-
1
-
-
0344490328
-
Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis
-
Angelov DN, Waibel S, Guntinas-Lichius O, Lenzen M, Neiss WF, et al. 2003. Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 100:4790-95
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4790-4795
-
-
Angelov, D.N.1
Waibel, S.2
Guntinas-Lichius, O.3
Lenzen, M.4
Neiss, W.F.5
-
2
-
-
0038240645
-
Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice
-
Austin L, Arendash GW, Gordon MN, Diamond DM, DiCarlo G, et al. 2003. Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice. Behav. Neurosci. 117:478-84
-
(2003)
Behav. Neurosci
, vol.117
, pp. 478-484
-
-
Austin, L.1
Arendash, G.W.2
Gordon, M.N.3
Diamond, D.M.4
DiCarlo, G.5
-
3
-
-
0037107177
-
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
-
Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, et al. 2002. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J. Neurosci. 22:7873-78
-
(2002)
J. Neurosci
, vol.22
, pp. 7873-7878
-
-
Bacskai, B.J.1
Kajdasz, S.T.2
McLellan, M.E.3
Games, D.4
Seubert, P.5
-
4
-
-
34247234606
-
Potential of active and passive immunizations for the prevention and therapy of transmissible spongiform encephalopathies
-
Bade S, Frey A. 2007. Potential of active and passive immunizations for the prevention and therapy of transmissible spongiform encephalopathies. Expert Rev. Vaccin. 6:153-68
-
(2007)
Expert Rev. Vaccin
, vol.6
, pp. 153-168
-
-
Bade, S.1
Frey, A.2
-
5
-
-
33644660826
-
Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-Abeta antibody
-
Bales KR, Tzavara ET, Wu S, Wade MR, Bymaster FP, et al. 2006. Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-Abeta antibody. J. Clin. Invest. 116:825-32
-
(2006)
J. Clin. Invest
, vol.116
, pp. 825-832
-
-
Bales, K.R.1
Tzavara, E.T.2
Wu, S.3
Wade, M.R.4
Bymaster, F.P.5
-
6
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F, Cannon C, Barbour R, Burke RL, Games D, et al. 2000. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6:916-19
-
(2000)
Nat. Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
-
7
-
-
0037452779
-
Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology
-
Bard F, Barbour R, Cannon C, Carretto R, Fox M, et al. 2003. Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc. Natl. Acad. Sci. USA 100:2023-28
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2023-2028
-
-
Bard, F.1
Barbour, R.2
Cannon, C.3
Carretto, R.4
Fox, M.5
-
8
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD
-
Bayer AJ, Bullock R, Jones RW, Wilkinson D, Paterson KR, et al. 2005. Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 64:94-101
-
(2005)
Neurology
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
Wilkinson, D.4
Paterson, K.R.5
-
9
-
-
3042592589
-
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
-
Benner EJ, Mosley RL, Destache CJ, Lewis TB, Jackson-Lewis V, et al. 2004. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 101:9435-40
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 9435-9440
-
-
Benner, E.J.1
Mosley, R.L.2
Destache, C.J.3
Lewis, T.B.4
Jackson-Lewis, V.5
-
10
-
-
0030805991
-
Frequency of stages of Alzheimer-related lesions in different age categories
-
Braak H, Braak E. 1997. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging 18:351-57
-
(1997)
Neurobiol. Aging
, vol.18
, pp. 351-357
-
-
Braak, H.1
Braak, E.2
-
11
-
-
85047691873
-
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
-
Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, et al. 2005. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J. Clin. Invest. 115:428-33
-
(2005)
J. Clin. Invest
, vol.115
, pp. 428-433
-
-
Brendza, R.P.1
Bacskai, B.J.2
Cirrito, J.R.3
Simmons, K.A.4
Skoch, J.M.5
-
12
-
-
48249111506
-
Anti-Abeta antibody treatment attenuates cognitive impairment in a mouse model of experimental traumatic brain injury
-
Presented at, Washington DC
-
