메뉴 건너뛰기




Volumn 8, Issue 1, 2009, Pages 16-30

Clearance of amyloid-β peptide across the blood-brain barrier: Implication for therapies in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; FC RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MYOCARDIN; RECOMBINANT LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 4; RECOMBINANT PROTEIN; SERUM RESPONSE FACTOR; UNCLASSIFIED DRUG; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; ANTIBODY; FC RECEPTOR, NEONATAL; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN RECEPTOR;

EID: 65649105035     PISSN: 18715273     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152709787601867     Document Type: Article
Times cited : (465)

References (140)
  • 1
    • 0028856460 scopus 로고
    • An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde
    • Alzheimer, A.; Stelzmann, R.A.; Schnitzlein, H.N.; Murtagh, F.R. An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde". Clin. Anat., 1995, 8(6), 429-31.
    • (1995) Clin. Anat , vol.8 , Issue.6 , pp. 429-431
    • Alzheimer, A.1    Stelzmann, R.A.2    Schnitzlein, H.N.3    Murtagh, F.R.4
  • 2
    • 35548940796 scopus 로고    scopus 로고
    • accessed Jan 16, 2009
    • Alzheimer's Association. 2008 Alzheimer's disease Facts and Figures. http://www.alz.org/national/documents/report_alzfactsfigures2008.pdf (accessed Jan 16, 2009).
    • (2008) Alzheimer's disease Facts and Figures
  • 3
    • 0242668337 scopus 로고    scopus 로고
    • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    • Kayed, R.; Head, E.; Thompson, J.L.; McIntire, T.M.; Milton, S.C.; Cotman, C.W.; Glabe, C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science, 2003, 300(5618), 486-9.
    • (2003) Science , vol.300 , Issue.5618 , pp. 486-489
    • Kayed, R.1    Head, E.2    Thompson, J.L.3    McIntire, T.M.4    Milton, S.C.5    Cotman, C.W.6    Glabe, C.G.7
  • 6
    • 0035950225 scopus 로고    scopus 로고
    • Clearing the brain's amyloid cobwebs
    • Selkoe, D.J. Clearing the brain's amyloid cobwebs. Neuron, 2001, 32(2), 177-80.
    • (2001) Neuron , vol.32 , Issue.2 , pp. 177-180
    • Selkoe, D.J.1
  • 8
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
    • Tanzi, R.E.; Bertram, L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell, 2005, 120(4), 545-55.
    • (2005) Cell , vol.120 , Issue.4 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 9
    • 29444434751 scopus 로고    scopus 로고
    • Amyloid double trouble
    • Hardy, J. Amyloid double trouble. Nat. Genet., 2006, 38(1), 11-2.
    • (2006) Nat. Genet , vol.38 , Issue.1 , pp. 11-12
    • Hardy, J.1
  • 10
    • 29444442794 scopus 로고    scopus 로고
    • Rovelet-Lecrux, A.; Hannequin, D.; Raux, G.; Le Meur, N.; Laquerriere, A.; Vital, A.; Dumanchin, C.; Feuillette, S.; Brice, A.; Vercelletto, M.; Dubas, F.; Frebourg, T.; Campion, D. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet., 2006, 38(1), 24-6.
    • Rovelet-Lecrux, A.; Hannequin, D.; Raux, G.; Le Meur, N.; Laquerriere, A.; Vital, A.; Dumanchin, C.; Feuillette, S.; Brice, A.; Vercelletto, M.; Dubas, F.; Frebourg, T.; Campion, D. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet., 2006, 38(1), 24-6.
  • 12
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
    • Haass, C.; Selkoe, D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol., 2007, 8(2), 101-12.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , Issue.2 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 13
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic, B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 2008, 57(2), 178-201.
    • (2008) Neuron , vol.57 , Issue.2 , pp. 178-201
    • Zlokovic, B.V.1
  • 15
    • 0005488219 scopus 로고    scopus 로고
    • Clearance of amyloid β-peptide from brain: Transport or metaboloism
    • Zlokovic, B.V.; Shinya, Y.; Holyzman, D.; Ghiso, J.; Frangione, B. Clearance of amyloid β-peptide from brain: transport or metaboloism. Nat. Med., 2000, 6, 718-719.
    • (2000) Nat. Med , vol.6 , pp. 718-719
    • Zlokovic, B.V.1    Shinya, Y.2    Holyzman, D.3    Ghiso, J.4    Frangione, B.5
  • 16
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Abeta peptide: The many roads to perdition
    • Tanzi, R.E.; Moir, R.D.; Wagner, S.L. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron, 2004, 43(5), 605-8.
    • (2004) Neuron , vol.43 , Issue.5 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 17
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • Zlokovic, B.V. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci., 2005, 28(4), 202-8.
    • (2005) Trends Neurosci , vol.28 , Issue.4 , pp. 202-208
    • Zlokovic, B.V.1
  • 18
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola, C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Rev. Neurosci., 2004, 5(5), 347-60.
    • (2004) Nat. Rev. Neurosci , vol.5 , Issue.5 , pp. 347-360
    • Iadecola, C.1
  • 19
    • 2542475986 scopus 로고    scopus 로고
    • Clearing amyloid through the blood-brain barrier
    • Zlokovic, B.V. Clearing amyloid through the blood-brain barrier. J. Neurochem., 2004, 89(4), 807-11.
    • (2004) J. Neurochem , vol.89 , Issue.4 , pp. 807-811
    • Zlokovic, B.V.1
  • 20
    • 58149373440 scopus 로고    scopus 로고
    • Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: Contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition
    • Han, B.H.; Zhou, M.L.; Abousaleh, F.; Brendza, R.P.; Dietrich, H.H.; Koenigsknecht-Talboo, J.; Cirrito, J.R.; Milner, E.; Holtzman, D.M.; Zipfel, G.J. Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition. J. Neurosci., 2008, 28(50), 13542-50.
