메뉴 건너뛰기




Volumn 188, Issue 1, 2004, Pages 52-64

Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease

Author keywords

Complement; Complement receptors; Inflammation; Microglia; Neurofibrillary tangles; Tau; Vaccination

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; COMPLEMENT COMPONENT CD11B RECEPTOR; COMPLEMENT RECEPTOR; CONGO RED; PROTEIN ANTIBODY; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 2942611429     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2004.03.016     Document Type: Article
Times cited : (110)

References (44)
  • 1
    • 0025875076 scopus 로고
    • Association of amyloid P component with complement proteins in neurologically diseased brain tissue
    • Akiyama H., Yamada T., Kawamata T., McGeer P.L. Association of amyloid P component with complement proteins in neurologically diseased brain tissue. Brain Res. 548:1991;349-352
    • (1991) Brain Res. , vol.548 , pp. 349-352
    • Akiyama, H.1    Yamada, T.2    Kawamata, T.3    McGeer, P.L.4
  • 2
    • 0027988641 scopus 로고
    • A large Swedish family with Alzheimer's disease with a codon 670/671 amyloid precursor protein mutation. a clinical and genealogical investigation
    • Axelman K., Basun H., Winblad B., Lannfelt L. A large Swedish family with Alzheimer's disease with a codon 670/671 amyloid precursor protein mutation. A clinical and genealogical investigation. Arch. Neurol. 51:1994;1193-1197
    • (1994) Arch. Neurol. , vol.51 , pp. 1193-1197
    • Axelman, K.1    Basun, H.2    Winblad, B.3    Lannfelt, L.4
  • 3
    • 0036127580 scopus 로고    scopus 로고
    • Set back to Alzheimer vaccine studies
    • Birmingham K., Frantz S. Set back to Alzheimer vaccine studies. Nat. Med. 8:2002;199-200
    • (2002) Nat. Med. , vol.8 , pp. 199-200
    • Birmingham, K.1    Frantz, S.2
  • 8
    • 0036169190 scopus 로고    scopus 로고
    • Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice
    • Gau J.T., Steinhilb M.L., Kao T.C., D'Amato C.J., Gaut J.R., Frey K.A., Turner R.S. Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice. Am. J. Pathol. 160:2002;731-738
    • (2002) Am. J. Pathol. , vol.160 , pp. 731-738
    • Gau, J.T.1    Steinhilb, M.L.2    Kao, T.C.3    D'Amato, C.J.4    Gaut, J.R.5    Frey, K.A.6    Turner, R.S.7
  • 12
    • 0028866435 scopus 로고
    • The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
    • Haass C., Lemere C.A., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L., Selkoe D.J. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat. Med. 1:1995;1291-1296
    • (1995) Nat. Med. , vol.1 , pp. 1291-1296
    • Haass, C.1    Lemere, C.A.2    Capell, A.3    Citron, M.4    Seubert, P.5    Schenk, D.6    Lannfelt, L.7    Selkoe, D.J.8
  • 13
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science. 256:1992;184-185
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 14
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 297:2002;353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 18
    • 0030612033 scopus 로고    scopus 로고
    • APPSw transgenic mice develop age-related a beta deposits and neuropil abnormalities, but no neuronal loss in CA1
    • Irizarry M.C., McNamara M., Fedorchak K., Hsiao K., Hyman B.T. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol. 56:1997;965-973
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 965-973
    • Irizarry, M.C.1    McNamara, M.2    Fedorchak, K.3    Hsiao, K.4    Hyman, B.T.5
  • 27
    • 0035693924 scopus 로고    scopus 로고
    • Inflammation, autotoxicity and Alzheimer disease
    • McGeer P.L., McGeer E.G. Inflammation, autotoxicity and Alzheimer disease. Neurobiol. Aging. 22:2001;799-809
    • (2001) Neurobiol. Aging , vol.22 , pp. 799-809
    • McGeer, P.L.1    McGeer, E.G.2
  • 28
    • 0037405981 scopus 로고    scopus 로고
    • Is there a future for vaccination as a treatment for Alzheimer's disease?
    • McGeer P.L., McGeer E. Is there a future for vaccination as a treatment for Alzheimer's disease? Neurobiol. Aging. 24:2003;391-395