Brody DL, Mac Donald CL, Fujimoto S, Conte V, Parsadanian M, et al. 2005. Anti-Abeta antibody treatment attenuates cognitive impairment in a mouse model of experimental traumatic brain injury. Presented at Annu. Natl. Neurotrauma Soc. Symp., 23rd, Washington DC
-
(2005)
Annu. Natl. Neurotrauma Soc. Symp., 23rd
-
-
Brody, D.L.1
Mac Donald, C.L.2
Fujimoto, S.3
Conte, V.4
Parsadanian, M.5
-
13
-
-
27144511230
-
Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease
-
Buttini M, Masliah E, Barbour R, Grajeda H, Motter R, et al. 2005. Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J. Neurosci. 25:9096-101
-
(2005)
J. Neurosci
, vol.25
, pp. 9096-9101
-
-
Buttini, M.1
Masliah, E.2
Barbour, R.3
Grajeda, H.4
Motter, R.5
-
14
-
-
33847776041
-
Active beta-amyloid immu-nization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid
-
Chen G, Chen KS, Kobayashi D, Barbour R, Motter R, et al. 2007. Active beta-amyloid immu-nization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid. J. Neurosci. 27:2654-62
-
(2007)
J. Neurosci
, vol.27
, pp. 2654-2662
-
-
Chen, G.1
Chen, K.S.2
Kobayashi, D.3
Barbour, R.4
Motter, R.5
-
15
-
-
0035877756
-
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
-
Chishti MA, Yang DS, Janus C, Phinney AL, Home P, et al. 2001. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 276:21562-70
-
(2001)
J. Biol. Chem
, vol.276
, pp. 21562-21570
-
-
Chishti, M.A.1
Yang, D.S.2
Janus, C.3
Phinney, A.L.4
Home, P.5
-
16
-
-
16644379264
-
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
-
Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, et al. 2005. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat. Neurosci. 8:79-84
-
(2005)
Nat. Neurosci
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
-
17
-
-
0141457897
-
Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice
-
Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, et al. 2003. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. J. Neurosci. 23:8532-38
-
(2003)
J. Neurosci
, vol.23
, pp. 8532-8538
-
-
Das, P.1
Howard, V.2
Loosbrock, N.3
Dickson, D.4
Murphy, M.P.5
-
18
-
-
0034746897
-
Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition
-
Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. 2001. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol. Aging 22:721-27
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 721-727
-
-
Das, P.1
Murphy, M.P.2
Younkin, L.H.3
Younkin, S.G.4
Golde, T.E.5
-
19
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, et al. 2003. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9:907-13
-
(2003)
Nat. Med
, vol.9
, pp. 907-913
-
-
Deane, R.1
Du Yan, S.2
Submamaryan, R.K.3
LaRue, B.4
Jovanovic, S.5
-
20
-
-
30844472909
-
IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
-
Deane R, Sagare A, Hamm K, Parisi M, LaRue B, et al. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J. Neurosci. 25:11495-503
-
(2005)
J. Neurosci
, vol.25
, pp. 11495-11503
-
-
Deane, R.1
Sagare, A.2
Hamm, K.3
Parisi, M.4
LaRue, B.5
-
21
-
-
0035902619
-
Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, et al. 2001. Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98:8850-55
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.C.4
Paul, S.M.5
-
22
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, et al. 2002. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat. Neurosci. 5:452-57
-
(2002)
Nat. Neurosci
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
Greene, S.J.4
DeMattos, R.B.5
-
23
-
-
0036327185
-
Human antibodies against amyloid beta peptide: A potential treatment for Alzheimer's disease
-
Dodel R, Hampel H, Depboylu C, Lin S, Gao F, et al. 2002. Human antibodies against amyloid beta peptide: a potential treatment for Alzheimer's disease. Ann. Neurol. 52:253-56
-
(2002)
Ann. Neurol
, vol.52
, pp. 253-256
-
-
Dodel, R.1
Hampel, H.2
Depboylu, C.3
Lin, S.4
Gao, F.5