    • (2008) J. Neurosci , vol.28 , Issue.50 , pp. 13542-13550
    • Han, B.H.1    Zhou, M.L.2    Abousaleh, F.3    Brendza, R.P.4    Dietrich, H.H.5    Koenigsknecht-Talboo, J.6    Cirrito, J.R.7    Milner, E.8    Holtzman, D.M.9    Zipfel, G.J.10
  • 21
    • 57449084208 scopus 로고    scopus 로고
    • Deane, R.; Sagare, A.; Hamm, K.; Parisi, M.; Lane, S.; Finn, M.B.; Holtzman, D.M.; Zlokovic, B.V. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J. Clin. Invest., 2008, 118(12), 4002-13.
    • Deane, R.; Sagare, A.; Hamm, K.; Parisi, M.; Lane, S.; Finn, M.B.; Holtzman, D.M.; Zlokovic, B.V. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J. Clin. Invest., 2008, 118(12), 4002-13.
  • 23
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • Ballatore, C.; Lee, V.M.; Trojanowski, J.Q. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat. Rev. Neurosci., 2007, 8(9), 663-72.
    • (2007) Nat. Rev. Neurosci , vol.8 , Issue.9 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 27
    • 7644225312 scopus 로고    scopus 로고
    • RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier
    • Deane, R.; Wu, Z.; Zlokovic, B.V. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke, 2004, 35(Suppl 1), 2628-31.
    • (2004) Stroke , vol.35 , Issue.SUPPL. 1 , pp. 2628-2631
    • Deane, R.1    Wu, Z.2    Zlokovic, B.V.3
  • 31
    • 0033943469 scopus 로고    scopus 로고
    • Clearance of amyloid beta-peptide from brain: Transport or metabolism?
    • Zlokovic, B.V.; Yamada, S.; Holtzman, D.; Ghiso, J.; Frangione, B. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat. Med., 2000, 6(7), 718-9.
    • (2000) Nat. Med , vol.6 , Issue.7 , pp. 718-719
    • Zlokovic, B.V.1    Yamada, S.2    Holtzman, D.3    Ghiso, J.4    Frangione, B.5
  • 32
    • 1942452552 scopus 로고    scopus 로고
    • Peptide and peptide analog transport systems at the blood-CSF barrier
    • Smith, D.E.; Johanson, C.E.; Keep, R.F. Peptide and peptide analog transport systems at the blood-CSF barrier. Adv. Drug Deliv. Rev., 2004, 56(12), 1765-91.
    • (2004) Adv. Drug Deliv. Rev , vol.56 , Issue.12 , pp. 1765-1791
    • Smith, D.E.1    Johanson, C.E.2    Keep, R.F.3
  • 33
    • 4644265281 scopus 로고    scopus 로고
    • The structure of the choroid plexus and the physiology of the choroid plexus epithelium
    • Redzic, Z.B.; Segal, M.B. The structure of the choroid plexus and the physiology of the choroid plexus epithelium. Adv. Drug Deliv. Rev., 2004, 56(12), 1695-716.
    • (2004) Adv. Drug Deliv. Rev , vol.56 , Issue.12 , pp. 1695-1716
    • Redzic, Z.B.1    Segal, M.B.2
  • 34
    • 34249007157 scopus 로고    scopus 로고
    • Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo
    • Zhang, S.; Murphy, T.H. Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo. PLoS Biol., 2007, 5(5), e119.
    • (2007) PLoS Biol , vol.5 , Issue.5
    • Zhang, S.1    Murphy, T.H.2
  • 36
    • 16944364644 scopus 로고    scopus 로고
    • Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma
    • Biere, A.L.; Ostaszewski, B.; Stimson, E.R.; Hyman, B.T.; Maggio, J.E.; Selkoe, D.J. Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. J. Biol. Chem., 1996, 271(51), 32916-22.
    • (1996) J. Biol. Chem , vol.271 , Issue.51 , pp. 32916-32922
    • Biere, A.L.1    Ostaszewski, B.2    Stimson, E.R.3    Hyman, B.T.4    Maggio, J.E.5    Selkoe, D.J.6
  • 37
    • 0030779128 scopus 로고    scopus 로고
    • Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta
    • Martel, C.L.; Mackic, J.B.; Matsubara, E.; Governale, S.; Miguel, C.; Miao, W.; McComb, J.G.; Frangione, B.; Ghiso, J.; Zlokovic, B.V. Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J Neurochem., 1997, 69(5), 1995-2004.
    • (1997) J Neurochem , vol.69 , Issue.5 , pp. 1995-2004
    • Martel, C.L.1    Mackic, J.B.2    Matsubara, E.3    Governale, S.4    Miguel, C.5    Miao, W.6    McComb, J.G.7    Frangione, B.8    Ghiso, J.9    Zlokovic, B.V.10
  • 39
    • 85161785924 scopus 로고    scopus 로고
    • Calero, M.; Rostagno, A.; Matsubara, E.; Zlokovic, B.; Frangione, B.; Ghiso, J. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc. Res. Tech., 2000, 50(4), 305-15.
    • Calero, M.; Rostagno, A.; Matsubara, E.; Zlokovic, B.; Frangione, B.; Ghiso, J. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc. Res. Tech., 2000, 50(4), 305-15.
  • 41
    • 0030611584 scopus 로고    scopus 로고
    • Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein
    • Narita, M.; Holtzman, D.M.; Schwartz, A.L.; Bu, G. Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J. Neurochem., 1997, 69(5), 1904-11.
    • (1997) J. Neurochem , vol.69 , Issue.5 , pp. 1904-1911
    • Narita, M.1    Holtzman, D.M.2    Schwartz, A.L.3    Bu, G.4
  • 43
    • 0029920929 scopus 로고    scopus 로고
    • Zlokovic, B.V.; Martel, C.L.; Matsubara, E.; McComb, J.G.; Zheng, G.; McCluskey, R.T.; Frangione, B.; Ghiso, J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc. Natl. Acad. Sci. U. S. A., 1996, 93(9), 4229-34.
