-
Alzheimer's disease
-
Cumming JL (2004) Alzheimer's disease. N Engl J Med 351, 56-67.
-
(2004)
N Engl J Med
, vol.351
, pp. 56-67
-
-
Cumming, J.L.1
-
17
-
-
5344277492
-
Microglia - Astrocyte interaction in Alzheimer's disease: Modulation of cell reactivity to Aβ
-
von Bernhardi R, Eugeńin J (2004) Microglia - astrocyte interaction in Alzheimer's disease: modulation of cell reactivity to Aβ. Brain Res 1025, 186-193.
-
(2004)
Brain Res
, vol.1025
, pp. 186-193
-
-
Von Bernhardi, R.1
Eugeńin, J.2
-
18
-
-
5344277556
-
Deciphering the molecular basis of memory failure in Alzheimer's Disease
-
Walsh DM, Selkoe DJ (2004) Deciphering the molecular basis of memory failure in Alzheimer's Disease. Neuron 44, 181-193
-
(2004)
Neuron
, vol.44
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
19
-
-
52449104934
-
Proinflammatory stimuli induce microglial cell-mediated APP-and Aβ-neurotoxicity in hippocampal cultures
-
Raḿirez G, Rey S, von Bernhardi R (2008) Proinflammatory stimuli induce microglial cell-mediated APP-and Aβ-neurotoxicity in hippocampal cultures. J Alzheimers Dis 15, 45-59.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 45-59
-
-
Raḿirez, G.1
Rey, S.2
Von Bernhardi, R.3
-
20
-
-
0034700471
-
Abeta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D (2000) Abeta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408, 979-982.
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
Schmidt, S.D.6
Chishti, M.A.7
Horne, P.8
Heslin, D.9
French, J.10
Mount, H.T.11
Nixon, R.A.12
Mercken, M.13
Bergeron, C.14
Fraser, P.E.15
St George-Hyslop, P.16
Westaway, D.17
-
21
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in a model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G,Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW (2000) A beta peptide vaccination prevents memory loss in a model of Alzheimer's disease. Nature 408, 982-985.
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
Hardy, J.6
Duff, K.7
Jantzen, P.8
Di Carlo, G.9
Wilcock, D.10
Connor, K.11
Hatcher, J.12
Hope, C.13
Gordon, M.14
Arendash, G.W.15
-
22
-
-
33748753481
-
Clearance of amyloidbeta in Alzheimer's disease: Progress, problems and perspectives
-
Wang YJ, Zhou HD, Zhou XF (2006) Clearance of amyloidbeta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 11, 931-938.
-
(2006)
Drug Discov Today
, vol.11
, pp. 931-938
-
-
Wang, Y.J.1
Zhou, H.D.2
Zhou, X.F.3
-
23
-
-
0037223101
-
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid
-
Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K (2003) Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci 23, 29-33.
-
(2003)
J Neurosci
, vol.23
, pp. 29-33
-
-
Matsuoka, Y.1
Saito, M.2
La Francois, J.3
Saito, M.4
Gaynor, K.5
Olm, V.6
Wang, L.7
Casey, E.8
Lu, Y.9
Shiratori, C.10
Lemere, C.11
Duff, K.12
-
24
-
-
20044370990
-
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
-
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM(2005) Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280, 5892-5901.
-
(2005)
J Biol Chem
, vol.280
, pp. 5892-5901
-
-
Yang, F.1
Lim, G.P.2
Begum, A.N.3
Ubeda, O.J.4
Simmons, M.R.5
Ambegaokar, S.S.6
Chen, P.P.7
Kayed, R.8
Glabe, C.G.9
Frautschy, S.A.10
Cole, G.M.11
-
25
-
-
2442483898
-
Peripheral treatment with enoxaparin, a lowmolecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease
-
Bergamaschini L, Rossi E, Storini C, Pizzimenti S, Distaso M, Perego C, De Luigi A, Vergani C, De Simoni MG (2004) Peripheral treatment with enoxaparin, a lowmolecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease. J Neurosci 24, 4181-4186.
-
(2004)
J Neurosci
, vol.24
, pp. 4181-4186
-
-
Bergamaschini, L.1
Rossi, E.2
Storini, C.3
Pizzimenti, S.4
Distaso, M.5
Perego, C.6
De Luigi, A.7
Vergani, C.8
De Simoni, M.G.9
-
26
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, DunnW, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S,Wogulis M, Yednock T, Games D, Seubert P (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker Swogulis, M.21
Yednock, T.22
Games, D.23
Seubert, P.24
more..
-
27
-
-
0030058382
-
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
-
Solomon B, Koppel R, Hanan E, Katzav T (1996) Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci USA 93, 452-455.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 452-455
-
-
Solomon, B.1
Koppel, R.2
Hanan, E.3
Katzav, T.4
-
28
-
-
0030971789
-
Disaggregation of Alzheimer beta-amyloid by site-directed mAb
-
Solomon B, Koppel R, Frankel D, Hanan-Aharon E (1997) Disaggregation of Alzheimer beta-amyloid by site-directed mAb. Proc Natl Acad Sci USA 94, 4109-4112.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4109-4112
-
-
Solomon, B.1
Koppel, R.2
Frankel, D.3
Hanan-Aharon, E.4
-
29
-
-
0035695216
-
Beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/ PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology
-
Vehmas AK, Borchelt DR, Price DL, McCarthy D, Willis-Karp M, Peper MJ, Rudow G, Luyinbazi J, Siew LT, Troncoso JC (2001) Beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/ PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology. DNA Cell Biol 20, 713-721.
-
(2001)
DNA Cell Biol
, vol.20
, pp. 713-721
-
-
Vehmas, A.K.1
Borchelt, D.R.2
Price, D.L.3
McCarthy, D.4
Willis-Karp, M.5
Peper, M.J.6
Rudow, G.7
Luyinbazi, J.8
Siew, L.T.9
Troncoso, J.C.10
-
30
-
-
33746885876
-
Papillomavirus like particles are an effective platform for amyloidbeta immunization in rabbits and transgenic mice
-
Zamora E, Handisurva A, Shafti-Keramat S, Borchelt D, Rudow G, Conant K, Cox C, Troncoso JC (2006) Papillomavirus like particles are an effective platform for amyloidbeta immunization in rabbits and transgenic mice. J Immunol 177, 262-2670.
-
(2006)
J Immunol
, vol.177
, pp. 262-2670
-
-
Zamora, E.1
Handisurva, A.2
Shafti-Keramat, S.3
Borchelt, D.4
Rudow, G.5
Conant, K.6
Cox, C.7
Troncoso, J.C.8
-
31
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease
-
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N,Weiss K, Welch B, Seubert P, Schenk D, Yednock T (2000) Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease. Nat Med 6, 916-919.
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
32
-
-
0035132326
-
Amyloid beta vaccination: Reduced plaques and improved cognition
-
Youkin SG (2001) Amyloid beta vaccination: reduced plaques and improved cognition. Nat Med 7, 18-19.
-
(2001)
Nat Med
, vol.7
, pp. 18-19
-
-
Youkin, S.G.1
-
33
-
-
47949132196
-
Active and passive immunotherapy for neurodegenerative disorders
-
Brody DL, Holtzman DM (2008) Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci 31, 175-193.
-
(2008)
Annu Rev Neurosci
, vol.31
, pp. 175-193
-
-
Brody, D.L.1
Holtzman, D.M.2
-
34
-
-
0034884382
-
Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
-
Sigurdsson EM, Scholtzova H, Mehta PD, Frangione B,Wisniewski T (2001) Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. AmJ Pathol 159, 439-447.
-
(2001)
AmJ Pathol
, vol.159
, pp. 439-447
-
-
Sigurdsson, E.M.1
Scholtzova, H.2
Mehta, P.D.3
Frangione, B.4
Wisniewski, T.5
-
35
-
-
0033801852
-
Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
-
Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ (2000) Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol 48, 567-579.
-
(2000)
Ann Neurol
, vol.48
, pp. 567-579
-
-
Weiner, H.L.1
Lemere, C.A.2
Maron, R.3
Spooner, E.T.4
Grenfell, T.J.5
Mori, C.6
Issazadeh, S.7
Hancock, W.W.8
Selkoe, D.J.9
-
36
-
-
0037424110
-
Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization
-
Frenkel D, Dewachter I, Van Leuven F, Solomon B (2003) Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization. Vaccine 21, 1060-1065.
-
(2003)
Vaccine
, vol.21
, pp. 1060-1065
-
-
Frenkel, D.1
Dewachter, I.2
Van Leuven, F.3
Solomon, B.4
-
37
-
-
13544277841
-
EFRH-phage immunization of Alzheimer's disease animal model improves behavioral performance in Morris water maze trials
-
Lavie V, Becker M, Cohen-Kupiec R, Yacoby I, Koppel R, Wedenig M, Hutter-Paier B, Solomon B (2004) EFRH-phage immunization of Alzheimer's disease animal model improves behavioral performance in Morris water maze trials. J Mol Neurosci 24, 105-113.
-
(2004)
J Mol Neurosci
, vol.24
, pp. 105-113
-
-
Lavie, V.1
Becker, M.2
Cohen-Kupiec, R.3
Yacoby, I.4
Koppel, R.5
Wedenig, M.6
Hutter-Paier, B.7
Solomon, B.8
-
38
-
-
14244252864
-
Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease
-
Hara H, Monsonego A,Yuasa K, Adachi K, Xiao X,Takeda S, Takahashi K, Weiner HL, Tabira T (2004) Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. J Alzheimers Dis 6, 483-488.