-
24
-
-
4644275963
-
Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease
-
Dodel RC, Du Y, Depboylu C, Hampel H, Frolich L, et al. 2004. Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 75:1472-74
-
(2004)
J. Neurol. Neurosurg. Psychiatry
, vol.75
, pp. 1472-1474
-
-
Dodel1
RC, D.Y.2
Depboylu, C.3
Hampel, H.4
Frolich, L.5
-
25
-
-
10744225948
-
Clinical manifestations of cerebral amyloid angiopathy-related inflammation
-
Eng JA, Frosch MP, Choi K, Rebeck GW, Greenberg SM. 2004. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann. Neurol. 55:250-56
-
(2004)
Ann. Neurol
, vol.55
, pp. 250-256
-
-
Eng, J.A.1
Frosch, M.P.2
Choi, K.3
Rebeck, G.W.4
Greenberg, S.M.5
-
26
-
-
33644832047
-
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
-
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, et al. 2006. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann. Neurol. 59:512-19
-
(2006)
Ann. Neurol
, vol.59
, pp. 512-519
-
-
Fagan, A.M.1
Mintun, M.A.2
Mach, R.H.3
Lee, S.Y.4
Dence, C.S.5
-
27
-
-
33947223454
-
Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
-
Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, et al. 2007. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch. Neurol. 64:343-49
-
(2007)
Arch. Neurol
, vol.64
, pp. 343-349
-
-
Fagan, A.M.1
Roe, C.M.2
Xiong, C.3
Mintun, M.A.4
Morris, J.C.5
-
28
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
-
Ferrer I, Boada Rovira M, Sanchez Guerra ML, Rey MJ, Costa-Jussa F. 2004. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol. 14:11-20
-
(2004)
Brain Pathol
, vol.14
, pp. 11-20
-
-
Ferrer, I.1
Boada Rovira, M.2
Sanchez Guerra, M.L.3
Rey, M.J.4
Costa-Jussa, F.5
-
29
-
-
18144415471
-
Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
-
Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, et al. 2005. Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology 64:1563-72
-
(2005)
Neurology
, vol.64
, pp. 1563-1572
-
-
Fox, N.C.1
Black, R.S.2
Gilman, S.3
Rossor, M.N.4
Griffith, S.G.5
-
30
-
-
24644435506
-
Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease
-
Frenkel D, Maron R, Burt DS, Weiner HL. 2005. Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J. Clin. Invest. 115:2423-33
-
(2005)
J. Clin. Invest
, vol.115
, pp. 2423-2433
-
-
Frenkel, D.1
Maron, R.2
Burt, D.S.3
Weiner, H.L.4
-
31
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, et al. 1995. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373:523-27
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
-
32
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, et al. 2005. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64:1553-62
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
Jenkins, L.4
Griffith, S.G.5
-
33
-
-
21144432949
-
Mucosal vaccination delays or prevents prion infection via an oral route
-
Goni F, Knudsen E, Schreiber F, Scholtzova H, Pankiewicz J, et al. 2005. Mucosal vaccination delays or prevents prion infection via an oral route. Neuroscience 133:413-21
-
(2005)
Neuroscience
, vol.133
, pp. 413-421
-
-
Goni, F.1
Knudsen, E.2
Schreiber, F.3
Scholtzova, H.4
Pankiewicz, J.5
-
34
-
-
33947216452
-
Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS
-
Haenggeli C, Julien JP, Lee Mosley R, Perez N, Dhar A, et al. 2007. Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS. Neurobiol. Dis. 26:146-52
-
(2007)
Neurobiol. Dis
, vol.26
, pp. 146-152
-
-
Haenggeli, C.1
Julien, J.P.2
Lee Mosley, R.3
Perez, N.4
Dhar, A.5
-
35
-
-
33947194272
-
Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells
-
Handisurya A, Gilch S, Winter D, Shafti-Keramat S, Maurer D, et al. 2007. Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells. FEBS J. 274:1747-58
-
(2007)
FEBS J
, vol.274
, pp. 1747-1758
-
-
Handisurya, A.1
Gilch, S.2
Winter, D.3
Shafti-Keramat, S.4
Maurer, D.5
-
36
-
-
21544468846
-
Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