    • Zlokovic, B.V.; Martel, C.L.; Matsubara, E.; McComb, J.G.; Zheng, G.; McCluskey, R.T.; Frangione, B.; Ghiso, J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc. Natl. Acad. Sci. U. S. A., 1996, 93(9), 4229-34.
  • 44
    • 34247506244 scopus 로고    scopus 로고
    • Bell, R.D.; Sagare, A.P.; Friedman, A.E.; Bedi, G.S.; Holtzman, D.M.; Deane, R.; Zlokovic, B.V. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab., 2007, 27(5), 909-18.
    • Bell, R.D.; Sagare, A.P.; Friedman, A.E.; Bedi, G.S.; Holtzman, D.M.; Deane, R.; Zlokovic, B.V. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab., 2007, 27(5), 909-18.
  • 46
    • 0030604067 scopus 로고    scopus 로고
    • Zlokovic, B.V. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci., 1996, 59(18), 1483-97.
    • Zlokovic, B.V. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci., 1996, 59(18), 1483-97.
  • 48
    • 0038038284 scopus 로고    scopus 로고
    • Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: A hypothesis
    • Silverberg, G.D.; Mayo, M.; Saul, T.; Rubenstein, E.; McGuire, D. Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol., 2003, 2(8), 506-11.
    • (2003) Lancet Neurol , vol.2 , Issue.8 , pp. 506-511
    • Silverberg, G.D.1    Mayo, M.2    Saul, T.3    Rubenstein, E.4    McGuire, D.5
  • 50
    • 0028054008 scopus 로고
    • Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier
    • Maness, L.M.; Banks, W.A.; Podlisny, M.B.; Selkoe, D.J.; Kastin, A.J. Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier. Life Sci., 1994, 55(21), 1643-50.
    • (1994) Life Sci , vol.55 , Issue.21 , pp. 1643-1650
    • Maness, L.M.1    Banks, W.A.2    Podlisny, M.B.3    Selkoe, D.J.4    Kastin, A.J.5
  • 51
    • 0029870240 scopus 로고    scopus 로고
    • Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs
    • Martel, C.L.; Mackic, J.B.; McComb, J.G.; Ghiso, J.; Zlokovic, B.V. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs. Neurosci. Lett., 1996, 206(2-3), 157-60.
    • (1996) Neurosci. Lett , vol.206 , Issue.2-3 , pp. 157-160
    • Martel, C.L.1    Mackic, J.B.2    McComb, J.G.3    Ghiso, J.4    Zlokovic, B.V.5
  • 52
    • 0031961832 scopus 로고    scopus 로고
    • Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy
    • Mackic, J.B.; Weiss, M.H.; Miao, W.; Kirkman, E.; Ghiso, J.; Calero, M.; Bading, J.; Frangione, B.; Zlokovic, B.V. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J. Neurochem., 1998, 70(1), 210-5.
    • (1998) J. Neurochem , vol.70 , Issue.1 , pp. 210-215
    • Mackic, J.B.1    Weiss, M.H.2    Miao, W.3    Kirkman, E.4    Ghiso, J.5    Calero, M.6    Bading, J.7    Frangione, B.8    Zlokovic, B.V.9
  • 53
    • 0032529151 scopus 로고    scopus 로고
    • Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
    • Mackic, J.B.; Stins, M.; McComb, J.G.; Calero, M.; Ghiso, J.; Kim, K.S.; Yan, S.D.; Stern, D.; Schmidt, A.M.; Frangione, B.; Zlokovic, B.V. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J. Clin. Invest., 1998, 102(4), 734-43.
    • (1998) J. Clin. Invest , vol.102 , Issue.4 , pp. 734-743
    • Mackic, J.B.1    Stins, M.2    McComb, J.G.3    Calero, M.4    Ghiso, J.5    Kim, K.S.6    Yan, S.D.7    Stern, D.8    Schmidt, A.M.9    Frangione, B.10    Zlokovic, B.V.11
  • 54
    • 0036627214 scopus 로고    scopus 로고
    • Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions
    • Mackic, J.B.; Bading, J.; Ghiso, J.; Walker, L.; Wisniewski, T.; Frangione, B.; Zlokovic, B.V. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vasc. Pharmacol., 2002, 38(6), 303-13.
    • (2002) Vasc. Pharmacol , vol.38 , Issue.6 , pp. 303-313
    • Mackic, J.B.1    Bading, J.2    Ghiso, J.3    Walker, L.4    Wisniewski, T.5    Frangione, B.6    Zlokovic, B.V.7
  • 55
    • 7744223882 scopus 로고    scopus 로고
    • Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: Application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice
    • LaRue, B.; Hogg, E.; Sagare, A.; Jovanovic, S.; Maness, L.; Maurer, C.; Deane, R.; Zlokovic, B.V. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J. Neurosci. Meth., 2004, 138(1-2), 233-42.
    • (2004) J. Neurosci. Meth , vol.138 , Issue.1-2 , pp. 233-242
    • LaRue, B.1    Hogg, E.2    Sagare, A.3    Jovanovic, S.4    Maness, L.5    Maurer, C.6    Deane, R.7    Zlokovic, B.V.8
  • 57
  • 58
    • 0024435745 scopus 로고
    • Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain
    • Zlokovic, B.V.; Mackic, J.B.; Djuricic, B.; Davson, H. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J. Neurochem., 1989, 53(5), 1333-40.
    • (1989) J. Neurochem , vol.53 , Issue.5 , pp. 1333-1340
    • Zlokovic, B.V.1    Mackic, J.B.2    Djuricic, B.3    Davson, H.4
  • 59
    • 0022257648 scopus 로고
    • Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine)
    • Zlokovic, B.V.; Begley, D.J.; Chain-Eliash, D.G. Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res., 1985, 336(1), 125-32.