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 483-488
-
-
Hara, H.1
Monsonego, A.2
Yuasa, K.3
Adachi, K.4
Xiao, X.5
Takeda, S.6
Takahashi, K.7
Weiner, H.L.8
Tabira, T.9
-
39
-
-
7944236860
-
Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease
-
Schiltz JG, Salzer U, Mohajeri MH, Franke D, Heinrich J, Pavlovic J,Wollmer MA, Nitsch RM, Moelling K (2004) Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease. J Mol Med 82, 706-714
-
(2004)
J Mol Med
, vol.82
, pp. 706-714
-
-
Schiltz, J.G.1
Salzer, U.2
Mohajeri, M.H.3
Franke, D.4
Heinrich, J.5
Pavlovic, J.6
Wollmer, M.A.7
Nitsch, R.M.8
Moelling, K.9
-
40
-
-
0036679142
-
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
-
Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E (2002) Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci USA 99, 10837-10842.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10837-10842
-
-
Wyss-Coray, T.1
Yan, F.2
Lin, A.H.3
Lambris, J.D.4
Alexander, J.J.5
Quigg, R.J.6
Masliah, E.7
-
41
-
-
14944352071
-
Inflammation and the degenerative diseases of aging
-
McGeer PL, McGeer EG (2004) Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci 1035, 101-104.
-
(2004)
Ann N y Acad Sci
, vol.1035
, pp. 101-104
-
-
McGeer, P.L.1
McGeer, E.G.2
-
42
-
-
0034734786
-
Detection of complement alternate pathway mRNA and proteins in the Alzheimer's disease brain
-
Strohmeyer R, Shen Y, Rogers J (2000) Detection of complement alternate pathway mRNA and proteins in the Alzheimer's disease brain. Neurobiol Aging 81, 7-18.
-
(2000)
Neurobiol Aging
, vol.81
, pp. 7-18
-
-
Strohmeyer, R.1
Shen, Y.2
Rogers, J.3
-
43
-
-
0026447529
-
Complement activation by β-amyloid in Alzheimer disease
-
Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren SD, Civin WH, Brachova L, Bradt B, Ward P (1992) Complement activation by β-amyloid in Alzheimer disease. Proc Natl Acad Sci USA 89, 10016-10020.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10016-10020
-
-
Rogers, J.1
Cooper, N.R.2
Webster, S.3
Schultz, J.4
McGeer, P.L.5
Styren, S.D.6
Civin, W.H.7
Brachova, L.8
Bradt, B.9
Ward, P.10
-
44
-
-
23044454999
-
Complement activation in very early Alzheimer disease
-
Zanjani H, Finch CE, Kemper C, Atkinson J, McKeel D, Morris JC, Price JL (2005) Complement activation in very early Alzheimer disease. Alzheimer Dis Assoc Disord 19, 55-66.
-
(2005)
Alzheimer Dis Assoc Disord
, vol.19
, pp. 55-66
-
-
Zanjani, H.1
Finch, C.E.2
Kemper, C.3
Atkinson, J.4
McKeel, D.5
Morris, J.C.6
Price, J.L.7
-
45
-
-
0034595821
-
Effects of incorporation of immunoglobulin g and complement component c1q on uptake and degradation of alzheimer's disease amyloid fibrils by Microglia
-
Brazil MI, Chung H, Maxfield FR (2000) Effects of Incorporation of Immunoglobulin G and Complement Component C1q on Uptake and Degradation of Alzheimer's Disease Amyloid Fibrils by Microglia. J Biol Chem 275, 16941-16947.
-
(2000)
J Biol Chem
, vol.275
, pp. 16941-16947
-
-
Brazil, M.I.1
Chung, H.2
Maxfield, F.R.3
-
46
-
-
27144511230
-
Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's dis ease
-
Buttini M, Masliah E, Barbour R, Grajeda H, Motter R, Jonson-Wood K, Khan K, Seubert P, Freedman S, Schenk D, Games D (2005) Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's dis ease. J Neurosci 25, 9096-9101.
-
(2005)
J Neurosci
, vol.25
, pp. 9096-9101
-
-
Buttini, M.1
Masliah, E.2
Barbour, R.3
Grajeda, H.4
Motter, R.5
Jonson-Wood, K.6
Khan, K.7
Seubert, P.8
Freedman, S.9
Schenk, D.10
Games, D.11
-
47
-
-
0034740197
-
Vaccination with soluble Abeta oligomers generates toxicityneutralizing antibodies
-
Lambert MP, Viola KL, Chromy BA, Chang L, Morgan TE, Yu J, Venton DL, Krafft GA, Finch CE, Klein WL (2001) Vaccination with soluble Abeta oligomers generates toxicityneutralizing antibodies. J Neurochem 79, 595-605.
-
(2001)
J Neurochem
, vol.79
, pp. 595-605
-
-
Lambert, M.P.1
Viola, K.L.2
Chromy, B.A.3
Chang, L.4
Morgan, T.E.5
Yu, J.6
Venton, D.L.7
Krafft, G.A.8
Finch, C.E.9
Klein, W.L.10
-
48
-
-
0035106780
-
Imaging of amyloidbeta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
-
Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT (2001) Imaging of amyloidbeta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 7, 369-372.
-
(2001)
Nat Med
, vol.7
, pp. 369-372
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
Christie, R.H.3
Carter, C.4
Games, D.5
Seubert, P.6
Schenk, D.7
Hyman, B.T.8
-
49
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummings DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98, 8850-8855.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8850-8855
-
-
De Mattos, R.B.1
Bales, K.R.2
Cummings, D.J.3
Dodart, J.C.4
Paul, S.M.5
Holtzman, D.M.6
-
50
-
-
0036852750
-
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
-
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P,Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P (2002) Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med 8, 1263-1269.
-
(2002)
Nat Med
, vol.8
, pp. 1263-1269
-
-
McLaurin, J.1
Cecal, R.2
Kierstead, M.E.3
Tian, X.4
Phinney, A.L.5
Manea, M.6
French, J.E.7
Lambermon, M.H.8
Darabie, A.A.9
Brown, M.E.10
Janus, C.11
Chishti, M.A.12
Horne, P.13
Westaway, D.14
Fraser, P.E.15
Mount, H.T.16
Przybylski, M.17
St George-Hyslop, P.18
-
51
-
-
33645220400
-
Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformationselective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
-
Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, Lee VM (2006) Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformationselective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem 281, 4292-4299.
-
(2006)
J Biol Chem
, vol.281
, pp. 4292-4299
-
-
Lee, E.B.1
Leng, L.Z.2
Zhang, B.3
Kwong, L.4
Trojanowski, J.Q.5
Abel, T.6
Lee, V.M.7
-
52
-
-
31044433933
-
Anti-Abeta42-and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model
-
Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, Mc-Gowan EM, Murphy MP, Golde TE (2006) Anti-Abeta42-and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest 116, 193-201.
-
(2006)
J Clin Invest
, vol.116
, pp. 193-201
-
-
Levites, Y.1
Das, P.2
Price, R.W.3
Rochette, M.J.4
Kostura, L.A.5
Mc-Gowan, E.M.6
Murphy, M.P.7
Golde, T.E.8
-
53
-
-
33744982670
-
Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice
-
Morgan D (2006) Modulation of microglial activation state following passive immunization in amyloid depositing transgenic mice. Neurochem Int 49, 190-194.
-
(2006)
Neurochem Int
, vol.49
, pp. 190-194
-
-
Morgan, D.1
-
54
-
-
31844439888
-
Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
-
Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM (2006). Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res 83, 374-384.
-
(2006)
J Neurosci Res
, vol.83
, pp. 374-384
-
-
Ma, Q.L.1
Lim, G.P.2
Harris-White, M.E.3
Yang, F.4
Ambegaokar, S.S.5
Ubeda, O.J.6
Glabe, C.G.7
Teter, B.8
Frautschy, S.A.9
Cole, G.M.10
-
55
-
-
0036703483
-
Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease
-
Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH (2002) Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease. J Neurosci 22, 6331-6335.
-
(2002)
J Neurosci
, vol.22
, pp. 6331-6335
-
-
Kotilinek, L.A.1
Bacskai, B.2
Westerman, M.3
Kawarabayashi, T.4
Younkin, L.5
Hyman, B.T.6
Younkin, S.7
Ashe, K.H.8
-
56
-
-
0036853548
-
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
-
Hock C, Konietzko U, Papassotiropoulos A,Wollmer A, Streffer J, von Rotz RC, Davey G, Moritz E, Nitsch RM (2002) Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat Med 8, 1270-1275.
-
(2002)
Nat Med
, vol.8
, pp. 1270-1275
-
-
Hock, C.1
Konietzko, U.2
Papassotiropoulos, A.3
Wollmer, A.4
Streffer, J.5
Von Rotz, R.C.6
Davey, G.7
Moritz, E.8
Nitsch, R.M.9
-
57
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD
-
Bayer AJ, Bullock R, Jones RW,Wilkinson D, Paterson KR, Jenkins L, Millais SB, Donoghue S (2005) Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 64, 94-101.
-
(2005)
Neurology
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
Wilkinson, D.4
Paterson, K.R.5
Jenkins, L.6
Millais, S.B.7
Donoghue, S.8
-
58
-
-
21344445485
-
Decline of immune responsiveness: A pathogenetic factor in Alzheimer's disease?
-
Richartz E, Stransky E, Batra A, Simon P, Lewczuk P, Buchkremer G, Bartels M, Schott K (2005) Decline of immune responsiveness: a pathogenetic factor in Alzheimer's disease? J Psychiatr Res 39, 535-543.
-
(2005)
J Psychiatr Res
, vol.39
, pp. 535-543
-
-
Richartz, E.1
Stransky, E.2
Batra, A.3
Simon, P.4
Lewczuk, P.5
Buchkremer, G.6
Bartels, M.7
Schott, K.8
-
59
-
-
34547779485
-
Reduced serum level of antibodies against amyloid beta peptide is associated with aging in Tg2576 mice
-
Sohn JH, So JO, Kim H, Nam EJ, Ha HJ, Kim YH, Mook-Jung I (2007) Reduced serum level of antibodies against amyloid beta peptide is associated with aging in Tg2576 mice. Biochem Biophys Res Commun 361, 800-804.
