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Volumn 14, Issue 11, 2009, Pages 4299-4325

Nuclear receptor ligands in therapy of cholestatic liver disease

Author keywords

Cholestasis; Constitutive androstane receptor; Farnesoid X activated receptor; Nuclear receptors; Pregnane X receptor; Review

Indexed keywords

CELL RECEPTOR; LIGAND;

EID: 63849111791     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3529     Document Type: Article
Times cited : (13)

References (292)
  • 1
    • 0036623233 scopus 로고    scopus 로고
    • Nuclear receptor regulation of hepatic function
    • DOI 10.1016/S0168-8278(02)00129-0, PII S0168827802001290
    • Karpen S J: Nuclear receptor regulation of hepatic function. J. Hepatol. 36, 832-850(2002) (Pubitemid 35177416)
    • (2002) Journal of Hepatology , vol.36 , Issue.6 , pp. 832-850
    • Karpen, S.J.1
  • 2
    • 33846821743 scopus 로고    scopus 로고
    • New perspectives for the treatment of cholestasis:Lessons from basic science applied clinically
    • DOI 10.1016/j.jhep.2006.12.001, PII S0168827806006660
    • Boyer J L: New perspectives for the treatment of cholestasis: lessons from basic science applied clinically. J. Hepatol. 46, 365-371(2007) (Pubitemid 46201718)
    • (2007) Journal of Hepatology , vol.46 , Issue.3 , pp. 365-371
    • Boyer, J.L.1
  • 3
    • 3242756610 scopus 로고    scopus 로고
    • CAR: Detailing new models
    • DOI 10.1016/j.tips.2004.06.007, PII S0165614704001762
    • Goodwin B & J. T. Moore: CAR: detailing new models. Trends Pharmacol. Sci. 25, 437-441(2004) (Pubitemid 38981560)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.8 , pp. 437-441
    • Goodwin, B.1    Moore, J.T.2
  • 4
    • 23344432870 scopus 로고    scopus 로고
    • Nuclear receptor ligands: Rational and effective therapy for chronic cholestatic liver disease?
    • DOI 10.1016/j.gastro.2005.06.053, PII S0016508505013326
    • Boyer J L: Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease? Gastroenterology 129, 735-740(2005) (Pubitemid 41102188)
    • (2005) Gastroenterology , vol.129 , Issue.2 , pp. 735-740
    • Boyer, J.L.1
  • 5
    • 33745774784 scopus 로고    scopus 로고
    • Role of nuclear receptors in the adaptive response to bile acids and cholestasis: Pathogenetic and therapeutic considerations
    • DOI 10.1021/mp060010s
    • Zollner G, H. U. Marschall, M. Wagner, M. Trauner: Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol. Pharm. 3, 231-251(2006) (Pubitemid 44021431)
    • (2006) Molecular Pharmaceutics , vol.3 , Issue.3 , pp. 231-251
    • Zollner, G.1    Marschall, H.-U.2    Wagner, M.3    Trauner, M.4
  • 6
    • 33947145065 scopus 로고    scopus 로고
    • Biliary secretion and excretion in health and disease: Current concepts
    • Hofmann A F: Biliary secretion and excretion in health and disease: current concepts. Ann. Hepatol. 6, 15-27(2007) (Pubitemid 46407485)
    • (2007) Annals of Hepatology , vol.6 , Issue.1 , pp. 15-27
    • Hofmann, A.F.1
  • 7
    • 33847011377 scopus 로고    scopus 로고
    • Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
    • DOI 10.1016/j.bbamcr.2006.04.014, PII S0167488906000978
    • Geier A, M. Wagner, C. G. Dietrich, M. Trauner: Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim. Biophys. Acta 1773, 283-308(2007) (Pubitemid 46275063)
    • (2007) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1773 , Issue.3 , pp. 283-308
    • Geier, A.1    Wagner, M.2    Dietrich, C.G.3    Trauner, M.4
  • 8
    • 33746861953 scopus 로고    scopus 로고
    • Molecular mechanisms of cholestasis
    • DOI 10.1007/s10354-006-0312-7
    • Zollner G & M. Trauner: Molecular mechanisms of cholestasis. Wien. Med. Wochenschr. 156, 380-385(2006) (Pubitemid 44182023)
    • (2006) Wiener Medizinische Wochenschrift , vol.156 , Issue.13-14 , pp. 380-385
    • Zollner, G.1    Trauner, M.2
  • 9
    • 20744446883 scopus 로고    scopus 로고
    • Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids
    • DOI 10.1074/jbc.M411520200
    • McCarthy T C, X. Li, C. J. Sinal: Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids. J. Biol. Chem. 280, 23232-23242(2005) (Pubitemid 40853235)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.24 , pp. 23232-23242
    • McCarthy, T.C.1    Li, X.2    Sinal, C.J.3
  • 11
    • 15444373825 scopus 로고    scopus 로고
    • Molecular regulation of hepatobiliary transport systems: Clinical implications for understanding and treating cholestasis
    • Trauner M, M. Wagner, P. Fickert, G. Zollner: Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J. Clin. Gastroenterol. 39, S111-S124 (2005) (Pubitemid 40397024)
    • (2005) Journal of Clinical Gastroenterology , vol.39 , Issue.SUPPL. 4
    • Trauner, M.1    Wagner, M.2    Fickert, P.3    Zollner, G.4
  • 14
    • 0035834769 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor
    • Song C S, I. Echchgadda, B. S. Baek, S. C. Ahn, T. Oh, A. K. Roy, B. Chatterjee: Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. J. Biol. Chem. 276, 42549-42556(2001)
    • (2001) J. Biol. Chem. , vol.276 , pp. 42549-42556
    • Song, C.S.1    Echchgadda, I.2    Baek, B.S.3    Ahn, S.C.4    Oh, T.5    Roy, A.K.6    Chatterjee, B.7
  • 15
    • 23144433067 scopus 로고    scopus 로고
    • Regulation of sulfotransferases by xenobiotic receptors
    • DOI 10.2174/1389200054633871
    • Runge-Morris M & T. A. Kocarek: Regulation of sulfotransferases by xenobiotic receptors. Curr. Drug Metab 6, 299-307(2005) (Pubitemid 41086764)
    • (2005) Current Drug Metabolism , vol.6 , Issue.4 , pp. 299-307
    • Runge-Morris, M.1    Kocarek, T.A.2
  • 16
    • 0032705258 scopus 로고    scopus 로고
    • Regulation of rat hepatic hydroxysteroid sulfotransferase (SULT2-40/41) gene expression by glucocorticoids: Evidence for a dual mechanism of transcriptional control
    • Runge-Morris M, W. Wu, T. A. Kocarek: Regulation of rat hepatic hydroxysteroid sulfotransferase (SULT2-40/41) gene expression by glucocorticoids: evidence for a dual mechanism of transcriptional control. Mol. Pharmacol. 56, 1198-1206(1999)
    • (1999) Mol. Pharmacol , vol.56 , pp. 1198-1206
    • Runge-Morris, M.1    Wu, W.2    Kocarek, T.A.3
  • 17
    • 9144231188 scopus 로고    scopus 로고
    • A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification
    • DOI 10.1124/mol.65.2.292
    • Saini S P, J. Sonoda, L. Xu, D. Toma, H. Uppal, Y. Mu, S. Ren, D. D. Moore, R. M. Evans, W. Xie: A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol. Pharmacol. 65, 292-300(2004) (Pubitemid 38134256)
    • (2004) Molecular Pharmacology , vol.65 , Issue.2 , pp. 292-300
    • Saini, S.P.S.1    Sonoda, J.2    Xu, L.3    Toma, D.4    Uppal, H.5    Mu, Y.6    Ren, S.7    Moore, D.D.8    Evans, R.M.9    Xie, W.10
  • 19
    • 30144431977 scopus 로고    scopus 로고
    • Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1
    • DOI 10.1016/S0076-6879(05)00010-8, PII S0076687905000108, 10, Phase II Conjugation Enzymes and Transport Systems
    • Chatterjee B, I. Echchgadda, C. S. Song: Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1. Methods Enzymol. 400, 165-191(2005) (Pubitemid 43052421)
    • (2005) Methods in Enzymology , vol.400 , pp. 165-191
    • Chatterjee, B.1    Echchgadda, I.2    Seog Song, C.3
  • 20
    • 1342265781 scopus 로고    scopus 로고
    • Dehydroepiandrosterone Sulfotransferase Is a Target for Transcriptional Induction by the Vitamin D Receptor
    • DOI 10.1124/mol.65.3.720
    • Echchgadda I, C. S. Song, A. K. Roy, B. Chatterjee: Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Mol. Pharmacol. 65, 720-729(2004) (Pubitemid 38264040)
    • (2004) Molecular Pharmacology , vol.65 , Issue.3 , pp. 720-729
    • Echchgadda, I.1    Song, C.S.2    Roy, A.K.3    Chatterjee, B.4
  • 23
    • 0035207243 scopus 로고    scopus 로고
    • Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat
    • Lee J, F. Azzaroli, L. Wang, C. J. Soroka, A. Gigliozzi, K. D. Setchell, W. Kramer, J. L. Boyer: Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 121, 1473-1484(2001) (Pubitemid 33140464)
    • (2001) Gastroenterology , vol.121 , Issue.6 , pp. 1473-1484
    • Lee, J.1    Azzaroli, F.2    Wang, L.3    Soroka, C.J.4    Gigliozzi, A.5    Setchell, K.D.R.6    Kramer, W.7    Boyer, J.L.8
  • 24
    • 0036186107 scopus 로고    scopus 로고
    • The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: Putative efflux pump for urinary cAMP and cGMP
    • van Aubel R A, P. H. Smeets, J. G. Peters, R. J. Bindels, F. G. Russel: The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J. Am. Soc. Nephrol. 13, 595-603(2002) (Pubitemid 34183923)
    • (2002) Journal of the American Society of Nephrology , vol.13 , Issue.3 , pp. 595-603
    • Van Aubel, R.A.M.H.1    Smeets, P.H.E.2    Peters, J.G.P.3    Bindels, R.J.M.4    Russel, F.G.M.5
  • 25
    • 1642316825 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat
    • DOI 10.1016/j.jhep.2003.12.001, PII S0168827803006354
    • Denk G U, C. J. Soroka, Y. Takeyama, W. S. Chen, J. D. Schuetz, J. L. Boyer: Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J. Hepatol. 40, 585-591(2004) (Pubitemid 38367779)
    • (2004) Journal of Hepatology , vol.40 , Issue.4 , pp. 585-591
    • Denk, G.U.1    Soroka, C.J.2    Takeyama, Y.3    Chen, W.-S.4    Schuetz, J.D.5    Boyer, J.L.6
  • 26
    • 0037827787 scopus 로고    scopus 로고
    • Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
    • DOI 10.1074/jbc.M207903200
    • Chen F, L. Ma, P. A. Dawson, C. J. Sinal, E. Sehayek, F. J. Gonzalez, J. Breslow, M. Ananthanarayanan, B. L. Shneider: Liver receptor homologue-1 mediates species-and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J. Biol. Chem. 278, 19909-19916(2003) (Pubitemid 36799181)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.22 , pp. 19909-19916
    • Chen, F.1    Ma, L.2    Dawson, P.A.3    Sinal, C.J.4    Sehayek, E.5    Gonzalez, F.J.6    Breslow, J.7    Ananthanarayanan, M.8    Shneider, B.L.9
  • 27
    • 3042828426 scopus 로고    scopus 로고
    • Bile acid-induced negative feedback regulation of the human ileal bile acid transporter
    • DOI 10.1002/hep.20295
    • Neimark E, F. Chen, X. Li, B. L. Shneider: Bile acid-induced negative feedback regulation of the human ileal bile acid transporter. Hepatology 40, 149-156(2004) (Pubitemid 38877576)
