Detection of complement alternative pathway mRNA and proteins in the Alzheimer's disease brain

Molecular Brain Research

Volumn 81, Issue 1-2, 2000, Pages 7-18

  Strohmeyer, Ron ^a,b   Shen, Yong ^a,b   Rogers, Joseph ^a,b  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b Molec Cell Biol Prog Arizona S   (United States)

Author keywords

Alternative complement pathway; Alzheimer's disease; Amyloid peptide; Factor B; Factor H; Factor I; Inflammation

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; AMYLOID BETA PROTEIN; COMPLEMENT COMPONENT C5; COMPLEMENT FACTOR D; COMPLEMENT FACTOR H; COMPLEMENT FACTOR I; MESSENGER RNA; PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; CONTROLLED STUDY; ENZYME DEGRADATION; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; PRIORITY JOURNAL;

AGED; ALZHEIMER DISEASE; COMPLEMENT; COMPLEMENT FACTOR B; COMPLEMENT FACTOR H; COMPLEMENT PATHWAY, ALTERNATIVE; FEMALE; FIBRINOGEN; FRONTAL LOBE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC;

EID: 0034734786     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00149-2     Document Type: Article

References (68)

1. Akiyama H., Ikeda K., Kondo H., McGeer P.L. Thrombin accumulation in brains of patients with Alzheimer's disease. Neurosci. Lett. 146:1992;152-154.
2. Akiyama H., McGeer P.L. Brain microglia constitutively express β-2 integrins. J. Neuroimmunol. 30:1990;81-93.
3. Andoh A., Fujiyama Y., Bamba T., Hosoda S. Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2. J. Immunol. 151:1993;4239-4247.
4. Barnum S.R., Ishii Y., Agrawal A., Volkanis J.E. Production and interferon-γ-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG. Biochem. J. 287:1992;595-601.
5. Barnum S.R., Jones J.L., Benveniste E.N. Interleukin-1 and tumor necrosis factor-mediated regulation of C3 expression in human astroglioma cells. Glia. 7:1993;225-236.
6. Barnum S.R. Complement biosynthesis in the central nervous system. Crit. Rev. Oral Biol. Med. 6:1995;132-146.
7. 2-macroglobulin indicate an acute phase state in Alzheimer's disease cortices. FEBS Lett. 285:1991;111-114.
8. Berge V., Johnson E., Berge K.E. Interleukin-1 alpha, interleukin 6 and tumor necrosis factor alpha increase the synthesis and expression of the functional alternative and terminal complement pathways by human umbilical vein endothelial cells in vitro. APMIS. 104:1996;213-219.
9. Blum-Degen D., Muller T., Kuhn W., Gerlach M., Przuntek H., Riederer P. Interleukin-1β and interleukin-6 are elevated in cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 202:1995;17-20.
10. Bradt B.M., Kolb W.P., Cooper N.R. Complement-dependent pro-inflammatory properties of the Alzheimer's disease β-peptide. J. Exp. Med. 188:1998;431-438.
11. Cacabelos R., Alverez X.A., Franco-Maside A., Fernandez-Novao L., Caamano J. Serum tumor necrosis factor (TNF) in Alzheimer's disease and multi-infarct dementia. Methods Findings Exp. Clin. Pharmacol. 16:1994;29-35.
12. Campbell R.D., Bentley D.R. The structure and genetics of the C2 and factor B genes. Immunol. Rev. 87:1985;19-37.
13. Catterall C.F., Lyons A., Sim R.B., Day A.J., Harris T.J. Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones. Biochem. J. 242:1987;849-856.
14. Colten H.R., Oi Y.M., Edelson P.J. Synthesis and secretion of complement proteins by macrophages. Ann. N. Y. Acad. Sci. 332:1979;482-490.
15. Dauchel H., Julen N., Lemercier C., Daveau M., Ozanne D., Fontaine M., Ripoche J. Expression of complement alternative pathway proteins by endothelial cell. Differential regulation by interleukin-1 and glucocorticoids. Eur. J. Immunol. 20:1990;1669-1675.
16. 2 (CD11b/CD18). J. Immunol. 160:1998;4057-4066.
17. Eikelenboom P., Hack C.E., Rozemuller J.M., Stam F.C. Complement activation in amyloid plaques in Alzheimer's disease. Virchows Arch. B Cell. Pathol. 56:1989;259-262.
18. Estaller C., Schwaeble W., Dierich M., Weiss E.H. Human complement factor H: Two complement factor H proteins are derived from alternatively spliced transcripts. Eur. J. Immunol. 21:1991;799-802.
19. Fillit H., Ding W., Buee L., Kalman J., Altstiel L., Lawlor B., Wolf-Klein G. Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci. Lett. 129:1991;318-320.
