메뉴 건너뛰기




Volumn 16, Issue 14, 1996, Pages 4491-4500

Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease

Author keywords

aging; Alzheimer's disease; entorhinal cortex; neuronal loss; perforant pathway; stereology

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; DEMENTIA; EFFERENT NERVE; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0029979798     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-14-04491.1996     Document Type: Article
Times cited : (1449)

References (74)
  • 1
    • 0002127846 scopus 로고
    • Hippocampal formation
    • Paxinos G, ed, San Diego: Academic
    • Amaral DG, Insausti R (1990) Hippocampal formation. In: The human nervous system (Paxinos G, ed), pp 19-31. San Diego: Academic.
    • (1990) The Human Nervous System , pp. 19-31
    • Amaral, D.G.1    Insausti, R.2
  • 2
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in cerebral cortex of patients with Alzheimer's disease
    • Arnold SE, Hyman BT, Flory J (1991) The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1:103-116.
    • (1991) Cereb Cortex , vol.1 , pp. 103-116
    • Arnold, S.E.1    Hyman, B.T.2    Flory, J.3
  • 3
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992a) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42:631-639.
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 4
    • 0026743110 scopus 로고
    • Distribution of Alzheimer-type pathological changes in nondemented elderly matches the pattern in Alzheimer's disease
    • Arriagada PV, Marzloff K, Hyman BT (1992b) Distribution of Alzheimer-type pathological changes in nondemented elderly matches the pattern in Alzheimer's disease. Neurology 42:1681-1688.
    • (1992) Neurology , vol.42 , pp. 1681-1688
    • Arriagada, P.V.1    Marzloff, K.2    Hyman, B.T.3
  • 5
    • 0017358355 scopus 로고
    • Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study
    • Berl
    • Ball MJ (1977) Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neuropathol (Berl) 37:111-118.
    • (1977) Acta Neuropathol , vol.37 , pp. 111-118
    • Ball, M.J.1
  • 6
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RLI, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.I.2    Beer, B.3    Lippa, A.S.4
  • 7
    • 0024208529 scopus 로고
    • The clinical dementia rating (CDR)
    • Berg L (1988) The clinical dementia rating (CDR). Psychopharmacol Bull 24:637-639.
    • (1988) Psychopharmacol Bull , vol.24 , pp. 637-639
    • Berg, L.1
  • 8
    • 0020386060 scopus 로고
    • Mild senile dementia of Alzheimer type: Research diagnostic criteria, recruitment, and description of a study population
    • Berg L, Hughes CP, Coben LA (1982) Mild senile dementia of Alzheimer type: research diagnostic criteria, recruitment, and description of a study population. J Neurol Neurosurg Psychiatry 45:962-968.
    • (1982) J Neurol Neurosurg Psychiatry , vol.45 , pp. 962-968
    • Berg, L.1    Hughes, C.P.2    Coben, L.A.3
  • 9
    • 0027468235 scopus 로고
    • Neuropathologic indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older
    • Berg L, McKeel Jr DW, Miller JP (1993) Neuropathologic indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50:349-358.
    • (1993) Arch Neurol , vol.50 , pp. 349-358
    • Berg, L.1    McKeel Jr., D.W.2    Miller, J.P.3
  • 10
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed G, Tomlinson BE, Roth M (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 114:797-811.
    • (1968) Br J Psychiatry , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 11
    • 0027316077 scopus 로고
    • Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathological changes
    • Bouras C, Hof PR, Morrison JH (1993) Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathological changes. Neurosci Lett 153:131-135.
    • (1993) Neurosci Lett , vol.153 , pp. 131-135
    • Bouras, C.1    Hof, P.R.2    Morrison, J.H.3
  • 12
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer related changes
    • Braak H, Braak E (1991) Neuropathological staging of Alzheimer related changes. Acta Neuropathol 82:239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 13
    • 0023939251 scopus 로고
    • Normal ageing, impaired cognitive function and senile dementia of the Alzheimer's type: A continuum?
    • Brayne C, Calloway P (1988) Normal ageing, impaired cognitive function and senile dementia of the Alzheimer's type: a continuum? Lancet 1:1265-1267.
    • (1988) Lancet , vol.1 , pp. 1265-1267
    • Brayne, C.1    Calloway, P.2
  • 14
    • 0026549426 scopus 로고
    • Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions
    • Cabalka LM, Hyman BT, Goodlett CR (1992) Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions. Neurobiol Aging 13:283-291.