-
(2007)
Biochem Biophys Res Commun
, vol.361
, pp. 800-804
-
-
Sohn, J.H.1
So, J.O.2
Kim, H.3
Nam, E.J.4
Ha, H.J.5
Kim, Y.H.6
Mook-Jung, I.7
-
60
-
-
61349097791
-
B-cell responses to vaccination at the extremes of age
-
Siegrist CA, Aspinall R (2009) B-cell responses to vaccination at the extremes of age. Nat Rev Immunol 9, 185-194.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 185-194
-
-
Siegrist, C.A.1
Aspinall, R.2
-
61
-
-
77049105986
-
Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors
-
Radaev S, Sun PD (2001) Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors. Curr Opin Invest Drugs 6, 35-47.
-
(2001)
Curr Opin Invest Drugs
, vol.6
, pp. 35-47
-
-
Radaev, S.1
Sun, P.D.2
-
62
-
-
0019223698
-
Effects of pH treatments and deglycosylation of rabbit immunoglobulin G on the binding of C1q
-
Winkelhake JL, Kunicki TJ, Elcombe BM, Aster RH (1980) Effects of pH treatments and deglycosylation of rabbit immunoglobulin G on the binding of C1q. J Biol Chem 255, 2822-2828.
-
(1980)
J Biol Chem
, vol.255
, pp. 2822-2828
-
-
Winkelhake, J.L.1
Kunicki, T.J.2
Elcombe, B.M.3
Aster, R.H.4
-
63
-
-
35748932661
-
Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration
-
Takata K, Hirata-Fukae C, Becker AG, Chishiro S, Gray AJ, Nishitomi K, Franz AH, Sakaguchi G, Kato A, Mattson MP, Laferla FM, Aisen PS, Kitamura Y, Matsuoka Y (2007) Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration. J Neurosci 26, 2458-2468.
-
(2007)
J Neurosci
, vol.26
, pp. 2458-2468
-
-
Takata, K.1
Hirata-Fukae, C.2
Becker, A.G.3
Chishiro, S.4
Gray, A.J.5
Nishitomi, K.6
Franz, A.H.7
Sakaguchi, G.8
Kato, A.9
Mattson, M.P.10
Laferla, F.M.11
Aisen, P.S.12
Kitamura, Y.13
Matsuoka, Y.14
-
64
-
-
27144450504
-
Deglycosylation of anti-beta amyloid antibodies inhibits microglia activation in Bv-2 cellular model
-
Rebe S, SolomonB(2005) Deglycosylation of anti-beta amyloid antibodies inhibits microglia activation in Bv-2 cellular model. Am J Alzheimers Dis Other Demen 20, 303-313.
-
(2005)
Am J Alzheimers Dis Other Demen
, vol.20
, pp. 303-313
-
-
Rebe, S.1
Solomon, B.2
-
65
-
-
33745111586
-
Intracranial administration of deglycosylated C-terminalspecific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice
-
Carty NC, Wilcock DM, Rosenthal A, Grimm J, Pons J, Ronan V, Gottschall PE, Gordon MN, Morgan D. (2006) Intracranial administration of deglycosylated C-terminalspecific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. J Neuroinflammation 3, 11.
-
(2006)
J Neuroinflammation
, vol.3
, pp. 11
-
-
Carty, N.C.1
Wilcock, D.M.2
Rosenthal, A.3
Grimm, J.4
Pons, J.5
Ronan, V.6
Gottschall, P.E.7
Gordon, M.N.8
Morgan, D.9
-
66
-
-
33745001453
-
Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
-
Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, Ronan V, Symmonds K, Gordon MN, Morgan D (2006) Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J Neurosci 26, 5340-5346.
-
(2006)
J Neurosci
, vol.26
, pp. 5340-5346
-
-
Wilcock, D.M.1
Alamed, J.2
Gottschall, P.E.3
Grimm, J.4
Rosenthal, A.5
Pons, J.6
Ronan, V.7
Symmonds, K.8
Gordon, M.N.9
Morgan, D.10
-
67
-
-
49549122035
-
Deglycosylated anti-Aβ antibody dose-response effects on pathology and memory in APP transgenic mice
-
Karlnoski RA, Rosenthal A, Alamed J, Ronan V, Gordon MN, Gottschall PE, Grimm J, Pons J, Morgan D (2008) Deglycosylated anti-Aβ antibody dose-response effects on pathology and memory in APP transgenic mice. J Neuroimmune Pharmacol 3, 187-197.
-
(2008)
J Neuroimmune Pharmacol
, vol.3
, pp. 187-197
-
-
Karlnoski, R.A.1
Rosenthal, A.2
Alamed, J.3
Ronan, V.4
Gordon, M.N.5
Gottschall, P.E.6
Grimm, J.7
Pons, J.8
Morgan, D.9
-
68
-
-
33750586141
-
Abeta species removal after abeta42 immunization
-
Nicoll JA, Barton E, Boche D, Neal JW, Ferrer I, Thompson P, Vlachouli C, Wilkinson D, Bayer A, Games D, Seubert P, Schenk D, Holmes C (2006) Abeta species removal after abeta42 immunization. J Neuropathol Exp Neurol 65, 1040-1048.
-
(2006)
J Neuropathol Exp Neurol
, vol.65
, pp. 1040-1048
-
-
Nicoll, J.A.1
Barton, E.2
Boche, D.3
Neal, J.W.4
Ferrer, I.5
Thompson, P.6
Vlachouli, C.7
Wilkinson, D.8
Bayer, A.9
Games, D.10
Seubert, P.11
Schenk, D.12
Holmes, C.13
-
69
-
-
34247113214
-
Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia
-
Bombois S, Maurage CA, Gompel M, Deramecourt V, Mackowiak-Cordoliani MA, Black RS, Lavielle R, Delacourte A, Pasquier F (2007) Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia. Arch Neurol 64, 583-587.
-
(2007)
Arch Neurol
, vol.64
, pp. 583-587
-
-
Bombois, S.1
Maurage, C.A.2
Gompel, M.3
Deramecourt, V.4
MacKowiak-Cordoliani, M.A.5
Black, R.S.6
Lavielle, R.7
Delacourte, A.8
Pasquier, F.9
-
70
-
-
10744230547
-
Sub acute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, Kirby LC, Jouanny P, Dubois B, Eisner L, Flitman S, Michel BF, Boada M, Frank A, Hock C (2003) Sub acute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61, 46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
Laurent, B.4
Puel, M.5
Kirby, L.C.6
Jouanny, P.7
Dubois, B.8
Eisner, L.9
Flitman, S.10
Michel, B.F.11
Boada, M.12
Frank, A.13
Hock, C.14
-
71
-
-
0036127580
-
Set back to Alzheimer vaccine studies
-
Birmingham K, Frantz S (2002) Set back to Alzheimer vaccine studies. Nat Med 8, 199-200.
-
(2002)
Nat Med
, vol.8
, pp. 199-200
-
-
Birmingham, K.1
Frantz, S.2
-
72
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
AN1792 (QS21)-201 Study Team
-
Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Rovira MB, Forette F, Orgogozo J-M (2005) AN1792 (QS21)-201 Study Team. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64, 1553-1562.
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
Jenkins, L.4
Griffith, S.G.5
Fox, N.C.6
Eisner, L.7
Kirby, L.8
Rovira, M.B.9
Forette, F.10
Orgogozo, J.-M.11
-
73
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C, Konietzko U, Streffer JR, Tracy J, Signorell A, Muller-Tillmanns B, Lemke U, Henke K, Moritz E, Garcia E, Wollmer MA, Umbricht D, de Quervain DJ, Hofmann M, Maddalena A, Papassotiropoulos A, Nitsch RM (2003) Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547-554.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
Tracy, J.4
Signorell, A.5
Muller-Tillmanns, B.6
Lemke, U.7
Henke, K.8
Moritz, E.9
Garcia, E.10
Wollmer, M.A.11
Umbricht, D.12
De Quervain, D.J.13
Hofmann, M.14
Maddalena, A.15
Papassotiropoulos, A.16
Nitsch, R.M.17
-
74
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9, 448-452.
-
(2003)
Nat Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
Weller, R.O.6
-
75
-
-
19944429065
-
Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
-
Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, Seubert P, Games D, Kirby L, Schenk D (2005) Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 64, 129-131.
-
(2005)
Neurology
, vol.64
, pp. 129-131
-
-
Masliah, E.1
Hansen, L.2
Adame, A.3
Crews, L.4
Bard, F.5
Lee, C.6
Seubert, P.7
Games, D.8
Kirby, L.9
Schenk, D.10
-
76
-
-
2542443382
-
Lessons from the AN 1792 Alzheimer vaccine: Lest we forget
-
Robinson SR, BishopGM,Lee HG,MünchG(2004) Lessons from the AN 1792 Alzheimer vaccine: lest we forget. Neurobiol Aging 25, 609-615.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 609-615
-
-
Robinson, S.R.1
Bishop, G.M.2
Lee, H.G.3
Münch, G.4
-
77
-
-
18144415471
-
Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
-
Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, Jenkins L, Koller M (2005) Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology 64, 1563-1572.
-
(2005)
Neurology
, vol.64
, pp. 1563-1572
-
-
Fox, N.C.1
Black, R.S.2
Gilman, S.3
Rossor, M.N.4
Griffith, S.G.5
Jenkins, L.6
Koller, M.7
-
78
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
-
Ferrer I, Boada Rovira M, Śanchez Guerra ML, Rey MJ, Costa-Jusśa F (2004) Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol 14, 11-20.
