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Volumn 45, Issue 12, 2004, Pages 2161-2173

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

Author keywords

Foam cell formation; Liver X receptors; Peroxisome proliferator activated receptors

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL; GLUCOSE; LIPID; LIVER X RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; VERY LOW DENSITY LIPOPROTEIN;

EID: 10044223533     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.R400010-JLR200     Document Type: Review
Times cited : (293)

References (147)
  • 1
    • 0025681443 scopus 로고
    • Charles-Edouard Brown-Sequard and the centennial of endocrinology
    • Wilson, J. D. 1990. Charles-Edouard Brown-Sequard and the centennial of endocrinology. J. Clin. Endocrinol. Metab. 71: 1403-1409.
    • (1990) J. Clin. Endocrinol. Metab. , vol.71 , pp. 1403-1409
    • Wilson, J.D.1
  • 2
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans, R. M. 1988. The steroid and thyroid hormone receptor superfamily. Science. 240: 889-895.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 3
    • 0032562263 scopus 로고    scopus 로고
    • Increasing burden of cardiovascular disease: Current knowledge and future directions for research on risk factors
    • Hennekens, C. H. 1998. Increasing burden of cardiovascular disease: current knowledge and future directions for research on risk factors. Circulation. 97: 1095-1102.
    • (1998) Circulation , vol.97 , pp. 1095-1102
    • Hennekens, C.H.1
  • 4
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross, R. 1999. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340: 115-126.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 5
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis: The road ahead
    • Glass, C., and J. Witztum. 2001. Atherosclerosis: the road ahead. Cell. 104: 503-516.
    • (2001) Cell , vol.104 , pp. 503-516
    • Glass, C.1    Witztum, J.2
  • 6
    • 0034122925 scopus 로고    scopus 로고
    • The role of scavenger receptors in the innate immune system
    • Gough, P. J., and S. Gordon. 2000. The role of scavenger receptors in the innate immune system. Microbes Infect. 2: 305-311.
    • (2000) Microbes Infect. , vol.2 , pp. 305-311
    • Gough, P.J.1    Gordon, S.2
  • 8
    • 0034780794 scopus 로고    scopus 로고
    • Class A scavenger receptors, macrophages, and atherosclerosis
    • Linton, M. F., and S. Fazio. 2001. Class A scavenger receptors, macrophages, and atherosclerosis. Curr. Opin. Lipidol. 12: 489-495.
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 489-495
    • Linton, M.F.1    Fazio, S.2
  • 9
    • 0033539313 scopus 로고    scopus 로고
    • Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood. Fate of Early Lesions in Children (FELIC) Study
    • Napoli, C., C. K. Glass, J. L. Witztum, R. Deutsch, F. P. D'Armiento, and W. Palinski. 1999. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood. Fate of Early Lesions in Children (FELIC) Study. Lancet. 354: 1234-1241.
    • (1999) Lancet , vol.354 , pp. 1234-1241
    • Napoli, C.1    Glass, C.K.2    Witztum, J.L.3    Deutsch, R.4    D'Armiento, F.P.5    Palinski, W.6
  • 10
  • 11
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby, P. 2002. Inflammation in atherosclerosis. Nature. 420:868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 12
    • 0027161563 scopus 로고
    • Long-term epidemiologic prediction of coronary disease. The Framingham experience
    • Kannel, W. B., and M. Larson. 1993. Long-term epidemiologic prediction of coronary disease. The Framingham experience. Cardiology. 82: 137-152.
    • (1993) Cardiology , vol.82 , pp. 137-152
    • Kannel, W.B.1    Larson, M.2
  • 13
    • 0037062657 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome, and coronary atherosclerosis
    • Grundy, S. M. 2002. Obesity, metabolic syndrome, and coronary atherosclerosis. Circulation. 105: 2696-2698.
    • (2002) Circulation , vol.105 , pp. 2696-2698
    • Grundy, S.M.1
  • 14
    • 0000661662 scopus 로고    scopus 로고
    • The molecular pharmacology of SERMs
    • McDonnell, D. P. 1999. The molecular pharmacology of SERMs. Trends Endocrinol. Metab. 10: 301-311.
    • (1999) Trends Endocrinol. Metab. , vol.10 , pp. 301-311
    • McDonnell, D.P.1
  • 18
    • 0035813090 scopus 로고    scopus 로고
    • Coregulator codes of transcriptional regulation by nuclear receptors
    • Rosenfeld, M. G., and C. K. Glass. 2001. Coregulator codes of transcriptional regulation by nuclear receptors. J. Biol. Chem. 276: 36865-36868.
