Amyloid β vaccination: Reduced plaques and improved cognition

Nature Medicine

Volumn 7, Issue 1, 2001, Pages 18-19

  Younkin, S G ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL BEHAVIOR; ANTIBODY PRODUCTION; HAMSTER; MAZE TEST; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SENILE PLAQUE; SHORT SURVEY; TASK PERFORMANCE; TRANSGENIC MOUSE; TREATMENT OUTCOME; VACCINATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; NEUROFIBRILLARY TANGLES; VACCINES;

ANIMALIA; CRICETINAE; MUS MUSCULUS;

EID: 0035132326     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/83292     Document Type: Short Survey

References (9)

1. A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease
2. Aβ immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
3. Vaccination with Aβ peptide prevents memory deficits in an animal model of Alzheimer's disease
4. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid protein
5. Place navigation impaired in rats with hippocampal lesions
6. Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPP mouse
7. Peripherally administered antibodies against amyloid beta peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
8. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
9. Increased amyloid-β 42(43) in brains of mice expressing mutant presenilin 1