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Volumn 18, Issue 1, 2004, Pages 38-43

Current Concepts and Future Prospects for Alzheimer Disease Vaccines

Author keywords

Alzheimer disease; Immunization; Vaccines

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN;

EID: 1542344385     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-200401000-00008     Document Type: Article
Times cited : (30)

References (52)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001;81:741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984; 120:885-890.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 3
    • 0033088258 scopus 로고    scopus 로고
    • Nomenclature of amyloid fibril proteins
    • Westermark P, Araki S, Benson MD, et al. Nomenclature of amyloid fibril proteins. Amyloid. 1999;6:63-66.
    • (1999) Amyloid , vol.6 , pp. 63-66
    • Westermark, P.1    Araki, S.2    Benson, M.D.3
  • 4
    • 0035877756 scopus 로고    scopus 로고
    • Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    • Chishti MA, Yang DS, Janus C, et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001;276:21562-21570.
    • (2001) J Biol Chem , vol.276 , pp. 21562-21570
    • Chishti, M.A.1    Yang, D.S.2    Janus, C.3
  • 5
    • 0034700471 scopus 로고    scopus 로고
    • A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C, Pearson J, McLaurin J, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 2000;408:979-982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3
  • 6
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    • Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 1995;373:523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3
  • 7
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996;274:99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3
  • 8
    • 0011444914 scopus 로고    scopus 로고
    • Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
    • Sturchler-Pierrat C, Abramowski D, Duke M, et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA. 1997;94:13287-13292.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13287-13292
    • Sturchler-Pierrat, C.1    Abramowski, D.2    Duke, M.3
  • 9
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
    • Mucke L, Masliah E, Yu GQ, et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000;20:4050-4058.
    • (2000) J Neurosci , vol.20 , pp. 4050-4058
    • Mucke, L.1    Masliah, E.2    Yu, G.Q.3
  • 10
    • 0037334107 scopus 로고    scopus 로고
    • Progressive age-related impairment of cognitive behavior in APP23 transgenic mice
    • Kelly PH, Bondolfi L, Hunziker D, et al. Progressive age-related impairment of cognitive behavior in APP23 transgenic mice. Neurobiol Aging. 2003;24:365-378.
    • (2003) Neurobiol Aging , vol.24 , pp. 365-378
    • Kelly, P.H.1    Bondolfi, L.2    Hunziker, D.3
  • 11
    • 0037159635 scopus 로고    scopus 로고
    • Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
    • Lalonde R, Dumont M, Staufenbiel M, et al. Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation. Brain Res. 2002;956:36-44.
    • (2002) Brain Res , vol.956 , pp. 36-44
    • Lalonde, R.1    Dumont, M.2    Staufenbiel, M.3
  • 12
    • 0037266894 scopus 로고    scopus 로고
    • Age-dependent cognitive decline in the APP23 model precedes amyloid deposition
    • Van Dam D, D'Hooge R, Staufenbiel M, et al. Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. Eur J Neurosci. 2003; 17:388-396.
    • (2003) Eur J Neurosci , vol.17 , pp. 388-396
    • Van Dam, D.1    D'Hooge, R.2    Staufenbiel, M.3
  • 13
  • 14
    • 0035479004 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease
    • Hock BJ Jr, Lamb BT. Transgenic mouse models of Alzheimer's disease. Trends Genet. 2001;17(suppl): 7-12.
    • (2001) Trends Genet , vol.17 , Issue.SUPPL. , pp. 7-12
    • Hock Jr., B.J.1    Lamb, B.T.2
  • 15
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse [see comments]. Nature. 1999;400:173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 16
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, Cannon C, Barbour R, et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000;6:916-919.
    • (2000) Nat Med , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 17
    • 0037452779 scopus 로고    scopus 로고
    • Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology
    • Bard F, Barbour R, Cannon C, et al. Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci USA. 2003; 100:2023-2028.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2023-2028
    • Bard, F.1    Barbour, R.2    Cannon, C.3
  • 18
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000;408:982-985.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 19
    • 0035689651 scopus 로고    scopus 로고
    • Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: Task specificity and correlations between Abeta deposition and spatial memory
    • Arendash GW, Gordon MN, Diamond DM, et al. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. DNA Cell Biol. 2001;20:737-744.