    • (1992) Neurobiol Aging , vol.13 , pp. 283-291
    • Cabalka, L.M.1    Hyman, B.T.2    Goodlett, C.R.3
  • 16
    • 0023472509 scopus 로고
    • Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
    • Coleman PD, Flood DG (1987) Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging 8:521-545.
    • (1987) Neurobiol Aging , vol.8 , pp. 521-545
    • Coleman, P.D.1    Flood, D.G.2
  • 17
    • 0011773912 scopus 로고
    • Is dendritic proliferation of surviving neurons a compensatory response to loss of neighbors in the aging brain?
    • Finger S, Levere TE, Almli CR, Stein DG, eds, New York: Plenum
    • Coleman PD, Flood DG (1988) Is dendritic proliferation of surviving neurons a compensatory response to loss of neighbors in the aging brain? In: Brain injury and recovery (Finger S, Levere TE, Almli CR, Stein DG, eds), pp 235-247. New York: Plenum.
    • (1988) Brain Injury and Recovery , pp. 235-247
    • Coleman, P.D.1    Flood, D.G.2
  • 18
    • 0025822216 scopus 로고
    • Retrospective postmortem dementia assessment. Validation of a new clinical interview to assist neuropathologic study
    • Davis PB, White H, Price JL (1991) Retrospective postmortem dementia assessment. Validation of a new clinical interview to assist neuropathologic study. Arch Neurol 48:613-617.
    • (1991) Arch Neurol , vol.48 , pp. 613-617
    • Davis, P.B.1    White, H.2    Price, J.L.3
  • 19
    • 0014723027 scopus 로고
    • Quantitative histological studies in the aged human brain. I. Senile plaques and neurofibrillary tangles in "normal" patients
    • Berl
    • Dayan AD (1970) Quantitative histological studies in the aged human brain. I. Senile plaques and neurofibrillary tangles in "normal" patients. Acta Neuropathol (Berl) 16:85-94.
    • (1970) Acta Neuropathol , vol.16 , pp. 85-94
    • Dayan, A.D.1
  • 20
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky ST, Scheff SW (1990) Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 27:457-464.
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • Dekosky, S.T.1    Scheff, S.W.2
  • 21
    • 0025289562 scopus 로고
    • Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person
    • Delaere P, Duyckaerts C, Masters C (1990) Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neurosci Lett 166:87-93.
    • (1990) Neurosci Lett , vol.166 , pp. 87-93
    • Delaere, P.1    Duyckaerts, C.2    Masters, C.3
  • 22
    • 0013287323 scopus 로고
    • How normal aging relates to dementia: A critique and classification
    • Samuel D, Algeri S, Gershon S, eds, New York: Raven
    • Drachman DA (1983) How normal aging relates to dementia: a critique and classification. In: Aging of the brain, Vol 22, Aging (Samuel D, Algeri S, Gershon S, eds), pp 19-31. New York: Raven.
    • (1983) Aging of the Brain, Vol 22, Aging , vol.22 , pp. 19-31
    • Drachman, D.A.1
  • 23
    • 0027994071 scopus 로고
    • If we live long enough, will be all demented?
    • Drachman DA (1994) If we live long enough, will be all demented? Neurology 44:1563-1565.
    • (1994) Neurology , vol.44 , pp. 1563-1565
    • Drachman, D.A.1
  • 25
    • 0023726688 scopus 로고
    • Limbic pathology in schizophrenia: The entorhinal region: A morphometric study
    • Falkai P, Bogerts B, Rozumek M (1988) Limbic pathology in schizophrenia: the entorhinal region: a morphometric study. Biol Psychiatry 24:515-521.
    • (1988) Biol Psychiatry , vol.24 , pp. 515-521
    • Falkai, P.1    Bogerts, B.2    Rozumek, M.3
  • 26
    • 0028864025 scopus 로고
    • Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease
    • Fukutani Y, Kobayashi K, Nakamura I (1995) Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease. Neurosci Lett 200:57-60.
    • (1995) Neurosci Lett , vol.200 , pp. 57-60
    • Fukutani, Y.1    Kobayashi, K.2    Nakamura, I.3
  • 27
    • 0030050286 scopus 로고    scopus 로고
    • Clinical and pathological correlates of Apolipoprotein E ∈4 in Alzheimer disease
    • Gómez-Isla T, West HL, Rebeck GW (1996) Clinical and pathological correlates of Apolipoprotein E ∈4 in Alzheimer disease. Ann Neurol 39:62-70.