    • (2001) J. Biol. Chem. , vol.276 , pp. 36865-36868
    • Rosenfeld, M.G.1    Glass, C.K.2
  • 19
    • 0037154974 scopus 로고    scopus 로고
    • Combinatorial control of gene expression by nuclear receptors and coregulators
    • McKenna, N. J., and B. W. O'Malley. 2002. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell. 108: 465-474.
    • (2002) Cell , vol.108 , pp. 465-474
    • McKenna, N.J.1    O'Malley, B.W.2
  • 20
  • 21
    • 0037022592 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling
    • Shi, Y., M. Hon, and R. M. Evans. 2002. The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc. Natl. Acad. Sci. USA. 99: 2613-2618.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 2613-2618
    • Shi, Y.1    Hon, M.2    Evans, R.M.3
  • 23
    • 0038517917 scopus 로고    scopus 로고
    • Liver X receptors interact with corepressors to regulate gene expression
    • Hu, X., S. Li, J. Wu, C. Xia, and D. S. Lala. 2003. Liver X receptors interact with corepressors to regulate gene expression. Mol. Endocrinol. 17: 1019-1026.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1019-1026
    • Hu, X.1    Li, S.2    Wu, J.3    Xia, C.4    Lala, D.S.5
  • 24
    • 0034650893 scopus 로고    scopus 로고
    • The coregulator exchange in transcriptional functions of nuclear receptors
    • Glass, C. K., and M. G. Rosenfeld. 2000. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14: 121-141.
    • (2000) Genes Dev. , vol.14 , pp. 121-141
    • Glass, C.K.1    Rosenfeld, M.G.2
  • 25
    • 1342264315 scopus 로고    scopus 로고
    • A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
    • Perissi, V., A. Aggarwal, C. K. Glass, D. W. Rose, and M. G. Rosenfeld. 2004. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 116: 511-526.
    • (2004) Cell , vol.116 , pp. 511-526
    • Perissi, V.1    Aggarwal, A.2    Glass, C.K.3    Rose, D.W.4    Rosenfeld, M.G.5
  • 26
    • 0041324898 scopus 로고    scopus 로고
    • The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: Molecular mechanisms for gene repression
    • De Bosscher, K., W. Vanden Berghe, and G. Haegeman. 2003. The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. Endocr. Rev. 24: 488-522.
    • (2003) Endocr. Rev. , vol.24 , pp. 488-522
    • De Bosscher, K.1    Vanden Berghe, W.2    Haegeman, G.3
  • 27
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote, M., A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass. 1998. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature. 391: 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 28
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • Joseph, S. B., A. Castrillo, B. A. Laffitte, D. J. Mangelsdorf, and P. Tontonoz. 2003. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9: 213-219.
    • (2003) Nat. Med. , vol.9 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 30
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • Peet, D. J., S. D. Turley, W. Ma, B. A. Janowski, J-M. A. Lobaccaro, R. E. Hammer, and D. J. Mangelsdorf. 1998. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell. 93: 693-704.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.-M.A.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 31
    • 0037166261 scopus 로고    scopus 로고
    • Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta
    • Repa, J. J., K. E. Berge, C. Pomajzl, J. A. Richardson, H. Hobbs, and D. J. Mangelsdorf. 2002. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J. Biol. Chem. 277: 18793-18800.
    • (2002) J. Biol. Chem. , vol.277 , pp. 18793-18800
    • Repa, J.J.1    Berge, K.E.2    Pomajzl, C.3    Richardson, J.A.4    Hobbs, H.5    Mangelsdorf, D.J.6
  • 33
    • 0035900749 scopus 로고    scopus 로고
    • Regulation of lipoprotein lipase by the oxysterol receptors, LXR-alpha and LXRbeta
    • Zhang, Y., J. J. Repa, K. Gauthier, and D. J. Mangelsdorf. 2001. Regulation of lipoprotein lipase by the oxysterol receptors, LXR-alpha and LXRbeta. J. Biol. Chem. 276: 43018-43024.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43018-43024
    • Zhang, Y.1    Repa, J.J.2    Gauthier, K.3    Mangelsdorf, D.J.4
  • 34
    • 0036915379 scopus 로고    scopus 로고
    • Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors
    • Mak, P. A., H. R. Kast-Woelbern, A. M. Anisfeld, and P. A. Edwards. 2002. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. J. Lipid Res. 43: 2037-2041.
    • (2002) J. Lipid Res. , vol.43 , pp. 2037-2041
    • Mak, P.A.1    Kast-Woelbern, H.R.2    Anisfeld, A.M.3    Edwards, P.A.4
  • 35
    • 0037199994 scopus 로고    scopus 로고
    • Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in marine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
    • Mak, P. A., B. A. Laffitte, C. Desrumaux, S. B. Joseph, L. K. Curtiss, D. J. Mangelsdorf, P. Tontonoz, and P. A. Edwards. 2002. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in marine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J. Biol. Chem. 277: 31900-31908.