    • (1985) Brain Res , vol.336 , Issue.1 , pp. 125-132
    • Zlokovic, B.V.1    Begley, D.J.2    Chain-Eliash, D.G.3
  • 60
    • 58149154704 scopus 로고    scopus 로고
    • Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier
    • Deane, R.; LaRue, B.; Sagare, A.P.; Castellino, F.J.; Zhong, Z.; Zlokovic, B.V. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J. Cereb. Blood Flow Metab., 2009, 29(1), 25-33.
    • (2009) J. Cereb. Blood Flow Metab , vol.29 , Issue.1 , pp. 25-33
    • Deane, R.1    LaRue, B.2    Sagare, A.P.3    Castellino, F.J.4    Zhong, Z.5    Zlokovic, B.V.6
  • 61
    • 0025213058 scopus 로고
    • A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig
    • Zlokovic, B.V.; Skundric, D.S.; Segal, M.B.; Lipovac, M.N.; Mackic, J.B.; Davson, H. A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp. Neurol., 1990, 107(3), 263-70.
    • (1990) Exp. Neurol , vol.107 , Issue.3 , pp. 263-270
    • Zlokovic, B.V.1    Skundric, D.S.2    Segal, M.B.3    Lipovac, M.N.4    Mackic, J.B.5    Davson, H.6
  • 62
    • 0025360288 scopus 로고
    • Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus
    • Segal, M.B.; Preston, J.E.; Collis, C.S.; Zlokovic, B.V. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. Am. J. Physiol., 1990, 258(5 Pt 2), F1288-94.
    • (1990) Am. J. Physiol , vol.258 , Issue.5 PART 2
    • Segal, M.B.1    Preston, J.E.2    Collis, C.S.3    Zlokovic, B.V.4
  • 63
    • 34147183707 scopus 로고    scopus 로고
    • Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease
    • Deane, R.; Zlokovic, B.V. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr. Alzheimer Res., 2007, 4(2), 191-7.
    • (2007) Curr. Alzheimer Res , vol.4 , Issue.2 , pp. 191-197
    • Deane, R.1    Zlokovic, B.V.2
  • 64
    • 48949117577 scopus 로고    scopus 로고
    • The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease
    • Deane, R.; Sagare, A.; Zlokovic, B.V. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr. Pharm. Des., 2008, 14(16), 1601-5.
    • (2008) Curr. Pharm. Des , vol.14 , Issue.16 , pp. 1601-1605
    • Deane, R.1    Sagare, A.2    Zlokovic, B.V.3
  • 66
    • 0033615356 scopus 로고    scopus 로고
    • N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression
    • Kislinger, T.; Fu, C.; Huber, B.; Qu, W.; Taguchi, A.; Du Yan, S.; Hofmann, M.; Yan, S.F.; Pischetsrieder, M.; Stern, D.; Schmidt, A.M. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J. Biol. Chem., 1999, 274(44), 31740-9.
    • (1999) J. Biol. Chem , vol.274 , Issue.44 , pp. 31740-31749
    • Kislinger, T.1    Fu, C.2    Huber, B.3    Qu, W.4    Taguchi, A.5    Du Yan, S.6    Hofmann, M.7    Yan, S.F.8    Pischetsrieder, M.9    Stern, D.10    Schmidt, A.M.11
  • 67
    • 0037038819 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts: A multiligand receptor magnifying cell stress in diverse pathologic settings
    • Stern, D.; Yan, S.D.; Yan, S.F.; Schmidt, A.M. Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings. Adv. Drug Deliv. Rev., 2002, 54(12), 1615-25.
    • (2002) Adv. Drug Deliv. Rev , vol.54 , Issue.12 , pp. 1615-1625
    • Stern, D.1    Yan, S.D.2    Yan, S.F.3    Schmidt, A.M.4
  • 68
    • 0033639245 scopus 로고    scopus 로고
    • Giri, R.; Shen, Y.; Stins, M.; Du Yan, S.; Schmidt, A.M.; Stern, D.; Kim, K.S.; Zlokovic, B.; Kalra, V.K. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am. J. Physiol. Cell Physiol., 2000, 279(6), C1772-81.
    • Giri, R.; Shen, Y.; Stins, M.; Du Yan, S.; Schmidt, A.M.; Stern, D.; Kim, K.S.; Zlokovic, B.; Kalra, V.K. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am. J. Physiol. Cell Physiol., 2000, 279(6), C1772-81.
  • 69
    • 0031561796 scopus 로고    scopus 로고
    • The putative blood-brain barrier transporter for the beta-amyloid binding protein apolipoprotein j is saturated at physiological concentrations
    • Shayo, M.; McLay, R.N.; Kastin, A.J.; Banks, W.A. The putative blood-brain barrier transporter for the beta-amyloid binding protein apolipoprotein j is saturated at physiological concentrations. Life Sci., 1997, 60(7), PL115-8.
    • (1997) Life Sci , vol.60 , Issue.7
    • Shayo, M.1    McLay, R.N.2    Kastin, A.J.3    Banks, W.A.4
  • 70
    • 70349548973 scopus 로고    scopus 로고
    • Pfizer, ClinicalTrials.gov: A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease. http://clinicaltrials.gov/ct2/show/NCT00566397?term=RAGE&rank=2 (accessed Jan 16, 2009).
    • Pfizer, ClinicalTrials.gov: A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease. http://clinicaltrials.gov/ct2/show/NCT00566397?term=RAGE&rank=2 (accessed Jan 16, 2009).
  • 72
    • 70349546062 scopus 로고    scopus 로고
    • Tertiary amides improves cerebral blood flow and behavioral performance in a mouse model of AD by blocking RAGE/ Aβ interaction. Program No. 704.3
    • Washington, DC
    • Deane, R.; Sagare, A.; Paquette, N.; Bell, R.; LaRue, B.; Ross, N.; Miller, B.; Zlokovic, B. Tertiary amides improves cerebral blood flow and behavioral performance in a mouse model of AD by blocking RAGE/ Aβ interaction. Program No. 704.3. 2008, Society for Neuroscience Meeting Planner, Washington, DC.
