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Volumn 8, Issue 11, 2002, Pages 1270-1275

Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

EID: 0036853548     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm783     Document Type: Article
Times cited : (279)

References (30)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe, D.J. Alzheimer's disease: Genes, proteins, and therapy. Physiol. Rev. 81, 741-766 (2001).
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 0035169318 scopus 로고    scopus 로고
    • Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Aβ immunization
    • Schenk, D., Games, D. & Seubert, P. Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Aβ immunization. J. Mol. Neurosci. 17, 259-267 (2001).
    • (2001) J. Mol. Neurosci. , vol.17 , pp. 259-267
    • Schenk, D.1    Games, D.2    Seubert, P.3
  • 3
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh, D.M. et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539 (2002).
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1
  • 4
    • 0034700480 scopus 로고    scopus 로고
    • A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease
    • Chen, G.Q. et al. A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408, 975-979 (2000).
    • (2000) Nature , vol.408 , pp. 975-979
    • Chen, G.Q.1
  • 5
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
    • Geula, C. et al. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nature Med. 4, 827-831 (1998).
    • (1998) Nature Med. , vol.4 , pp. 827-831
    • Geula, C.1
  • 6
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ 42 fibrils
    • Götz, J., Chen, F., van Dorpe, J. & Nitsch, R.M. Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils. Science 293, 1491-1495 (2001).
    • (2001) Science , vol.293 , pp. 1491-1495
    • Götz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.M.4
  • 7
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1
  • 8
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916-919 (2000).
    • (2000) Nature Med. , vol.6 , pp. 916-919
    • Bard, F.1
  • 9
    • 0034884382 scopus 로고    scopus 로고
    • Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
    • Sigurdsson, E.M., Scholtzova, H., Mehta, P.D., Frangione, B. & Wisniewski, T. Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am. J. Pathol. 159, 439-447 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 439-447
    • Sigurdsson, E.M.1    Scholtzova, H.2    Mehta, P.D.3    Frangione, B.4    Wisniewski, T.5
  • 10
    • 84984755327 scopus 로고    scopus 로고
    • Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan, D. et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408, 982-985 (2000).
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1
  • 11
    • 0034700471 scopus 로고    scopus 로고
    • Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus, C. et al. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408, 979-982 (2000).
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1
  • 12
    • 0035132326 scopus 로고    scopus 로고
    • Amyloid β vaccination: Reduced plaques and improved cognition
    • Younkin, S.G. Amyloid β vaccination: Reduced plaques and improved cognition. Nature Med. 7, 18-19 (2001).
    • (2001) Nature Med. , vol.7 , pp. 18-19
    • Younkin, S.G.1
  • 13
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B. et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98, 8850-8855 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1
  • 14
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-β efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos, R.B., Bales, K.R., Cummins, D.J., Paul, S.M. & Holtzman, D.M. Brain to plasma amyloid-β efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295, 2264-2267 (2002).
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 16
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • Backskai, B.J. et al. Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Med. 7, 369-372 (2001).
    • (2001) Nature Med. , vol.7 , pp. 369-372
    • Backskai, B.J.1
  • 18
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
    • Hsiao, K. et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274, 99-102 (1996).
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1
  • 19
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-β 42(43) in brains of mice expressing mutant presenilin 1
    • Duff, K. et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713 (1996).
    • (1996) Nature , vol.383 , Issue.43 , pp. 710-713
    • Duff, K.1
  • 20
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb, L. et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Med. 4, 97-100 (1998).
    • (1998) Nature Med. , vol.4 , pp. 97-100
    • Holcomb, L.1
  • 21
    • 0033809909 scopus 로고    scopus 로고
    • Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons
    • van Dorpe, J. et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons. Am. J. Pathol. 157, 1283-1298 (2000).
    • (2000) Am. J. Pathol. , vol.157 , pp. 1283-1298
    • Van Dorpe, J.1
  • 22
    • 13044265226 scopus 로고    scopus 로고
    • Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
    • Calhoun, M.E. et al. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc. Natl. Acad. Sci. USA 96, 14088-14093 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14088-14093
    • Calhoun, M.E.1
  • 23
    • 0028810244 scopus 로고
    • Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
    • Hsiao, K.K. et al. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15, 1203-1218 (1995).
    • (1995) Neuron , vol.15 , pp. 1203-1218
    • Hsiao, K.K.1
  • 24
    • 0035149317 scopus 로고    scopus 로고
    • T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Iglesias, A., Bauer, J., Litzenburger, T., Schubart, A. & Linington, C. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36, 220-234 (2001).
    • (2001) Glia , vol.36 , pp. 220-234
    • Iglesias, A.1    Bauer, J.2    Litzenburger, T.3    Schubart, A.4    Linington, C.5
  • 25
    • 0035968932 scopus 로고    scopus 로고
    • Amyloid β peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier
    • Poduslo, J.F. & Curran, G.L. Amyloid β peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier. Neuroreport 12, 3197-3200 (2001).
    • (2001) Neuroreport , vol.12 , pp. 3197-3200
    • Poduslo, J.F.1    Curran, G.L.2
  • 26
    • 0034992393 scopus 로고    scopus 로고
    • Autoantibodies to amyloid-β and Alzheimer's disease
    • Hyman, B. T. et al. Autoantibodies to amyloid-β and Alzheimer's disease. Ann. Neurol. 49, 808-810 (2001).
    • (2001) Ann. Neurol. , vol.49 , pp. 808-810
    • Hyman, B.T.1
  • 27
    • 0035964312 scopus 로고    scopus 로고
    • Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease
    • Monsonego, A., Maron, R., Zota, V., Selkoe, D.J. & Weiner, H.L. Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98, 10273-10278 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10273-10278
    • Monsonego, A.1    Maron, R.2    Zota, V.3    Selkoe, D.J.4    Weiner, H.L.5
  • 28
    • 0037203825 scopus 로고    scopus 로고
    • Nerve inflammation halts trial for Alzheimer's drug
    • Check, E. Nerve inflammation halts trial for Alzheimer's drug. Nature 415, 462 (2002).
    • (2002) Nature , vol.415 , pp. 462
    • Check, E.1
  • 29
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann, G. et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944 (1984).
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1
  • 30
    • 0016823810 scopus 로고
    • Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • Folstein, M.F., Folstein, S.E. & McHugh, P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189-198 (1975).
    • (1975) J. Psychiatr. Res. , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3


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