    • (1996) Ann Neurol , vol.39 , pp. 62-70
    • Gómez-Isla, T.1    West, H.L.2    Rebeck, G.W.3
  • 28
    • 0026619292 scopus 로고
    • Stereology: The fast lane between neuroanatomy and brain function or still only a tightrope?
    • Gundersen HJG (1992) Stereology: the fast lane between neuroanatomy and brain function or still only a tightrope? Acta Neurol Scand 137:8-13.
    • (1992) Acta Neurol Scand , vol.137 , pp. 8-13
    • Gundersen, H.J.G.1
  • 29
    • 0024595972 scopus 로고
    • Synaptic loss in Alzheimer's disease and other dementias
    • Hamos JE, DeGennaro LJ, Drachman DA (1989) Synaptic loss in Alzheimer's disease and other dementias. Neurology 39:355-361.
    • (1989) Neurology , vol.39 , pp. 355-361
    • Hamos, J.E.1    DeGennaro, L.J.2    Drachman, D.A.3
  • 30
    • 0028025185 scopus 로고
    • Quantitative investigations on the human entorhinal area: Left-right asymmetry and age related changes
    • Berl
    • Heinsen H, Henn R, Eisenmenger W (1994) Quantitative investigations on the human entorhinal area: left-right asymmetry and age related changes. Anat Embryol (Berl) 190:181-194.
    • (1994) Anat Embryol , vol.190 , pp. 181-194
    • Heinsen, H.1    Henn, R.2    Eisenmenger, W.3
  • 31
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • Hirsch E, Graybiel AM, Agid YA (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334:345-348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.1    Graybiel, A.M.2    Agid, Y.A.3
  • 32
    • 0026726282 scopus 로고
    • Evidence of early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques
    • Hof PR, Bierer LM, Perl DP (1992) Evidence of early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques. Arch Neurol 49:946-953.
    • (1992) Arch Neurol , vol.49 , pp. 946-953
    • Hof, P.R.1    Bierer, L.M.2    Perl, D.P.3
  • 33
    • 0028948391 scopus 로고
    • Age-related distribution of neuropathological changes in the cerebral cortex of patients with Down syndrome. Quantitative regional analysis and comparison with Alzheimer's disease
    • Hof PR, Bouras C, Perl DP (1995) Age-related distribution of neuropathological changes in the cerebral cortex of patients with Down syndrome. Quantitative regional analysis and comparison with Alzheimer's disease. Arch Neurol 52:379-391.
    • (1995) Arch Neurol , vol.52 , pp. 379-391
    • Hof, P.R.1    Bouras, C.2    Perl, D.P.3
  • 34
    • 0020040238 scopus 로고
    • A new clinical scale for the staging of dementia
    • Hughes CP, Berg L, Danzier WL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140:566-572.
    • (1982) Br J Psychiatry , vol.140 , pp. 566-572
    • Hughes, C.P.1    Berg, L.2    Danzier, W.L.3
  • 35
    • 0021145680 scopus 로고
    • Alzheimer's disease: Cell specific pathology isolates the hippocampal formation in Alzheimer's disease
    • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer's disease: cell specific pathology isolates the hippocampal formation in Alzheimer's disease. Science 225:1168-1170.
    • (1984) Science , vol.225 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 36
    • 0022535539 scopus 로고
    • Perforant pathway changes and the memory impairment of Alzheimer's disease
    • Hyman BT, Van Hoesen GW, Kromer LJ, Damasio AR (1986) Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol 20:472-481.
    • (1986) Ann Neurol , vol.20 , pp. 472-481
    • Hyman, B.T.1    Van Hoesen, G.W.2    Kromer, L.J.3    Damasio, A.R.4
  • 37
    • 0027490070 scopus 로고
    • The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution
    • Hyman BT, Marzloff K, Arriagada PV (1993) The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J Neuropathol Exp Neurol 52:594-600.
    • (1993) J Neuropathol Exp Neurol , vol.52 , pp. 594-600
    • Hyman, B.T.1    Marzloff, K.2    Arriagada, P.V.3
  • 38
    • 0002931170 scopus 로고
    • Quantitative neuropathology in Alzheimer's disease: Neuronal loss in high-order association cortex parallels dementia
    • Iqbal K, Mortimer JA, Winblad B, Wisniewski HM, eds, New York: Wiley
    • Hyman BT, West HL, Gómez-Isla T (1995) Quantitative neuropathology in Alzheimer's disease: neuronal loss in high-order association cortex parallels dementia. In: Research advances in Alzheimer's disease and related disorders (Iqbal K, Mortimer JA, Winblad B, Wisniewski HM, eds), pp 453-460. New York: Wiley.