20. Fischer B., Schmol H., Riederer P., Bauer J., Platt D., Popa-Wagner A. Complement C1q and C3 mRNA expression in the frontal cortex of Alzheimer's patients. J. Mol. Med. 73:1995;465-471.
21. Gasque P., Julen N., Ischenko A.M., Picot C., Mauger C., Chauzy C., Ripoche J., Fontaine M. Expression of complement components of the alternative pathway by glioma cell lines. J. Immunol. 149:1992;1381-1387.
22. Gasque P., Morgan B.P. Complement regulatory protein expression by a human oligodendrocyte cell line: Cytokine regulation and comparison with astrocytes. Immunology. 89:1996;338-347.
23. Gordon D.L., Avery V.M., Adrian D.L., Sadlon T.A. Detection of complement protein mRNA in human astrocytes by the polymerase chain reaction. J. Neurosci. Methods. 45:1992;191-197.
24. Griffin W.S., Sheng J.G., Roberts G.W., Mrak R.E. Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54:1995;276-281.
25. Griffin W.S., Stanley L.C., Chen L., White L., MacLeod V., Perrot L.J., White C.L., Araoz C. Brain interleukin-1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA. 86:1989;7611-7615.
26. Hartung H.P., Hadding U. Synthesis of complement by macrophages and modulation of their functions through complement activation. Springer Semin. Immunopathol. 6:(4):1983;283-326.
27. Imamura T., Ohtsuka H., Matsushita M., Tsuruta J., Okada H., Kambara T. A new biological activity of the complement factor H: Identification of the precursor of the major macrophage-chemotactic factor in delayed hypersensitivity reaction sites of guinea pigs. Biochem. Biophys. Res. Commun. 185:1992;505-509.
28. Ishii T., Haga S., Kametani F. Presence of immunoglobulins and complements in the amyloid plaques in the brain of patients with Alzheimer's disease. Pouplard-Barthelaix A., Emile J., Christen Y. Immunology and Alzheimer's Disease. 1988;17-29 Springer, Berlin.
29. Ishii T., Haga S. Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques. Acta Neuropathol. 63:1984;296-300.
30. Itagaki S., Akiyama H., Saito H., McGeer P.L. Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease. Brain Res. 645:1994;78-84.
31. Jiang H., Burdick D., Glabe C.G., Cotman C.W., Tenner A.J. β-amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J. Immunol. 152:1994;5050-5059.
32. Johnson S.A., Lampert-Etchells M., Pasinetti G.M., Rozovsky I., Finch C.E. Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Neurobiol. Aging. 13:1992;641-648.
33. Legoedec J., Gasque P., Jeanne J.F., Fontaine M. Expression of the complement alternative pathway by human myoblasts in vitro: biosynthesis of C3, factor B, factor H and factor I. Eur. J. Immunol. 25:1995;3460-3466.
34. Lemercier C., Julen N., Coulpier N., Dauchel H., Ozanne D., Fontaine M., Ripoche J. Differential modulation by glucocorticoids of alternative complement protein secretion in cells of the monocyte/macrophage lineage. Eur. J. Immunol. 22:1992;909-915.
35. Lue L.F., Kuo Y.M., Roher A., Brachova L., Shen Y., Sue L., Beach T., Kurth J.H., Rydel R.E., Rogers J. Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 2000;. in press.
36. Lue L.F., Brachova L., Civin W.H., Rogers J. Inflammation, Aβ deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J. Neuropathol. Exp. Neurol. 55:1996;1083-1088.
37. McGeer E.G., McGeer P.L. The importance of inflammatory mechanisms in Alzheimer disease. Exp. Gerontol. 33:1998;371-378.
38. McGeer P.L., Akiyama H., Itagaki S., McGeer E.G. Activation of the classical complement pathway in the brain tissue of Alzheimer's disease patients. Neurosci. Lett. 107:1989;341-346.
39. McGeer P.L., Kawamata T., Walker D.G. Distribution of clusterin in Alzheimer brain tissue. Brain Res. 579:1992;337-341.
40. McGeer P.L., McGeer E.G. Complement proteins and complement inhibitors in Alzheimer's disease. Res. Immunol. 143:1992;621-624.
41. Meri S., Jarva H. Complement regulation. Vox Sang. 74:1998;291-302.
42. Mirra S.S., Hyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., Vogel F.S., Hughes J.P., Van Belle G., Berg L. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:1991;479-481.
43. Mole J.E., Anderson J.K., Davison E.A., Woods D.E. Complete primary structure for the zymogen of human complement factor B. J. Biol. Chem. 259:1984;3407-3412.
44. Muller-Eberhard H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57:1988;321-347.