-
(2004)
Brain Pathol
, vol.14
, pp. 11-20
-
-
Ferrer, I.1
Boada Rovira, M.2
Śanchez Guerra, M.L.3
Rey, M.J.4
Costa-Jusśa, F.5
-
79
-
-
33748767945
-
Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: A biochemical analysis
-
Patton RL, Kalback WM, Esh CL, Kokiohn TA, Van Vickle GD, Luers DC, Kuo YM, Lopez J, Brune D, Ferrer I, Masliah E, Newel AJ, Beach TG, Castano EM, Roher AE (2006) Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. Am J Pathol 169, 1048-1063.
-
(2006)
Am J Pathol
, vol.169
, pp. 1048-1063
-
-
Patton, R.L.1
Kalback, W.M.2
Esh, C.L.3
Kokiohn, T.A.4
Van Vickle, G.D.5
Luers, D.C.6
Kuo, Y.M.7
Lopez, J.8
Brune, D.9
Ferrer, I.10
Masliah, E.11
Newel, A.J.12
Beach, T.G.13
Castano, E.M.14
Roher, A.E.15
-
80
-
-
58149129243
-
Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
-
Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA (2008) Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 131, 3299-3310.
-
(2008)
Brain
, vol.131
, pp. 3299-3310
-
-
Boche, D.1
Zotova, E.2
Weller, R.O.3
Love, S.4
Neal, J.W.5
Pickering, R.M.6
Wilkinson, D.7
Holmes, C.8
Nicoll, J.A.9
-
81
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebocontrolled phase i trial
-
Holmes C, Boche D,Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA (2008) Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebocontrolled phase I trial. Lancet 372, 216-223.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
82
-
-
0032989712
-
Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
-
Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol 45, 358-368.
-
(1999)
Ann Neurol
, vol.45
, pp. 358-368
-
-
Price, J.L.1
Morris, J.C.2
-
83
-
-
4644275963
-
Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease
-
Dodel RC, Du Y, Depboylu C, Hampel H, Frolich L, Haag A, Hemmeter U, Paulsen S, Teipel SJ, Brettschneider S, Spottke A, Nolker C, Moller HJ,Wei X, FarlowM, Sommer N, Oertel WH (2004) Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease. J Neurol Neurosurg Psychiatry 75, 1472-1474.
-
(2004)
J Neurol Neurosurg Psychiatry
, vol.75
, pp. 1472-1474
-
-
Dodel, R.C.1
Du, Y.2
Depboylu, C.3
Hampel, H.4
Frolich, L.5
Haag, A.6
Hemmeter, U.7
Paulsen, S.8
Teipel, S.J.9
Brettschneider, S.10
Spottke, A.11
Nolker, C.12
Moller, H.J.13
Wei, X.14
Farlow, M.15
Sommer, N.16
Oertel, W.H.17
-
84
-
-
70049083865
-
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Relkin NR, Szabo P, Adamiak B, Burgut T, Monthe C, Lent RW, Younkin S,Younkin L, Schiff R,Weksler ME(2009) 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging 30, 1728-1736.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1728-1736
-
-
Relkin, N.R.1
Szabo, P.2
Adamiak, B.3
Burgut, T.4
Monthe, C.5
Lent, R.W.6
Younkin, S.7
Younkin, L.8
Schiff, R.9
Weksler, M.E.10
-
85
-
-
60549112186
-
Immunization in Alzheimer's disease: Naïve hope or realistic clinical potential?
-
Foster JK, Verdile G, Bates KA, Martins RN (2009) Immunization in Alzheimer's disease: naïve hope or realistic clinical potential? Mol Psychiatry 14, 239-251.
-
(2009)
Mol Psychiatry
, vol.14
, pp. 239-251
-
-
Foster, J.K.1
Verdile, G.2
Bates, K.A.3
Martins, R.N.4
-
86
-
-
13644249899
-
Human monoclonal antibodies against amyloid-beta from healthy adults
-
Geylis V, Kourilov V, Meiner Z, Nennesmo I, Bogdanovic N, Steinitz M (2005) Human monoclonal antibodies against amyloid-beta from healthy adults. Neurobiol Aging 26, 597-606.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 597-606
-
-
Geylis, V.1
Kourilov, V.2
Meiner, Z.3
Nennesmo, I.4
Bogdanovic, N.5
Steinitz, M.6
-
87
-
-
28744434297
-
Immunotherapy of Alzheimer's disease (AD): From murine models to anti-amyloid beta (Abeta) human monoclonal antibodies
-
Geylis V, Steinitz M (2006) Immunotherapy of Alzheimer's disease (AD): from murine models to anti-amyloid beta (Abeta) human monoclonal antibodies. Autoimmun Rev 5, 33-39.
-
(2006)
Autoimmun Rev
, vol.5
, pp. 33-39
-
-
Geylis, V.1
Steinitz, M.2
-
88
-
-
33344460820
-
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch
-
Ghochikyan A, Mkrtichyan M, Petrushina I, Movsesyan N, Karapetyan A, Cribbs DH, Agadjanyan MG (2006a) Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch. Vaccine 24, 2275-2282.
-
(2006)
Vaccine
, vol.24
, pp. 2275-2282
-
-
Ghochikyan, A.1
Mkrtichyan, M.2
Petrushina, I.3
Movsesyan, N.4
Karapetyan, A.5
Cribbs, D.H.6
Agadjanyan, M.G.7
-
89
-
-
33846430934
-
Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates
-
Ghochikyan A, Petrushina I, Lees A, Vasilevko V, Movsesyan N, Karapetyan A, Agadjanyan MG, Cribbs DH (2006b) Abeta-immunotherapy for Alzheimer's disease using mannan-amyloid-Beta peptide immunoconjugates. DNA Cell Biol 25, 571-580.
-
(2006)
DNA Cell Biol
, vol.25
, pp. 571-580
-
-
Ghochikyan, A.1
Petrushina, I.2
Lees, A.3
Vasilevko, V.4
Movsesyan, N.5
Karapetyan, A.6
Agadjanyan, M.G.7
Cribbs, D.H.8
-
90
-
-
4644292773
-
Hopes remain for an Alzheimer's vaccine
-
Schenk D (2004) Hopes remain for an Alzheimer's vaccine. Nature 431, 398.
-
(2004)
Nature
, vol.431
, pp. 398
-
-
Schenk, D.1
-
91
-
-
0037436022
-
Cerebral hemorrhage and amyloid-beta
-
Atwood CS, Perry G, SmithMA(2003) Cerebral hemorrhage and amyloid-beta. Science 299, 1014.
-
(2003)
Science
, vol.299
, pp. 1014
-
-
Atwood, C.S.1
Perry, G.2
Smith, M.A.3
-
92
-
-
34247876141
-
Therapies for Alzheimer's disease
-
Melnikova I (2007) Therapies for Alzheimer's disease. Nat Rev Drug Discov 6, 341-342.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 341-342
-
-
Melnikova, I.1
-
93
-
-
38449088277
-
Antibody-based approaches in Alzheimer's research: Safety, pharmacokinetics, metabolism, and analytical tools
-
Lichtlen P, Mohajeri MH (2007) Antibody-based approaches in Alzheimer's research: safety, pharmacokinetics, metabolism, and analytical tools. J Neurochem 104, 859-874.
-
(2007)
J Neurochem
, vol.104
, pp. 859-874
-
-
Lichtlen, P.1
Mohajeri, M.H.2
-
94
-
-
35648994903
-
Molecular basis for passive immunotherapy of Alzheimer's disease
-
Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C (2007) Molecular basis for passive immunotherapy of Alzheimer's disease. Proc Natl Acad Sci USA 104, 15659-15664.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 15659-15664
-
-
Gardberg, A.S.1
Dice, L.T.2
Ou, S.3
Rich, R.L.4
Helmbrecht, E.5
Ko, J.6
Wetzel, R.7
Myszka, D.G.8
Patterson, P.H.9
Dealwis, C.10
-
95
-
-
34548763861
-
The underestimated potential of the immune system in prevention of Alzheimer's disease pathology
-
Mohajeri MH(2007) The underestimated potential of the immune system in prevention of Alzheimer's disease pathology. Bioessays 29, 927-932.
-
(2007)
Bioessays
, vol.29
, pp. 927-932
-
-
Mohajeri, M.H.1
-
96
-
-
38149006154
-
CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation
-
Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J (2008) CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation. Neurobiol Dis 29, 336-353.
-
(2008)
Neurobiol Dis
, vol.29
, pp. 336-353
-
-
Obregon, D.1
Hou, H.2
Bai, Y.3
Nikolic, W.V.4
Mori, T.5
Luo, D.6
Zeng, J.7
Ehrhart, J.8
Fernandez, F.9
Morgan, D.10
Giunta, B.11
Town, T.12
Tan, J.13
-
97
-
-
0029787599
-
Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils
-
El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD (1996) Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature 382, 716-719.
-
(1996)
Nature
, vol.382
, pp. 716-719
-
-
El Khoury, J.1
Hickman, S.E.2
Thomas, C.A.3
Cao, L.4
Silverstein, S.C.5
Loike, J.D.6
-
98
-
-
0037531198
-
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
-
Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D (2003) Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci 23, 3745-3751.
-
(2003)
J Neurosci
, vol.23
, pp. 3745-3751
-
-
Wilcock, D.M.1
Di Carlo, G.2
Henderson, D.3
Jackson, J.4
Clarke, K.5
Ugen, K.E.6
Gordon, M.N.7
Morgan, D.8
-
99
-
-
1642497601
-
Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
-
Wilcock DM, Munireddy SK, Rosenthal A, Ugen KE, Gordon MN, Morgan D (2004) Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol Dis 15, 11-20.