    • (2008) Society for Neuroscience Meeting Planner
    • Deane, R.1    Sagare, A.2    Paquette, N.3    Bell, R.4    LaRue, B.5    Ross, N.6    Miller, B.7    Zlokovic, B.8
  • 73
    • 0035046073 scopus 로고    scopus 로고
    • The LDL receptor gene family: (un)expected signal transducers in the brain
    • Herz, J. The LDL receptor gene family: (un)expected signal transducers in the brain. Neuron, 2001, 29(3), 571-81.
    • (2001) Neuron , vol.29 , Issue.3 , pp. 571-581
    • Herz, J.1
  • 74
    • 0034836428 scopus 로고    scopus 로고
    • Herz, J.; Strickland, D.K. LRP: a multifunctional scavenger and signaling receptor. J. Clin. Invest., 2001, 108(6), 779-84.
    • Herz, J.; Strickland, D.K. LRP: a multifunctional scavenger and signaling receptor. J. Clin. Invest., 2001, 108(6), 779-84.
  • 75
    • 0029887302 scopus 로고    scopus 로고
    • Willnow, T.E.; Rohlmann, A.; Horton, J.; Otani, H.; Braun, J.R.; Hammer, R.E.; Herz, J. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J., 1996, 15(11), 2632-9.
    • Willnow, T.E.; Rohlmann, A.; Horton, J.; Otani, H.; Braun, J.R.; Hammer, R.E.; Herz, J. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J., 1996, 15(11), 2632-9.
  • 76
    • 34249780798 scopus 로고    scopus 로고
    • Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII
    • Meijer, A.B.; Rohlena, J.; van der Zwaan, C.; van Zonneveld, A.J.; Boertjes, R.C.; Lenting, P.J.; Mertens, K. Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII. Biochim. Biophys. Acta., 2007, 1774(6), 714-22.
    • (2007) Biochim. Biophys. Acta , vol.1774 , Issue.6 , pp. 714-722
    • Meijer, A.B.1    Rohlena, J.2    van der Zwaan, C.3    van Zonneveld, A.J.4    Boertjes, R.C.5    Lenting, P.J.6    Mertens, K.7
  • 77
    • 0035057838 scopus 로고    scopus 로고
    • Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein
    • Obermoeller-McCormick, L.M.; Li, Y.; Osaka, H.; FitzGerald, D.J.; Schwartz, A.L.; Bu, G. Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein. J. Cell Sci., 2001, 114(Pt 5), 899-908.
    • (2001) J. Cell Sci , vol.114 , Issue.PART 5 , pp. 899-908
    • Obermoeller-McCormick, L.M.1    Li, Y.2    Osaka, H.3    FitzGerald, D.J.4    Schwartz, A.L.5    Bu, G.6
  • 78
    • 20244381143 scopus 로고    scopus 로고
    • Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process
    • Benchenane, K.; Berezowski, V.; Fernandez-Monreal, M.; Brillault, J.; Valable, S.; Dehouck, M.P.; Cecchelli, R.; Vivien, D.; Touzani, O.; Ali, C. Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process. Stroke, 2005, 36(5), 1065-70.
    • (2005) Stroke , vol.36 , Issue.5 , pp. 1065-1070
    • Benchenane, K.1    Berezowski, V.2    Fernandez-Monreal, M.3    Brillault, J.4    Valable, S.5    Dehouck, M.P.6    Cecchelli, R.7    Vivien, D.8    Touzani, O.9    Ali, C.10
  • 79
    • 0035947646 scopus 로고    scopus 로고
    • Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates
    • Li, Y.; Lu, W.; Marzolo, M. P.; Bu, G. Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates. J. Biol. Chem., 2001, 276(21), 18000-6.
    • (2001) J. Biol. Chem , vol.276 , Issue.21 , pp. 18000-18006
    • Li, Y.1    Lu, W.2    Marzolo, M.P.3    Bu, G.4
  • 80
    • 0032509346 scopus 로고    scopus 로고
    • Trommsdorff, M.; Borg, J.P.; Margolis, B.; Herz, J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem., 1998, 273(50), 33556-60.
    • Trommsdorff, M.; Borg, J.P.; Margolis, B.; Herz, J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem., 1998, 273(50), 33556-60.
  • 81
    • 0034682827 scopus 로고    scopus 로고
    • Gotthardt, M.; Trommsdorff, M.; Nevitt, M.F.; Shelton, J.; Richardson, J.A.; Stockinger, W.; Nimpf, J.; Herz, J. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J. Biol. Chem., 2000, 275(33), 25616-24.
    • Gotthardt, M.; Trommsdorff, M.; Nevitt, M.F.; Shelton, J.; Richardson, J.A.; Stockinger, W.; Nimpf, J.; Herz, J. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J. Biol. Chem., 2000, 275(33), 25616-24.
  • 82
    • 0036271796 scopus 로고    scopus 로고
    • Phosphorylation of LRP1: Regulation of transport and signal transduction
    • van der Geer, P. Phosphorylation of LRP1: regulation of transport and signal transduction. Trends Cardiovasc. Med., 2002, 12(4), 160-5.
    • (2002) Trends Cardiovasc. Med , vol.12 , Issue.4 , pp. 160-165
    • van der Geer, P.1
  • 83
    • 0032557542 scopus 로고    scopus 로고
    • Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein
    • Bu, G.; Sun, Y.; Schwartz, A.L.; Holtzman, D.M. Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein. J. Biol. Chem., 1998, 273(21), 13359-65.
    • (1998) J. Biol. Chem , vol.273 , Issue.21 , pp. 13359-13365
    • Bu, G.1    Sun, Y.2    Schwartz, A.L.3    Holtzman, D.M.4
  • 84
    • 0030752288 scopus 로고    scopus 로고
    • Kang, D.E.; Saitoh, T.; Chen, X.; Xia, Y.; Masliah, E.; Hansen, L.A.; Thomas, R.G.; Thal, L.J.; Katzman, R. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurology, 1997, 49(1), 56-61.