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 149-156
    • Neimark, E.1    Chen, F.2    Li, X.3    Shneider, B.L.4
  • 28
    • 0037163053 scopus 로고    scopus 로고
    • Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor α
    • DOI 10.1074/jbc.M203511200
    • Jung D, M. Fried, G. A. Kullak-Ublick: Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 277, 30559-30566(2002) (Pubitemid 34970749)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.34 , pp. 30559-30566
    • Jung, D.1    Fried, M.2    Kullak-Ublick, G.A.3
  • 29
    • 0346607187 scopus 로고    scopus 로고
    • Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor
    • DOI 10.1136/gut.53.1.78
    • Jung D, A. C. Fantin, U. Scheurer, M. Fried, G. A. Kullak-Ublick: Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Gut 53, 78-84(2004) (Pubitemid 38083014)
    • (2004) Gut , vol.53 , Issue.1 , pp. 78-84
    • Jung, D.1    Fantin, A.C.2    Scheurer, U.3    Fried, M.4    Kullak-Ublick, G.A.5
  • 30
    • 0035080391 scopus 로고    scopus 로고
    • Cellular localization and up-regulation of multidrug resistance- associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
    • DOI 10.1053/jhep.2001.23501
    • Soroka C J, J. M. Lee, F. Azzaroli, J. L. Boyer: Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 33, 783-791(2001) (Pubitemid 32246625)
    • (2001) Hepatology , vol.33 , Issue.4 , pp. 783-791
    • Soroka, C.J.1    Lee, J.M.2    Azzaroli, F.3    Boyer, J.L.4
  • 41
    • 37249015421 scopus 로고    scopus 로고
    • Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    • DOI 10.1194/jlr.M700330-JLR200
    • Kim I, S. H. Ahn, T. Inagaki, M. Choi, S. Ito, G. L. Guo, S. A. Kliewer, F. J. Gonzalez: Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J. Lipid Res. 48, 2664-2672(2007) (Pubitemid 350272851)
    • (2007) Journal of Lipid Research , vol.48 , Issue.12 , pp. 2664-2672
    • Kim, I.1    Ahn, S.-H.2    Inagaki, T.3    Choi, M.4    Ito, S.5    Guo, G.L.6    Kliewer, S.A.7    Gonzalez, F.J.8
  • 43
    • 0036296149 scopus 로고    scopus 로고
    • Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
    • DOI 10.1016/S0006-291X(02)00196-1, PII S0006291X02001961
    • Beigneux A P, A. H. Moser, J. K. Shigenaga, C. Grunfeld, K. R. Feingold: Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response. Biochem. Biophys. Res. Commun. 293, 145-149(2002) (Pubitemid 34694183)
    • (2002) Biochemical and Biophysical Research Communications , vol.293 , Issue.1 , pp. 145-149
    • Beigneux, A.P.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 44
    • 0034717067 scopus 로고    scopus 로고
    • The acute phase response is associated with retinoid X receptor repression in rodent liver
    • DOI 10.1074/jbc.M000953200
    • Beigneux A P, A. H. Moser, J. K. Shigenaga, C. Grunfeld, K. R. Feingold: The acute phase response is associated with retinoid X receptor repression in rodent liver. J. Biol. Chem. 275, 16390-16399(2000) (Pubitemid 30366957)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.21 , pp. 16390-16399
    • Beigneux, A.P.1    Moser, A.H.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 45
    • 38149085905 scopus 로고    scopus 로고
    • Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release
    • Zhou M, R. Wu, W. Dong, A. Jacob, P. Wang: Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release. Am. J. Physiol Regul. Integr. Comp Physiol 294, R84-R92 (2008)
    • (2008) Am. J. Physiol Regul. Integr. Comp Physiol , vol.294
    • Zhou, M.1    Wu, R.2    Dong, W.3    Jacob, A.4    Wang, P.5
  • 46
    • 0035844156 scopus 로고    scopus 로고
    • Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun. N-terminal kinase pathway
    • Gupta S, R. T. Stravitz, P. Dent, P. B. Hylemon: Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun. N-terminal kinase pathway. J. Biol. Chem. 276, 15816-15822(2001)
    • (2001) J. Biol. Chem. , vol.276 , pp. 15816-15822
    • Gupta, S.1    Stravitz, R.T.2    Dent, P.3    Hylemon, P.B.4
  • 47
    • 18144387309 scopus 로고    scopus 로고
    • Endotoxin leads to rapid subcellular relocalization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation
    • Ghose R, T. L. Zimmerman, S. Thevananther, S. J. Karpen: Endotoxin leads to rapid subcellular relocalization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl. Recept. 2, 4(2004)
    • (2004) Nucl. Recept , vol.2 , pp. 4
    • Ghose, R.1    Zimmerman, T.L.2    Thevananther, S.3    Karpen, S.J.4
  • 48
    • 0031738416 scopus 로고    scopus 로고
    • Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
    • Vos T A, G. J. Hooiveld, H. Koning, S. Childs, D. K. Meijer, H. Moshage, P. L. Jansen, M. Muller: Upregulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 28, 1637-1644(1998) (Pubitemid 28549135)
    • (1998) Hepatology , vol.28 , Issue.6 , pp. 1637-1644
    • Vos, T.A.1    Hooiveld, G.J.E.J.2    Koning, H.3    Childs, S.4    Meijer, D.K.F.5    Moshage, H.6    Jansen, P.L.M.7    Muller, M.8
  • 49
    • 23744470316 scopus 로고    scopus 로고
    • Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: A quantitative colocalization study
    • DOI 10.1002/jemt.20184
    • Zinchuk V, O. Zinchuk, T. Okada: Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study. Microsc. Res. Tech. 67, 65-70(2005) (Pubitemid 41129255)
    • (2005) Microscopy Research and Technique , vol.67 , Issue.2 , pp. 65-70
    • Zinchuk, V.1    Zinchuk, O.2    Okada, T.3
  • 51
    • 12244299840 scopus 로고    scopus 로고
    • Lipopolysaccharide represses cholesterol 7-alpha hydroxylase and induces binding activity to the bile acid response element II
    • DOI 10.1046/j.1365-2362.2003.01079.x
    • Dikopoulos N, H. Weidenbach, G. Adler, R. M. Schmid: Lipopolysaccharide represses cholesterol 7-alpha hydroxylase and induces binding activity to the bile acid response element II. Eur. J. Clin. Invest 33, 58-64(2003) (Pubitemid 36051292)
    • (2003) European Journal of Clinical Investigation , vol.33 , Issue.1 , pp. 58-64
    • Dikopoulos, N.1    Weidenbach, H.2    Adler, G.3    Schmid, R.M.4
  • 52
    • 0029877596 scopus 로고    scopus 로고
    • Endotoxin, TNF, and IL-1 decrease cholesterol 7α-hydroxylase mRNA levels and activity
    • Feingold K R, D. K. Spady, A. S. Pollock, A. H. Moser, C. Grunfeld: Endotoxin, TNF, and IL-1 decrease cholesterol 7 alpha-hydroxylase mRNA levels and activity. J. Lipid Res. 37, 223-228(1996) (Pubitemid 26078941)
    • (1996) Journal of Lipid Research , vol.37 , Issue.2 , pp. 223-228
    • Feingold, K.R.1    Spady, D.K.2    Pollock, A.S.3    Moser, A.H.4    Grunfeld, C.5
  • 57
    • 0036137072 scopus 로고    scopus 로고
    • Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
    • DOI 10.1124/jpet.300.1.97
    • Cherrington N J, D. P. Hartley, N. Li, D. R. Johnson, C. D. Klaassen: Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J. Pharmacol. Exp. Ther. 300, 97-104(2002) (Pubitemid 34028514)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.300 , Issue.1 , pp. 97-104
    • Cherrington, N.J.1    Hartley, D.P.2    Li, N.3    Johnson, D.R.4    Klaassen, C.D.5
  • 58
    • 0035033560 scopus 로고    scopus 로고
    • Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and dispostion of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • Dietrich C G, D. R. de Waart, R. Ottenhoff, A. H. Bootsma, A. H. van Gennip, R. P. Elferink: Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo. Carcinogenesis 22, 805-811(2001) (Pubitemid 32447929)
    • (2001) Carcinogenesis , vol.22 , Issue.5 , pp. 805-811
    • Dietrich, C.G.1    De Waart, D.R.2    Ottenhoff, R.3    Bootsma, A.H.4    Van Gennip, A.H.5    Oude Elferink, R.P.J.6
  • 59
    • 0037269403 scopus 로고    scopus 로고
    • +-dependent bile-acid transporter
    • DOI 10.1042/BJ20021081
    • Zelcer N, T. Saeki, I. Bot, A. Kuil, P. Borst: Transport of bile acids in multidrug-resistanceprotein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. Biochem. J. 369, 23-30(2003) (Pubitemid 36174121)
    • (2003) Biochemical Journal , vol.369 , Issue.1 , pp. 23-30
    • Zelcer, N.1    Saeki, T.2    Bot, I.3    Kuil, A.4    Borst, P.5
  • 61
    • 0034723163 scopus 로고    scopus 로고
    • ATP-dependent transport of bile salts by rat multidrug resistance- associated protein 3 (Mrp3)
    • DOI 10.1074/jbc.275.4.2905
    • Hirohashi T, H. Suzuki, H. Takikawa, Y. Sugiyama: ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3) J. Biol. Chem. 275, 2905-2910(2000) (Pubitemid 30082066)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2905-2910
    • Hirohashi, T.1    Suzuki, H.2    Takikawa, H.3    Sugiyama, Y.4
  • 62
    • 0036149075 scopus 로고    scopus 로고
    • Transport activity of human MRP3 expressed in Sf9 cells: Comparative studies with rat MRP3
    • DOI 10.1023/A:1013699130991
    • Akita H, H. Suzuki, T. Hirohashi, H. Takikawa, Y. Sugiyama: Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm. Res. 19, 34-41(2002) (Pubitemid 34075104)
    • (2002) Pharmaceutical Research , vol.19 , Issue.1 , pp. 34-41
    • Akita, H.1    Suzuki, H.2    Hirohashi, T.3    Takikawa, H.4    Sugiyama, Y.5
  • 63
    • 0035831094 scopus 로고    scopus 로고
    • Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
    • DOI 10.1016/S0005-2736(00)00355-2, PII S0005273600003552
    • Akita H, H. Suzuki, K. Ito, S. Kinoshita, N. Sato, H. Takikawa, Y. Sugiyama: Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim. Biophys. Acta 1511, 7-16(2001) (Pubitemid 32206667)
    • (2001) Biochimica et Biophysica Acta - Biomembranes , vol.1511 , Issue.1 , pp. 7-16
    • Akita, H.1    Suzuki, H.2    Ito, K.3    Kinoshita, S.4    Sato, N.5    Takikawa, H.6    Sugiyama, Y.7
  • 64
    • 0030873388 scopus 로고    scopus 로고
    • Monohydroxy bile acid induced cholestasis: Role of biotransformation
    • Yousef I M, G. Bouchard, B. Tuchweber, G. L. Plaa: Monohydroxy bile acid induced cholestasis: role of biotransformation. Drug Metab Rev. 29, 167-181(1997) (Pubitemid 27293608)
    • (1997) Drug Metabolism Reviews , vol.29 , Issue.1-2 , pp. 167-181
    • Yousef, I.M.1    Bouchard, G.2    Tuchweber, B.3    Plaa, G.L.4
  • 66
    • 3042620358 scopus 로고    scopus 로고
    • Cholestasis: Human disease and experimental animal models
    • Rodriguez-Garay E A: Cholestasis: human disease and experimental animal models. Ann. Hepatol. 2, 150-158(2003)