    • (2001) DNA Cell Biol , vol.20 , pp. 737-744
    • Arendash, G.W.1    Gordon, M.N.2    Diamond, D.M.3
  • 20
    • 0034530636 scopus 로고    scopus 로고
    • Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice
    • Lemere CA, Maron R, Spooner ET, et al. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann NY Acad Sci. 2000;920:328-331.
    • (2000) Ann NY Acad Sci , vol.920 , pp. 328-331
    • Lemere, C.A.1    Maron, R.2    Spooner, E.T.3
  • 21
    • 0033801852 scopus 로고    scopus 로고
    • Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
    • Weiner HL, Lemere CA, Maron R, et al. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol. 2000;48:567-579.
    • (2000) Ann Neurol , vol.48 , pp. 567-579
    • Weiner, H.L.1    Lemere, C.A.2    Maron, R.3
  • 22
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    • Dodart JC, Bales KR, Gannon KS, et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci. 2002;5:452-457.
    • (2002) Nat Neurosci , vol.5 , pp. 452-457
    • Dodart, J.C.1    Bales, K.R.2    Gannon, K.S.3
  • 23
    • 0036703483 scopus 로고    scopus 로고
    • Reversible memory loss in a mouse transgenic model of Alzheimer's disease
    • Kotilinek LA, Bacskai B, Westerman M, et al. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci. 2002;22: 6331-6335.
    • (2002) J Neurosci , vol.22 , pp. 6331-6335
    • Kotilinek, L.A.1    Bacskai, B.2    Westerman, M.3
  • 24
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
    • Orgogozo JM, Gilman S, Dartigues JF, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology. 2003;61:46-54.
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3
  • 25
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
    • Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat Rev Neurosci. 2002;3:824-828.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 824-828
    • Schenk, D.1
  • 26
    • 0036852750 scopus 로고    scopus 로고
    • Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
    • McLaurin J, Cecal R, Kierstead ME, et al. Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med. 2002;8:1263-1269.
    • (2002) Nat Med , vol.8 , pp. 1263-1269
    • McLaurin, J.1    Cecal, R.2    Kierstead, M.E.3
  • 27
    • 85069061681 scopus 로고    scopus 로고
    • Non-human primates vaccinated with Alzheimer's Aβ develop anti-peptide antibodies and elevated plasma Aβ but sera lack obvious tissue amyloid plaque immunoreactivity
    • in press
    • Gandy S, DeMattos RB, Lemere C, et al. Non-human primates vaccinated with Alzheimer's Aβ develop anti-peptide antibodies and elevated plasma Aβ but sera lack obvious tissue amyloid plaque immunoreactivity. Alzheimer Dis Assoc Disord. (in press).
    • Alzheimer Dis Assoc Disord
    • Gandy, S.1    DeMattos, R.B.2    Lemere, C.3
  • 28
    • 0038100154 scopus 로고    scopus 로고
    • Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    • Hock C, Konietzko U, Streffer JR, et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron. 2003;38:547-554.
    • (2003) Neuron , vol.38 , pp. 547-554
    • Hock, C.1    Konietzko, U.2    Streffer, J.R.3
  • 29
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • Bacskai BJ, Kajdasz ST, Christie RH, et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med. 2001;7:369-372.
    • (2001) Nat Med , vol.7 , pp. 369-372
    • Bacskai, B.J.1    Kajdasz, S.T.2    Christie, R.H.3
  • 30
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
    • Bacskai BJ, Kajdasz ST, McLellan ME, et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci. 2002;22:7873-7878.
    • (2002) J Neurosci , vol.22 , pp. 7873-7878
    • Bacskai, B.J.1    Kajdasz, S.T.2    McLellan, M.E.3
  • 32
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, et al. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 2001;98:8850-8855.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3
  • 33
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, et al. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science. 2002;295:2264-2267.
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3
  • 34
    • 0041332884 scopus 로고    scopus 로고
    • Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice
    • Lemere CA, Spooner ET, LaFrancois J, et al. Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice. Neurobiol Dis. 2003;14:10-18.
    • (2003) Neurobiol Dis , vol.14 , pp. 10-18
    • Lemere, C.A.1    Spooner, E.T.2    LaFrancois, J.3
  • 35
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • McLean CA, Cherny RA, Fraser FW, et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol. 1999,46:860-866.
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Fraser, F.W.3
  • 36
    • 0034237142 scopus 로고    scopus 로고
    • Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody
    • Frenkel D, Solomon B, Benhar I. Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody. J Neuroimmunol. 2000;106:23-31.
    • (2000) J Neuroimmunol , vol.106 , pp. 23-31
    • Frenkel, D.1    Solomon, B.2    Benhar, I.3