    • Kang, D.E.; Saitoh, T.; Chen, X.; Xia, Y.; Masliah, E.; Hansen, L.A.; Thomas, R.G.; Thal, L.J.; Katzman, R. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease. Neurology, 1997, 49(1), 56-61.
  • 85
    • 0032513938 scopus 로고    scopus 로고
    • Lambert, J.C.; Wavrant-De Vrieze, F.; Amouyel, P.; Chartier-Harlin, M.C. Association at LRP gene locus with sporadic late-onset Alzheimer's disease. Lancet, 1998, 351(9118), 1787-8.
    • Lambert, J.C.; Wavrant-De Vrieze, F.; Amouyel, P.; Chartier-Harlin, M.C. Association at LRP gene locus with sporadic late-onset Alzheimer's disease. Lancet, 1998, 351(9118), 1787-8.
  • 86
    • 0033064585 scopus 로고    scopus 로고
    • Wavrant-DeVrieze, F.; Lambert, J.C.; Stas, L.; Crook, R.; Cottel, D.; Pasquier, F.; Frigard, B.; Lambrechts, M.; Thiry, E.; Amouyel, P.; Tur, J.P.; Chartier-Harlin, M.C.; Hardy, J.; Van Leuven, F. Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease. Hum. Genet., 1999, 104(5), 432-4.
    • Wavrant-DeVrieze, F.; Lambert, J.C.; Stas, L.; Crook, R.; Cottel, D.; Pasquier, F.; Frigard, B.; Lambrechts, M.; Thiry, E.; Amouyel, P.; Tur, J.P.; Chartier-Harlin, M.C.; Hardy, J.; Van Leuven, F. Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease. Hum. Genet., 1999, 104(5), 432-4.
  • 87
    • 13544268338 scopus 로고    scopus 로고
    • Genetic-morphologic association study: Association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy
    • Christoforidis, M.; Schober, R.; Krohn, K. Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy. Neuropathol. Appl. Neurobiol., 2005, 31(1), 11-9.
    • (2005) Neuropathol. Appl. Neurobiol , vol.31 , Issue.1 , pp. 11-19
    • Christoforidis, M.1    Schober, R.2    Krohn, K.3
  • 89
    • 0028894661 scopus 로고
    • Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/ low-density-lipoprotein receptor-related protein
    • Rebeck, G.W.; Harr, S.D.; Strickland, D.K.; Hyman, B.T. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/ low-density-lipoprotein receptor-related protein. Ann. Neurol., 1995, 37(2), 211-7.
    • (1995) Ann. Neurol , vol.37 , Issue.2 , pp. 211-217
    • Rebeck, G.W.1    Harr, S.D.2    Strickland, D.K.3    Hyman, B.T.4
  • 91
    • 2442498577 scopus 로고    scopus 로고
    • FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein
    • Pietrzik, C.U.; Yoon, I.S.; Jaeger, S.; Busse, T.; Weggen, S.; Koo, E.H. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J. Neurosci., 2004, 24, 4259-65.
    • (2004) J. Neurosci , vol.24 , pp. 4259-4265
    • Pietrzik, C.U.1    Yoon, I.S.2    Jaeger, S.3    Busse, T.4    Weggen, S.5    Koo, E.H.6
  • 93
    • 0032589297 scopus 로고    scopus 로고
    • Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons
    • Qiu, Z.; Strickland, D.K.; Hyman, B.T.; Rebeck, G.W. Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. J. Neurochem., 1999, 73(4), 1393-8.
    • (1999) J. Neurochem , vol.73 , Issue.4 , pp. 1393-1398
    • Qiu, Z.1    Strickland, D.K.2    Hyman, B.T.3    Rebeck, G.W.4
  • 95
    • 20444374712 scopus 로고    scopus 로고
    • LRP and Alzheimer's disease
    • Zerbinatti, C.V.; Bu, G. LRP and Alzheimer's disease. Rev. Neurosci., 2005, 16(2), 123-35.
    • (2005) Rev. Neurosci , vol.16 , Issue.2 , pp. 123-135
    • Zerbinatti, C.V.1    Bu, G.2
  • 96
    • 10744231924 scopus 로고    scopus 로고
    • Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
    • Zerbinatti, C.V.; Wozniak, D.F.; Cirrito, J.; Cam, J.A.; Osaka, H.; Bales, K.R.; Zhuo, M.; Paul, S.M.; Holtzman, D.M.; Bu, G. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc. Natl. Acad. Sci. USA, 2004, 101(4), 1075-80.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.4 , pp. 1075-1080
    • Zerbinatti, C.V.1    Wozniak, D.F.2    Cirrito, J.3    Cam, J.A.4    Osaka, H.5    Bales, K.R.6    Zhuo, M.7    Paul, S.M.8    Holtzman, D.M.9    Bu, G.10
  • 97
    • 0035984815 scopus 로고    scopus 로고
    • Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: A SPECT study in a primate model of cerebral amyloid angiopathy
    • Bading, J.R.; Yamada, S.; Mackic, J.B.; Kirkman, L.; Miller, C.; Calero, M.; Ghiso, J.; Frangione, B.; Zlokovic, B.V. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J. Drug Target, 2002, 10(4), 359-68.
    • (2002) J. Drug Target , vol.10 , Issue.4 , pp. 359-368
    • Bading, J.R.1    Yamada, S.2    Mackic, J.B.3    Kirkman, L.4    Miller, C.5    Calero, M.6    Ghiso, J.7    Frangione, B.8    Zlokovic, B.V.9
  • 100
    • 0036227489 scopus 로고    scopus 로고
    • Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood
    • Monro, O.R.; Mackic, J.B.; Yamada, S.; Segal, M.B.; Ghiso, J.; Maurer, C.; Calero, M.; Frangione, B.; Zlokovic, B.V. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol. Aging, 2002, 23(3), 405-12.
