Targeting amyloid-β peptide (Aβ) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Aβ precursor protein (APP) transgenic mice

Journal of Biological Chemistry

Volumn 281, Issue 7, 2006, Pages 4292-4299

  Lee, Edward B ^a   Leng, Lewis Z ^a   Zhang, Bin ^a   Kwong, Linda ^a   Trojanowski, John Q ^a,c   Abel, Ted ^b   Lee, Virginia M Y ^a,c,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Department of Geriatric Medicine and Gerontology ^*  (United States)

^d Center for Neurodegenerative Disease Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MURINE MODELS; PASSIVE IMMUNIZATION; PRECURSOR PROTEIN;

ANTIBODIES; BIOCHEMISTRY; CONFORMATIONS; DIMERS; IMMUNIZATION; MOLECULAR BIOLOGY; OLIGOMERS; PATHOLOGY;

PROTEINS;

AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; DIMER; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY NAB61; OLIGOMER; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG PROTEIN BINDING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; IMMUNOTHERAPY; LEARNING; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SENILE PLAQUE; SPATIAL MEMORY; TRANSGENIC MOUSE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; GENETICS; HAMSTER; IMMUNOLOGY; LEARNING DISORDER; MEMORY DISORDER; METABOLISM;

MURINAE; MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; FEMALE; IMMUNIZATION, PASSIVE; LEARNING DISORDERS; MEMORY DISORDERS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN CONFORMATION;

EID: 33645220400     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511018200     Document Type: Article

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