    • (2003) Ann. Hepatol , vol.2 , pp. 150-158
    • Rodriguez-Garay, E.A.1
  • 70
    • 34547870567 scopus 로고    scopus 로고
    • Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
    • DOI 10.1111/j.1478-3231.2007.01506.x
    • Zollner G, M. Wagner, P. Fickert, D. Silbert, J. Gumhold, K. Zatloukal, H. Denk, M. Trauner: Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis. Liver Int. 27, 920-929(2007) (Pubitemid 47261945)
    • (2007) Liver International , vol.27 , Issue.7 , pp. 920-929
    • Zollner, G.1    Wagner, M.2    Fickert, P.3    Silbert, D.4    Gumhold, J.5    Zatloukal, K.6    Denk, H.7    Trauner, M.8
  • 72
    • 0030249353 scopus 로고    scopus 로고
    • Bile acid synthesis and biliary hydrophobicity during obstructive jaundice in rats
    • DOI 10.1006/jsre.1996.0345
    • Naito T, S. Kuroki, K. Chijiiwa, M. Tanaka: Bile acid synthesis and biliary hydrophobicity during obstructive jaundice in rats. J. Surg. Res. 65, 70-76(1996) (Pubitemid 26339197)
    • (1996) Journal of Surgical Research , vol.65 , Issue.1 , pp. 70-76
    • Naito, T.1    Kuroki, S.2    Chijiiwa, K.3    Tanaka, M.4
  • 73
    • 0019519798 scopus 로고
    • Altered bile acid metabolism in primary biliary cirrhosis
    • DOI 10.1007/BF01313580
    • Raedsch R, B. H. Lauterburg, A. F. Hofmann: Altered bile acid metabolism in primary biliary cirrhosis. Dig. Dis. Sci. 26, 394-401(1981) (Pubitemid 11120725)
    • (1981) Digestive Diseases and Sciences , vol.26 , Issue.5 , pp. 394-401
    • Raedsch, R.1    Lauterburg, B.H.2    Hofmann, A.F.3
  • 74
    • 0024819478 scopus 로고
    • Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: Effect of ursodeoxycholic acid treatment
    • Batta A K, R. Arora, G. Salen, G. S. Tint, D. Eskreis, S. Katz: Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment. J. Lipid Res. 30, 1953-1962(1989) (Pubitemid 20030374)
    • (1989) Journal of Lipid Research , vol.30 , Issue.12 , pp. 1953-1962
    • Batta, A.K.1    Arora, R.2    Salen, G.3    Tint, G.S.4    Eskreis, D.5    Katz, S.6
  • 75
    • 0042508785 scopus 로고    scopus 로고
    • 75Se- homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration
    • DOI 10.1136/gut.52.9.1371
    • Lanzini A, M. G. De Tavonatti, B. Panarotto, S. Scalia, A. Mora, F. Benini, O. Baisini, F. Lanzarotto: Intestinal absorption of the bile acid analogue 75Sehomocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration. Gut 52, 1371-1375(2003) (Pubitemid 37026473)
    • (2003) Gut , vol.52 , Issue.9 , pp. 1371-1375
    • Lanzini, A.1    De Tavonatti, M.G.2    Panarotto, B.3    Scalia, S.4    Mora, A.5    Benini, F.6    Baisini, O.7    Lanzarotto, F.8
  • 76
    • 33244460809 scopus 로고    scopus 로고
    • Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis
    • DOI 10.1136/gut.2005.067389
    • Hruz P, C. Zimmermann, H. Gutmann, L. Degen, U. Beuers, L. Terracciano, J. Drewe, C. Beglinger: Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis. Gut 55, 395-402(2006) (Pubitemid 43273323)
    • (2006) Gut , vol.55 , Issue.3 , pp. 395-402
    • Hruz, P.1    Zimmermann, C.2    Gutmann, H.3    Degen, L.4    Beuers, U.5    Terracciano, L.6    Drewe, J.7    Beglinger, C.8
  • 78
    • 0037635407 scopus 로고    scopus 로고
    • Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy
    • DOI 10.1080/00365520310000807
    • Eloranta M L, T. Hakli, M. Hiltunen, S. Helisalmi, K. Punnonen, S. Heinonen: Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy. Scand. J. Gastroenterol. 38, 648-652(2003) (Pubitemid 36724045)
    • (2003) Scandinavian Journal of Gastroenterology , vol.38 , Issue.6 , pp. 648-652
    • Eloranta, M.-L.1    Hakli, T.2    Hiltunen, M.3    Helisalmi, S.4    Punnonen, K.5    Heinonen, S.6
  • 81
    • 36549054059 scopus 로고    scopus 로고
    • Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy
    • DOI 10.1016/j.jhep.2007.08.015, PII S0168827807005636
    • Sookoian S, G. Castano, A. Burgueno, T. F. Gianotti, C. J. Pirola: Association of the multidrugresistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy. J. Hepatol. 48, 125-132(2008) (Pubitemid 350191993)
    • (2008) Journal of Hepatology , vol.48 , Issue.1 , pp. 125-132
    • Sookoian, S.1    Castano, G.2    Burgueno, A.3    Gianotti, T.F.4    Pirola, C.J.5
  • 85
    • 21344464658 scopus 로고    scopus 로고
    • Intrahepatic cholestasis: Summary of an American Association for the Study of Liver Diseases Single-Topic Conference
    • DOI 10.1002/hep.20729
    • Balistreri W F, J. A. Bezerra, P. Jansen, S. J. Karpen, B. L. Shneider, F. J. Suchy: Intrahepatic cholestasis: summary of an American Association for the Study of Liver Diseases single-topic conference. Hepatology 42, 222-235(2005) (Pubitemid 40911332)
    • (2005) Hepatology , vol.42 , Issue.1 , pp. 222-235
    • Balistreri, W.F.1    Bezerra, J.A.2    Jansen, P.3    Karpen, S.J.4    Shneider, B.L.5    Suchy, F.J.6
  • 86
    • 0141891445 scopus 로고    scopus 로고
    • Genetic cholestasis, causes and consequences for hepatobiliary transport
    • Jansen P L & E. Sturm: Genetic cholestasis, causes and consequences for hepatobiliary transport. Liver Int. 23, 315-322(2003) (Pubitemid 37259200)
    • (2003) Liver International , vol.23 , Issue.5 , pp. 315-322
    • Jansen, P.L.M.1    Sturm, E.2
  • 88
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal C J, M. Tohkin, M. Miyata, J. M. Ward, G. Lambert, F. J. Gonzalez: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102, 731-744(2000)
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 94
    • 0035056827 scopus 로고    scopus 로고
    • The causes of obvious jaundice in South West Wales: Perceptions versus reality
    • DOI 10.1136/gut.48.3.409
    • Whitehead M W, I. Hainsworth, J. G. Kingham: The causes of obvious jaundice in South West Wales: perceptions versus reality. Gut 48, 409-413(2001) (Pubitemid 32269572)
    • (2001) Gut , vol.48 , Issue.3 , pp. 409-413
    • Whitehead, M.W.1    Hainsworth, I.2    Kingham, J.G.C.3
  • 95
    • 0001635170 scopus 로고
    • Jaundice associated with severe bacterial infection in young infants
    • Hamilton J R & A. Sass-Kortsak: Jaundice associated with severe bacterial infection in young infants. J. Pediatr. 63, 121-132(1963)
    • (1963) J. Pediatr , vol.63 , pp. 121-132
    • Hamilton, J.R.1    Sass-Kortsak, A.2
  • 96
    • 0036300959 scopus 로고    scopus 로고
    • Male sex predisposes the newborn surgical patient to parenteral nutrition-associated cholestasis and to sepsis
    • Albers M J, D. A. Gast-Bakker, N. A. van Dam, G. C. Madern, D. Tibboel: Male sex predisposes the newborn surgical patient to parenteral nutritionassociated cholestasis and to sepsis. Arch. Surg. 137, 789-793(2002) (Pubitemid 34743167)
    • (2002) Archives of Surgery , vol.137 , Issue.7 , pp. 789-793
    • Albers, M.J.I.J.1    De Gast-Bakker, D.-A.H.2    Van Dam, N.A.M.3    Madern, G.C.4    Tibboel, D.5
  • 97
    • 33846426043 scopus 로고    scopus 로고
    • Sepsis-induced cholestasis
    • DOI 10.1002/hep.21480
    • Chand N & A. J. Sanyal: Sepsis-induced cholestasis. Hepatology 45, 230-241(2007) (Pubitemid 46144383)
    • (2007) Hepatology , vol.45 , Issue.1 , pp. 230-241
    • Chand, N.1    Sanyal, A.J.2
  • 98
    • 0026517062 scopus 로고
    • New developments in glucuronidation research: Report of a workshop on "glucuronidation, its role in health and disease"
    • Jansen P L, G. J. Mulder, B. Burchell, K. W. Bock: New developments in glucuronidation research: report of a workshop on "glucuronidation, its role in health and disease". Hepatology 15, 532-544(1992)
    • (1992) Hepatology , vol.15 , pp. 532-544
    • Jansen, P.L.1    Mulder, G.J.2    Burchell, B.3    Bock, K.W.4
  • 99
    • 0029070075 scopus 로고
    • Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes
    • Roelofsen H, C. T. Bakker, B. Schoemaker, M. Heijn, P. L. Jansen, R. P. Elferink: Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes. Hepatology 21, 1649-1657(1995)
    • (1995) Hepatology , vol.21 , pp. 1649-1657
    • Roelofsen, H.1    Bakker, C.T.2    Schoemaker, B.3    Heijn, M.4    Jansen, P.L.5    Elferink, R.P.6
  • 100
    • 0036867195 scopus 로고    scopus 로고
    • Liver in sepsis and systemic inflammatory response syndrome
    • DOI 10.1016/S1089-3261(02)00058-2, PII S1089326102000582
    • Szabo G, L. Romics, Jr., G. Frendl: Liver in sepsis and systemic inflammatory response syndrome. Clin. Liver Dis. 6, 1045-66, x (2002) (Pubitemid 36026462)
    • (2002) Clinics in Liver Disease , vol.6 , Issue.4 , pp. 1045-1066
    • Szabo, G.1    Romics Jr., L.2    Frendl, G.3
  • 104
    • 0029886277 scopus 로고    scopus 로고
    • Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents
    • DOI 10.1053/gast.1996.v111.pm8698199
    • Green R M, D. Beier, J. L. Gollan: Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111, 193-198(1996) (Pubitemid 26226899)
    • (1996) Gastroenterology , vol.111 , Issue.1 , pp. 193-198
    • Green, R.M.1    Beier, D.2    Gollan, J.L.3
  • 105
    • 0029120107 scopus 로고
    • Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxininduced cholestasis
    • Whiting J F, R. M. Green, A. B. Rosenbluth, J. L. Gollan: Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxininduced cholestasis. Hepatology 22, 1273-1278(1995)
    • (1995) Hepatology , vol.22 , pp. 1273-1278
    • Whiting, J.F.1    Green, R.M.2    Rosenbluth, A.B.3    Gollan, J.L.4
  • 106
    • 1642356720 scopus 로고    scopus 로고
    • Sepsis and cholestasis
    • DOI 10.1016/S1089-3261(03)00134-X, PII S108932610300134X
    • Moseley R H: Sepsis and cholestasis. Clin. Liver Dis. 8, 83-94(2004) (Pubitemid 38373671)
    • (2004) Clinics in Liver Disease , vol.8 , Issue.1 , pp. 83-94
    • Moseley, R.H.1
  • 108
    • 0036786429 scopus 로고    scopus 로고
    • Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia
    • Hartmann G, A. K. Cheung, M. Piquette-Miller: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J. Pharmacol. Exp. Ther. 303, 273-281(2002)
    • (2002) J. Pharmacol. Exp. Ther , vol.303 , pp. 273-281
    • Hartmann, G.1    Cheung, A.K.2    Piquette-Miller, M.3
  • 109
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • DOI 10.1074/jbc.275.4.2247
    • Friedman S L: Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275, 2247-2250(2000) (Pubitemid 30081976)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2247-2250