    • (1995) Research Advances in Alzheimer's Disease and Related Disorders , pp. 453-460
    • Hyman, B.T.1    West, H.L.2    Gómez-Isla, T.3
  • 39
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42:1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 40
    • 0020683904 scopus 로고
    • Preliminary report on affective symptoms in the early stages of senile dementia of the Alzheimer type
    • Knesevich JW, Martin RL, Berg L, Danziger W (1983) Preliminary report on affective symptoms in the early stages of senile dementia of the Alzheimer type. Am J Psychiatry 140:233-235.
    • (1983) Am J Psychiatry , vol.140 , pp. 233-235
    • Knesevich, J.W.1    Martin, R.L.2    Berg, L.3    Danziger, W.4
  • 41
    • 0029085626 scopus 로고
    • Transient memory impairment in monkeys with bilateral lesions of the entorhinal cortex
    • Leonard BW, Amaral DG, Squire LR, Zola-Morgan S (1995) Transient memory impairment in monkeys with bilateral lesions of the entorhinal cortex. J Neurosci 15:5637-5659.
    • (1995) J Neurosci , vol.15 , pp. 5637-5659
    • Leonard, B.W.1    Amaral, D.G.2    Squire, L.R.3    Zola-Morgan, S.4
  • 42
    • 0028952008 scopus 로고
    • The "Preclinical phase" of probable Alzheimer's disease
    • Linn RT, Wolf PA, Bachman DL (1995) The "Preclinical phase" of probable Alzheimer's disease. Arch Neurol 52:485-490.
    • (1995) Arch Neurol , vol.52 , pp. 485-490
    • Linn, R.T.1    Wolf, P.A.2    Bachman, D.L.3
  • 43
    • 0026563496 scopus 로고
    • Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses
    • Lippa CF, Hamos JE, Pulaski-Salo D (1992) Alzheimer's disease and aging: effects on perforant pathway perikarya and synapses. Neurobiol Aging 13:405-411.
    • (1992) Neurobiol Aging , vol.13 , pp. 405-411
    • Lippa, C.F.1    Hamos, J.E.2    Pulaski-Salo, D.3
  • 44
    • 0028848661 scopus 로고
    • Cognitive test performance in detecting, staging, and tracking Alzheimer's disease
    • Locascio JJ, Growdon JH, Corkin S (1995) Cognitive test performance in detecting, staging, and tracking Alzheimer's disease. Arch Neurol 52:1087-1099.
    • (1995) Arch Neurol , vol.52 , pp. 1087-1099
    • Locascio, J.J.1    Growdon, J.H.2    Corkin, S.3
  • 45
    • 0024503377 scopus 로고
    • The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
    • Mann DM, Esiri MM (1989) The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J Neurol Sci 89:169-179.
    • (1989) J Neurol Sci , vol.89 , pp. 169-179
    • Mann, D.M.1    Esiri, M.M.2
  • 46
    • 0023225114 scopus 로고
    • The topographic distribution of senile plaques and neurofibrillary tangles in the brains of non-demented persons of different ages
    • Mann DMA, Tucker CM, Yates PO (1987) The topographic distribution of senile plaques and neurofibrillary tangles in the brains of non-demented persons of different ages. Neuropathol Appl Neurobiol 13:123-139.
    • (1987) Neuropathol Appl Neurobiol , vol.13 , pp. 123-139
    • Mann, D.M.A.1    Tucker, C.M.2    Yates, P.O.3
  • 47
    • 0026032039 scopus 로고
    • Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's disease
    • Masliah E, Terry RD, Alford M (1991) Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's disease. Am J Pathol 138:235-246.
    • (1991) Am J Pathol , vol.138 , pp. 235-246
    • Masliah, E.1    Terry, R.D.2    Alford, M.3
  • 48
    • 0027320508 scopus 로고
    • Interlaboratory histopathologic assessment of Alzheimer neuropathology: Different methodologies yield comparable diagnostic results
    • McKeel Jr DW, Ball MJ, Price JL (1993) Interlaboratory histopathologic assessment of Alzheimer neuropathology: different methodologies yield comparable diagnostic results. Alzheimer Dis Assoc Disord 7:136-151.