-
(2004)
Neurobiol Dis
, vol.15
, pp. 11-20
-
-
Wilcock, D.M.1
Munireddy, S.K.2
Rosenthal, A.3
Ugen, K.E.4
Gordon, M.N.5
Morgan, D.6
-
100
-
-
1942452266
-
Specificity of mechanisms for plaque removal after A beta immunotherapy for Alzheimer disease
-
Akiyama H, McGeer PL (2004) Specificity of mechanisms for plaque removal after A beta immunotherapy for Alzheimer disease. Nat Med 10, 117-118
-
(2004)
Nat Med
, vol.10
, pp. 117-118
-
-
Akiyama, H.1
McGeer, P.L.2
-
101
-
-
18144453796
-
Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease
-
DeWitt DA, Perry G, Cohen M, Doller C, Silver J (1998) Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp Neurol 149, 329-340.
-
(1998)
Exp Neurol
, vol.149
, pp. 329-340
-
-
De Witt, D.A.1
Perry, G.2
Cohen, M.3
Doller, C.4
Silver, J.5
-
102
-
-
24044503374
-
Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid
-
Alarćon R, Fuenzalida C, Santib́añez M, von Bernhardi R (2005) Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. J Biol Chem 280, 30406-30415.
-
(2005)
J Biol Chem
, vol.280
, pp. 30406-30415
-
-
Alarćon, R.1
Fuenzalida, C.2
Santib́añez, M.3
Von Bernhardi, R.4
-
103
-
-
3042845492
-
Microglia and Alzheimer's disease pathogenesis
-
Streit WJ (2004) Microglia and Alzheimer's disease pathogenesis. J Neurosci Res 77, 1-8.
-
(2004)
J Neurosci Res
, vol.77
, pp. 1-8
-
-
Streit, W.J.1
-
105
-
-
34147115541
-
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
-
El Khoury J,Toft M, Hickman SE, Means TK,Terada K, Geula C, Luster AD (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 13, 432-438.
-
(2007)
Nat Med
, vol.13
, pp. 432-438
-
-
El Khoury, J.1
Toft, M.2
Hickman, S.E.3
Means, T.K.4
Terada, K.5
Geula, C.6
Luster, A.D.7
-
106
-
-
0036849021
-
Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
-
Rogers J, Strohmeyer R, Kovelowski CJ, Li R (2002) Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40, 260-269.
-
(2002)
Glia
, vol.40
, pp. 260-269
-
-
Rogers, J.1
Strohmeyer, R.2
Kovelowski, C.J.3
Li, R.4
-
107
-
-
34547889114
-
Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin
-
Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J (2007) Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci USA 104, 12849-12854.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12849-12854
-
-
Fiala, M.1
Liu, P.T.2
Espinosa-Jeffrey, A.3
Rosenthal, M.J.4
Bernard, G.5
Ringman, J.M.6
Sayre, J.7
Zhang, L.8
Zaghi, J.9
Dejbakhsh, S.10
Chiang, B.11
Hui, J.12
Mahanian, M.13
Baghaee, A.14
Hong, P.15
Cashman, J.16
-
108
-
-
0037019859
-
The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: Implications for Alzheimer's disease
-
Hoozemans JJ,Veerhuis R, Janssen I, van Elk EJ, Rozemuller AJ, Eikelenboom P (2002) The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease. Brain Res 951, 218-226.
-
(2002)
Brain Res
, vol.951
, pp. 218-226
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Janssen, I.3
Van Elk, E.J.4
Rozemuller, A.J.5
Eikelenboom, P.6
-
109
-
-
33646841989
-
Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner
-
Floden AM, Combs CK (2006) Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner. J Neurosci 26, 4644-4648.
-
(2006)
J Neurosci
, vol.26
, pp. 4644-4648
-
-
Floden, A.M.1
Combs, C.K.2
-
110
-
-
0037107177
-
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
-
Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT (2002) Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci 22, 7873-7878.
-
(2002)
J Neurosci
, vol.22
, pp. 7873-7878
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
McLellan, M.E.3
Games, D.4
Seubert, P.5
Schenk, D.6
Hyman, B.T.7
-
111
-
-
0141457897
-
Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/-knock-out mice
-
Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE (2003) Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/-knock-out mice. J Neurosci 23, 8532-8538.
-
(2003)
J Neurosci
, vol.23
, pp. 8532-8538
-
-
Das, P.1
Howard, V.2
Loosbrock, N.3
Dickson, D.4
Murphy, M.P.5
Golde, T.E.6
-
112
-
-
0034237142
-
Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody
-
Frenkel D, Solomon B, Benhar I (2000) Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody. J Neuroimmunol 106, 23-31.
-
(2000)
J Neuroimmunol
, vol.106
, pp. 23-31
-
-
Frenkel, D.1
Solomon, B.2
Benhar, I.3
-
113
-
-
0038204838
-
CD36 mediates the innate host response to beta-amyloid
-
El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD (2003) CD36 mediates the innate host response to beta-amyloid. J Exp Med 197, 1657-1666.
-
(2003)
J Exp Med
, vol.197
, pp. 1657-1666
-
-
El Khoury, J.B.1
Moore, K.J.2
Means, T.K.3
Leung, J.4
Terada, K.5
Toft, M.6
Freeman, M.W.7
Luster, A.D.8
-
114
-
-
33645650780
-
Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide
-
Chen K, Iribarren P, Hu J, Chen J, Gong W, Cho EH, Lockett S, Dunlop NM, Wang JM (2006) Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide. J Biol Chem 281, 3651-3659.
-
(2006)
J Biol Chem
, vol.281
, pp. 3651-3659
-
-
Chen, K.1
Iribarren, P.2
Hu, J.3
Chen, J.4
Gong, W.5
Cho, E.H.6
Lockett, S.7
Dunlop, N.M.8
Wang, J.M.9
-
115
-
-
23444448277
-
LPS receptor (CD14): A receptor for phagocytosis of Alzheimer's amyloid peptide
-
Liu Y, Walter S, Stagi M, Cherny D, Letiembre M, Schulz-Schaeffer W, Heine H, Penke B, Neumann H, Fassbender K (2005) LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain 128, 1778-1789.
-
(2005)
Brain
, vol.128
, pp. 1778-1789
-
-
Liu, Y.1
Walter, S.2
Stagi, M.3
Cherny, D.4
Letiembre, M.5
Schulz-Schaeffer, W.6
Heine, H.7
Penke, B.8
Neumann, H.9
Fassbender, K.10
-
116
-
-
32344440522
-
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
-
Simard AR, Soulet D, Gowing G, Julien JP, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49, 489-502.
-
(2006)
Neuron
, vol.49
, pp. 489-502
-
-
Simard, A.R.1
Soulet, D.2
Gowing, G.3
Julien, J.P.4
Rivest, S.5
-
117
-
-
21444454120
-
Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients
-
Fiala M, Lin J, Ringman J,Kermani-Arab V, Tsao G, Patel A, Lossinsky AS, Graves MC, Gustavson A, Sayre J, Sofroni E, Suarez T, Chiappelli F, Bernard G (2005) Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis 7, 221-232.
-
(2005)
J Alzheimers Dis
, vol.7
, pp. 221-232
-
-
Fiala, M.1
Lin, J.2
Ringman, J.3
Kermani-Arab, V.4
Tsao, G.5
Patel, A.6
Lossinsky, A.S.7
Graves, M.C.8
Gustavson, A.9
Sayre, J.10
Sofroni, E.11
Suarez, T.12
Chiappelli, F.13
Bernard, G.14
-
118
-
-
11844255779
-
Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
-
Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, Koistinaho J (2005) Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiol Dis 18, 134-142.
-
(2005)
Neurobiol Dis
, vol.18
, pp. 134-142
-
-
Malm, T.M.1
Koistinaho, M.2
Pärepalo, M.3
Vatanen, T.4
Ooka, A.5
Karlsson, S.6
Koistinaho, J.7
-
119
-
-
44949173099
-
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
-
Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA (2008) Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med 14, 681-687.
-
(2008)
Nat Med
, vol.14
, pp. 681-687
-
-
Town, T.1
Laouar, Y.2
Pittenger, C.3
Mori, T.4
Szekely, C.A.5
Tan, J.6
Duman, R.S.7
Flavell, R.A.8
-
120
-
-
36148995408
-
A limited role for microglia in antibody mediated plaque clearance in APP mice
-
Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ (2007) A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiol Dis 28, 286-292.
-
(2007)
Neurobiol Dis
, vol.28
, pp. 286-292
-
-
Garcia-Alloza, M.1
Ferrara, B.J.2
Dodwell, S.A.3
Hickey, G.A.4
Hyman, B.T.5
Bacskai, B.J.6
-
121
-
-
0037155581
-
Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummings DJ, Paul SM, Holtzman DM (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295, 2264-2267.
-
(2002)
Science
, vol.295
, pp. 2264-2267
-
-
De Mattos, R.B.1
Bales, K.R.2
Cummings, D.J.3
Paul, S.M.4
Holtzman, D.M.5
-
122
-
-
0037038820
-
Vascular disorder in Alzheimer's disease: Role in pathogenesis of dementia and therapeutic targets
-
Zlokovic BV (2002) Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets. Adv Drug Deliv Rev 54, 1553-1559.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 1553-1559
-
-
Zlokovic, B.V.1
-
123
-
-
0033621739
-
Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
-
Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC (2000) Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med 6, 143-150.
-
(2000)
Nat Med
, vol.6
, pp. 143-150
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Watanabe, K.4
Sekiguchi, M.5
Hosoki, E.6
Kawashima-Morishima, M.7
Lee, H.J.8
Hama, E.9
Sekine-Aizawa, Y.10
Saido, T.C.11
-
124
-
-
0034521392
-
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106, 1489-1499.