    • Friedman, S.L.1
  • 110
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman S L: Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 88, 125-172(2008)
    • (2008) Physiol Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 111
    • 0033921113 scopus 로고    scopus 로고
    • An immortalized rat liver stellate cell line (HSC-T6): A new cell model for the study of retinoid metabolism in vitro
    • Vogel S, R. Piantedosi, J. Frank, A. Lalazar, D. C. Rockey, S. L. Friedman, W. S. Blaner: An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J. Lipid Res. 41, 882-893(2000) (Pubitemid 30434319)
    • (2000) Journal of Lipid Research , vol.41 , Issue.6 , pp. 882-893
    • Vogel, S.1    Piantedosi, R.2    Frank, J.3    Lalazar, A.4    Rockey, D.C.5    Friedman, S.L.6    Blaner, W.S.7
  • 112
    • 0037095629 scopus 로고    scopus 로고
    • 2(I) collagen promoter by retinoic acid and retinoid X receptors
    • DOI 10.1016/S0003-9861(02)00058-9, PII S0003986102000589
    • Wang L, L. R. Tankersley, M. Tang, J. J. Potter, E. Mezey: Regulation of the murine alpha (2) (I) collagen promoter by retinoic acid and retinoid X receptors. Arch. Biochem. Biophys. 401, 262-270(2002) (Pubitemid 34848629)
    • (2002) Archives of Biochemistry and Biophysics , vol.401 , Issue.2 , pp. 262-270
    • Wang, L.1    Rennie Tankersley, L.2    Tang, M.3    Potter, J.J.4    Mezey, E.5
  • 119
    • 0842308111 scopus 로고    scopus 로고
    • Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    • DOI 10.1016/j.bbrc.2004.01.038
    • Kawaguchi K, I. Sakaida, M. Tsuchiya, K. Omori, T. Takami, K. Okita: Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Biochem. Biophys. Res. Commun. 315, 187-195(2004) (Pubitemid 38175204)
    • (2004) Biochemical and Biophysical Research Communications , vol.315 , Issue.1 , pp. 187-195
    • Kawaguchi, K.1    Sakaida, I.2    Tsuchiya, M.3    Omori, K.4    Takami, T.5    Okita, K.6
  • 122
    • 18844432520 scopus 로고    scopus 로고
    • Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
    • DOI 10.1042/BJ20041598
    • Marek C J, S. J. Tucker, D. K. Konstantinou, L. J. Elrick, D. Haefner, C. Sigalas, G. I. Murray, B. Goodwin, M. C. Wright: Pregnenolone- 16alphacarbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem. J. 387, 601-608(2005) (Pubitemid 40685693)
    • (2005) Biochemical Journal , vol.387 , Issue.3 , pp. 601-608
    • Marek, C.J.1    Tucker, S.J.2    Konstantinou, D.K.3    Elrick, L.J.4    Haefner, D.5    Sigalas, C.6    Murray, G.I.7    Goodwin, B.8    Wright, M.C.9
  • 123
    • 0038713221 scopus 로고    scopus 로고
    • The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells
    • DOI 10.1053/jhep.2003.50176
    • Gascon-Barre M, C. Demers, A. Mirshahi, S. Neron, S. Zalzal, A. Nanci: The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells. Hepatology 37, 1034-1042(2003) (Pubitemid 36538680)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1034-1042
    • Gascon-Barre, M.1    Demers, C.2    Mirshahi, A.3    Neron, S.4    Zalzal, S.5    Nanci, A.6
  • 125
    • 0038207707 scopus 로고    scopus 로고
    • Impact of oestrogens on the progression of liver disease
    • Shimizu I: Impact of oestrogens on the progression of liver disease. Liver Int. 23, 63-69(2003) (Pubitemid 37265776)
    • (2003) Liver International , vol.23 , Issue.1 , pp. 63-69
    • Shimizu, I.1
  • 126
    • 0033053455 scopus 로고    scopus 로고
    • Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats
    • Yasuda M, I. Shimizu, M. Shiba, S. Ito: Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats. Hepatology 29, 719-727(1999) (Pubitemid 29109585)
    • (1999) Hepatology , vol.29 , Issue.3 , pp. 719-727
    • Yasuda, M.1    Shimizu, I.2    Shiba, M.3    Ito, S.4
  • 127
    • 0029810140 scopus 로고    scopus 로고
    • Subcellular distribution of glucocorticoid receptor in cultured rat and human liver-derived cells and cell lines: Influence of dexamethasone
    • DOI 10.1053/jhep.1996.v24.pm0008855200
    • Raddatz D, M. Henneken, T. Armbrust, G. Ramadori: Subcellular distribution of glucocorticoid receptor in cultured rat and human liver-derived cells and cell lines: influence of dexamethasone. Hepatology 24, 928-933(1996) (Pubitemid 26334297)
    • (1996) Hepatology , vol.24 , Issue.I4 , pp. 928-933
    • Raddatz, D.1    Henneken, M.2    Armbrust, T.3    Ramadori, G.4
  • 128
    • 7644244675 scopus 로고    scopus 로고
    • The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
    • DOI 10.1053/j.gastro.2004.08.001, PII S0016508504013903
    • Fiorucci S, E. Antonelli, G. Rizzo, B. Renga, A. Mencarelli, L. Riccardi, S. Orlandi, R. Pellicciari, A. Morelli: The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 127, 1497-1512(2004) (Pubitemid 39457775)
    • (2004) Gastroenterology , vol.127 , Issue.5 , pp. 1497-1512
    • Fiorucci, S.1    Antonelli, E.2    Rizzo, G.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6    Orlandi, S.7    Pellicciari, R.8    Morelli, A.9
  • 129
    • 25644443217 scopus 로고    scopus 로고
    • Cross-talk between farnesoid-x-receptor (FXR) and peroxisome proliferator-activated receptor γ contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis
    • DOI 10.1124/jpet.105.085597
    • Fiorucci S, G. Rizzo, E. Antonelli, B. Renga, A. Mencarelli, L. Riccardi, A. Morelli, M. Pruzanski, R. Pellicciari: Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. J. Pharmacol. Exp. Ther. 315, 58-68(2005) (Pubitemid 41380498)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.315 , Issue.1 , pp. 58-68
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6    Morelli, A.7    Pruzanski, M.8    Pellicciari, R.9
  • 130
    • 0023014011 scopus 로고
    • Current problems in diagnosis of biliary disease and cholestasis
    • Desmet V J: Current problems in diagnosis of biliary disease and cholestasis. Semin. Liver Dis. 6, 233-245(1986) (Pubitemid 17203552)
    • (1986) Seminars in Liver Disease , vol.6 , Issue.3 , pp. 233-245
    • Desmet, V.J.1
  • 132
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • DOI 10.1038/nm820
    • Joseph S B, A. Castrillo, B. A. Laffitte, D. J. Mangelsdorf, P. Tontonoz: Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9, 213-219(2003) (Pubitemid 36227724)
    • (2003) Nature Medicine , vol.9 , Issue.2 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 135
    • 33748702268 scopus 로고    scopus 로고
    • Nuclear receptors versus inflammation: mechanisms of transrepression
    • DOI 10.1016/j.tem.2006.08.005, PII S1043276006001561
    • Pascual G & C. K. Glass: Nuclear receptors versus inflammation: mechanisms of transrepression. Trends Endocrinol. Metab 17, 321-327(2006) (Pubitemid 44397567)
    • (2006) Trends in Endocrinology and Metabolism , vol.17 , Issue.8 , pp. 321-327
    • Pascual, G.1    Glass, C.K.2
  • 136
    • 26444471700 scopus 로고    scopus 로고
    • A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
    • DOI 10.1038/nature03988, PII N03988
    • Pascual G, A. L. Fong, S. Ogawa, A. Gamliel, A. C. Li, V. Perissi, D. W. Rose, T. M. Willson, M. G. Rosenfeld, C. K. Glass: A SUMOylationdependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437, 759-763(2005) (Pubitemid 41486547)
    • (2005) Nature , vol.437 , Issue.7059 , pp. 759-763
    • Pascual, G.1    Fong, A.L.2    Ogawa, S.3    Gamliel, A.4    Li, A.C.5    Perissi, V.6    Rose, D.W.7    Willson, T.M.8    Rosenfeld, M.G.9    Glass, C.K.10
  • 137
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • DOI 10.1172/JCI27883
    • Zelcer N & P. Tontonoz: Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest 116, 607-614(2006) (Pubitemid 43326865)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 139
    • 0030824266 scopus 로고    scopus 로고
    • A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation
    • DOI 10.1074/jbc.272.34.21467
    • Liden J, F. Delaunay, I. Rafter, J. Gustafsson, S. Okret: A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation. J. Biol. Chem. 272, 21467-21472(1997) (Pubitemid 27374019)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.34 , pp. 21467-21472
    • Liden, J.1    Delaunay, F.2    Rafter, I.3    Gustafsson, J.-A.4    Okret, S.5
  • 141
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • Auphan N, J. A. Didonato, C. Rosette, A. Helmberg, M. Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270, 286-290(1995)
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    Didonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 142
    • 0030632683 scopus 로고    scopus 로고
    • Immunoregulatory genes and immunosuppression by glucocorticoids
    • Auphan N, J. A. Didonato, A. Helmberg, C. Rosette, M. Karin: Immunoregulatory genes and immunosuppression by glucocorticoids. Arch. Toxicol. Suppl 19, 87-95(1997)
    • (1997) Arch. Toxicol , Issue.19 SUPPL. , pp. 87-95
    • Auphan, N.1    Didonato, J.A.2    Helmberg, A.3    Rosette, C.4    Karin, M.5
  • 143
    • 13244258414 scopus 로고    scopus 로고
    • The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice
    • DOI 10.1124/jpet.104.076141
    • Teng S & M. Piquette-Miller: The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. J. Pharmacol. Exp. Ther. 312, 841-848(2005) (Pubitemid 40189587)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.2 , pp. 841-848
    • Teng, S.1    Piquette-Miller, M.2
  • 144
    • 0014955307 scopus 로고
    • In vivo and in vitro suppression of humoral and cellular immunological response by rifampicin
    • Paunescu E: In vivo and in vitro suppression of humoral and cellular immunological response by rifampicin. Nature 228, 1188-1190(1970)
    • (1970) Nature , vol.228 , pp. 1188-1190
    • Paunescu, E.1
  • 145
    • 0015878693 scopus 로고
    • Inhibition of the immune response in vitro by rifampicin and derivatives
    • Doria G & G. Agarossi: Inhibition of the immune response in vitro by rifampicin and derivatives. Scand. J. Respir. Dis. Suppl 84, 23-26(1973)
    • (1973) Scand. J. Respir. Dis. Suppl , vol.84 , pp. 23-26
    • Doria, G.1    Agarossi, G.2
  • 146
    • 0024255668 scopus 로고
    • Antibiotics and immunity: Effects of antibiotics on mitogen responsiveness of lymphocytes and interleukin-2 production