-
Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, et al. 2005. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J. Neurosci. 25:6213-20
-
(2005)
J. Neurosci
, vol.25
, pp. 6213-6220
-
-
Hartman, R.E.1
Izumi, Y.2
Bales, K.R.3
Paul, S.M.4
Wozniak, D.F.5
-
37
-
-
33845935564
-
Solution state characterization of amyloid beta-derived diffusible ligands
-
Hepler RW, Grimm KM, Nahas DD, Breese R, Dodson EC, et al. 2006. Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry 45:15157-67
-
(2006)
Biochemistry
, vol.45
, pp. 15157-15167
-
-
Hepler, R.W.1
Grimm, K.M.2
Nahas, D.D.3
Breese, R.4
Dodson, E.C.5
-
38
-
-
0035812752
-
Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies
-
Heppner FL, Musahl C, Arrighi I, Klein MA, Rulicke T, et al. 2001. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 294:178-82
-
(2001)
Science
, vol.294
, pp. 178-182
-
-
Heppner, F.L.1
Musahl, C.2
Arrighi, I.3
Klein, M.A.4
Rulicke, T.5
-
39
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C, Konietzko U, Streffer JR, Tracy J, Signorell A, et al. 2003. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38:547-54
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
Tracy, J.4
Signorell, A.5
-
40
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, et al. 1996. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
-
41
-
-
31844443343
-
Herceptin: HERalding a new era in breast cancer care but at what cost?
-
Hutchinson L, DeVita VT Jr. 2005. Herceptin: HERalding a new era in breast cancer care but at what cost? Nat. Clin. Pract. Oncol. 2:595
-
(2005)
Nat. Clin. Pract. Oncol
, vol.2
, pp. 595
-
-
Hutchinson, L.1
DeVita Jr., V.T.2
-
42
-
-
0034700471
-
Abeta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, et al. 2000. Abeta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408:979-82
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
-
43
-
-
10044250141
-
Head injury and dementia
-
Jellinger KA. 2004. Head injury and dementia. Curr. Opin. Neurol. 17:719-23
-
(2004)
Curr. Opin. Neurol
, vol.17
, pp. 719-723
-
-
Jellinger, K.A.1
-
45
-
-
0031020909
-
Amyloid precursor protein processing and Abeta42 deposition in a transgenic mouse model of Alzheimer disease
-
Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, et al. 1997. Amyloid precursor protein processing and Abeta42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA 94:1550-55
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1550-1555
-
-
Johnson-Wood, K.1
Lee, M.2
Motter, R.3
Hu, K.4
Gordon, G.5
-
46
-
-
10744232413
-
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
-
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, et al. 2004. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55:306-19
-
(2004)
Ann. Neurol
, vol.55
, pp. 306-319
-
-
Klunk, W.E.1
Engler, H.2
Nordberg, A.3
Wang, Y.4
Blomqvist, G.5
-
47
-
-
34249984684
-
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
-
Klunk WE, Price JC, Mathis CA, Tsopelas ND, Lopresti BJ, et al. 2007. Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J. Neurosci. 27:6174-84
-
(2007)
J. Neurosci
, vol.27
, pp. 6174-6184
-
-
Klunk, W.E.1
Price, J.C.2
Mathis, C.A.3
Tsopelas, N.D.4
Lopresti, B.J.5
-
48
-
-
21044453723
-
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo
-
Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, et al. 2005. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat. Med. 11:556-61
-
(2005)
Nat. Med
, vol.11
, pp. 556-561
-
-
Klyubin, I.1
Walsh, D.M.2
Lemere, C.A.3
Cullen, W.K.4
Shankar, G.M.5
-
49
-
-
0034635335
-
Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
-
Knappik A, Ge L, Honegger A, Pack P, Fischer M, et al. 2000. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. J. Mol. Biol. 296:57-86
-
(2000)
J. Mol. Biol
, vol.296
, pp. 57-86
-
-
Knappik, A.1
Ge, L.2
Honegger, A.3
Pack, P.4
Fischer, M.5
-
50
-
-
0036703483
-