-
(2000)
J Clin Invest
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
Calero, M.4
Bading, J.5
Frangione, B.6
Holtzman, D.M.7
Miller, C.A.8
Strickland, D.K.9
Ghiso, J.10
Zlokovic, B.V.11
-
125
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 5, 452-457.
-
(2002)
Nat Neurosci
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
Greene, S.J.4
De Mattos, R.B.5
Mathis, C.6
De Long, C.A.7
Wu, S.8
Wu, X.9
Holtzman, D.M.10
Paul, S.M.11
-
126
-
-
37149008108
-
Experimental investigation of antibody-mediated clearance mechanisms of amyloid-β in CNS of Tg-SwDI Transgenic Mice
-
Vasilevko V, Xu F, Previti ML,Van Nostrand WE, Cribbs DH (2007) Experimental Investigation of Antibody-Mediated Clearance Mechanisms of Amyloid-β in CNS of Tg-SwDI Transgenic Mice. J Neurosci 27, 13376-13383.
-
(2007)
J Neurosci
, vol.27
, pp. 13376-13383
-
-
Vasilevko, V.1
Xu, F.2
Previti, M.L.3
Van Nostrand, W.E.4
Cribbs, D.H.5
-
127
-
-
0033103657
-
High affinity binding of monoclonal antibodies to the sequential epitope EFRH of beta-amyloid peptide is essential for modulation of fibrillar aggregation
-
Frenkel D, Balass M, Katchalski-Katzir E, Solomon B (1999) High affinity binding of monoclonal antibodies to the sequential epitope EFRH of beta-amyloid peptide is essential for modulation of fibrillar aggregation. J Neuroimmunol 95, 136-142.
-
(1999)
J Neuroimmunol
, vol.95
, pp. 136-142
-
-
Frenkel, D.1
Balass, M.2
Katchalski-Katzir, E.3
Solomon, B.4
-
128
-
-
21044453723
-
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo
-
Klyubin I,Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ (2005) Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11, 556-561.
-
(2005)
Nat Med
, vol.11
, pp. 556-561
-
-
Klyubin, I.1
Walsh, D.M.2
Lemere, C.A.3
Cullen, W.K.4
Shankar, G.M.5
Betts, V.6
Spooner, E.T.7
Jiang, L.8
Anwyl, R.9
Selkoe, D.J.10
Rowan, M.J.11
-
129
-
-
0036953160
-
Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease
-
Banks WA, Terrell B, Farr SA, Robinson SM, Nonaka N, Morley JE (2002). Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease. Peptides 23, 2223-2226.
-
(2002)
Peptides
, vol.23
, pp. 2223-2226
-
-
Banks, W.A.1
Terrell, B.2
Farr, S.A.3
Robinson, S.M.4
Nonaka, N.5
Morley, J.E.6
-
130
-
-
65649105035
-
Clearance of amyloid-beta peptide across the blood-brain barrier: Implication for therapies in Alzheimer's disease
-
Deane R, Bell RD, Sagare A, Zlokovic BV (2009) Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets 8, 16-30.
-
(2009)
CNS Neurol Disord Drug Targets
, vol.8
, pp. 16-30
-
-
Deane, R.1
Bell, R.D.2
Sagare, A.3
Zlokovic, B.V.4
-
131
-
-
33645528251
-
Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease
-
Simard AR, Rivest S (2006) Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease. Mol Psychiatry 11, 327-335.
-
(2006)
Mol Psychiatry
, vol.11
, pp. 327-335
-
-
Simard, A.R.1
Rivest, S.2
-
132
-
-
24644438615
-
Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: Implications for Alzheimer therapeutics
-
Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM (2005) Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J Neuropathol Exp Neurol 64, 743-753.
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 743-753
-
-
Morgan, D.1
Gordon, M.N.2
Tan, J.3
Wilcock, D.4
Rojiani, A.M.5
-
133
-
-
41749116202
-
Glial cell dysregulation: A new perspective on Alzheimer disease
-
von Bernhardi R (2007) Glial cell dysregulation: a new perspective on Alzheimer disease. Neurotox Res 12, 215-232.
-
(2007)
Neurotox Res
, vol.12
, pp. 215-232
-
-
Von Bernhardi, R.1
-
134
-
-
34547215215
-
Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels
-
Rakover I, Arbel M, Solomon B (2007) Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels. Neurodegener Dis 4, 392-402.
-
(2007)
Neurodegener Dis
, vol.4
, pp. 392-402
-
-
Rakover, I.1
Arbel, M.2
Solomon, B.3
-
135
-
-
34547840292
-
Decrease in neuroinflammation after immunisation with synthetic prion peptides in an animal model of scrapie
-
Servida F, Ravasi C, Puricelli M, Formentin EA, Dall'Ara P, Poli G (2007) Decrease in neuroinflammation after immunisation with synthetic prion peptides in an animal model of scrapie. Vet Res Commun 31 Suppl 1, 265-267.
-
(2007)
Vet Res Commun
, vol.31
, Issue.SUPPL. 1
, pp. 265-267
-
-
Servida, F.1
Ravasi, C.2
Puricelli, M.3
Formentin, E.A.4
Dall'Ara, P.5
Poli, G.6
-
136
-
-
33746239693
-
Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice
-
Ethell DW, Shippy D, Cao C, Cracchiolo JR, Runfeldt M, Blake B, Arendash GW(2006) Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice. Neurobiol Dis 23, 351-361.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 351-361
-
-
Ethell, D.W.1
Shippy, D.2
Cao, C.3
Cracchiolo, J.R.4
Runfeldt, M.5
Blake, B.6
Arendash, G.W.7
-
137
-
-
62149141329
-
Abeta-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS
-
Cao C, Arendash GW, Dickson A, Mamcarz MB, Lin X, Ethell DW(2009) Abeta-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS. Neurobiol Dis 34, 63-70.
-
(2009)
Neurobiol Dis
, vol.34
, pp. 63-70
-
-
Cao, C.1
Arendash, G.W.2
Dickson, A.3
Mamcarz, M.B.4
Lin, X.5
Ethell, D.W.6
-
138
-
-
17444387480
-
Protection of rat primary hippocampal cultures from Aβ cytotoxicity by pro-inflammatory molecules is mediated by astrocytes
-
Raḿirez G, Toro R, Döbeli H, von Bernhardi R (2005) Protection of rat primary hippocampal cultures from Aβ cytotoxicity by pro-inflammatory molecules is mediated by astrocytes. Neurobiol Dis 19, 243-254.
-
(2005)
Neurobiol Dis
, vol.19
, pp. 243-254
-
-
Raḿirez, G.1
Toro, R.2
Döbeli, H.3
Von Bernhardi, R.4
-
139
-
-
47849103782
-
Neuroinflammation and synaptic plasticity: Theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders
-
Di Filippo M, Sarchielli P, Picconi B, Calabresi P (2008) Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders. Trends Pharmacol Sci 29, 402-412.
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 402-412
-
-
Di Filippo, M.1
Sarchielli, P.2
Picconi, B.3
Calabresi, P.4
-
140
-
-
33846959825
-
Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo
-
Ryu JK, Tran KC, McLarnon JG (2007) Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo. Glia 55, 439-451.
-
(2007)
Glia
, vol.55
, pp. 439-451
-
-
Ryu, J.K.1
Tran, K.C.2
McLarnon, J.G.3
-
141
-
-
51349127386
-
Differential neutrophil infiltration contributes to regional differences in brain inflammation in the substantia nigra pars compacta and cortex
-
Ji KA, Eu MY, Kang SH, Gwag BJ, Jou I, Joe EH (2008) Differential neutrophil infiltration contributes to regional differences in brain inflammation in the substantia nigra pars compacta and cortex. Glia 56, 1039-1047.
-
(2008)
Glia
, vol.56
, pp. 1039-1047
-
-
Ji, K.A.1
Eu, M.Y.2
Kang, S.H.3
Gwag, B.J.4
Jou, I.5
Joe, E.H.6
-
142
-
-
47249153639
-
Neuroinflammation facilitates LIF entry into brain: Role of TNF
-
Pan W, Yu C, Hsuchou H, Zhang Y, Kastin AJ (2008) Neuroinflammation facilitates LIF entry into brain: role of TNF. Am J Physiol Cell Physiol 294, C1436-1442.
-
(2008)
Am J Physiol Cell Physiol
, vol.294
-
-
Pan, W.1
Yu, C.2
Hsuchou, H.3
Zhang, Y.4
Kastin, A.J.5
-
143
-
-
33645816954
-
Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease
-
Dickstein DL, Biron KE, Ujiie M, Pfeifer CG, Jeffries AR, Jefferies WA (2006) Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease. FASEB J 20, 426-433.
-
(2006)
FASEB J
, vol.20
, pp. 426-433
-
-
Dickstein, D.L.1
Biron, K.E.2
Ujiie, M.3
Pfeifer, C.G.4
Jeffries, A.R.5
Jefferies, W.A.6
-
144
-
-
20944446609
-
Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL
-
Aktas O, Smorodchenko A, Brocke S, Infante-Duarte C, Schulze Topphoff U, Vogt J, Prozorovski T, Meier S, Osmanova V, Pohl E, Bechmann I, Nitsch R, Zipp F (2005) Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron 46, 421-432.
-
(2005)
Neuron
, vol.46
, pp. 421-432
-
-
Aktas, O.1
Smorodchenko, A.2
Brocke, S.3
Infante-Duarte, C.4
Schulze Topphoff, U.5
Vogt, J.6
Prozorovski, T.7
Meier, S.8
Osmanova, V.9
Pohl, E.10
Bechmann, I.11
Nitsch, R.12
Zipp, F.13
-
145
-
-
33846957719
-
Neuronal damage in brain inflammation
-
Aktas O, Ullrich O, Infante-Duarte C, NitschR, Zipp F (2007) Neuronal damage in brain inflammation. Arch Neurol 64, 185-189.