  • 37
    • 0030058382 scopus 로고    scopus 로고
    • Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
    • Solomon B, Koppel R, Hanan E, et al. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci USA. 1996;93:452-455.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 452-455
    • Solomon, B.1    Koppel, R.2    Hanan, E.3
  • 38
    • 0030971789 scopus 로고    scopus 로고
    • Disaggregation of Alzheimer beta-amyloid by site-directed mAb
    • Solomon B, Koppel R, Frankel D, et al. Disaggregation of Alzheimer beta-amyloid by site-directed mAb. Proc Natl Acad Sci USA. 1997;94: 4109-4112.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4109-4112
    • Solomon, B.1    Koppel, R.2    Frankel, D.3
  • 39
    • 0037112201 scopus 로고    scopus 로고
    • Cerebral hemorrhage after passive anti-Abeta immunotherapy
    • Pfeifer M, Boncristiano S, Bondolfi L, et al. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science. 2002;298:1379.
    • (2002) Science , vol.298 , pp. 1379
    • Pfeifer, M.1    Boncristiano, S.2    Bondolfi, L.3
  • 40
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll JA, Wilkinson D, Holmes C, et al. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med. 2003;9:448-452.
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3
  • 41
    • 0037531198 scopus 로고    scopus 로고
    • Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
    • Wilcock DM, DiCarlo G, Henderson D, et al. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci. 2003;23:3745-3751.
    • (2003) J Neurosci , vol.23 , pp. 3745-3751
    • Wilcock, D.M.1    DiCarlo, G.2    Henderson, D.3
  • 42
    • 0031593604 scopus 로고    scopus 로고
    • Mechanisms of cell death in Alzheimer disease: Immunopathology
    • McGeer PL, McGeer EG. Mechanisms of cell death in Alzheimer disease: immunopathology. J Neural Transm Suppl. 1998;54:159-166.
    • (1998) J Neural Transm Suppl , vol.54 , pp. 159-166
    • McGeer, P.L.1    McGeer, E.G.2
  • 43
    • 0030250567 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease pathogenesis
    • Rogers J, Webster S, Lue LF, et al. Inflammation and Alzheimer's disease pathogenesis. Neurobiol Aging. 1996;17:681-686.
    • (1996) Neurobiol Aging , vol.17 , pp. 681-686
    • Rogers, J.1    Webster, S.2    Lue, L.F.3
  • 44
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21:383-421.
    • (2000) Neurobiol Aging , vol.21 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3
  • 45
    • 0041886776 scopus 로고    scopus 로고
    • Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
    • Monsonego A, Zota V, Karni A, et al. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003;112:415-422.
    • (2003) J Clin Invest , vol.112 , pp. 415-422
    • Monsonego, A.1    Zota, V.2    Karni, A.3
  • 46
    • 0041428141 scopus 로고    scopus 로고
    • Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid beta-peptide presentation to Th1 cells
    • Monsonego A, Imitola J, Zota V, et al. Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid beta-peptide presentation to Th1 cells. J Immunol. 2003;171:2216-2224.
    • (2003) J Immunol , vol.171 , pp. 2216-2224
    • Monsonego, A.1    Imitola, J.2    Zota, V.3
  • 47
    • 0035487106 scopus 로고    scopus 로고
    • Interventional strategies against prion diseases
    • Aguzzi A, Glatzel M, Montrasio F, et al. Interventional strategies against prion diseases. Nat Rev Neurosci. 2001;2:745-749.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 745-749
    • Aguzzi, A.1    Glatzel, M.2    Montrasio, F.3
  • 49
    • 0035812752 scopus 로고    scopus 로고
    • Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies
    • Heppner FL, Musahl C, Arrighi I, et al. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science. 2001; 294:178-182.
    • (2001) Science , vol.294 , pp. 178-182
    • Heppner, F.L.1    Musahl, C.2    Arrighi, I.3
  • 50
    • 0036317750 scopus 로고    scopus 로고
    • Immunization delays the onset of prion disease in mice
    • Sigurdsson EM, Brown DR, Daniels M, et al. Immunization delays the onset of prion disease in mice. Am J Pathol. 2002;161:13-17.
    • (2002) Am J Pathol , vol.161 , pp. 13-17
    • Sigurdsson, E.M.1    Brown, D.R.2    Daniels, M.3
  • 51
    • 0037461583 scopus 로고    scopus 로고
    • Anti-prion antibodies for prophylaxis following prion exposure in mice
    • Sigurdsson EM, Sy MS, Li R, et al. Anti-prion antibodies for prophylaxis following prion exposure in mice. Neurosci Lett. 2003;336:185-187.
    • (2003) Neurosci Lett , vol.336 , pp. 185-187
    • Sigurdsson, E.M.1    Sy, M.S.2    Li, R.3
  • 52
    • 0037422133 scopus 로고    scopus 로고
    • Monoclonal antibodies inhibit prion replication and delay the development of prion disease
    • White AR, Enever P, Tayebi M, et al. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature. 2003;422: 80-83.
    • (2003) Nature , vol.422 , pp. 80-83
    • White, A.R.1    Enever, P.2    Tayebi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.