Reversible memory loss in a mouse transgenic model of Alzheimer's disease
-
Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, et al. 2002. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J. Neurosci. 22:6331-35
-
(2002)
J. Neurosci
, vol.22
, pp. 6331-6335
-
-
Kotilinek, L.A.1
Bacskai, B.2
Westerman, M.3
Kawarabayashi, T.4
Younkin, L.5
-
51
-
-
33645220400
-
Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
-
Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, et al. 2006. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J. Biol. Chem. 281:4292-99
-
(2006)
J. Biol. Chem
, vol.281
, pp. 4292-4299
-
-
Lee, E.B.1
Leng, L.Z.2
Zhang, B.3
Kwong, L.4
Trojanowski, J.Q.5
-
52
-
-
24644458809
-
Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies
-
Lee M, Bard F, Johnson-Wood K, Lee C, Hu K, et al. 2005. Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies. Ann. Neurol. 58:430-35
-
(2005)
Ann. Neurol
, vol.58
, pp. 430-435
-
-
Lee, M.1
Bard, F.2
Johnson-Wood, K.3
Lee, C.4
Hu, K.5
-
53
-
-
84880185178
-
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now
-
Lee VM, Trojanowski JQ. 2006. Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now. J. Alzheimers Dis. 9:257-62
-
(2006)
J. Alzheimers Dis
, vol.9
, pp. 257-262
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
54
-
-
0345862278
-
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy
-
Legleiter J, Czilli DL, Gitter B, DeMattos RB, Holtzman DM, et al. 2004. Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy. J. Mol. Biol. 335:997-1006
-
(2004)
J. Mol. Biol
, vol.335
, pp. 997-1006
-
-
Legleiter, J.1
Czilli, D.L.2
Gitter, B.3
DeMattos, R.B.4
Holtzman, D.M.5
-
55
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, et al. 2006. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440:352-57
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesne, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
-
56
-
-
0344629707
-
Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations
-
Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, et al. 2003. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. J. Neurosci. 23:10879-83
-
(2003)
J. Neurosci
, vol.23
, pp. 10879-10883
-
-
Lombardo, J.A.1
Stern, E.A.2
McLellan, M.E.3
Kajdasz, S.T.4
Hickey, G.A.5
-
57
-
-
19944429065
-
Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
-
Masliah E, Hansen L, Adame A, Crews L, Bard F, et al. 2005a. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 64:129-31
-
(2005)
Neurology
, vol.64
, pp. 129-131
-
-
Masliah, E.1
Hansen, L.2
Adame, A.3
Crews, L.4
Bard, F.5
-
58
-
-
0035830408
-
Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
-
Masliah E, Mallory M, Alford M, DeTeresa R, Hansen LA, et al. 2001. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology 56:127-29
-
(2001)
Neurology
, vol.56
, pp. 127-129
-
-
Masliah, E.1
Mallory, M.2
Alford, M.3
DeTeresa, R.4
Hansen, L.A.5
-
59
-
-
20444413356
-
Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease
-
Masliah E, Rockenstein E, Adame A, Alford M, Crews L, et al. 2005b. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron 46:857-68
-
(2005)
Neuron
, vol.46
, pp. 857-868
-
-
Masliah, E.1
Rockenstein, E.2
Adame, A.3
Alford, M.4
Crews, L.5
-
60
-
-
0037031861
-
Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
-
Mohajeri MH, Saini K, Schultz JG, Wollmer MA, Hock C, et al. 2002. Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation. J. Biol. Chem. 277:33012-17
-
(2002)
J. Biol. Chem
, vol.277
, pp. 33012-33017
-
-
Mohajeri, M.H.1
Saini, K.2
Schultz, J.G.3
Wollmer, M.A.4
Hock, C.5
-
61
-
-
84984755327
-
Abeta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, et al. 2000. Abeta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408:982-85
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
-
62
-
-
0021173996
-
Developments of a water-maze procedure for studying spatial learning in the rat