-
(2007)
Arch Neurol
, vol.64
, pp. 185-189
-
-
Aktas, O.1
Ullrich, O.2
Infante-Duarte, C.3
Nitsch, R.4
Zipp, F.5
-
146
-
-
28444499085
-
Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis
-
Steinman L, Zamvil SS (2005) Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. Trends Immunol 26, 565-571.
-
(2005)
Trends Immunol
, vol.26
, pp. 565-571
-
-
Steinman, L.1
Zamvil, S.S.2
-
147
-
-
1542344385
-
Current concepts and future prospects for Alzheimer disease vaccines
-
Heppner FL, Gandy S, McLaurin J (2004) Current concepts and future prospects for Alzheimer disease vaccines. Alzheimer Dis Assoc Disord 18, 38-43.
-
(2004)
Alzheimer Dis Assoc Disord
, vol.18
, pp. 38-43
-
-
Heppner, F.L.1
Gandy, S.2
McLaurin, J.3
-
148
-
-
0035915621
-
Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
-
Neuropathology Group. Medical Research Council Cognitive Function and Aging Study, Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
-
Neuropathology Group. Medical Research Council Cognitive Function and Aging Study (2001) Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 357, 169-175.
-
(2001)
Lancet
, vol.357
, pp. 169-175
-
-
-
149
-
-
33749506795
-
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
-
Engler H, Forsberg A, Almkvist O, Blomquist G, Larsson E, Savitcheva I,Wall A, Ringheim A, Lngström B, Nordberg A (2006) Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 129, 2856-2866.
-
(2006)
Brain
, vol.129
, pp. 2856-2866
-
-
Engler, H.1
Forsberg, A.2
Almkvist, O.3
Blomquist, G.4
Larsson, E.5
Savitcheva, I.6
Wall, A.7
Ringheim, A.8
Lngström, B.9
Nordberg, A.10
-
150
-
-
24344489466
-
The unfolded protein response is activated in Alzheimer's disease
-
DOI 10.1007/s00401-005-1038-0
-
Hoozemans JJ, Veerhuis R, Van Haastert ES, Rozemuller JM, Baas F, Eikelenboom P, Scheper W(2005) The unfolded protein response is activated in Alzheimer's disease. Acta Neuropathol 110, 165-172. (Pubitemid 41245205)
-
(2005)
Acta Neuropathologica
, vol.110
, Issue.2
, pp. 165-172
-
-
Hoozemans, J.J.M.1
Veerhuis, R.2
Van Haastert, E.S.3
Rozemuller, J.M.4
Baas, F.5
Eikelenboom, P.6
Scheper, W.7
-
151
-
-
65349093893
-
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus
-
Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Eikelenboom P, Scheper W(2009) The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol 174, 1241-1251.
-
(2009)
Am J Pathol
, vol.174
, pp. 1241-1251
-
-
Hoozemans, J.J.1
Van Haastert, E.S.2
Nijholt, D.A.3
Rozemuller, A.J.4
Eikelenboom, P.5
Scheper, W.6
-
152
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293, 1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
153
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
154
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43, 321-332.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
La Ferla, F.M.5
-
155
-
-
0029979798
-
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
-
Ǵomez-Isla T, Price JL, McKeel DWJr, Morris JC, Growdon JH, Hyman BT (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 16, 4491-4500.
-
(1996)
J Neurosci
, vol.16
, pp. 4491-4500
-
-
Ǵomez-Isla, T.1
Price, J.L.2
McKeel Jr., D.W.3
Morris, J.C.4
Growdon, J.H.5
Hyman, B.T.6
-
156
-
-
63849193695
-
Microglial activation and amyloid deposition in mild cognitive impairment: A PET study
-
Okello A, Edison P, Archer HA, Turkheimer FE, Kennedy J, Bullock R, Walker Z, Kennedy A, Fox N, Rossor M, Brooks DJ (2009) Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 72, 56-62.
-
(2009)
Neurology
, vol.72
, pp. 56-62
-
-
Okello, A.1
Edison, P.2
Archer, H.A.3
Turkheimer, F.E.4
Kennedy, J.5
Bullock, R.6
Walker, Z.7
Kennedy, A.8
Fox, N.9
Rossor, M.10
Brooks, D.J.11
-
157
-
-
65549129594
-
Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease
-
Yuyama K,Yanagisawa K (2009) Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease. J Neurochem 109, 1250-1260.
-
(2009)
J Neurochem
, vol.109
, pp. 1250-1260
-
-
Yuyama, K.1
Yanagisawa, K.2
-
158
-
-
51149120624
-
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
-
Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. JNeurosci 28, 8354-8860.
-
(2008)
JNeurosci
, vol.28
, pp. 8354-8860
-
-
Hickman, S.E.1
Allison, E.K.2
El Khoury, J.3
-
159
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesńe S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440, 352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesńe, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
160
-
-
34248190279
-
A beta oligomers - A decade of discovery
-
Walsh DM, Selkoe DJ (2007) A beta oligomers - a decade of discovery. J Neurochem 101, 1172-1184.
-
(2007)
J Neurochem
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
161
-
-
33845639102
-
Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models
-
Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, Kim J, McGowan E, Reed DK, Rosenberry TL, Das P, Golde TE (2006b) Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB J 20, 2576-2578.
-
(2006)
FASEB J
, vol.20
, pp. 2576-2578
-
-
Levites, Y.1
Smithson, L.A.2
Price, R.W.3
Dakin, R.S.4
Yuan, B.5
Sierks, M.R.6
Kim, J.7
McGowan, E.8
Reed, D.K.9
Rosenberry, T.L.10
Das, P.11
Golde, T.E.12
-
162
-
-
36248941497
-
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric aß species in amyloid precursor protein transgenic mice
-
Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG (2007) Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric aß species in amyloid precursor protein transgenic mice. J Neurosci 27, 12721-21231
-
(2007)
J Neurosci
, vol.27
, pp. 12721-21231
-
-
Petrushina, I.1
Ghochikyan, A.2
Mktrichyan, M.3
Mamikonyan, G.4
Movsesyan, N.5
Davtyan, H.6
Patel, A.7
Head, E.8
Cribbs, D.H.9
Agadjanyan, M.G.10
-
163
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414, 212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
164
-
-
43249122280
-
Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: A randomised phase II trial
-
Tarenflurbil Phase II Study investigators
-
Wilcock GK, Black SE, Hendrix SB, Zavitz KH, Swabb EA, Laughlin MA; Tarenflurbil Phase II Study investigators (2008) Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. Lancet Neurol 7, 483-493.
-
(2008)
Lancet Neurol
, vol.7
, pp. 483-493
-
-
Wilcock, G.K.1
Black, S.E.2
Hendrix, S.B.3
Zavitz, K.H.4
Swabb, E.A.5
Laughlin, M.A.6
-
165
-
-
57449095998
-
Selective amyloid-beta lowering agents
-
Wolfe MS (2008) Selective amyloid-beta lowering agents. BMC Neurosci 9 Suppl 2, S4.
-
(2008)
BMC Neurosci
, vol.9
, Issue.SUPPL. 2
-
-
Wolfe, M.S.1
-
166
-
-
46749097518
-
Inhibition and modulation of gammasecretase for Alzheimer's disease
-
Wolfe MS (2008) Inhibition and modulation of gammasecretase for Alzheimer's disease. Neurotherapeutics 5, 391-398.
-
(2008)
Neurotherapeutics
, vol.5
, pp. 391-398
-
-
Wolfe, M.S.1
-
167
-
-
61849185913
-
Recent developments in Alzheimer's disease therapeutics
-
Rafii MS, Aisen PS (2009) Recent developments in Alzheimer's disease therapeutics. BMC Med 19, 7.
-
(2009)
BMC Med
, vol.19
, pp. 7
-
-
Rafii, M.S.1
Aisen, P.S.2
-
168
-
-
47549107705
-
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
-
ADAPT Research Group
-
ADAPT Research Group, Martin BK, Szekely C, Brandt J, Piantadosi S, Breitner JC, Craft S, Evans D, Green R, Mullan M (2008) Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 65, 896-905.
-
(2008)
Arch Neurol
, vol.65
, pp. 896-905
-
-
Martin, B.K.1
Szekely, C.2
Brandt, J.3
Piantadosi, S.4
Breitner, J.C.5
Craft, S.6
Evans, D.7
Green, R.8
Mullan, M.9
-
169
-
-
12544258201
-
Secretase inhibitors for Alzheimer's disease: Challenges of a promiscuous protease
-
Pollack SJ, Lewis H (2005) Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease. Curr Opin Invest Drugs 6, 35-47.
-
(2005)
Curr Opin Invest Drugs
, vol.6
, pp. 35-47
-
-
Pollack, S.J.1
Lewis, H.2
-
170
-
-
2942611429
-
Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
-
Schwab C, Hosokawa M, McGeer PL (2004) Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease. Exp Neurol 188, 52-64.
-
(2004)
Exp Neurol
, vol.188
, pp. 52-64
-
-
Schwab, C.1
Hosokawa, M.2
McGeer, P.L.3
-
171
-
-
0036898144
-
Pharmacokinetics and biodistribution of genetically engineered antibodies
-
Batra SK, Jain M,Wittel UA, Chauhan SC, Colcher D (2002) Pharmacokinetics and biodistribution of genetically engineered antibodies. Curr Opin Biotechnol 13, 603-608.
-
(2002)
Curr Opin Biotechnol
, vol.13
, pp. 603-608
-
-
Batra, S.K.1
Jain, M.2
Wittel, U.A.3
Chauhan, S.C.4
Colcher, D.5
-
172
-
-
2642578354
-
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity
-
Liu R, Yuan B, Emadi S, Zameer A, Schulz P, McAllister C, Lyubchenko Y, Goud G, Sierks MR (2004) Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry 43, 6959-6967.