    • (2002) Neurobiol. Aging , vol.23 , Issue.3 , pp. 405-412
    • Monro, O.R.1    Mackic, J.B.2    Yamada, S.3    Segal, M.B.4    Ghiso, J.5    Maurer, C.6    Calero, M.7    Frangione, B.8    Zlokovic, B.V.9
  • 101
    • 2442594971 scopus 로고    scopus 로고
    • Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor
    • Davis, J.; Xu, F.; Deane, R.; Romanov, G.; Previti, M.L.; Zeigler, K.; Zlokovic, B.V.; Van Nostrand, W.E. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J. Biol. Chem., 2004, 279(19), 20296-306.
    • (2004) J. Biol. Chem , vol.279 , Issue.19 , pp. 20296-20306
    • Davis, J.1    Xu, F.2    Deane, R.3    Romanov, G.4    Previti, M.L.5    Zeigler, K.6    Zlokovic, B.V.7    Van Nostrand, W.E.8
  • 103
    • 0034812412 scopus 로고    scopus 로고
    • The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family
    • Bu, G. The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family. Int. Rev. Cytol., 2001, 209, 79-116.
    • (2001) Int. Rev. Cytol , vol.209 , pp. 79-116
    • Bu, G.1
  • 104
    • 40849102300 scopus 로고    scopus 로고
    • LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model
    • Nazer, B.; Hong, S.; Selkoe, D.J. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol. Dis., 2008, 30(1), 94-102.
    • (2008) Neurobiol. Dis , vol.30 , Issue.1 , pp. 94-102
    • Nazer, B.1    Hong, S.2    Selkoe, D.J.3
  • 106
    • 33846471269 scopus 로고    scopus 로고
    • Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype
    • Chow, N.; Bell, R.D.; Deane, R.; Streb, J.W.; Chen, J.; Brooks, A.; Van Nostrand, W.; Miano, J.M.; Zlokovic, B.V. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc. Natl. Acad. Sci. USA, 2007, 104(3), 823-8.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , Issue.3 , pp. 823-828
    • Chow, N.1    Bell, R.D.2    Deane, R.3    Streb, J.W.4    Chen, J.5    Brooks, A.6    Van Nostrand, W.7    Miano, J.M.8    Zlokovic, B.V.9
  • 107
    • 33745588826 scopus 로고    scopus 로고
    • Tamaki, C.; Ohtsuki, S.; Iwatsubo, T.; Hashimoto, T.; Yamada, K.; Yabuki, C.; Terasaki, T. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharm. Res., 2006, 23(7), 1407-16.
    • Tamaki, C.; Ohtsuki, S.; Iwatsubo, T.; Hashimoto, T.; Yamada, K.; Yabuki, C.; Terasaki, T. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharm. Res., 2006, 23(7), 1407-16.
  • 108
    • 34748856161 scopus 로고    scopus 로고
    • Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes
    • Tamaki, C.; Ohtsuki, S.; Terasaki, T. Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes. Mol. Pharmacol., 2007, 72(4), 850-5.
    • (2007) Mol. Pharmacol , vol.72 , Issue.4 , pp. 850-855
    • Tamaki, C.1    Ohtsuki, S.2    Terasaki, T.3
  • 109
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody, D.L.; Holtzman, D.M. Active and passive immunotherapy for neurodegenerative disorders. Annu. Rev. Neurosci., 2008, 31, 175-93.
    • (2008) Annu. Rev. Neurosci , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 110
    • 41149149333 scopus 로고    scopus 로고
    • The role of the immune system in clearance of Abeta from the brain
    • Boche, D.; Nicoll, J.A. The role of the immune system in clearance of Abeta from the brain. Brain Pathol., 2008, 18(2), 267-78.
    • (2008) Brain Pathol , vol.18 , Issue.2 , pp. 267-278
    • Boche, D.1    Nicoll, J.A.2
  • 111
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • Selkoe, D.J.; Schenk, D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol., 2003, 43, 545-84.
    • (2003) Annu. Rev. Pharmacol. Toxicol , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 115
    • 0141457897 scopus 로고    scopus 로고
    • Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice
    • Das, P.; Howard, V.; Loosbrock, N.; Dickson, D.; Murphy, M.P.; Golde, T.E. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. J. Neurosci., 2003, 23(24), 8532-8.
    • (2003) J. Neurosci , vol.23 , Issue.24 , pp. 8532-8538
    • Das, P.1    Howard, V.2    Loosbrock, N.3    Dickson, D.4    Murphy, M.P.5    Golde, T.E.6
  • 117
    • 0034884382 scopus 로고    scopus 로고
    • Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
    • Sigurdsson, E.M.; Scholtzova, H.; Mehta, P.D.; Frangione, B.; Wisniewski, T. Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am. J. Pathol., 2001, 159(2), 439-47.
    • (2001) Am. J. Pathol , vol.159 , Issue.2 , pp. 439-447
    • Sigurdsson, E.M.1    Scholtzova, H.2    Mehta, P.D.3    Frangione, B.4    Wisniewski, T.5
  • 120
    • 0037531198 scopus 로고    scopus 로고
    • Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
    • Wilcock, D.M.; DiCarlo, G.; Henderson, D.; Jackson, J.; Clarke, K.; Ugen, K.E.; Gordon, M.N.; Morgan, D. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J. Neurosci., 2003, 23(9), 3745-51.
    • (2003) J. Neurosci , vol.23 , Issue.9 , pp. 3745-3751
    • Wilcock, D.M.1    DiCarlo, G.2    Henderson, D.3    Jackson, J.4    Clarke, K.5    Ugen, K.E.6    Gordon, M.N.7    Morgan, D.8
  • 123
    • 58549089731 scopus 로고    scopus 로고
    • Trouche, S.G.; Asuni, A.; Rouland, S.; Wisniewski, T.; Frangione, B.; Verdier, J.M.; Sigurdsson, E.M.; Mestre-Frances, N. Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine, 2008, advance online publication: doi:10.1016/j.vaccine.2008. 12.012, Dec. 27, 2008.
