Development of a safe oral Aβ vaccine using recombinant adeno-associated virus vector for Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 6, Issue 5, 2004, Pages 483-488

  Hara, Hideo ^a   Monsonego, Alon ^b   Yuasa, Katsutoshi ^c   Adachi, Kayo ^a   Xiao, Xiao ^d   Takeda, Shin'Ichi ^c   Takahashi, Keikichi ^a   Weiner, Howard L ^b   Tabira, Takeshi ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-21}; AMYLOID BETA PROTEIN[1-43]; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG; ALZHEIMER DISEASE VACCINE; COMPLEMENTARY DNA; LEUKOCYTE ANTIGEN; PRIMER DNA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; IMMUNE RESPONSE; IMMUNOPHARMACOLOGY; INTESTINE EPITHELIUM CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; T LYMPHOCYTE; TRANSGENIC MOUSE; VACCINATION; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT; ADENO ASSOCIATED VIRUS; ANIMAL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE VECTOR; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; ORAL DRUG ADMINISTRATION; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ALZHEIMER VACCINES; AMYLOID BETA-PROTEIN; ANIMALS; ANTIGENS, CD; BLOTTING, WESTERN; DEPENDOVIRUS; DNA PRIMERS; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC;

EID: 14244252864     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2004-6504     Document Type: Article

References (22)

1. D.J. Selkoe, Alzheimer's disease: genes, proteins and therapies, Physiol Rev 81 (2001), 742-761.
2. D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, Z. Liao, I. Lieberburg, R. Motter, L. Mutter, F. Soriano, G, Shopp, N. Vasquez, C. Vandevert, S. Walker, M. Wogulis, T. Yednock, D. Games and P. Seubert, Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse, Nature 400 (1999), 173-177.
3. H.L. Weiner, C.A. Lemere, R. Maron, E.T. Spooner, T.J. Grenfell, C. Mori, S. Issazadeh, W.W Hancock and D.J. Selkoe, Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease, Ann Neurol 48 (2000), 567-579.
4. F. Bard, C. Cannon, R. Barbour, R.L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, I. Lieberburg, R. Motter, M. Nguyen, F. Soriano, N. Vasquez, K. Weiss, B. Welch, P. Seubert, D. Schenk and T. Yednock, Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease, Nat Med 6 (2000), 916-919.
5. C. Janus, J. Pearson, J. McLaurin, P.M. Mathews, Y. Jiang, S.D. Schmidt, M.A. Chishti, P. Horne, D. Heslin, J. French, H.T. Mount, R.A. Nixon, M. Mercken, C. Bergeron, P.E. Fraser, P. St George-Hyslop and D. Westaway, Aβ peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease, Nature 408 (2000), 979-982.
6. D. Morgan, D.M. Diamond, P.E. Gottschall, K.E. Ugen, C. Dickey, J. Hardy, K. Duff, P. Jantzen, G. DiCarlo, D. Wilcock, K. Connor, J. Hatcher, C. Hope, M. Gordon and G.W Arendash, Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease, Nature 408 (2000), 982-985.
7. J.M. Orgogozo, S. Gilman, J.F. Dartigues, B. Laurent, M. Puel, L.C. Kirby, P. Jouanny, B. Dubois, L. Eisner, S. Flitman, B.F. Michel, M. Boada, A. Frank and C. Hock, Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization, Neurology 61 (2003), 46-54.
8. J.A. Nicoll, D. Wilkinson, C. Holmes, P. Steart, H. Markham and R.O. Weller, Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide : a case report, Nat Med 9 (2003), 448-452.
9. C. Hock, U. Konietzko, J.R. Streffer, J. Tracy, A. Signorell, B. Muller-Tillmanns, U. Lemke, K. Henke, E. Moritz, E. Garcia, M.A. Wollmer, D. Umbricht, D.J. de Quervain, M. Hofmann, A. Maddalena, A. Papassotiropoulos and R.M. Nitsch, Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease, Neuron 38 (2003), 547-554.
10. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang and G. Cole, Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice, Science 274 (1996), 99-102.
11. S. Zolotukhin, M. Potter, W.W. Hauswirth, J. Guy and N.A. Muzyczka, humanized green fluorescent protein cDNA adapted for high-level expression in mammalian cells, J Virol 70 (1996), 4646-4654.
12. X. Xiao, J. Li and R.J. Samulski, Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus, J Virol 72 (1998), 2224-2232.
13. D.H. Chui, H. Tanahashi, K. Ozawa, S. Ikeda, F. Checler, O. Ueda, H. Suzuki, W. Araki, H. Inoue, K. Shirotani, K. Takahashi, F. Gallyas and T. Tabira, Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation, Nat Med 5 (1999), 560-564.
14. B. Solomon, R. Koppel, D. Frankel and E. Hanan-Aharon, Disaggregation of Alzheimer beta-amyloid by site-directed mAb, Proc Natl Acad Sci USA 94 (1997), 4109-412.
15. A.M.C. Faria and H.L. Weiner, Oral tolerance: mechanisms and therapeutic applications, Adv Immunol 73 (1999), 153-264.
16. A. Monsonego, R. Maron, V. Zota, D.J. Selkoe and H.L. Weiner, Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease, Proc Natl Acad Sci USA 98 (2001), 10273-10278.
17. J. McLaurin, R. Cecal, M.E. Kierstead, X. Tian, A.L. Phinney, M. Manea, J.E. French, M.H. Lambermon, A.A. Darabie, M.E. Brown, C. Janus, M.A. Chishti, P. Horne, D. Westaway, P.E. Fraser, H.T. Mount, M. Przybylski and P. St George-Hyslop, Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis, Nat Med 8 (2002), 1263-1269.
18. D. Frenkel, O. Katz and B. Solomon, Immunization against Alzheimer's beta-amyloid plaques via EFRH phage administration, Proc Natl Acatl Sci USA 97 (2000), 11455-11459.
19. F. Bard, R. Barbour, C. Cannon, R. Carretto, M. Fox, D. Games, T. Guido, K. Hoenow, K. Hu, K. Johnson-Wood, K. Khan, D. Kholodenko, C. Lee, M. Lee, R. Motter, M. Nguyen, A. Reed, D. Schenk, P. Tang, N. Vasquez, P. Seubert and T. Yednock, Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology, Proc Natl Aca. Sci USA 100 (2003), 2023-2028.
20. R.B. DeMattos, K.R. Bales, D.J. Cummins, J.C. Dodart, S.M. Paul and D.M. Holtsman, Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease, Proc Natl Acad Sci USA 98 (2001), 8850-8855.
21. R.B. DeMattos, K.R. Bales, D.J. Cummins, S.M. Paul and D.M. Holtsman, Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease, Science 295 (2002), 2264-2267.
22. MJ. During, CW. Symes, PA. Lawlor, J. Lin, J. Dunning, HL. Fitzsimons, D. Poulsen, P. Leone, R. Xu, BL. Dicker, J. Lipski and D. Young, An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy, Science 287 (2000), 1453-1460.