    • (2002) J. Biol. Chem. , vol.277 , pp. 31900-31908
    • Mak, P.A.1    Laffitte, B.A.2    Desrumaux, C.3    Joseph, S.B.4    Curtiss, L.K.5    Mangelsdorf, D.J.6    Tontonoz, P.7    Edwards, P.A.8
  • 37
    • 0034115889 scopus 로고    scopus 로고
    • ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
    • Oram, J. F., and A. M. Vaughan. 2000. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Curr. Opin. Lipidol. 11: 253-260.
    • (2000) Curr. Opin. Lipidol. , vol.11 , pp. 253-260
    • Oram, J.F.1    Vaughan, A.M.2
  • 38
    • 0033780216 scopus 로고    scopus 로고
    • ABC transporters in cellular lipid trafficking
    • Schmitz, G., W. E. Kaminski, and E. Orso. 2000. ABC transporters in cellular lipid trafficking. Curr. Opin. Lipidol. 11: 493-501.
    • (2000) Curr. Opin. Lipidol. , vol.11 , pp. 493-501
    • Schmitz, G.1    Kaminski, W.E.2    Orso, E.3
  • 39
    • 0035205221 scopus 로고    scopus 로고
    • Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis
    • Attie, A. D., J. P. Kastelein, and M. R. Hayden. 2001. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42: 1717-1726.
    • (2001) J. Lipid Res. , vol.42 , pp. 1717-1726
    • Attie, A.D.1    Kastelein, J.P.2    Hayden, M.R.3
  • 40
    • 0032797141 scopus 로고    scopus 로고
    • The ABCs of cholesterol efflux
    • Young, S. G., and C. J. Fielding. 1999. The ABCs of cholesterol efflux. Nat. Genet. 22: 316-318.
    • (1999) Nat. Genet. , vol.22 , pp. 316-318
    • Young, S.G.1    Fielding, C.J.2
  • 45
    • 0034637128 scopus 로고    scopus 로고
    • ABC1 gene expression and apoA-1-mediated cholesterol efflux are regulated by LXR
    • Schwartz, K., R. M. Lawn, and D. P. Wade. 2000. ABC1 gene expression and apoA-1-mediated cholesterol efflux are regulated by LXR. Biochem. Biophys. Res. Commun. 274: 794-802.
    • (2000) Biochem. Biophys. Res. Commun. , vol.274 , pp. 794-802
    • Schwartz, K.1    Lawn, R.M.2    Wade, D.P.3
  • 46
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • Costet, P., Y. Luo, N. Wang, and A. R. Tall. 2000. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 275: 28240-28245.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 47
    • 0034640288 scopus 로고    scopus 로고
    • Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols
    • Venkateswaran, A., J. J. Repa, J. M. Lobaccaro, A. Bronson, D. J. Mangelsdorf, and P. A. Edwards. 2000. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. J. Biol. Chem. 275: 14700-14707.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14700-14707
    • Venkateswaran, A.1    Repa, J.J.2    Lobaccaro, J.M.3    Bronson, A.4    Mangelsdorf, D.J.5    Edwards, P.A.6
  • 51
    • 3042798281 scopus 로고    scopus 로고
    • ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
    • Wang, N., D. Lan, W. Chen, F. Matsuura, and A. R. Tall. 2004. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc. Natl. Acad. Sci. USA. 101: 9774-9779.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 9774-9779
    • Wang, N.1    Lan, D.2    Chen, W.3    Matsuura, F.4    Tall, A.R.5
  • 52
    • 8544251324 scopus 로고    scopus 로고
    • Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein
    • In press
    • Nakamura, K., M. A. Kennedy, A. Baldan, D. D. Bojanic, K. Lyons, and P. A. Edwards. 2004. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J. Biol. Chem. In press.
    • (2004) J. Biol. Chem.
    • Nakamura, K.1    Kennedy, M.A.2    Baldan, A.3    Bojanic, D.D.4    Lyons, K.5    Edwards, P.A.6
  • 53
    • 0035914330 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
    • Fu, X., J. G. Menke, Y. Chen, G. Zhou, K. L. MacNaul, S. D. Wright, C. P. Sparrow, and E. G. Lund. 2001. 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J. Biol. Chem. 276: 38378-38387.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38378-38387
    • Fu, X.1    Menke, J.G.2    Chen, Y.3    Zhou, G.4    MacNaul, K.L.5    Wright, S.D.6    Sparrow, C.P.7    Lund, E.G.8
  • 56
    • 0038193542 scopus 로고    scopus 로고
    • Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages
    • Castrillo, A., S. B. Joseph, C. Marathe, D. J. Mangelsdorf, and P. Tontonoz. 2003. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J. Biol. Chem. 278: 10443-10449.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10443-10449
    • Castrillo, A.1    Joseph, S.B.2    Marathe, C.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 57
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne, B., and W. Wahli. 1999. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20: 649-688.
