Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

Acta Neuropathologica

Volumn 118, Issue 4, 2009, Pages 475-485

  Streit, Wolfgang J ^a   Braak, Heiko ^b,c   Xue, Qing Shan ^a   Bechmann, Ingo ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

Aging; Alzheimer's disease; Dementia; Down syndrome; Microglia

Indexed keywords

AMYLOID BETA PROTEIN; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CELL ACTIVATION; CELL AGING; CELL FUNCTION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; DISEASE SEVERITY; DOWN SYNDROME; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFECTION; MALE; MICROGLIA; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPIL THREAD; NEUROPROTECTION; PATHOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENESCENCE; SENILE PLAQUE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; CEREBRAL CORTEX; DOWN SYNDROME; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE AGED; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; NEUROPIL THREADS; TAU PROTEINS;

EID: 69949118284     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-009-0556-6     Document Type: Article

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