    • (1993) Alzheimer Dis Assoc Disord , vol.7 , pp. 136-151
    • McKeel Jr., D.W.1    Ball, M.J.2    Price, J.L.3
  • 49
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA group under the auspices of Dept. of HHS Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA group under the auspices of Dept. of HHS Task Force on Alzheimer's Disease. Neurology 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 50
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Pt 2. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel Jr DW (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). Pt 2. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel Jr., D.W.3
  • 51
    • 0028347949 scopus 로고
    • Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: A study of the Consortium to Establish a Registry for Alzheimer's disease (CERAD)
    • Mirra SS, Gearing M, McKeel Jr DW (1994) Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: a study of the Consortium to Establish a Registry for Alzheimer's disease (CERAD). J Neuropathol Exp Neurol 53:303-315.
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 303-315
    • Mirra, S.S.1    Gearing, M.2    McKeel Jr., D.W.3
  • 52
    • 0027425211 scopus 로고
    • The clinical dementia rating (CDR): Current version and scoring rules
    • Morris JC (1993) The clinical dementia rating (CDR): current version and scoring rules. Neurology 43:2412-2414.
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 53
    • 0023879429 scopus 로고
    • Early Alzheimer's disease. Diagnostic considerations
    • Morris JC, Fulling K (1988) Early Alzheimer's disease. Diagnostic considerations. Arch Neurol 45:345-349.
    • (1988) Arch Neurol , vol.45 , pp. 345-349
    • Morris, J.C.1    Fulling, K.2
  • 54
    • 0023944331 scopus 로고
    • Validation of clinical diagnostic criteria for Alzheimer's disease
    • Morris JC, McKeel Jr DW, Fulling K (1988) Validation of clinical diagnostic criteria for Alzheimer's disease. Ann Neurol 24:17-22.
    • (1988) Ann Neurol , vol.24 , pp. 17-22
    • Morris, J.C.1    McKeel Jr., D.W.2    Fulling, K.3
  • 55
    • 0025780497 scopus 로고
    • Very mild Alzheimer's disease: Informant-based clinical, psychometric, and pathologic distinction from normal aging
    • Morris JC, McKeel Jr DW, Storandt M (1991) Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology 41:469-478.
    • (1991) Neurology , vol.41 , pp. 469-478
    • Morris, J.C.1    McKeel Jr., D.W.2    Storandt, M.3
  • 56
    • 0029892175 scopus 로고    scopus 로고
    • Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease
    • in press
    • Morris JC, Storandt M, McKeel Jr DW (1996) Cerebral amyloid deposition and diffuse plaques in "normal" aging: evidence for presymptomatic and very mild Alzheimer's disease. Neurology, in press.
    • (1996) Neurology
    • Morris, J.C.1    Storandt, M.2    McKeel Jr., D.W.3
  • 57
    • 0028831582 scopus 로고
    • Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria
    • Nagy Z, Esiri MM, Jobst KA (1995) Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. Dementia 6:21-31.
    • (1995) Dementia , vol.6 , pp. 21-31
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3
  • 58
    • 0016837052 scopus 로고
    • A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients
    • Pfeiffer E (1975) A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc 23:433-441.
    • (1975) J Am Geriatr Soc , vol.23 , pp. 433-441
    • Pfeiffer, E.1
  • 59
    • 0027504932 scopus 로고
    • The relationship between tangle and plaque formation during healthy aging and mild dementia
    • Price JL (1993) The relationship between tangle and plaque formation during healthy aging and mild dementia. Neurobiol Aging 14:661-663.
    • (1993) Neurobiol Aging , vol.14 , pp. 661-663
    • Price, J.L.1
  • 60
    • 0025770134 scopus 로고
    • The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
    • Price JL, Davis PB, Morris JC, White DL (1991) The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 12:295-312.
    • (1991) Neurobiol Aging , vol.12 , pp. 295-312
    • Price, J.L.1    Davis, P.B.2    Morris, J.C.3    White, D.L.4
  • 61
    • 0001087067 scopus 로고
    • The hippocampal formation of the primate
    • Jones EG, ed, New York: Plenum
    • Rosene DL, Van Hoesen GW (1987) The hippocampal formation of the primate. In: The cerebral cortex (Jones EG, ed), pp 345-456. New York: Plenum.
