A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease

Neurobiology of Disease

Volumn 14, Issue 3, 2003, Pages 365-379

  Zhang, Jianmin ^a   Wu, Xiaobing ^b   Qin, Chuan ^c   Qi, Jin ^a   Ma, Shibin ^a   Zhang, Huiyuan ^a   Kong, Qingli ^a   Chen, Dongqing ^a   Ba, Denian ^a   He, Wei ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b AGTC Gene Technology Company Ltd   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CHOLERA TOXIN B SUBUNIT; HYBRID PROTEIN; IMMUNOGLOBULIN G; MUTANT PROTEIN; PROTEIN SUBUNIT; RECOMBINANT VACCINE; VIRUS VACCINE;

ADENOVIRUS; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BEHAVIOR DISORDER; COGNITION; CONTROLLED STUDY; DRUG EFFECT; GENE OVEREXPRESSION; IMMUNOGLOBULIN BLOOD LEVEL; IN VIVO STUDY; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; VACCINATION;

EID: 10744225891     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2003.07.005     Document Type: Article

References (41)

1. Bacskai B.J., Kajdasz S.T., McLellan M.E., Games D., Seubert P., Schenk D., Hyman B.T. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J. Neurosci. 22:2002;7873-7878.
2. Bard F., Cannon C., Barbour R., Burke R.L., Games D., Grajeda H., Guido T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Lieberburg I., Motter R., Nguyen M., Soriano F., Vasquéz N., Weiss K., Welch B., Seubert P., Schenk D., Yednock T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6:2000;916-919.
3. Cavallaro S., Meiri N., Yi C.L., Musco S., Ma W., Goldberg J., Alkon D.L. Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Proc. Natl. Acad. Sci. USA. 94:1997;9669-9673.
4. Chen G., Chen K.S., Knox J., Inglis J., Bernard A., Martin S.J., Justice A., McConlogue L., Games D., Freedman S.B., Morris R.G. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature. 408:2000;975-979.
5. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., Snyder S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA. 88:1991;6368-6371.
6. DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.C., Paul S.M., Holtzman D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 98:2001;8850-8855.
7. DeMattos R.B., Bales K.R., Cummins D.J., Paul S.M., Holtzman D.M. Brain to plasma amyloid-betefflux a measure of brain amyloid burden in a mouse model of Alzheimer's disease . Science. 295:2002;2264-2267.
8. Dewachter I., van Dorpe J., Spittaels K., Tesseur I., Van Den H.C., Moechars D., Van Leuven F. Modeling Alzheimer's disease in transgenic mice effect of age and of presenilin 1 on amyloid biochemistry and pathology in APP/London mice . Exp. Gerontol. 35:2000;831-841.
9. During M.J., Symes C.W., Lawlor P.A., Lin J., Dunning J., Fitzsimons H.L., Poulsen D., Leone P., Xu R., Dicker B.L., Lipski J., Young D. An oral vaccine against NMDAR with efficacy in experimental stroke and epilepsy. Science. 287:2000;1453-1460.
10. During M.J., Xu R., Young D., Kaplitt M.G., Sherwin R.S., Leone P. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nat. Med. 4:1998;1131-1135.
11. Frenkel D., Katz O., Solomon B. Immunization against Alzheimer's beta-amyloid plaques via EFRH phage administration. Proc. Natl. Acad. Sci. USA. 97:2000;11455-11459.
12. Gass P., Wolfer D.P., Balschun D., Rudolph D., Frey U., Lipp H.P., Schutz G. Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn. Mem. 5:1998;274-288.
13. Ghersi-Egea J.F., Gorevic P.D., Ghiso J., Frangione B., Patlak C.S., Fenstermacher J.D. Fate of cerebrospinal fluid-borne amyloid beta-peptide rapid clearance into blood and appreciable accumulation by cerebral arteries . J. Neurochem. 67:1996;880-883.
14. Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease progress and problems on the road to therapeutics . Science. 297:2002;353-356.
15. Janus C., D'Amelio S., Amitay O., Chishti M.A., Strome R., Fraser P., Carlson G.A., Roder J.C., George-Hyslop P., Westaway D. Spatial learning in transgenic mice expressing human presenilin (PS1) transgenes. Neurobiol. Aging. 21:2000;541-549.
16. Janus C., Pearson J., McLaurin J., Mathews P.M., Jiang Y., Schmidt S.D., Chishti M.A., Horne P., Heslin D., French J., Mount H.T., Nixon R.A., Mercken M., Bergeron C., Fraser P.E., George-Hyslop P., Westaway D. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408:2000;979-982.
17. Jindal R.M., Karanam M., Shah R. Prevention of diabetes in the NOD mouse by intra-muscular injection of recombinant adeno-associated virus containing the preproinsulin II gene. Int. J. Exp. Diabetes Res. 2:2001;129-138.
18. Johnson-Wood K., Lee M., Motter R., Hu K., Gordon G., Barbour R., Khan K., Gordon M., Tan H., Games D., Lieberburg I., Schenk D., Seubert P., McConlogue L. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94:1997;1550-1555.