-
Morris R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11:47-60
-
(1984)
J. Neurosci. Methods
, vol.11
, pp. 47-60
-
-
Morris, R.1
-
63
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, et al. 2003. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 9:448-52
-
(2003)
Nat. Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
-
64
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. 2004. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43:321-32
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
LaFerla, F.M.5
-
65
-
-
33144487701
-
Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
-
Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, et al. 2006a. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J. Biol. Chem. 281:1599-604
-
(2006)
J. Biol. Chem
, vol.281
, pp. 1599-1604
-
-
Oddo, S.1
Caccamo, A.2
Tran, L.3
Lambert, M.P.4
Glabe, C.G.5
-
66
-
-
33846015514
-
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
-
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, et al. 2006b. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J. Biol. Chem. 281:39413-23
-
(2006)
J. Biol. Chem
, vol.281
, pp. 39413-39423
-
-
Oddo, S.1
Vasilevko, V.2
Caccamo, A.3
Kitazawa, M.4
Cribbs, D.H.5
-
67
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, et al. 2003. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61:46-54
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
Laurent, B.4
Puel, M.5
-
68
-
-
33748767945
-
Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: A biochemical analysis
-
Patton RL, Kalback WM, Esh CL, Kokjohn TA, Van Vickie GD, et al. 2006. Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. Am. J. Pathol. 169:1048-63
-
(2006)
Am. J. Pathol
, vol.169
, pp. 1048-1063
-
-
Patton, R.L.1
Kalback, W.M.2
Esh, C.L.3
Kokjohn, T.A.4
Van Vickie, G.D.5
-
69
-
-
0037112201
-
Cerebral hemorrhage after passive anti-Abeta immunotherapy
-
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, et al. 2002. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 298:1379
-
(2002)
Science
, vol.298
, pp. 1379
-
-
Pfeifer, M.1
Boncristiano, S.2
Bondolfi, L.3
Stalder, A.4
Deller, T.5
-
70
-
-
0034849725
-
Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
-
Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, et al. 2001. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch. Neurol. 58:1395-402
-
(2001)
Arch. Neurol
, vol.58
, pp. 1395-1402
-
-
Price, J.L.1
Ko, A.I.2
Wade, M.J.3
Tsou, S.K.4
McKeel, D.W.5
-
71
-
-
0032989712
-
Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
-
Price JL, Morris JC. 1999. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Am. Neurol. 45:358-68
-
(1999)
Am. Neurol
, vol.45
, pp. 358-368
-
-
Price, J.L.1
Morris, J.C.2
-
72
-
-
19944431509
-
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
-
Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, et al. 2005. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. J. Neurosci. 25:629-36
-
(2005)
J. Neurosci
, vol.25
, pp. 629-636
-
-
Racke, M.M.1
Boone, L.I.2
Hepburn, D.L.3
Parsadainian, M.4
Bryan, M.T.5
-
73
-
-
19944428649
-
Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
-
Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, et al. 2005. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433:73-77
-
(2005)
Nature
, vol.433
, pp. 73-77
-
-
Rothstein, J.D.1
Patel, S.2
Regan, M.R.3
Haenggeli, C.4
Huang, Y.H.5
-
74
-
-
0345276568
-
Synaptic pathology in Alzheimer's disease: A review of ultrastructural studies
-
Scheff SW, Price DA. 2003. Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies. Neurobiol. Aging 24:1029-46
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 1029-1046
-
-
Scheff, S.W.1
Price, D.A.2
-
75
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, et al. 1999. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-77