    • Ibrahim M S, Z. A. Maged, A. Haron, R. Y. Khalil, A. M. Attallah: Antibiotics and immunity: effects of antibiotics on mitogen responsiveness of lymphocytes and interleukin-2 production. Chemioterapia. 7, 369-372(1988) (Pubitemid 19039750)
    • (1988) Chemioterapia , vol.7 , Issue.6 , pp. 369-372
    • Ibrahim, M.S.1    Maged, Z.A.2    Haron, A.3    Khalil, R.Y.4    Attallah, A.M.5
  • 149
    • 35348837827 scopus 로고    scopus 로고
    • Bile acids promote the expression of hepatitis C virus in replicon-harboring cells
    • DOI 10.1128/JVI.00795-07
    • Chang K O & D. W. George: Bile acids promote the expression of hepatitis C virus in repliconharboring cells. J. Virol. 81, 9633-9640(2007) (Pubitemid 350067669)
    • (2007) Journal of Virology , vol.81 , Issue.18 , pp. 9633-9640
    • Chang, K.-O.1    George, D.W.2
  • 152
    • 41949140343 scopus 로고    scopus 로고
    • Differential inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by the small heterodimer partner
    • DOI 10.1128/JVI.02507-07
    • Oropeza C E, L. Li, A. McLachlan: Differential inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by the small heterodimer partner. J. Virol. 82, 3814-3821(2008) (Pubitemid 351521218)
    • (2008) Journal of Virology , vol.82 , Issue.8 , pp. 3814-3821
    • Oropeza, C.E.1    Li, L.2    McLachlan, A.3
  • 155
    • 33846837288 scopus 로고    scopus 로고
    • Clinical predictors for hepatocellular carcinoma in patients with primary biliary cirrhosis
    • DOI 10.1016/j.cgh.2006.09.031, PII S1542356506009670
    • Suzuki A, J. Lymp, J. Donlinger, F. Mendes, P. Angulo, K. Lindor: Clinical predictors for hepatocellular carcinoma in patients with primary biliary cirrhosis. Clin. Gastroenterol. Hepatol. 5, 259-264(2007) (Pubitemid 46216931)
    • (2007) Clinical Gastroenterology and Hepatology , vol.5 , Issue.2 , pp. 259-264
    • Suzuki, A.1    Lymp, J.2    Donlinger, J.3    Mendes, F.4    Angulo, P.5    Lindor, K.6
  • 158
    • 0041467406 scopus 로고    scopus 로고
    • Primary biliary cirrhosis and hepatocellular carcinoma
    • DOI 10.1016/S1568-9972(02)00050-2, PII S1568997202000502
    • Findor J, X. S. He, J. Sord, R. Terg, M. E. Gershwin: Primary biliary cirrhosis and hepatocellular carcinoma. Autoimmun. Rev. 1, 220-225(2002) (Pubitemid 38340256)
    • (2002) Autoimmunity Reviews , vol.1 , Issue.4 , pp. 220-225
    • Findor, J.1    He, X.-S.2    Sord, J.3    Terg, R.4    Gershwin, M.E.5
  • 160
    • 0042025385 scopus 로고    scopus 로고
    • Liver disease associated with alpha1-antitrypsin deficiency
    • Rosen H R: Liver disease associated with alpha1-antitrypsin deficiency. Clin. Liver Dis. 2, 175-185(1998)
    • (1998) Clin. Liver Dis , vol.2 , pp. 175-185
    • Rosen, H.R.1
  • 161
    • 38649086066 scopus 로고    scopus 로고
    • Dissecting the genetic susceptibility for cholangiocarcinoma in primary sclerosing cholangitis
    • DOI 10.1002/hep.22100
    • Lazaridis K N: Dissecting the genetic susceptibility for cholangiocarcinoma in primary sclerosing cholangitis. Hepatology 47, 8-10(2008) (Pubitemid 351171034)
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 8-10
    • Lazaridis, K.N.1
  • 163
    • 0141828972 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis
    • DOI 10.2174/1566524033479537
    • Yu S, S. Rao, J. K. Reddy: Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis. Curr. Mol. Med. 3, 561-572(2003) (Pubitemid 37168598)
    • (2003) Current Molecular Medicine , vol.3 , Issue.6 , pp. 561-572
    • Yu, S.1    Rao, S.2    Reddy, J.K.3
  • 165
    • 38849184816 scopus 로고    scopus 로고
    • PPARα activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
    • DOI 10.1172/JCI33594
    • Tanaka N, K. Moriya, K. Kiyosawa, K. Koike, F. J. Gonzalez, T. Aoyama: PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J. Clin. Invest 118, 683-694(2008) (Pubitemid 351206557)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.2 , pp. 683-694
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3    Koike, K.4    Gonzalez, F.J.5    Aoyama, T.6
  • 168
    • 33744521897 scopus 로고    scopus 로고
    • Estrogen Receptor α Polymorphisms Associated With Susceptibility to Hepatocellular Carcinoma in Hepatitis B Virus Carriers
    • DOI 10.1053/j.gastro.2006.02.030, PII S0016508506003866
    • Zhai Y, G. Zhou, G. Deng, W. Xie, X. Dong, X. Zhang, L. Yu, H. Yang, X. Yuan, H. Zhang, L. Zhi, Z. Yao, Y. Shen, B. Qiang, F. He: Estrogen receptor alpha polymorphisms associated with susceptibility to hepatocellular carcinoma in hepatitis B virus carriers. Gastroenterology 130, 2001-2009(2006) (Pubitemid 43816947)
    • (2006) Gastroenterology , vol.130 , Issue.7 , pp. 2001-2009
    • Zhai, Y.1    Zhou, G.2    Deng, G.3    Xie, W.4    Dong, X.5    Zhang, X.6    Yu, L.7    Yang, H.8    Yuan, X.9    Zhang, H.10    Zhi, L.11    Yao, Z.12    Shen, Y.13    Qiang, B.14    He, F.15
  • 169
    • 0034599681 scopus 로고    scopus 로고
    • 3
    • DOI 10.1016/S0304-3835(99)00416-4, PII S0304383599004164
    • Pourgholami M H, J. Akhter, Y. Lu, D. L. Morris: In vitro and in vivo inhibition of liver cancer cells by 1, 25-dihydroxyvitamin D3. Cancer Lett. 151, 97-102(2000) (Pubitemid 30155590)
    • (2000) Cancer Letters , vol.151 , Issue.1 , pp. 97-102
    • Pourgholami, M.H.1    Akhter, J.2    Lu, Y.3    Morris, D.L.4
  • 170
    • 34447098081 scopus 로고    scopus 로고
    • Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    • DOI 10.1093/carcin/bgl249
    • Kim I, K. Morimura, Y. Shah, Q. Yang, J. M. Ward, F. J. Gonzalez: Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 28, 940-946(2007) (Pubitemid 47072176)
    • (2007) Carcinogenesis , vol.28 , Issue.5 , pp. 940-946
    • Kim, I.1    Morimura, K.2    Shah, Y.3    Yang, Q.4    Ward, J.M.5    Gonzalez, F.J.6
  • 171
    • 32944455363 scopus 로고    scopus 로고
    • Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells
    • Roy D, S. Sarkar, Q. Felty: Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. Front Biosci. 11, 889-898(2006) (Pubitemid 43256429)
    • (2006) Frontiers in Bioscience , vol.11 , Issue.P.889-11981 , pp. 889-898
    • Roy, D.1    Sarkar, S.2    Felty, Q.3
  • 172
    • 34247517355 scopus 로고    scopus 로고
    • The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
    • DOI 10.1016/j.cbi.2006.12.003, PII S0009279706003553
    • Guillouzo A, A. Corlu, C. Aninat, D. Glaise, F. Morel, C. Guguen-Guillouzo: The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem. Biol. Interact. 168, 66-73(2007) (Pubitemid 46659919)
    • (2007) Chemico-Biological Interactions , vol.168 , Issue.1 , pp. 66-73
    • Guillouzo, A.1    Corlu, A.2    Aninat, C.3    Glaise, D.4    Morel, F.5    Guguen-Guillouzo, C.6
  • 173
    • 5644295430 scopus 로고    scopus 로고
    • The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    • DOI 10.1158/0008-5472.CAN-04-1459
    • Yamamoto Y, R. Moore, T. L. Goldsworthy, M. Negishi, R. R. Maronpot: The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res. 64, 7197-7200(2004) (Pubitemid 39372050)
    • (2004) Cancer Research , vol.64 , Issue.20 , pp. 7197-7200
    • Yamamoto, Y.1    Moore, R.2    Goldsworthy, T.L.3    Negishi, M.4    Maronpot, R.R.5
  • 174
  • 176
    • 37349010675 scopus 로고    scopus 로고
    • FXR signaling in metabolic disease
    • DOI 10.1016/j.febslet.2007.11.015, PII S0014579307011593
    • Zhang Y & P. A. Edwards: FXR signaling in metabolic disease. FEBS Lett. 582, 10-18(2008) (Pubitemid 350297240)
    • (2008) FEBS Letters , vol.582 , Issue.1 , pp. 10-18
    • Zhang, Y.1    Edwards, P.A.2
  • 177
    • 42249111748 scopus 로고    scopus 로고
    • The roles of nuclear receptors CAR and PXR in hepatic energy metabolism
    • Konno Y, M. Negishi, S. Kodama: The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug Metab Pharmacokinet. 23, 8-13(2008)
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 8-13
    • Konno, Y.1    Negishi, M.2    Kodama, S.3
  • 178
    • 40049109970 scopus 로고    scopus 로고
    • Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis
    • Hansen M K & T. M. Connolly: Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis. Curr. Opin. Investig. Drugs 9, 247-255(2008) (Pubitemid 351323377)
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.3 , pp. 247-255
    • Hansen, M.K.1    Connolly, T.M.2
  • 179
    • 34247155688 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus
    • DOI 10.2174/157339907779802067
    • Jay M A & J. Ren: Peroxisome proliferatoractivated receptor (PPAR) in metabolic syndrome and type 2 diabetes mellitus. Curr. Diabetes Rev. 3, 33-39(2007) (Pubitemid 46592792)
    • (2007) Current Diabetes Reviews , vol.3 , Issue.1 , pp. 33-39
    • Jay, M.A.1    Ren, J.2
  • 180
    • 39749171761 scopus 로고    scopus 로고
    • Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response
    • DOI 10.1021/mp700103m
    • Moreau A, M. J. Vilarem, P. Maurel, J. M. Pascussi: Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response. Mol. Pharm. 5, 35-41(2008) (Pubitemid 351300032)
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.1 , pp. 35-41
    • Moreau, A.1    Vilarem, M.J.2    Maurel, P.3    Pascussi, J.M.4
  • 181
    • 39749098685 scopus 로고    scopus 로고
    • PXR and LXR in hepatic steatosis: A new dog and an old dog with new tricks
    • DOI 10.1021/mp700121u
    • Lee J H, J. Zhou, W. Xie: PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks. Mol. Pharm. 5, 60-66(2008) (Pubitemid 351300035)
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.1 , pp. 60-66
    • Jung, H.L.1    Zhou, J.2    Xie, W.3
  • 182
    • 39649096642 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathogenesis and potential for nuclear receptors as therapeutic targets
    • DOI 10.1021/mp700110z
    • George J & C. Liddle: Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. Mol. Pharm. 5, 49-59(2008) (Pubitemid 351300034)
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.1 , pp. 49-59
    • George, J.1    Liddle, C.2
  • 185
    • 34547597709 scopus 로고    scopus 로고
    • PPARalpha in atherosclerosis and inflammation
    • Zandbergen F & J. Plutzky: PPARalpha in atherosclerosis and inflammation. Biochim. Biophys. Acta 1771, 972-982(2007)
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 972-982
    • Zandbergen, F.1    Plutzky, J.2
  • 186
    • 34247491040 scopus 로고    scopus 로고
    • FXR: A promising target for the metabolic syndrome?