    • (2003) Neurobiol. Aging , vol.24 , pp. 391-395
    • McGeer, P.L.1    McGeer, E.2
  • 29
    • 0024317005 scopus 로고
    • Activation of the classical complement pathway in brain tissue of Alzheimer patients
    • McGeer P.L., Akiyama H., Itagaki S., McGeer E.G. Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci. Lett. 107:1989;341-346
    • (1989) Neurosci. Lett. , vol.107 , pp. 341-346
    • McGeer, P.L.1    Akiyama, H.2    Itagaki, S.3    McGeer, E.G.4
  • 30
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll J.A., Wilkinson D., Holmes C., Steart P., Markham H., Weller R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 9:2003;448-452
    • (2003) Nat. Med. , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 33
    • 0036118795 scopus 로고    scopus 로고
    • Complement activated C4d immunoreactive oligodendrocytes delineate small cortical plaques in multiple sclerosis
    • Schwab C., McGeer P.L. Complement activated C4d immunoreactive oligodendrocytes delineate small cortical plaques in multiple sclerosis. Exp. Neurol. 174:2002;81-88
    • (2002) Exp. Neurol. , vol.174 , pp. 81-88
    • Schwab, C.1    McGeer, P.L.2
  • 34
    • 0030780063 scopus 로고    scopus 로고
    • Dystrophic neurites are associated with the majority of early stage extracellular neurofibrillary tangles in parkinsonism-dementia complex of Guam
    • Schwab C., Steele J.C., McGeer P.L. Dystrophic neurites are associated with the majority of early stage extracellular neurofibrillary tangles in parkinsonism-dementia complex of Guam. Acta Neuropathol. 94:1997;486-492
    • (1997) Acta Neuropathol. , vol.94 , pp. 486-492
    • Schwab, C.1    Steele, J.C.2    McGeer, P.L.3
  • 35
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe D.J. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature. 399:1999;A23-A31
    • (1999) Nature , vol.399 , pp. 23-A31
    • Selkoe, D.J.1
  • 36
    • 0032732637 scopus 로고    scopus 로고
    • Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model
    • Shi J., Perry G., Aliev G., Smith M.A., Ashe K.H., Friedland R.P. Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model. NeuroReport. 10:1999;3229-3232
    • (1999) NeuroReport , vol.10 , pp. 3229-3232
    • Shi, J.1    Perry, G.2    Aliev, G.3    Smith, M.A.4    Ashe, K.H.5    Friedland, R.P.6
  • 37
    • 0034531476 scopus 로고    scopus 로고
    • Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model
    • Sturchler-Pierrat C., Staufenbiel M. Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model. Ann. N. Y. Acad. Sci. 920:2000;134-139
    • (2000) Ann. N. Y. Acad. Sci. , vol.920 , pp. 134-139
    • Sturchler-Pierrat, C.1    Staufenbiel, M.2
  • 39
    • 0035805091 scopus 로고    scopus 로고
    • Apolipoprotein e deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer's disease
    • Terai K., Iwai A., Kawabata S., Sasamata M., Miyata K., Yamaguchi T. Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: implications for the pathogenesis of Alzheimer's disease. Brain Res. 900:2001;48-56
    • (2001) Brain Res. , vol.900 , pp. 48-56
    • Terai, K.1    Iwai, A.2    Kawabata, S.3    Sasamata, M.4    Miyata, K.5    Yamaguchi, T.6
  • 40
    • 0035837274 scopus 로고    scopus 로고
    • β-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease
    • Terai K., Iwai A., Kawabata S., Tasaki Y., Watanabe T., Miyata K., Yamaguchi T. β-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease. Neuroscience. 104:2001;299-310
    • (2001) Neuroscience , vol.104 , pp. 299-310
    • Terai, K.1    Iwai, A.2    Kawabata, S.3    Tasaki, Y.4    Watanabe, T.5    Miyata, K.6    Yamaguchi, T.7
  • 44
    • 0033061855 scopus 로고    scopus 로고
    • Up-regulated production and activation of the complement system in Alzheimer's disease brain
    • Yasojima K., Schwab C., McGeer E.G., McGeer P.L. Up-regulated production and activation of the complement system in Alzheimer's disease brain. Am. J. Pathol. 154:1999;927-936
    • (1999) Am. J. Pathol. , vol.154 , pp. 927-936
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.