Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4-10 and inhibit cytotoxicity and fibrillogenesis

Nature Medicine

Volumn 8, Issue 11, 2002, Pages 1263-1269

  McLaurin, J ^a,b   Cecal, R ^c   Kierstead, M E ^a,b   Tian, X ^c   Phinney, A L ^a   Manea, M ^c   French, J E ^a   Lambermon, M H L ^a   Darabie, A A ^a   Brown, M E ^a   Janus, C ^a   Chishti, M A ^a   Horne, P ^a   Westaway, D ^a,b   Fraser, P E ^a,b   Mount, H T J ^a,d   Przybylski, M ^c   St George Hyslop, P ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF KONSTANZ   (Germany)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2B; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; GLIOSIS; IMMUNIZATION; INFLAMMATION; MASS SPECTROMETRY; MEMORY DISORDER; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SERUM; SPATIAL MEMORY; T LYMPHOCYTE; TRANSGENIC MOUSE;

ALZHEIMER VACCINES; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIBODIES; BRAIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA;

ANIMALIA; MUS MUSCULUS;

EID: 0036852750     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm790     Document Type: Article

References (36)

1. Small, D.H., Mok, S.S. & Bornstein, J.C. Alzheimer's disease and Aβ-toxicity: From top to bottom. Nature Rev. Neurosci. 2, 595-598 (2001).
2. Chishti, M.A. et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 276, 21562-21570 (2001).
3. Janus, C. et al. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408, 979-982 (2000).
4. Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
5. Morgan, D. et al. Vaccination with Aβ peptide prevents memory deficits in an animal model of Alzheimer's disease. Nature 408, 982-985 (2000).
6. Check, E. Nerve inflammation halts trial for Alzheimer's drug. Nature 415, 462 (2002).
7. Marshall AG, Hendrickson, CL, Jackson, GS. Fourier transform ion cyclotron resonance mass spectrometry: A primer. Mass Spectrom. Rev. 17, 1-35 (1998).
8. Macht, M., Fiedler, W., Kürzinger, K. & Przybylski, M. Mass spectrometric mapping of protein epitope structures of the myocardial infarct markers myoglobin and troponin T. Biochemistry 35, 156333-15639 (1996).
9. Suckau, D. et al. Molecular epitope identification by limited proteolysis of an immobilized antigen-antibody complex and mass spectrometric peptide mapping. Proc. Natl. Acad. Sci. USA 87, 9848-9852 (1990).
10. Przybylski, M. et al. Approaches to the characterisation of tertiary and supramolecular protein structures by combination of protein chemistry and mass spectrometry. in New Methods for the Study of Biomolecular Complexes, 17-43 (Kluwer Acad. Publ., Amsterdam, 1998).
11. Papace, C.I., Hoyes, J. & Tomer, K.B. Direct analysis of affinity-bound analytes by MALDI/TOF-MS. Anal. Chem. 199, 2609-2613 (1994).
12. Kohlmann, M. et al. Epitope identification of the carboxy-terminal cytosolic domain of the Alzheimer's amyloid precursor protein (APP) with a monoclonal mouse anti-APP antibody by high resolution mass spectrometry. J. Pept. Sci. (in the press).
13. Hochleitner, E.O., Borchers, C., Parker, C., Bienstock, R.J. & Tomer, K.B. Characterisation of a discontinuous epitope of the human immunodeficiency virus (HIV) core protein p24 by epitope excision and differential chemical modification followed by mass spectrometric peptide mapping analysis. Protein Sci. 9, 487-496 (2000).
14. Yang, D.S. et al. Assembly of Alzheimer's amyloid-β fibrils and approaches for therapeutic intervention. Amyloid 8, 10-19 (2001).
15. Walsh, D.M. et al. Amyloid-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J. Biol. Chem. 274, 25945-25952 (1999).
16. Hartley, D.M. et al. Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J. Neurosci. 19, 8876-8884 (1999).
17. Bard, F. et al. Peripherally administered antibodies against amyloid β-pepticle enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916-919 (2000).
18. DeMattos, R.B. et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98, 8850-8855 (2001).
19. Fridman, W.H. & Sautes, C. Cell-mediated effects of immunoglobulins, in Molecular Biology Intelligence Unit (Springer, New York, 1997).
20. Solomon, B., Koppel, R., Hanan, E. & Katzav, T. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer β-amyloid peptide. Proc. Natl. Acad. Sci. USA 93, 452-455 (1996).
21. Solomon, B., Koppel, R., Frankel, D. & Hanan-Aharon, E. Disaggregation of Alzheimer β-amyloid by site-directed mAb. Proc. Natl. Acad. Sci. USA 94, 4109-4112 (1997).
22. Frenkel, D., Solomon, B. & Benhar, I. Modulation of Alzheimer's β-amyloid neurotoxicity by site-directed single-chain antibody. J. Neuroimmunol. 106, 23-31 (2000).
23. Kuo, Y.-M. et al. Comparative analysis of amyloid-β chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's Disease brains. J. Biol. Chem. 276, 12991-12998 (2001).
24. Kalback, W. et al. APP Transgenic mice Tg2576 accumulate Aβ peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry 41, 922-928 (2002).
25. Gowing, E. et al. Chemical characterization of Aβ 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease J. Biol. Chem. 269, 10987-10990 (1994).
26. Delgado, M. & Ganea, D. VIP and PACAP enhance the in vivo generation of memory TH2 Cells by inhibiting peripheral deletion of antigen-specific effectors. Arch Physiol Biochem. 109, 372-376 (2001).
27. McLean, C.A. et al. Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease Ann. Neurol. 46, 860-866 (1999).
28. Walsh, D.M. et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539 (2002).
29. Youhnovski, N. et al. Thin chip microspray systems coupled to fourier transform-ICR mass spectrometry. Angew. Chem. Int. Ed. Engl. (in the press).
30. Fligge, T.A., Reinhard, C., Harter, C., Wieland, & F.T. Przybylski, M. Oligomerisation peptides analogous to the cytoplasmic domains of coatamer receptors revealed by mass spectrometry, Biochemistry 39, 8491-8496 (2000).
31. Bauer, S.H., Wiechers, M.F., Bruns, K., Przybylski, M. & Stuermer, C.A.O. Isolation and identification of the plasma membrane-associated intracellular protein reggie-2 from goldfish brain by chromatography and fourier transform-ion cyclotron resonance mass spectrometry. Anal. Biochem. 298, 25-31 (2001).
32. Mayer-Fligge, P. et al. Synthesis and structural characterisation of human-identical lung surfactant protein SP-C. J. Pept. Sci. 4, 355-363 (1998).
33. Altin, J.G. et al. A one-step procedure for biotinylation and chemical crosslinking of lymphocyte surface intracellular membrane-associated molecules. Anal. Biochem. 224, 382-389 (1995).
34. Craig, D.B., Wong, J.C.Y. & Dovici, N.J. Detection of attomolar concentrations of alkaline phosphatase by capillary electrophoresis using laser-induced fluorescence detection. Anal. Chem. 68, 697-701 (1996).
35. McLaurin, J., Golomb, R., Jurewicz, A., Antel, J,P. & Fraser, P.E. Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit aβ-induced toxicity. J. Biol. Chem. 275, 18495-18502 (2000).
36. Jucker, M. et al. Age-related deposition of glia-associated fibrillar material in brains of C578L/6 mice. Neuroscience 60, 875-889 (1994).