    • DOI 10.1016/j.tips.2007.03.002, PII S0165614707000703
    • Cariou B & B. Staels: FXR: a promising target for the metabolic syndrome? Trends Pharmacol. Sci. 28, 236-243(2007) (Pubitemid 46661001)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.5 , pp. 236-243
    • Cariou, B.1    Staels, B.2
  • 187
    • 0027482390 scopus 로고
    • Ursodeoxycholic acid in the Ursidae: Biliary bile acids of bears, pandas, and related carnivores
    • Hagey L R, D. L. Crombie, E. Espinosa, M. C. Carey, H. Igimi, A. F. Hofmann: Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores. J. Lipid Res. 34, 1911-1917(1993) (Pubitemid 23324966)
    • (1993) Journal of Lipid Research , vol.34 , Issue.11 , pp. 1911-1917
    • Hagey, L.R.1    Crombie, D.L.2    Espinosa, E.3    Carey, M.C.4    Igimi, H.5    Hofmann, A.F.6
  • 190
    • 38549123480 scopus 로고    scopus 로고
    • Medical Treatment of Cholestatic Liver Disease
    • DOI 10.1016/j.cld.2007.11.013, PII S1089326107001213
    • Paumgartner G & T. Pusl: Medical treatment of cholestatic liver disease. Clin. Liver Dis. 12, 53-80(2008) (Pubitemid 351163144)
    • (2008) Clinics in Liver Disease , vol.12 , Issue.1 , pp. 53-80
    • Paumgartner, G.1    Pusl, T.2
  • 193
  • 195
    • 0035861563 scopus 로고    scopus 로고
    • Functional modulation of the glucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid
    • Miura T, R. Ouchida, N. Yoshikawa, K. Okamoto, Y. Makino, T. Nakamura, C. Morimoto, I. Makino, H. Tanaka: Functional modulation of the glucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid. J. Biol. Chem. 276, 47371-47378(2001)
    • (2001) J. Biol. Chem. , vol.276 , pp. 47371-47378
    • Miura, T.1    Ouchida, R.2    Yoshikawa, N.3    Okamoto, K.4    Makino, Y.5    Nakamura, T.6    Morimoto, C.7    Makino, I.8    Tanaka, H.9
  • 196
    • 0026485634 scopus 로고
    • Ursodeoxycholic aciddependent activation of the glucocorticoid receptor
    • Tanaka H & I. Makino: Ursodeoxycholic aciddependent activation of the glucocorticoid receptor. Biochem. Biophys. Res. Commun. 188, 942-948(1992)
    • (1992) Biochem. Biophys. Res. Commun , vol.188 , pp. 942-948
    • Tanaka, H.1    Makino, I.2
  • 197
    • 12244277409 scopus 로고    scopus 로고
    • Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: Identification of a distal glucocorticoid response element
    • DOI 10.1210/me.2002-0244
    • Pascussi J M, M. Busson-Le Coniat, P. Maurel, M. J. Vilarem: Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. Mol. Endocrinol. 17, 42-55(2003) (Pubitemid 36132658)
    • (2003) Molecular Endocrinology , vol.17 , Issue.1 , pp. 42-55
    • Pascussi, J.M.1    Busson-Le Coniat, M.2    Maurel, P.3    Vilarem, M.-J.4
  • 199
    • 0035914368 scopus 로고    scopus 로고
    • Antiepileptic drugs increase plasma levels of 4betahydroxycholesterol in humans: Evidence for involvement of cytochrome p450 3A4
    • Bodin K, L. Bretillon, Y. Aden, L. Bertilsson, U. Broome, C. Einarsson, U. Diczfalusy: Antiepileptic drugs increase plasma levels of 4betahydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. J. Biol. Chem. 276, 38685-38689(2001)
    • (2001) J. Biol. Chem. , vol.276 , pp. 38685-38689
    • Bodin, K.1    Bretillon, L.2    Aden, Y.3    Bertilsson, L.4    Broome, U.5    Einarsson, C.6    Diczfalusy, U.7
  • 200
    • 33846415057 scopus 로고    scopus 로고
    • Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate
    • DOI 10.1124/jpet.106.106922
    • Gerk P M, W. Li, V. Megaraj, M. Vore: Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. J. Pharmacol. Exp. Ther. 320, 893-899(2007) (Pubitemid 46147973)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.2 , pp. 893-899
    • Gerk, P.M.1    Li, W.2    Megaraj, V.3    Vore, M.4
  • 201
    • 0036725044 scopus 로고    scopus 로고
    • Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
    • DOI 10.1053/jhep.2002.36088
    • Paumgartner G & U. Beuers: Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 36, 525-531(2002) (Pubitemid 34977162)
    • (2002) Hepatology , vol.36 , Issue.3 , pp. 525-531
    • Paumgartner, G.1    Beuers, U.2
  • 203
    • 0022650127 scopus 로고
    • Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor- ursodeoxycholate in rodents
    • Yoon Y B, L. R. Hagey, A. F. Hofmann, D. Gurantz, E. L. Michelotti, J. H. Steinbach: Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology 90, 837-852(1986) (Pubitemid 16124759)
    • (1986) Gastroenterology , vol.90 , Issue.4 , pp. 837-852
    • Yoon, Y.B.1    Hagey, L.R.2    Hofmann, A.F.3
  • 204
    • 0019507465 scopus 로고
    • Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: The national cooperative gallstone study. A controlled trial of efficacy and safety
    • Schoenfield L J & J. M. Lachin: Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study. A controlled trial of efficacy and safety. Ann. Intern. Med. 95, 257-282(1981) (Pubitemid 11052694)
    • (1981) Annals of Internal Medicine , vol.95 , Issue.3 , pp. 257-282
    • Schoenfield, L.J.1    Lachin, J.M.2    Baum, R.A.3
  • 205
    • 0033611305 scopus 로고    scopus 로고
    • The continuing importance of bile acids in liver and intestinal disease
    • Hofmann A F: The continuing importance of bile acids in liver and intestinal disease. Arch. Intern. Med. 159, 2647-2658(1999)
    • (1999) Arch. Intern. Med , vol.159 , pp. 2647-2658
    • Hofmann, A.F.1
  • 206
    • 33749344968 scopus 로고    scopus 로고
    • Nuclear bile acid receptor FXR as pharmacological target: Are we there yet?
    • DOI 10.1016/j.febslet.2006.07.082, PII S0014579306009501
    • Modica S & A. Moschetta: Nuclear bile acid receptor FXR as pharmacological target: are we there yet? FEBS Lett. 580, 5492-5499(2006) (Pubitemid 44488553)
    • (2006) FEBS Letters , vol.580 , Issue.23 , pp. 5492-5499
    • Modica, S.1    Moschetta, A.2
  • 209
    • 26244441014 scopus 로고    scopus 로고
    • The Farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism
    • Claudel T, B. Staels, F. Kuipers: The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler. Thromb. Vasc. Biol. 25, 2020-2030(2005)
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 210
    • 11144318237 scopus 로고    scopus 로고
    • Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    • DOI 10.1038/nm1138
    • Moschetta A, A. L. Bookout, D. J. Mangelsdorf: Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat. Med. 10, 1352-1358(2004) (Pubitemid 40022717)
    • (2004) Nature Medicine , vol.10 , Issue.12 , pp. 1352-1358
    • Moschetta, A.1    Bookout, A.L.2    Mangelsdorf, D.J.3
  • 212
    • 79959562403 scopus 로고    scopus 로고
    • Expression of bile acid transport and detoxification systems and their regulatory nuclear receptors in human hepatic stellate cells
    • Zollner G, A. Caligiuri, P. Fickert, M. Wagner, D. Silbert, M. Pinzani, M. Trauner: Expression of bile acid transport and detoxification systems and their regulatory nuclear receptors in human hepatic stellate cells. J Hepatol 46, S135 (2007)
    • (2007) J Hepatol , vol.46
    • Zollner, G.1    Caligiuri, A.2    Fickert, P.3    Wagner, M.4    Silbert, D.5    Pinzani, M.6    Trauner, M.7
  • 214
    • 34848833785 scopus 로고    scopus 로고
    • Primary biliary cirrhosis, hyperlipidemia, and atherosclerotic risk: A systematic review
    • DOI 10.1016/j.atherosclerosis.2006.11.036, PII S0021915006007271
    • Sorokin A, J. L. Brown, P. D. Thompson: Primary biliary cirrhosis, hyperlipidemia, and atherosclerotic risk: a systematic review. Atherosclerosis 194, 293-299(2007) (Pubitemid 47513107)
    • (2007) Atherosclerosis , vol.194 , Issue.2 , pp. 293-299
    • Sorokin, A.1    Brown, J.L.2    Thompson, P.D.3
  • 215
    • 1542781600 scopus 로고    scopus 로고
    • A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR
    • DOI 10.1172/JCI200418385
    • Huang W, J. Zhang, D. D. Moore: A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J. Clin. Invest 113, 137-143(2004) (Pubitemid 38541640)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.1 , pp. 137-143
    • Huang, W.1    Zhang, J.2    Moore, D.D.3
  • 216
    • 0036209248 scopus 로고    scopus 로고
    • Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
    • Kliewer S A & T. M. Willson: Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J. Lipid Res. 43, 359-364(2002) (Pubitemid 34252265)
    • (2002) Journal of Lipid Research , vol.43 , Issue.3 , pp. 359-364
    • Kliewer, S.A.1    Willson, T.M.2
  • 217
    • 0024591301 scopus 로고
    • Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis
    • Bachs L, A. Pares, M. Elena, C. Piera, J. Rodes: Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis. Lancet 1, 574-576(1989) (Pubitemid 19074002)
    • (1989) Lancet , vol.1 , Issue.8638 , pp. 574-576
    • Bachs, L.1    Pares, A.2    Elena, M.3    Piera, C.4    Rodes, J.5
  • 218
    • 0016609715 scopus 로고
    • Phenobarbital effects in cholestatic liver diseases
    • Bloomer J R & J. L. Boyer: Phenobarbital effects in cholestatic liver diseases. Ann. Intern. Med. 82, 310-317(1975)
    • (1975) Ann. Intern. Med , vol.82 , pp. 310-317
    • Bloomer, J.R.1    Boyer, J.L.2
  • 219
    • 0015516798 scopus 로고
    • The effects of phenobarbital on bile salts and bilirubin in patients with intrahepatic and extrahepatic cholestasis
    • Stiehl A, M. M. Thaler, W. H. Admirand: The effects of phenobarbital on bile salts and bilirubin in patients with intrahepatic and extrahepatic cholestasis. N. Engl. J. Med. 286, 858-861(1972)
    • (1972) N. Engl. J. Med , vol.286 , pp. 858-861
    • Stiehl, A.1    Thaler, M.M.2    Admirand, W.H.3
  • 220
    • 0032172828 scopus 로고    scopus 로고
    • Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of γ-glutamyl transpeptidase
    • DOI 10.1016/S0002-9270(98)00353-0, PII S0002927098003530
    • Cancado E L, R. M. Leitao, F. J. Carrilho, A. A. Laudanna: Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of gammaglutamyl transpeptidase. Am. J. Gastroenterol. 93, 1510-1517(1998) (Pubitemid 29075191)
    • (1998) American Journal of Gastroenterology , vol.93 , Issue.9 , pp. 1510-1517
    • Cancado, E.L.R.1    Leitao, R.M.C.2    Carrilho, F.J.3    Laudanna, A.A.4
  • 222
    • 0036179358 scopus 로고    scopus 로고
    • Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis
    • DOI 10.1136/gut.50.3.436
    • Prince M I, A. D. Burt, D. E. Jones: Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis. Gut 50, 436-439(2002) (Pubitemid 34161065)
    • (2002) Gut , vol.50 , Issue.3 , pp. 436-439
    • Prince, M.I.1    Burt, A.D.2    Jones, D.E.J.3
  • 223
    • 23044436687 scopus 로고    scopus 로고
    • CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
    • DOI 10.1002/hep.20784
    • Wagner M, E. Halilbasic, H. U. Marschall, G. Zollner, P. Fickert, C. Langner, K. Zatloukal, H. Denk, M. Trauner: CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Hepatology 42, 420-430(2005) (Pubitemid 41061095)
    • (2005) Hepatology , vol.42 , Issue.2 , pp. 420-430