19. Koeberl D.D., Bonham L., Halbert C.L., Allen J.M., Birkebak T., Miller A.D. Persistent, therapeutically relevant levels of human granulocyte colony-stimulating factor in mice after systemic delivery of adeno-associated virus vectors. Hum. Gene Ther. 10:1999;2133-2140.
20. McGhee J.R., Mestecky J., Dertzbaugh M.T., Eldridge J.H., Hirasawa M., Kiyono H. The mucosal immune system from fundamental concepts to vaccine development . Vaccine. 10:1992;75-88.
21. McKenzie S.J., Halsey J.F. Cholera toxin B subunit as a carrier protein to stimulate a mucosal immune response. J. Immunol. 133:1984;1818-1824.
22. Morgan D., Diamond D.M., Gottschall P.E., Ugen K.E., Dickey C., Hardy J., Duff K., Jantzen P., DiCarlo G., Wilcock D., Connor K., Hatcher J., Hope C., Gordon M., Arendash G.W. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408:2000;982-985.
23. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods. 11:1984;47-60.
24. Nashar T.O., Hirst T.R., Williams N.A. Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin receptor interaction up-regulates MHC class II. B7, CD40, CD25 and ICAM-1 . Immunology. 91:1997;572-578.
25. Ploix C., Bergerot I., Durand A., Czerkinsky C., Holmgren J., Thivolet C. Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells. Diabetes. 48:1999;2150-2156.
26. Prasad K.M., Yang Z., Bleich D., Nadler J.L. Adeno-associated virus vector mediated gene transfer to pancreatic beta cells. Gene Ther. 7:2000;1553-1561.
27. Samulski R.J., Chang L.S., Shenk T. Helper-free stocks of recombinant adeno-associated viruses normal integration does not require viral gene expression . J. Virol. 63:1989;3822-3828.
28. Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guido T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Liao Z., Lieberburg I., Motter R., Mutter L., Soriano F., Shopp G., Vasquez N., Vandevert C., Walker S., Wogulis M., Yednock T., Games D., Seubert P. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 400:1999;173-177.
29. Shibata M., Yamada S., Kumar S.R., Calero M., Bading J., Frangione B., Holtzman D.M., Miller C.A., Strickland D.K., Ghiso J., Zlokovic B.V. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106:2000;1489-1499.
30. Steiner H., Capell A., Leimer U., Haass C. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease. Eur. Arch. Psychiatry Clin. Neurosci. 249:1999;266-270.
31. Sturchler-Pierrat C., Abramowski D., Duke M., Wiederhold K.H., Mistl C., Rothacher S., Ledermann B., Burki K., Frey P., Paganetti P.A., Waridel C., Calhoun M.E., Jucker M., Probst A., Staufenbiel M., Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl. Acad. Sci. USA. 94:1997;13287-13292.
32. Sugahara T., Pixley M.R., Minami S., Perlas E., Ben Menahem D., Hsueh A.J., Boime I. Biosynthesis of a biologically active single peptide chain containing the human common alpha and chorionic gonadotropin beta subunits in tandem. Proc. Natl. Acad. Sci. USA. 92:1995;2041-2045.
33. Wehner J.M., Sleight S., Upchurch M. Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Res. 523:1990;181-187.
34. Weiner H.L., Selkoe D.J. Inflammation and therapeutic vaccination in CNS diseases. Nature. 420:2002;879-884.
35. Williams N.A., Hirst T.R., Nashar T.O. Immune modulation by the cholera-like enterotoxins from adjuvant to therapeutic . Immunol. Today. 20:1999;95-101.
36. Woogen S.D., Turo K., Dieleman L.A., Beagley K.W., Elson C.O. Inhibition of murine T cell activation by cholera toxin B subunit is not mediated through the phosphatidylinositol second messenger system. J. Immunol. 150:1993;3274-3283.
37. Wu H.Y., Nikolova E.B., Beagley K.W., Russell M.W. Induction of antibody-secreting cells and T-helper and memory cells in murine nasal lymphoid tissue. Immunology. 88:1996;493-500.
38. Xin K.Q., Ooki T., Mizukami H., Hamajima K., Okudela K., Hashimoto K., Kojima Y., Jounai N., Kumamoto Y., Sasaki S., Klinman D., Ozawa K., Okuda K. Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses. Hum. Gene Ther. 13:2002;1571-1581.
39. Xin K.Q., Urabe M., Yang J., Nomiyama K., Mizukami H., Hamajima K., Nomiyama H., Saito T., Imai M., Monahan J., Okuda K., Ozawa K., Okuda K. A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus. Hum. Gene Ther. 12:2001;1047-1061.
40. Yang Y.W., Kotin R.M. Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors. Pharmacol. Res. 17:2000;1056-1061.
41. Zlokovic B.V., Martel C.L., Matsubara E., McComb J.G., Zheng G., McCluskey R.T., Frangione B., Ghiso J. Glycoprotein 330/megalin probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers . Proc. Natl. Acad. Sci. USA. 93:1996;4229-4234.