    • (1987) The Cerebral Cortex , pp. 345-456
    • Rosene, D.L.1    Van Hoesen, G.W.2
  • 62
    • 0022658446 scopus 로고
    • The association of clinical and neurological findings and its bearing on the classification and aetiology of Alzheimer's disease
    • Roth M (1986) The association of clinical and neurological findings and its bearing on the classification and aetiology of Alzheimer's disease. Br Med Bull 42:42-50.
    • (1986) Br Med Bull , vol.42 , pp. 42-50
    • Roth, M.1
  • 63
    • 0027973771 scopus 로고
    • Hippocampal connectivity and Alzheimer's dementia: Effects of synapse loss and tangle frequency in a two-component model
    • Samuel W, Masliah E, Hill LR (1994) Hippocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model. Neurology 44:2081-2088.
    • (1994) Neurology , vol.44 , pp. 2081-2088
    • Samuel, W.1    Masliah, E.2    Hill, L.R.3
  • 64
    • 0030068746 scopus 로고    scopus 로고
    • Entorhinal cortex modules of the human brain
    • Solodkin A, Van Hoesen GW (1996) Entorhinal cortex modules of the human brain. J Comp Neurol 365:610-627.
    • (1996) J Comp Neurol , vol.365 , pp. 610-627
    • Solodkin, A.1    Van Hoesen, G.W.2
  • 65
    • 0017083935 scopus 로고
    • Topographic organization of the projections from the entorhinal area to hippocampal formation of the rat
    • Steward O (1976) Topographic organization of the projections from the entorhinal area to hippocampal formation of the rat. J Comp Neurol 167:285-314.
    • (1976) J Comp Neurol , vol.167 , pp. 285-314
    • Steward, O.1
  • 66
    • 0024506466 scopus 로고
    • Very mild senile dementia of the Alzheimer type. II. Psychometric test performance
    • Storandt M, Hill RD (1989) Very mild senile dementia of the Alzheimer type. II. Psychometric test performance. Arch Neurol 46:383-386.
    • (1989) Arch Neurol , vol.46 , pp. 383-386
    • Storandt, M.1    Hill, R.D.2
  • 67
    • 0019494341 scopus 로고
    • Some morphometric aspects of the brain in senile dementia of the Alzheimer type
    • Terry RD, Peck A, DeTeresa R (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 10:184-192.
    • (1981) Ann Neurol , vol.10 , pp. 184-192
    • Terry, R.D.1    Peck, A.2    DeTeresa, R.3
  • 68
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3
  • 69
    • 0014326852 scopus 로고
    • Observations on the brains of non-demented old people
    • Tomlinson BE, Blessed G, Roth M (1968) Observations on the brains of non-demented old people. J Neurol Sci 7:331-356.
    • (1968) J Neurol Sci , vol.7 , pp. 331-356
    • Tomlinson, B.E.1    Blessed, G.2    Roth, M.3
  • 70
    • 0026571268 scopus 로고
    • Ageing of the human entorhinal cortex and subicular complex
    • Trillo L, Gonzalo LM (1992) Ageing of the human entorhinal cortex and subicular complex. Histol Histopathol 7:17-22.
    • (1992) Histol Histopathol , vol.7 , pp. 17-22
    • Trillo, L.1    Gonzalo, L.M.2
  • 71
    • 0027194462 scopus 로고
    • New stereological methods for counting neurons
    • West M (1993) New stereological methods for counting neurons. Neurobiol Aging 14:275-285.
    • (1993) Neurobiol Aging , vol.14 , pp. 275-285
    • West, M.1
  • 72
    • 0025327731 scopus 로고
    • Unbiased stereological estimation of the number of neurons in the human hippocampus
    • West MJ, Gundersen HJG (1990) Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 296:1-22.
    • (1990) J Comp Neurol , vol.296 , pp. 1-22
    • West, M.J.1    Gundersen, H.J.G.2
  • 73
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • West MJ, Coleman PD, Flood DG, Troncoso JC (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344:769-772.
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncoso, J.C.4
  • 74
    • 0028149026 scopus 로고
    • Severity of memory impairment in monkeys as a function of locus and extent of damage within the medial temporal lobe memory system
    • Zola-Morgan S, Squire LR, Ramus SJ (1994) Severity of memory impairment in monkeys as a function of locus and extent of damage within the medial temporal lobe memory system. Hippocampus 4:483-495.
    • (1994) Hippocampus , vol.4 , pp. 483-495
    • Zola-Morgan, S.1    Squire, L.R.2    Ramus, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.