    • Wagner, M.1    Halilbasic, E.2    Marschall, H.-U.3    Zollner, G.4    Fickert, P.5    Langner, C.6    Zatloukal, K.7    Denk, H.8    Trauner, M.9
  • 224
    • 0242665373 scopus 로고    scopus 로고
    • Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity
    • DOI 10.1074/jbc.M307145200
    • Guo G L, G. Lambert, M. Negishi, J. M. Ward, H. B. Brewer, Jr., S. A. Kliewer, F. J. Gonzalez, C. J. Sinal: Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J. Biol. Chem. 278, 45062-45071(2003) (Pubitemid 37432638)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.46 , pp. 45062-45071
    • Guo, G.L.1    Lambert, G.2    Negishi, M.3    Ward, J.M.4    Brewer Jr., H.B.5    Kliewer, S.A.6    Gonzalez, F.J.7    Sinal, C.J.8
  • 225
    • 2442485772 scopus 로고    scopus 로고
    • The Nuclear Receptor CAR Is a Regulator of Thyroid Hormone Metabolism during Caloric Restriction
    • DOI 10.1074/jbc.M313601200
    • Maglich J M, J. Watson, P. J. McMillen, B. Goodwin, T. M. Willson, J. T. Moore: The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J. Biol. Chem. 279, 19832-19838(2004) (Pubitemid 38623423)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.19 , pp. 19832-19838
    • Maglich, J.M.1    Watson, J.2    McMillen, P.J.3    Goodwin, B.4    Willson, T.M.5    Moore, J.T.6
  • 227
    • 0037064177 scopus 로고    scopus 로고
    • Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
    • DOI 10.1126/science.1073502
    • Zhang J, W. Huang, S. S. Chua, P. Wei, D. D. Moore: Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298, 422-424(2002) (Pubitemid 35176352)
    • (2002) Science , vol.298 , Issue.5592 , pp. 422-424
    • Zhang, J.1    Huang, W.2    Chua, S.S.3    Wei, P.4    Moore, D.D.5
  • 228
    • 0032873241 scopus 로고    scopus 로고
    • Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: Results of a prospective double-blind trial
    • DOI 10.1016/S0016-5085(99)70351-3
    • Leuschner M, K. P. Maier, J. Schlichting, S. Strahl, G. Herrmann, H. H. Dahm, H. Ackermann, J. Happ, U. Leuschner: Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: results of a prospective double-blind trial. Gastroenterology 117, 918-925(1999) (Pubitemid 29468235)
    • (1999) Gastroenterology , vol.117 , Issue.4 , pp. 918-925
    • Leuschner, M.1    Maier, K.-P.2    Schlichting, J.3    Strahl, S.4    Herrmann, G.5    Dahm, H.H.6    Ackermann, H.7    Happ, J.8    Leuschner, U.9
  • 229
    • 0030198972 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and prednisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis
    • DOI 10.1016/S0168-8278(96)80327-8
    • Leuschner M, S. Guldutuna, T. You, K. Hubner, S. Bhatti, U. Leuschner: Ursodeoxycholic acid and prednisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis. J. Hepatol. 25, 49-57(1996) (Pubitemid 26267092)
    • (1996) Journal of Hepatology , vol.25 , Issue.1 , pp. 49-57
    • Leuschner, M.1    Guldutuna, S.2    You, T.3    Hubner, K.4    Bhatti, S.5    Leuschner, U.6
  • 230
    • 0026673728 scopus 로고
    • A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results
    • Mitchison H C, J. M. Palmer, M. F. Bassendine, A. J. Watson, C. O. Record, O. F. James: A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results. J. Hepatol. 15, 336-344(1992)
    • (1992) J. Hepatol , vol.15 , pp. 336-344
    • Mitchison, H.C.1    Palmer, J.M.2    Bassendine, M.F.3    Watson, A.J.4    Record, C.O.5    James, O.F.6
  • 231
    • 16244417776 scopus 로고    scopus 로고
    • Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: A three-year randomized trial
    • DOI 10.1002/hep.20646
    • Rautiainen H, P. Karkkainen, A. L. Karvonen, H. Nurmi, P. Pikkarainen, H. Nuutinen, M. Farkkila: Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial. Hepatology 41, 747-752(2005) (Pubitemid 40462936)
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 747-752
    • Rautiainen, H.1    Karkkainen, P.2    Karvonen, A.-L.3    Nurmi, H.4    Pikkarainen, P.5    Nuutinen, H.6    Farkkila, M.7
  • 234
    • 0033664347 scopus 로고    scopus 로고
    • Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: Consequences on cytochrome P450 gene regulation
    • Pascussi J M, S. Gerbal-Chaloin, J. M. Fabre, P. Maurel, M. J. Vilarem: Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol. Pharmacol. 58, 1441-1450(2000)
    • (2000) Mol. Pharmacol , vol.58 , pp. 1441-1450
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Fabre, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 235
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi J M, L. Drocourt, J. M. Fabre, P. Maurel, M. J. Vilarem: Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol. Pharmacol. 58, 361-372(2000) (Pubitemid 30497480)
    • (2000) Molecular Pharmacology , vol.58 , Issue.2 , pp. 361-372
    • Pascussi, J.-M.1    Drocourt, L.2    Fabre, J.-M.3    Maurel, P.4    Vilarem, M.-J.5
  • 237
    • 25844516609 scopus 로고    scopus 로고
    • Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-β1-induced apoptosis in rat hepatocytes
    • DOI 10.1002/hep.20870
    • Sola S, J. D. Amaral, R. E. Castro, R. M. Ramalho, P. M. Borralho, B. T. Kren, H. Tanaka, C. J. Steer, C. M. Rodrigues: Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes. Hepatology 42, 925-934(2005) (Pubitemid 41401131)
    • (2005) Hepatology , vol.42 , Issue.4 , pp. 925-934
    • Sola, S.1    Amaral, J.D.2    Castro, R.E.3    Ramalho, R.M.4    Borralho, P.M.5    Kren, B.T.6    Tanaka, H.7    Steer, C.J.8    Rodrigues, C.M.P.9
  • 238
    • 38849104576 scopus 로고    scopus 로고
    • Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells
    • DOI 10.1172/JCI33156
    • Arenas F, I. Hervias, M. Uriz, R. Joplin, J. Prieto, J. F. Medina: Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. J. Clin. Invest 118, 695-709(2008) (Pubitemid 351206558)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.2 , pp. 695-709
    • Arenas, F.1    Hervias, I.2    Uriz, M.3    Joplin, R.4    Prieto, J.5    Medina, J.F.6
  • 240
    • 0032125406 scopus 로고    scopus 로고
    • Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone
    • Gitlin N, N. L. Julie, C. L. Spurr, K. N. Lim, H. M. Juarbe: Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone. Ann. Intern. Med. 129, 36-38(1998) (Pubitemid 28304650)
    • (1998) Annals of Internal Medicine , vol.129 , Issue.1 , pp. 36-38
    • Gitlin, N.1    Julie, N.L.2    Spurr, C.L.3    Lim, K.N.4    Juarbe, H.M.5
  • 241
    • 0035813014 scopus 로고    scopus 로고
    • Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate
    • DOI 10.1016/S0300-483X(01)00460-7, PII S0300483X01004607
    • Funk C, M. Pantze, L. Jehle, C. Ponelle, G. Scheuermann, M. Lazendic, R. Gasser: Troglitazoneinduced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. Toxicology 167, 83-98(2001) (Pubitemid 32830949)
    • (2001) Toxicology , vol.167 , Issue.1 , pp. 83-98
    • Funk, C.1    Pantze, M.2    Jehle, L.3    Ponelle, C.4    Scheuermann, G.5    Lazendic, M.6    Gasser, R.7
  • 242
    • 33846186365 scopus 로고    scopus 로고
    • Effect of thiazolidinediones on bile acid transport in rat liver
    • DOI 10.1016/j.lfs.2006.11.001, PII S0024320506008538
    • Snow K L & R. H. Moseley: Effect of thiazolidinediones on bile acid transport in rat liver. Life Sci. 80, 732-740(2007) (Pubitemid 46107994)
    • (2007) Life Sciences , vol.80 , Issue.8 , pp. 732-740
    • Snow, K.L.1    Moseley, R.H.2
  • 243
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • DOI 10.1053/jhep.2003.50193
    • Neuschwander-Tetri B A & S. H. Caldwell: Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37, 1202-1219(2003) (Pubitemid 36538699)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 244
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
    • DOI 10.1053/jhep.2003.50420
    • Neuschwander-Tetri B A, E. M. Brunt, K. R. Wehmeier, D. Oliver, B. R. Bacon: Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 38, 1008-1017(2003) (Pubitemid 37221684)
    • (2003) Hepatology , vol.38 , Issue.4 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 246
    • 33746340885 scopus 로고    scopus 로고
    • Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: Relationship to histological improvement
    • DOI 10.1016/j.cgh.2006.05.005, PII S1542356506004708
    • Lutchman G, K. Promrat, D. E. Kleiner, T. Heller, M. G. Ghany, J. A. Yanovski, T. J. Liang, J. H. Hoofnagle: Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement. Clin. Gastroenterol. Hepatol. 4, 1048-1052(2006) (Pubitemid 44118842)
    • (2006) Clinical Gastroenterology and Hepatology , vol.4 , Issue.8 , pp. 1048-1052
    • Lutchman, G.1    Promrat, K.2    Kleiner, D.E.3    Heller, T.4    Ghany, M.G.5    Yanovski, J.A.6    Liang, T.J.7    Hoofnagle, J.H.8
  • 248
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptors alpha and gamma are activated by indomethacin and other non-steroidal antiinflammatory drugs
    • Lehmann J M, J. M. Lenhard, B. B. Oliver, G. M. Ringold, S. A. Kliewer: Peroxisome proliferatoractivated receptors alpha and gamma are activated by indomethacin and other non-steroidal antiinflammatory drugs. J. Biol. Chem. 272, 3406-3410(1997)
    • (1997) J. Biol. Chem. , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 249
    • 10044223533 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptors alpha and gamma are activated by indomethacin and other non-steroidal antiinflammatory drugs
    • Li A C & C. K. Glass: Peroxisome proliferatoractivated receptors alpha and gamma are activated by indomethacin and other non-steroidal antiinflammatory drugs. J. Lipid Res. 45, 2161-2173(2004)
    • (2004) J. Lipid Res , vol.45 , pp. 2161-2173
    • Li, A.C.1    Glass, C.K.2
  • 253
    • 34547108415 scopus 로고    scopus 로고
    • Rosiglitazone attenuates suppression of RXRα-dependent gene expression in inflamed liver
    • DOI 10.1016/j.jhep.2006.09.008, PII S0168827806005514
    • Ghose R, J. Mulder, R. J. von Furstenberg, S. Thevananther, F. Kuipers, S. J. Karpen: Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver. J. Hepatol. 46, 115-123(2007) (Pubitemid 44827424)
    • (2007) Journal of Hepatology , vol.46 , Issue.1 , pp. 115-123
    • Ghose, R.1    Mulder, J.2    Von Furstenberg, R.J.3    Thevananther, S.4    Kuipers, F.5    Karpen, S.J.6
  • 254
    • 0037010478 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor γ and retinoid X receptor heterodimer in hepatogastroenterological diseases
    • DOI 10.1016/S0140-6736(02)11395-X
    • Dubuquoy L, S. Dharancy, S. Nutten, S. Pettersson, J. Auwerx, P. Desreumaux: Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet 360, 1410-1418(2002) (Pubitemid 35341309)
    • (2002) Lancet , vol.360 , Issue.9343 , pp. 1410-1418
    • Dubuquoy, L.1    Dharancy, S.2    Nutten, S.3    Pettersson, S.4    Auwerx, J.5    Desreumaux, P.6
  • 255
    • 0037821923 scopus 로고    scopus 로고
    • Bezafibrate treatment: A new medical approach for PBC patients?