45. Nabil K., Rihn B., Jaurand M.C., Vignaud J.M., Ripoche J., Martinet Y., Martinet N. Identification of human complement factor H as a chemotactic protein for monocytes. Biochem. J. 326:1997;377-383.
46. Ohtsuka H., Imamura T., Matsushita M., Tanase S., Okada H., Ogawa M., Kambara T. Thrombin generates monocyte chemotactic activity from complement factor H. Immunology. 80:1993;140-145.
47. Ollert M.W., David K., Bredehorst R., Vogel C.W. Classical complement pathway activation on nucleated cells. Role of factor H in the control of deposited C3b. J. Immunol. 155:1995;4955-4962.
48. Pangburn M.K. The alternative pathway. Hughes-Jones N.C. Immunobiology of the Complement System. 1986;45-62 Academic Press.
49. Perlmutter D.H., Goldberger G., Dinarello C.A., Mizel S.B., Colten H.R. Regulation of class III major histocompatability complex gene products by interleukin-1. Science. 232:1986;850-852.
50. Perlmutter D.H., Goldberger G., Dinarello C.A., Mizel S.B., Colten H.R. Regulation of class III major histocompatability complex gene products by interleukin-1. Science. 232:1986;850-852.
51. Pike C.J., Walencewicz A.J., Glabe C.G., Cotman C.W. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 56:1991;311-314.
52. Rogers J., Cooper N.R., Webster S., Schultz J., McGeer P.L., Styren S.D., Civin W.H., Brachova L., Bradt B., Warcl P., Lieberburg I. Complement activation by β-amyloid in Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 89:1992;10016-10020.
53. Rogers J., O'Barr S. Inflammatory mediators in Alzheimer's disease. Wasco W., Tanzi R.E. Molecular Mechanisms of Dementia. 1996;177-198 Humana Press, Totowa, NJ.
54. Rogers J., Webster S., Lue L.F., Brachova L., Civin W.H., Emmerling M., Shivers B., Walker D., McGeer P. Inflammation and Alzheimer's disease pathogenesis. Neurobiol. Aging. 17:1996;681-686.
55. Schultz J., Schaller J., McKinley M., Bradt B., Cooper N., May P., Rogers J. Enhanced cytotoxicity of amyloid β-peptide by a complement dependent mechanism. Neurosci. Lett. 175:1994;99-102.
56. Schwaeble W., Zwirner J., Schulz T.F., Linke R.P., Dierich M.P., Weiss E.H. Human complement factor H: Expression of an additional truncated gene product of 43 kDa in human liver. Eur. J. Immunol. 17:1987;1485-1489.
57. Shen Y., Li R., McGeer E.G., McGeer P.L. Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain. Brain Res. 769:1997;391-395.
58. Sheng J.G., Mrak R.E., Griffin W.S. Microglial interleukin-1α expression in brain regions in Alzheimer's disease: Correlation with neuritic plaque distribution. Neuropathol. Appl. Neurobiol. 21:1995;290-301.
59. Terai K., Walker D.G., McGeer E.G., McGeer P.L. Neurons express proteins of the classical complement pathway in Alzheimer's disease. Brain Res. 769:1997;385-390.
60. Vastag M., Skopal J., Kramer J., Kolev K., Csonka E., Machovich R., Nagy Z. Endothelial cells cultured from human brain microvessels produce complement proteins factor H, factor B, C1 inhibitor, and C4. Immunobiology. 199:1998;5-13.
61. Walker D.G., McGeer P.L. Complement gene expression in human brain: comparison between normal and Alzheimer's disease cases. Mol. Brain Res. 14:1992;106-109.
62. Watanabe I., Horiuchi T., Fujita S. Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-γ-stimulated human fibroblasts, glioblastoma cell line A172, and monocytes. Biochem. J. 305:1995;425-431.
63. Watson M.D., Roher A.E., Kim K.S., Spiegel K., Emmerling M.R. Complement interactions with amyloid-β1-42: a nidus for inflammation in AD brains. Int. J. Exp. Clin. Invest. 4:1997;147-156.
64. Webster S., Glabe C., Rogers J. Multivalent binding of complement protein C1q to the amyloid β-peptide promotes the nucleation phase of Aβ aggregation. Biochem. Biophys. Res. Commun. 217:1995;869-875.
65. Webster S., O'Barr S., Rogers J. Enhanced aggregation and β structure of amyloid β peptide after co-incubation with C1q. J. Neurosci. Res. 39:1994;448-456.
66. Webster S.D., Lue L.F., McKinley M., Rogers J. Ultrastructural localization of complement proteins to neuronal membranes and β-amyloid containing Alzheimer's disease pathology. Neurosci. Abstr. 18:1992;765.
67. 2-macroglobulin, and C-reactive protein. Brain Res. 629:1993;245-252.
68. Zipfel P.F., Skerka C. Complement factor H and related proteins: an expanding family of complement-regulatory proteins? Immunol. Today. 15:1994;121-126.