Absence of β-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia

Archives of Neurology

Volumn 64, Issue 4, 2007, Pages 583-587

  Bombois, Stéphanie ^a   Maurage, Claude Alain ^a,b   Gompel, Marie ^b   Deramecourt, Vincent ^a   Mackowiak Cordoliani, Marie Anne ^a   Black, Ronald S ^c   Lavielle, Rodolphe ^d   Delacourte, André ^b   Pasquier, Florence ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

^c PFIZER INC   (United States)

^d Wyeth Pharma   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; BETA SECRETASE; QS 21; RIVASTIGMINE; SYNUCLEIN; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CASE REPORT; CLINICAL FEATURE; DIFFUSE LEWY BODY DISEASE; FEMALE; GAIT DISORDER; HAND TREMOR; HUMAN; HUMAN TISSUE; IMMUNIZATION; MINI MENTAL STATE EXAMINATION; MUSCLE HYPERTONIA; NEUROIMAGING; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 34247113214     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.64.4.583     Document Type: Article

References (20)

1. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65: 1863-1872.
2. Deramecourt V, Bombois S, Maurage CA, et al. Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies. J Neuropathol Exp Neurol. 2006;65:278-288.
3. Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999; 400:173-177.
4. Janus C, Pearson J, McLaurin J, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 2000;408:979-982.
5. Orgogozo J-M, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology. 2003;61: 46-54.
6. Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case-report. Nat Med. 2003;9:448-452.
7. Ferrer I, Boada Rovira M, Sanchez Guerra ML, Rey MJ, Costa-Jussa F. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol. 2004;14:11-20.
8. Masliah E, Hansen L, Adame A, et al. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology. 2005;64:129-131.
9. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34:939-944.
10. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl). 1991;82:239-259.
11. Delacourte A, Sergeant N, Champain D, et al. Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology. 2002;59:398-407.
12. Delacourte A, David J-P, Sergeant N, et al. The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease. Neurology. 1999;52:1158-1165.
13. Lippa CF, Ozawa K, Mann DM, et al. Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease. Arch Neurol. 1999;56:1111-1118.
14. Popescu A, Lippa CF, Lee VM, Trojanowski JQ. Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with taubased inclusions. Arch Neurol. 2004;61:1915-1919.
15. Bacskai BJ, Kajdasz ST, Christie RH, et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med. 2001;7:369-372.
16. Hansen LA, Masliah E, Galasko D, Terry R. Plaque-only Alzheimer disease is usually the Lewy variant, and vice versa. J Neuropathol Exp Neurol. 1993;52:648-654.
17. Dickson DW, Crystal H, Mattiace LA, et al. Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Acta Neuropathol (Berl). 1989;78:572-584.
18. Armstrong RA, Cairns NJ, Lantos PL. beta-Amyloid (A beta) deposition in the medial temporal lobe of patients with dementia with Lewy bodies. Neurosci Lett. 1997;227:193-196.
19. Lee M, Bard F, Johnson-Wood K, et al. Abeta immunization in Alzheimer's disease generates Abeta N-terminal antibodies. Ann Neurol. 2005;58:430-435.
20. Gilman S, Koller M, Black RS, et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology. 2005;64:1553-1562.