    • Kanda T, O. Yokosuka, F. Imazeki, H. Saisho: Bezafibrate treatment: a new medical approach for PBC patients? J. Gastroenterol. 38, 573-578(2003) (Pubitemid 36857389)
    • (2003) Journal of Gastroenterology , vol.38 , Issue.6 , pp. 573-578
    • Kanda, T.1    Yokosuka, O.2    Imazeki, F.3    Saisho, H.4
  • 256
    • 0036143517 scopus 로고    scopus 로고
    • Investigation into the efficacy of bezafibrate against primary biliary cirrhosis, with histological references from cases receiving long term monotherapy [10]
    • DOI 10.1016/S0002-9270(01)03975-2
    • Kurihara T, A. Maeda, M. Shigemoto, K. Yamashita, E. Hashimoto: Investigation into the efficacy of bezafibrate against primary biliary cirrhosis, with histological references from cases receiving long term monotherapy. Am. J. Gastroenterol. 97, 212-214(2002) (Pubitemid 34059800)
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.1 , pp. 212-214
    • Kurihara, T.1    Maeda, A.2    Shigemoto, M.3    Yamashita, K.4    Hashimoto, E.5
  • 257
    • 0033792659 scopus 로고    scopus 로고
    • Bezafibrate in the treatment of primary biliary cirrhosis: Comparison with ursodeoxycholic acid
    • Kurihara T, A. Niimi, A. Maeda, M. Shigemoto, K. Yamashita: Bezafibrate in the treatment of primary biliary cirrhosis: comparison with ursodeoxycholic acid. Am. J. Gastroenterol. 95, 2990-2992(2000)
    • (2000) Am. J. Gastroenterol , vol.95 , pp. 2990-2992
    • Kurihara, T.1    Niimi, A.2    Maeda, A.3    Shigemoto, M.4    Yamashita, K.5
  • 258
    • 0033989267 scopus 로고    scopus 로고
    • Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: A preliminary study [15]
    • DOI 10.1016/S0002-9270(99)00726-1
    • Nakai S, T. Masaki, K. Kurokohchi, A. Deguchi, M. Nishioka: Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: a preliminary study. Am. J. Gastroenterol. 95, 326-327(2000) (Pubitemid 30041596)
    • (2000) American Journal of Gastroenterology , vol.95 , Issue.1 , pp. 326-327
    • Nakai, S.1    Masaki, T.2    Kurokohchi, K.3    Deguchi, A.4    Nishioka, M.5
  • 259
    • 0034962007 scopus 로고    scopus 로고
    • Effect of bezafibrate in primary biliary cirrhosis: A pilot study
    • DOI 10.1034/j.1600-0676.2001.021003223.x
    • Ohmoto K, Y. Mitsui, S. Yamamoto: Effect of bezafibrate in primary biliary cirrhosis: a pilot study. Liver 21, 223-224(2001) (Pubitemid 32586582)
    • (2001) Liver , vol.21 , Issue.3 , pp. 223-224
    • Ohmoto, K.1    Mitsui, Y.2    Yamamoto, S.3
  • 262
    • 0029055416 scopus 로고
    • Marked improvement in cholestasis and hypercholesterolemia with simvastatin in a patient with primary biliary cirrhosis
    • Kamisako T & Y. Adachi: Marked improvement in cholestasis and hypercholesterolemia with simvastatin in a patient with primary biliary cirrhosis. Am. J. Gastroenterol. 90, 1187-1188(1995)
    • (1995) Am. J. Gastroenterol , vol.90 , pp. 1187-1188
    • Kamisako, T.1    Adachi, Y.2
  • 264
    • 0036102527 scopus 로고    scopus 로고
    • Simvastatin in primary biliary cirrhosis: Effects on serum lipids and distinct disease markers
    • DOI 10.1016/S0168-8278(02)00006-5, PII S0168827802000065
    • Ritzel U, U. Leonhardt, M. Nather, G. Schafer, V. W. Armstrong, G. Ramadori: Simvastatin in primary biliary cirrhosis: effects on serum lipids and distinct disease markers. J. Hepatol. 36, 454-458(2002) (Pubitemid 34407331)
    • (2002) Journal of Hepatology , vol.36 , Issue.4 , pp. 454-458
    • Ritzel, U.1    Leonhardt, U.2    Nather, M.3    Schafer, G.4    Armstrong, V.W.5    Ramadori, G.6
  • 266
    • 0033061551 scopus 로고    scopus 로고
    • Enhancement of mdr2 gene transcription mediates the biliary transfer of phosphatidylcholine supplied by an increased biosynthesis in the pravastatin- treated rat
    • DOI 10.1002/hep.510290620
    • Carrella M, D. Feldman, S. Cogoi, A. Csillaghy, P. A. Weinhold: Enhancement of mdr2 gene transcription mediates the biliary transfer of phosphatidylcholine supplied by an increased biosynthesis in the pravastatin-treated rat. Hepatology 29, 1825-1832(1999) (Pubitemid 29247057)
    • (1999) Hepatology , vol.29 , Issue.6 , pp. 1825-1832
    • Carrella, M.1    Feldman, D.2    Cogoi, S.3    Csillaghy, A.4    Weinhold, P.A.5
  • 268
    • 8544237037 scopus 로고    scopus 로고
    • Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-α-dependent
    • DOI 10.1074/jbc.M407461200
    • Landrier J F, C. Thomas, J. Grober, H. Duez, F. Percevault, M. Souidi, C. Linard, B. Staels, P. Besnard: Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent. J. Biol. Chem. 279, 45512-45518(2004) (Pubitemid 39491537)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.44 , pp. 45512-45518
    • Landrier, J.-F.1    Thomas, C.2    Grober, J.3    Duez, H.4    Percevault, F.5    Souidi, M.6    Linard, C.7    Staels, B.8    Besnard, P.9
  • 269
    • 0037325403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPARα)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
    • DOI 10.1042/BJ20020981
    • Kok T, V. W. Bloks, H. Wolters, R. Havinga, P. L. Jansen, B. Staels, F. Kuipers: Peroxisome proliferator-activated receptor alpha (PPARalpha) - mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. Biochem. J. 369, 539-547(2003) (Pubitemid 36246237)
    • (2003) Biochemical Journal , vol.369 , Issue.3 , pp. 539-547
    • Kok, T.1    Bloks, V.W.2    Wolters, H.3    Havinga, R.4    Jansen, P.L.M.5    Staels, B.6    Kuipers, F.7
  • 270
    • 38849137817 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: An experimental study
    • Cindoruk M, M. Kerem, T. Karakan, B. Salman, O. Akin, M. Alper, O. Erdem, S. Unal: Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study. BMC. Gastroenterol. 7, 44(2007)
    • (2007) BMC. Gastroenterol , vol.7 , pp. 44
    • Cindoruk, M.1    Kerem, M.2    Karakan, T.3    Salman, B.4    Akin, O.5    Alper, M.6    Erdem, O.7    Unal, S.8
  • 271
    • 25444530047 scopus 로고    scopus 로고
    • Transcriptional regulation of hepatobiliary transport systems in health and disease: Implications for a rationale approach to the treatment of intrahepatic cholestasis
    • Wagner M & M. Trauner: Transcriptional regulation of hepatobiliary transport systems in health and disease: implications for a rationale approach to the treatment of intrahepatic cholestasis. Ann. Hepatol. 4, 77-99(2005)
    • (2005) Ann. Hepatol , vol.4 , pp. 77-99
    • Wagner, M.1    Trauner, M.2
  • 272
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann J M, D. D. McKee, M. A. Watson, T. M. Willson, J. T. Moore, S. A. Kliewer: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest 102, 1016-1023(1998) (Pubitemid 28419246)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.5 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 273
    • 15744395646 scopus 로고    scopus 로고
    • Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor α transcription factor
    • DOI 10.1124/mol.104.005389
    • Fang H L, S. C. Strom, H. Cai, C. N. Falany, T. A. Kocarek, M. Runge-Morris: Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. Mol. Pharmacol. 67, 1257-1267(2005) (Pubitemid 40410426)
    • (2005) Molecular Pharmacology , vol.67 , Issue.4 , pp. 1257-1267
    • Fang, H.-L.1    Strom, S.C.2    Cai, H.3    Falany, C.N.4    Kocarek, T.A.5    Runge-Morris, M.6
  • 275
    • 0033999108 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription
    • Marrapodi M & J. Y. Chiang: Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. J. Lipid Res. 41, 514-520(2000) (Pubitemid 30220654)
    • (2000) Journal of Lipid Research , vol.41 , Issue.4 , pp. 514-520
    • Marrapodi, M.1    Chiang, J.Y.L.2
  • 277
    • 0036738444 scopus 로고    scopus 로고
    • Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver
    • Rudling M, B. Angelin, L. Stahle, E. Reihner, S. Sahlin, H. Olivecrona, I. Bjorkhem, C. Einarsson: Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver. J. Clin. Endocrinol. Metab 87, 4307-4313(2002)
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , pp. 4307-4313
    • Rudling, M.1    Angelin, B.2    Stahle, L.3    Reihner, E.4    Sahlin, S.5    Olivecrona, H.6    Bjorkhem, I.7    Einarsson, C.8
  • 278
    • 0034331437 scopus 로고    scopus 로고
    • The effect of peroxisomeproliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene
    • Patel D D, B. L. Knight, A. K. Soutar, G. F. Gibbons, D. P. Wade: The effect of peroxisomeproliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene. Biochem. J. 351 Pt 3, 747-753(2000)
    • (2000) Biochem. J , vol.351 , Issue.3 PART , pp. 747-753
    • Patel, D.D.1    Knight, B.L.2    Soutar, A.K.3    Gibbons, G.F.4    Wade, D.P.5
  • 279
    • 0035570381 scopus 로고    scopus 로고
    • Fibrates suppress bile acid synthesis via peroxisome proliferator- activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression
    • Post S M, H. Duez, P. P. Gervois, B. Staels, F. Kuipers, H. M. Princen: Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression. Arterioscler. Thromb. Vasc. Biol. 21, 1840-1845(2001) (Pubitemid 34219790)
    • (2001) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.21 , Issue.11 , pp. 1840-1845
    • Post, S.M.1    Duez, H.2    Gervois, P.P.3    Staels, B.4    Kuipers, F.5    Princen, H.M.G.6
  • 280
    • 0037315190 scopus 로고    scopus 로고
    • Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor
    • DOI 10.1210/me.2002-0120
    • Pineda T., I. T. Claudel, C. Duval, V. Kosykh, J. C. Fruchart, B. Staels: Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Mol. Endocrinol. 17, 259-272(2003) (Pubitemid 36183149)
    • (2003) Molecular Endocrinology , vol.17 , Issue.2 , pp. 259-272
    • Torra, I.P.1    Claudel, T.2    Duval, C.3    Kosykh, V.4    Fruchart, J.-C.5    Staels, B.6
  • 282
    • 30144431977 scopus 로고    scopus 로고
    • Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1
    • DOI 10.1016/S0076-6879(05)00010-8, PII S0076687905000108, 10, Phase II Conjugation Enzymes and Transport Systems
    • Chatterjee B, I. Echchgadda, C. S. Song: Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1. Methods Enzymol. 400, 165-191(2005) (Pubitemid 43052421)
    • (2005) Methods in Enzymology , vol.400 , pp. 165-191
    • Chatterjee, B.1    Echchgadda, I.2    Seog Song, C.3
  • 284
    • 33645235673 scopus 로고    scopus 로고
    • 1, 25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor
    • Honjo Y, S. Sasaki, Y. Kobayashi, H. Misawa, H. Nakamura: 1, 25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor. J. Endocrinol. 188, 635-643(2006)
    • (2006) J. Endocrinol , vol.188 , pp. 635-643
    • Honjo, Y.1    Sasaki, S.2    Kobayashi, Y.3    Misawa, H.4    Nakamura, H.5
  • 285
    • 0031722771 scopus 로고    scopus 로고
    • Comparative effects of secondary bile acids, deoxycholic and lithocholic acids, on aberrant crypt foci growth in the postinitiation phases of colon carcinogenesis
    • Baijal P K, D. W. Fitzpatrick, R. P. Bird: Comparative effects of secondary bile acids, deoxycholic and lithocholic acids, on aberrant crypt foci growth in the postinitiation phases of colon carcinogenesis. Nutr. Cancer 31, 81-89(1998) (Pubitemid 28428067)
    • (1998) Nutrition and Cancer , vol.31 , Issue.2 , pp. 81-89
    • Baijal, P.K.1    Fitzpatrick, D.W.2    Bird, R.P.3
  • 286
    • 0018749426 scopus 로고
    • Effect of cholesterol metabolites and promoting effect of lithocholic acid in colon carcinogenesis in germ-free and conventional F344 rats
    • Reddy B S & K. Watanabe: Effect of cholesterol metabolites and promoting effect of lithocholic acid in colon carcinogenesis in germ-free and conventional F344 rats. Cancer Res. 39, 1521-1524(1979) (Pubitemid 9172667)
    • (1979) Cancer Research , vol.39 , Issue.5 , pp. 1521-1524
    • Reddy, B.S.1    Watanabe, K.2
  • 289
    • 0033714093 scopus 로고    scopus 로고
    • Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha
    • Song C & S. Liao: Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha. Endocrinology 141, 4180-4184(2000)
    • (2000) Endocrinology , vol.141 , pp. 4180-4184
    • Song, C.1    Liao, S.2
  • 290
    • 0033854882 scopus 로고    scopus 로고
    • Selective activation of liver X receptor alpha by 6α-hydroxy bile acids and analogs
    • DOI 10.1016/S0039-128X(00)00127-6, PII S0039128X00001276
    • Song C, R. A. Hiipakka, S. Liao: Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs. Steroids 65, 423-427(2000) (Pubitemid 30628370)
    • (2000) Steroids , vol.65 , Issue.8 , pp. 423-427
    • Song, C.1    Hiipakka, R.A.2    Liao, S.3
  • 291
    • 33747040567 scopus 로고    scopus 로고
    • The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice
    • DOI 10.1002/hep.21259
    • Verreault M, K. Senekeo-Effenberger, J. Trottier, J. A. Bonzo, J. Belanger, J. Kaeding, B. Staels, P. Caron, R. H. Tukey, O. Barbier: The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology 44, 368-378(2006) (Pubitemid 44214876)
    • (2006) Hepatology , vol.44 , Issue.2 , pp. 368-378
    • Verreault, M.1    Senekeo-Effenberger, K.2    Trottier, J.3    Bonzo, J.A.4    Belanger, J.5    Kaeding, J.6    Staels, B.7    Caron, P.8    Tukey, R.H.9    Barbier, O.10
  • 292
    • 23044445820 scopus 로고    scopus 로고
    • Exercising the nuclear option to treat cholestasis: CAR and PXR ligands
    • DOI 10.1002/hep.20833
    • Karpen S. J.: Exercising the nuclear option to treat cholestasis: CAR and PXR ligands. Hepatology 42(2), 266-9(2005) (Pubitemid 41061077)
    • (2005) Hepatology , vol.42 , Issue.2 , pp. 266-269
    • Karpen, S.J.1


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