Selective activation of liver X receptor alpha by 6α-hydroxy bile acids and analogs

Steroids

Volumn 65, Issue 8, 2000, Pages 423-427

  Song, Ching ^a   Hiipakka, Richard A ^a   Liao, Shutsung ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Bile acids; Cholesterol; Hyodeoxycholic acid; LXR; Nuclear receptors; Oxysterols

Indexed keywords

3ALPHA,6ALPHA DIOL 5BETA CHOLANOIC ACID; 3ALPHA,6ALPHA,7ALPHA TRIOL 5BETA CHOLANOIC ACID; 3BETA OL DELTA5 CHOLENOIC ACID; 6ALPHA HYDROXY BILE ACID; BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; GLYCO 3ALPHA,6ALPHA DIOL 5BETA CHOLANOIC ACID; HYBRID PROTEIN; HYODEOXYCHOLIC ACID; LIVER X RECEPTOR ALPHA; OXYGENASE; OXYSTEROL; STEROID 7ALPHA HYDROXYLASE; TAURO 3ALPHA,6ALPHA DIOL 5BETA CHOLANOIC ACID; TAURO 3ALPHA,6ALPHA,7ALPHA TRIOL 5 BETA CHOLANOIC ACID; UBIQUITOUS NUCLEAR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CULTURE MEDIUM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; REACTION ANALYSIS; REPORTER GENE; TRANSACTIVATION;

BILE ACIDS AND SALTS; CELL LINE; CHENODEOXYCHOLIC ACID; CHOLIC ACIDS; DNA-BINDING PROTEINS; HUMANS; KIDNEY; LIGANDS; LITHOCHOLIC ACID; NUCLEAR RECEPTOR COACTIVATOR 2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RECOMBINANT PROTEINS; RETINOID X RECEPTORS; TAURODEOXYCHOLIC ACID; TRANSCRIPTION FACTORS;

EID: 0033854882     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00127-6     Document Type: Article

References (30)

1. Bjorkhem I. Mechanism of degradation of the steroid side chain in the formation of bile acids. J Lipid Res. 33:1992;455-471.
2. Chiang J.Y.L. Regulation of bile acid synthesis [In Process Citation]. Front Biosci. 3:1998;D176-D193.
3. Anderson K.E., Kok E., Javitt N.B. Bile acid synthesis in man metabolism of 7 -hydroxycholesterol- 14 C and 26-hydroxycholesterol- 3 H. J Clin Invest. 51:1972;112-117.
4. Axelson M., Sjovall J. Potential bile acid precursors in plasma-possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man. J Steroid Biochem. 36:1990;631-640.
5. Araya Z., Wikvall K. 6α-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochim Biophys Acta. 1438:1999;47-54.
6. Einarsson K. On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154. J Biol Chem. 241:1966;534-539.
7. Summerfield J.A., Billing B.H., Shackleton C.H. Identification of bile acids in the serum and urine in cholestasis. Evidence for 6α-hydroxylation of bile acids in man. Biochem J. 154:1976;507-516.
8. Kano M., Matsumoto M., Kamano T., Tsurumaru M. ELISA determination of serum hyocholic acid concentrations in humans and their possible clinical significance. Hepatogastroenterology. 46:1999;983-984.
9. Lehmann J.M., Kliewer S.A., Moore L.B., et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 272:1997;3137-3140.
10. Peet D.J., Turley S.D., Ma W., et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 93:1998;693-704.
11. Crestani M., Sadeghpour A., Stroup D., Galli G., Chiang J.Y. Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors. J Lipid Res. 39:1998;2192-2200.
12. Wang H., Chen J., Hollister K., Sowers L.C., Forman B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell. 3:1999;543-553.
13. Parks D.J., Blanchard S.G., Bledsoe R.K., et al. Bile acids natural ligands for an orphan nuclear receptor [see comments]. Science. 284:1999;1365-1368.
14. Makishima M., Okamoto A.Y., Repa J.J., et al. Identification of a nuclear receptor for bile acids [see comments]. Science. 284:1999;1362-1365.
15. Apfel R., Benbrook D., Lernhardt E., Ortiz M.A., Salbert G., Pfahl M. A novel orphan receptor specific for a subset of thyroid hormone- responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol. 14:1994;7025-7035.
16. Willy P.J., Umesono K., Ong E.S., Evans R.M., Heyman R.A., Mangelsdorf D.J. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9:1995;1033-1045.
17. Song C., Hiipakka R.A., Kokontis J.M., Liao S. Ubiquitous receptor structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones. Ann N Y Acad Sci. 761:1995;38-49.
18. Shinar D.M., Endo N., Rutledge S.J., Vogel R., Rodan G.A., Schmidt A. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene. 147:1994;273-276.
19. Teboul M., Enmark E., Li Q., Wikstrom A.C., Pelto-Huikko M., Gustafsson J.A. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc Natl Acad Sci U S A. 92:1995;2096-2100.
20. Seol W., Choi H.S., Moore D.D. Isolation of proteins that interact specifically with the retinoid X receptor two novel orphan receptors. Mol Endocrinol. 9:1995;72-85.
21. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 383:1996;728-731.
22. Hong H., Kohli K., Trivedi A., Johnson D.L., Stallcup M.R. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci USA. 93:1996;4948-4952.
23. Chiang J.Y., Stroup D. Identification and characterization of a putative bile acid-responsive element in cholesterol 7 α-hydroxylase gene promoter. J Biol Chem. 269:1994;17502-17507.
24. Janowski B.A., Grogan M.J., Jones S.A., et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci USA. 96:1999;266-271.
25. Sakakura H., Kimura N., Takeda H., Komatsu H., Ishizaki K., Nagata S. Simultaneous determination of bile acids in rat liver tissue by high-performance liquid chromatography (HPLC). J Chromatogr B Biomed Sci Appl. 718:1998;33-40.
26. Schwarz M., Lund E.G., Setchell K.D.R., et al. Disruption of cholesterol 7α-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7α- hydroxylase. J Biol Chem. 271:1996;18024-18031.
27. Pandak W.M., Heuman D.M., Redford K., et al. Hormonal regulation of cholesterol 7α-hydroxylase specific activity, mRNA levels, and transcriptional activity in vivo in the rat. J Lipid Res. 38:1997;2483-2491.
28. Javitt N.B. Bile acid synthesis from cholesterol regulatory and auxiliary pathways. Faseb J. 8:1994;1308-1311.
29. Murakami S., Kondo-Ohta Y., Tomisawa K. Improvement in cholesterol metabolism in mice given chronic treatment of taurine and fed a high-fat diet. Life Sci. 64:1999;83-91.
30. Stravitz R.T., Hylemon P.B., Heuman D.M., et al. Transcriptional regulation of cholesterol 7 α-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes. J Biol Chem. 268:1993;13987-13993.