Reduction of β-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization

Vaccine

Volumn 21, Issue 11-12, 2003, Pages 1060-1065

  Frenkel, Dan ^a   Dewachter, Ilse ^b   Van Leuven, Fred ^b   Solomon, Beka ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Alzheimer's plaque clearance; APP transgenic mice; EFRH epitope

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; PROTEIN EFRH; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIOPHAGE; BRAIN; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNIZATION; MOUSE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ALZHEIMER VACCINES; AMYLOID BETA-PROTEIN; ANIMALS; AUTOANTIBODIES; BRAIN CHEMISTRY; EPITOPES; HUMANS; IMMUNIZATION; INOVIRUS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MODELS, ANIMAL; PEPTIDE LIBRARY; SENILE PLAQUES; VACCINES, SYNTHETIC;

EID: 0037424110     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00609-6     Document Type: Article

References (18)

1. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:2001;741-766.
2. Levy-Lahad E., Tsuang D., Bird T.D. Recent advances in the genetics of Alzheimer's disease. J. Geriatr. Psychiatry Neurol. 11:1998;42-54.
3. Lee V.M. Regulation of tau phosphorylation in Alzheimer's disease. Ann. N. Y. Acad. Sci. 777:1996;107-113.
4. Clippingdale Wade J.D., Barrow C.J. The amyloid-beta peptide and its role in Alzheimer's disease. J. Peptide Sci. 7:2001;227-249.
5. Saido T.C. Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid. Neurobiol. Aging. 19:1998;S69-S75.
6. Schenk D., Barbour R., Dunn W.et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 400:1999;173-177.
7. Bard F., Cannon C., Barbour R.et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6:2000;916-919.
8. Chen G., Chen K.S., Knox J.et al. Learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature. 408:2000;975-979.
9. Janus C., Pearson J., McLaurin J.et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408:2000;979-982.
10. Munch G., Robinson S.R. Potential neurotoxic inflammatory responses to Aβ vaccination in humans. J. Neural Transm. 109:2002;1081-1087.
11. Solomon B., Koppel R., Frankel D., Hanan-Aharon E. Disaggregation of Alzheimer beta-amyloid by site-directed mAb. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4109-4112.
12. Solomon B., Koppel R., Hanan E., Katzav T. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc. Natl. Acad. Sci. U.S.A. 93:1996;452-455.
13. Frenkel D., Balass M., Solomon B. N-terminal EFRH sequence of Alzheimer's beta-amyloid peptide represents the epitope of its anti-aggregating antibodies. J. Neuroimmunol. 88:1998;85-90.
14. Dewachter I., Van Dorpe J., Smeijers L. Aging increased amyloid peptide and caused amyloid plaques in brain of old APP[V717I] transgenic mice by a different mechanism than mutant presenilin 1. J. Neurosci. 20:2000;6452-6458.
15. Moechars D., Dewachter I., Lorent K.et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 274:1999;6483-6492.
16. Van Dorpe J., Smeijers L., Dewachter I.et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons. Am. J. Pathol. 157:2000;1283-1298.
17. Frenkel D., Katz O., Solomon B. Immunization against Alzheimer's beta-amyloid plaques via EFRH phage administration. Proc. Natl. Acad. Sci. U.S.A. 97:2000;11455-11459.
18. Frenkel D., Kariv N., Solomon B. Generation of auto-antibodies towards Alzheimer's disease vaccination. Vaccine. 19:2001;2615-2619.