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
-
76
-
-
33645728523
-
Neurodegenerative diseases: New concepts of pathogenesis and their therapeutic implications
-
Skovronsky DM, Lee VM, Trojanowski JQ. 2006. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications. Annu. Rev. Pathol. Mech. Dis. 1:151-70
-
(2006)
Annu. Rev. Pathol. Mech. Dis
, vol.1
, pp. 151-170
-
-
Skovronsky, D.M.1
Lee, V.M.2
Trojanowski, J.Q.3
-
77
-
-
0031689796
-
Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein
-
Smith DH, Nakamura M, McIntosh TK, Wang J, Rodriguez A, et al. 1998. Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein. Am. J. Pathol. 153:1005-10
-
(1998)
Am. J. Pathol
, vol.153
, pp. 1005-1010
-
-
Smith, D.H.1
Nakamura, M.2
McIntosh, T.K.3
Wang, J.4
Rodriguez, A.5
-
79
-
-
0030058382
-
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
-
Solomon B, Koppel R, Hanan E, Katzav T. 1996. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc. Natl. Acad. Sci. USA 93:452-55
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 452-455
-
-
Solomon, B.1
Koppel, R.2
Hanan, E.3
Katzav, T.4
-
80
-
-
26944481138
-
The F(ab)′2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain
-
Tamura Y, Hamajima K, Matsui K, Yanoma S, Narita M, et al. 2005. The F(ab)′2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain. Neurobiol. Dis. 20:541-49
-
(2005)
Neurobiol. Dis
, vol.20
, pp. 541-549
-
-
Tamura, Y.1
Hamajima, K.2
Matsui, K.3
Yanoma, S.4
Narita, M.5
-
81
-
-
33644841593
-
Treatment and prevention of primary intracerebral hemorrhage
-
Towfighi A, Greenberg SM, Rosand J. 2005. Treatment and prevention of primary intracerebral hemorrhage. Semin. Neurol. 25:445-52
-
(2005)
Semin. Neurol
, vol.25
, pp. 445-452
-
-
Towfighi, A.1
Greenberg, S.M.2
Rosand, J.3
-
82
-
-
33847787621
-
Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
-
Urushitani M, Ezzi SA, Julien JP. 2007. Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 104:2495-500
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 2495-2500
-
-
Urushitani, M.1
Ezzi, S.A.2
Julien, J.P.3
-
83
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, et al. 2002. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-39
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
-
84
-
-
5344277556
-
Deciphering the molecular basis of memory failure in Alzheimer's disease
-
Walsh DM, Selkoe DJ. 2004. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 44:181-93
-
(2004)
Neuron
, vol.44
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
85
-
-
0037422133
-
Monoclonal antibodies inhibit prion replication and delay the development of prion disease
-
White AR, Enever P, Tayebi M, Mushens R, Linehan J, et al. 2003. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature 422:80-83
-
(2003)
Nature
, vol.422
, pp. 80-83
-
-
White, A.R.1
Enever, P.2
Tayebi, M.3
Mushens, R.4
Linehan, J.5
-
86
-
-
0037531198
-
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
-
Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, et al. 2003. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J. Neurosci. 23:3745-51
-
(2003)
J. Neurosci
, vol.23
, pp. 3745-3751
-
-
Wilcock, D.M.1
DiCarlo, G.2
Henderson, D.3
Jackson, J.4
Clarke, K.5
-
87
-
-
1642497601
-
Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
-
Wilcock DM, Munireddy SK, Rosenthal A, Ugen KE, Gordon MN, et al. 2004a. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol. Dis. 15:11-20
-
(2004)
Neurobiol. Dis
, vol.15
, pp. 11-20
-
-
Wilcock, D.M.1
Munireddy, S.K.2
Rosenthal, A.3
Ugen, K.E.4
Gordon, M.N.5
-
88
-
-
14244255355
-
Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
-
Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, et al. 2004b. Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J. Neuroinflamm. 1:24
-
(2004)
J. Neuroinflamm
, vol.1
, pp. 24
-
-
Wilcock, D.M.1
Rojiani, A.2
Rosenthal, A.3
Subbarao, S.4
Freeman, M.J.5
|