-
(2004)
Biochemistry
, vol.43
, pp. 6959-6967
-
-
Liu, R.1
Yuan, B.2
Emadi, S.3
Zameer, A.4
Schulz, P.5
McAllister, C.6
Lyubchenko, Y.7
Goud, G.8
Sierks, M.R.9
-
173
-
-
33646064717
-
Amelioration of amyloid load by anti-Aβ single-chain antibody in Alzheimer mouse model
-
Fukuchi K, Accavitti-Loper MA, Kim HD, Tahara K, Cao Y, Lewis TL, Caughey RC, Kim H, Lalonde R (2006) Amelioration of amyloid load by anti-Aβ single-chain antibody in Alzheimer mouse model. Biochem Biophys Res Commun 344, 79-86.
-
(2006)
Biochem Biophys Res Commun
, vol.344
, pp. 79-86
-
-
Fukuchi, K.1
Accavitti-Loper, M.A.2
Kim, H.D.3
Tahara, K.4
Cao, Y.5
Lewis, T.L.6
Caughey, R.C.7
Kim, H.8
Lalonde, R.9
-
174
-
-
0036047653
-
Generation and brain delivery of anti-aggregating antibodies against beta-amyloid plaques using phage display technology
-
Solomon B, Frenkel D (2002) Generation and brain delivery of anti-aggregating antibodies against beta-amyloid plaques using phage display technology. J Neural Transm Suppl 62, 321-325.
-
(2002)
J Neural Transm Suppl
, vol.62
, pp. 321-325
-
-
Solomon, B.1
Frenkel, D.2
-
175
-
-
22244486057
-
Production, purification, and characterization of human scFv antibodies expressed in Saccharomyces cerevisiae, Pichia pastoris, and Escherichia coli
-
Miller KD, Weaver-Feldhaus J, Gray SA, Siegel RW, Feldhaus MJ (2005) Production, purification, and characterization of human scFv antibodies expressed in Saccharomyces cerevisiae, Pichia pastoris, and Escherichia coli. Protein Expr Purif 42, 255-267.
-
(2005)
Protein Expr Purif
, vol.42
, pp. 255-267
-
-
Miller, K.D.1
Weaver-Feldhaus, J.2
Gray, S.A.3
Siegel, R.W.4
Feldhaus, M.J.5
-
176
-
-
10744225891
-
A novel recombinant adenoassociated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease
-
Zhang J, Wu X, Qin C, Qi J, Ma S, Zhang H, Kong Q, Chen D, Ba D, He W (2003) A novel recombinant adenoassociated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease. Neurobiol Dis 14, 365-379.
-
(2003)
Neurobiol Dis
, vol.14
, pp. 365-379
-
-
Zhang, J.1
Wu, X.2
Qin, C.3
Qi, J.4
Ma, S.5
Zhang, H.6
Kong, Q.7
Chen, D.8
Ba, D.9
He, W.10
-
177
-
-
0041886776
-
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
-
Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL (2003) Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest 112, 415-422.
-
(2003)
J Clin Invest
, vol.112
, pp. 415-422
-
-
Monsonego, A.1
Zota, V.2
Karni, A.3
Krieger, J.I.4
Bar-Or, A.5
Bitan, G.6
Budson, A.E.7
Sperling, R.8
Selkoe, D.J.9
Weiner, H.L.10
-
178
-
-
24644435506
-
Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease
-
Frenkel D, Maron R, Burt DS, Weiner H (2005) Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest 115, 2423-2433.
-
(2005)
J Clin Invest
, vol.115
, pp. 2423-2433
-
-
Frenkel, D.1
Maron, R.2
Burt, D.S.3
Weiner, H.4
-
179
-
-
34548203883
-
Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease
-
Kim HD, Jin JJ, Maxwell JA, Fukuchi K (2007) Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease. Immunol Lett 112, 30-38.
-
(2007)
Immunol Lett
, vol.112
, pp. 30-38
-
-
Kim, H.D.1
Jin, J.J.2
Maxwell, J.A.3
Fukuchi, K.4
-
180
-
-
33747048954
-
[11C] PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
-
Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC (2006) [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 67, 446-452.
-
(2006)
Neurology
, vol.67
, pp. 446-452
-
-
Mintun, M.A.1
Larossa, G.N.2
Sheline, Y.I.3
Dence, C.S.4
Lee, S.Y.5
MacH, R.H.6
Klunk, W.E.7
Mathis, C.A.8
De Kosky, S.T.9
Morris, J.C.10
-
181
-
-
34247596133
-
Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease
-
de Leon MJ, Mosconi L, Blennow K, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Tsui W, Saint Louis LA, Sobanska L, Brys M, Li Y, Rich K, Rinne J, Rusinek H (2007) Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease. Ann N Y Acad Sci 1097, 114-145.
-
(2007)
Ann N y Acad Sci
, vol.1097
, pp. 114-145
-
-
De Leon, M.J.1
Mosconi, L.2
Blennow, K.3
De Santi, S.4
Zinkowski, R.5
Mehta, P.D.6
Pratico, D.7
Tsui, W.8
Saint Louis, L.A.9
Sobanska, L.10
Brys, M.11
Li, Y.12
Rich, K.13
Rinne, J.14
Rusinek, H.15
-
182
-
-
35948933394
-
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
-
Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, Friedman LF, Galasko DR, Jutel M, Karydas A, Kaye JA, Leszek J, Miller BL, Minthon L, Quinn JF, Rabinovici GD, Robinson WH, Sabbagh MN, So YT, Sparks DL, Tabaton M, Tinklenberg J, Yesavage JA, Tibshirani R, Wyss-Coray T (2007) Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med 13, 1359-1362.
-
(2007)
Nat Med
, vol.13
, pp. 1359-1362
-
-
Ray, S.1
Britschgi, M.2
Herbert, C.3
Takeda-Uchimura, Y.4
Boxer, A.5
Blennow, K.6
Friedman, L.F.7
Galasko, D.R.8
Jutel, M.9
Karydas, A.10
Kaye, J.A.11
Leszek, J.12
Miller, B.L.13
Minthon, L.14
Quinn, J.F.15
Rabinovici, G.D.16
Robinson, W.H.17
Sabbagh, M.N.18
So, Y.T.19
Sparks, D.L.20
Tabaton, M.21
Tinklenberg, J.22
Yesavage, J.A.23
Tibshirani, R.24
Wyss-Coray, T.25
more..
-
183
-
-
49349092320
-
PET imaging of amyloid deposition in patients with mild cognitive impairment
-
Forsberg A, Engler H, Almkvist O, Blomquist G, Hagman G, Wall A, Ringheim A, Lngström B, Nordberg A (2008) PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging 29, 1456-1465.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1456-1465
-
-
Forsberg, A.1
Engler, H.2
Almkvist, O.3
Blomquist, G.4
Hagman, G.5
Wall, A.6
Ringheim, A.7
Lngström, B.8
Nordberg, A.9
-
185
-
-
66249116626
-
Preclinical evidence of Alzheimer changes: Convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings
-
Petrie EC, Cross DJ, Galasko D, Schellenberg GD, Raskind MA, Peskind ER, Minoshima S (2009) Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings. Arch Neurol 66, 632-637.
-
(2009)
Arch Neurol
, vol.66
, pp. 632-637
-
-
Petrie, E.C.1
Cross, D.J.2
Galasko, D.3
Schellenberg, G.D.4
Raskind, M.A.5
Peskind, E.R.6
Minoshima, S.7
-
186
-
-
0035693924
-
Inflammation, autotoxicity and Alzheimer disease
-
McGeer PL, McGeer EG (2001) Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22, 799-809.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 799-809
-
-
McGeer, P.L.1
McGeer, E.G.2
-
187
-
-
62449242294
-
Contribution of vascular risk factors to the progression in Alzheimer disease
-
Helzner EP, Luchsinger JA, Scarmeas N, Cosentino S, Brickman AM, Glymour MM, Stern Y (2009) Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol 66, 343-348.
-
(2009)
Arch Neurol
, vol.66
, pp. 343-348
-
-
Helzner, E.P.1
Luchsinger, J.A.2
Scarmeas, N.3
Cosentino, S.4
Brickman, A.M.5
Glymour, M.M.6
Stern, Y.7
-
188
-
-
33748471099
-
Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
-
Wyss-Coray T (2006) Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 12, 1005-1015.
-
(2006)
Nat Med
, vol.12
, pp. 1005-1015
-
-
Wyss-Coray, T.1
-
189
-
-
35848962080
-
Disease-modifying therapies for Alzheimer disease: Challenges to early intervention
-
Cummings JL, Doody R, Clark C (2007) Disease-modifying therapies for Alzheimer disease: challenges to early intervention. Neurology 69, 1622-1634.
-
(2007)
Neurology
, vol.69
, pp. 1622-1634
-
-
Cummings, J.L.1
Doody, R.2
Clark, C.3
-
190
-
-
57649221161
-
Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: Lights and shadows
-
Pratic̀o D (2008) Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows. Ann N Y Acad Sci 1147, 70-78.
-
(2008)
Ann N y Acad Sci
, vol.1147
, pp. 70-78
-
-
Pratic̀o, D.1
-
191
-
-
69949118284
-
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
-
Streit WJ, Braak H, Xue QS, Bechmann I (2009) Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol 118, 475-485.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 475-485
-
-
Streit, W.J.1
Braak, H.2
Xue, Q.S.3
Bechmann, I.4
-
192
-
-
33744735681
-
Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders
-
McCarty MF (2006) Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. Med Hypotheses 67, 251-269.
-
(2006)
Med Hypotheses
, vol.67
, pp. 251-269
-
-
McCarty, M.F.1
|