    • Trouche, S.G.; Asuni, A.; Rouland, S.; Wisniewski, T.; Frangione, B.; Verdier, J.M.; Sigurdsson, E.M.; Mestre-Frances, N. Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine, 2008, advance online publication: doi:10.1016/j.vaccine.2008. 12.012, Dec. 27, 2008.
  • 127
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B.; Bales, K.R.; Cummins, D.J.; Dodart, J.C.; Paul, S.M.; Holtzman, D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 2001, 98(15), 8850-5.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.15 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 128
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B.; Bales, K.R.; Cummins, D.J.; Paul, S.M.; Holtzman, D.M. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science, 2002, 295(5563), 2264-7.
    • (2002) Science , vol.295 , Issue.5563 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 129
    • 30844472909 scopus 로고    scopus 로고
    • IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor
    • Deane, R.; Sagare, A.; Hamm, K.; Parisi, M.; LaRue, B.; Guo, H.; Wu, Z.; Holtzman, D.M.; Zlokovic, B.V. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J. Neurosci., 2005, 25(50), 11495-503.
    • (2005) J. Neurosci , vol.25 , Issue.50 , pp. 11495-11503
    • Deane, R.1    Sagare, A.2    Hamm, K.3    Parisi, M.4    LaRue, B.5    Guo, H.6    Wu, Z.7    Holtzman, D.M.8    Zlokovic, B.V.9
  • 130
    • 0037223101 scopus 로고    scopus 로고
    • Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid
    • Matsuoka, Y.; Saito, M.; LaFrancois, J.; Saito, M.; Gaynor, K.; Olm, V.; Wang, L.; Casey, E.; Lu, Y.; Shiratori, C.; Lemere, C.; Duff, K. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J. Neurosci., 2003, 23(1), 29-33.
    • (2003) J. Neurosci , vol.23 , Issue.1 , pp. 29-33
    • Matsuoka, Y.1    Saito, M.2    LaFrancois, J.3    Saito, M.4    Gaynor, K.5    Olm, V.6    Wang, L.7    Casey, E.8    Lu, Y.9    Shiratori, C.10    Lemere, C.11    Duff, K.12
  • 131
    • 0022552302 scopus 로고
    • Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey
    • Balin, B.J.; Broadwell, R.D.; Salcman, M.; el-Kalliny, M. Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J. Comp. Neurol., 1986, 251(2), 260-80.
    • (1986) J. Comp. Neurol , vol.251 , Issue.2 , pp. 260-280
    • Balin, B.J.1    Broadwell, R.D.2    Salcman, M.3    el-Kalliny, M.4
  • 132
    • 0027322295 scopus 로고
    • Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system
    • Broadwell, R.D.; Sofroniew, M.V. Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp. Neurol., 1993, 120(2), 245-63.
    • (1993) Exp. Neurol , vol.120 , Issue.2 , pp. 245-263
    • Broadwell, R.D.1    Sofroniew, M.V.2
  • 133
    • 0036953160 scopus 로고    scopus 로고
    • Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease
    • Banks, W.A.; Terrell, B.; Farr, S.A.; Robinson, S.M.; Nonaka, N.; Morley, J.E. Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease. Peptides, 2002, 23(12), 2223-6.
    • (2002) Peptides , vol.23 , Issue.12 , pp. 2223-2226
    • Banks, W.A.1    Terrell, B.2    Farr, S.A.3    Robinson, S.M.4    Nonaka, N.5    Morley, J.E.6
  • 136
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
    • Bacskai, B.J.; Kajdasz, S.T.; McLellan, M.E.; Games, D.; Seubert, P.; Schenk, D.; Hyman, B.T. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J. Neurosci., 2002, 22(18), 7873-8.
    • (2002) J. Neurosci , vol.22 , Issue.18 , pp. 7873-7878
    • Bacskai, B.J.1    Kajdasz, S.T.2    McLellan, M.E.3    Games, D.4    Seubert, P.5    Schenk, D.6    Hyman, B.T.7
  • 137
    • 0036079202 scopus 로고    scopus 로고
    • Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier
    • Schlachetzki, F.; Zhu, C.; Pardridge, W.M. Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier. J. Neurochem., 2002, 81(1), 203-6.
    • (2002) J. Neurochem , vol.81 , Issue.1 , pp. 203-206
    • Schlachetzki, F.1    Zhu, C.2    Pardridge, W.M.3
  • 138
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: The neonatal Fc receptor comes of age
    • Roopenian, D.C.; Akilesh, S. FcRn: the neonatal Fc receptor comes of age. Nat. Rev. Immunol., 2007, 7(9), 715-25.
    • (2007) Nat. Rev. Immunol , vol.7 , Issue.9 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 139
    • 37149008108 scopus 로고    scopus 로고
    • Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice
    • Vasilevko, V.; Xu, F.; Previti, M.L.; Van Nostrand, W.E.; Cribbs, D.H. Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. J. Neurosci., 2007, 27(49), 13376-83.
    • (2007) J. Neurosci , vol.27 , Issue.49 , pp. 13376-13383
    • Vasilevko, V.1    Xu, F.2    Previti, M.L.3    Van Nostrand, W.E.4    Cribbs, D.H.5
  • 140
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-beta deposits in brains of lining mice permits direct observation of clearance of plaques with immunotherapy
    • Bacskai, B J.; Kajdasz, S.T.; Christie, R.H.; Carter, C.; Games, D.; Seubert, P.; Schenk, D.; Hyman, B.T. Imaging of amyloid-beta deposits in brains of lining mice permits direct observation of clearance of plaques with immunotherapy. Nat. Med., 2001, 7(3), 369-72.
    • (2001) Nat. Med , vol.7 , Issue.3 , pp. 369-372
    • Bacskai, B.J.1    Kajdasz, S.T.2    Christie, R.H.3    Carter, C.4    Games, D.5    Seubert, P.6    Schenk, D.7    Hyman, B.T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.