    • (1999) Endocr. Rev. , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 58
    • 0033998334 scopus 로고    scopus 로고
    • The PPARs: From orphan receptors to drug discovery
    • Willson, T., P. Brown, D. Sternbach, and B. Henke. 2000. The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43: 527-550.
    • (2000) J. Med. Chem. , vol.43 , pp. 527-550
    • Willson, T.1    Brown, P.2    Sternbach, D.3    Henke, B.4
  • 59
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347: 645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 60
    • 0027525576 scopus 로고
    • The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs
    • Issemann, I., R. A. Prince, J. D. Tugwood, and S. Green. 1993. The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J. Mol. Endocrinol. 11: 37-47.
    • (1993) J. Mol. Endocrinol. , vol.11 , pp. 37-47
    • Issemann, I.1    Prince, R.A.2    Tugwood, J.D.3    Green, S.4
  • 61
    • 0029144018 scopus 로고
    • Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
    • Schoonjans, K., M. Watanabe, H. Suzuki, A. Mahfoudi, G. Krey, W. Wahli, P. Grimaldi, B. Staels, T. Yamamoto, and J. Auwerx. 1995. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J. Biol. Chem. 270: 19269-19276.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19269-19276
    • Schoonjans, K.1    Watanabe, M.2    Suzuki, H.3    Mahfoudi, A.4    Krey, G.5    Wahli, W.6    Grimaldi, P.7    Staels, B.8    Yamamoto, T.9    Auwerx, J.10
  • 62
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
    • Motojima, K., P. Passilly, J. M. Peters, F. J. Gonzalez, and N. Latruffe. 1998. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J. Biol. Chem. 273: 16710-16714.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3    Gonzalez, F.J.4    Latruffe, N.5
  • 63
    • 0028276397 scopus 로고
    • Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
    • Rodriguez, J. C., G. Gil-Gomez, F. G. Hegardt, and D. Haro. 1994. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J. Biol. Chem. 269: 18767-18772.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18767-18772
    • Rodriguez, J.C.1    Gil-Gomez, G.2    Hegardt, F.G.3    Haro, D.4
  • 65
    • 0032475854 scopus 로고    scopus 로고
    • The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erb-alpha mediate the species-specific regulation of apolipoprotein A-1 expression by fibrates
    • Vu-Dac, N., S. Chopin-Delannoy, P. Gervois, E. Bonnelye, G. Martin, J. C. Fruchart, V. Laudet, and B. Staels. 1998. The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erb-alpha mediate the species-specific regulation of apolipoprotein A-1 expression by fibrates. J. Biol. Chem. 273: 25713-25720.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25713-25720
    • Vu-Dac, N.1    Chopin-Delannoy, S.2    Gervois, P.3    Bonnelye, E.4    Martin, G.5    Fruchart, J.C.6    Laudet, V.7    Staels, B.8
  • 68
    • 0037423555 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages
    • Chinetti, G., S. Lestavel, J. C. Fruchart, V. Clavey, and B. Staels. 2003. Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages. Circ. Res. 92: 212-217.
    • (2003) Circ. Res. , vol.92 , pp. 212-217
    • Chinetti, G.1    Lestavel, S.2    Fruchart, J.C.3    Clavey, V.4    Staels, B.5
  • 70
    • 0035141142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: Comparison with PPAR-gamma activation
    • Ye, J. M., P. J. Doyle, M. A. Iglesias, D. G. Watson, G. J. Cooney, and E. W. Kraegen. 2001. Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation. Diabetes. 50: 411-417.
    • (2001) Diabetes , vol.50 , pp. 411-417
    • Ye, J.M.1    Doyle, P.J.2    Iglesias, M.A.3    Watson, D.G.4    Cooney, G.J.5    Kraegen, E.W.6
  • 71
    • 0037025390 scopus 로고    scopus 로고
    • WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-Z1P/F-1 mice
    • Chou, C. J., M. Haluzik, C. Gregory, K. R. Dietz, C. Vinson, O. Gavrilova, and M. L. Reitman. 2002. WY14,643, a peroxisome proliferator- activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-Z1P/F-1 mice. J. Biol. Chem. 277: 24484-24489.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24484-24489
    • Chou, C.J.1    Haluzik, M.2    Gregory, C.3    Dietz, K.R.4    Vinson, C.5    Gavrilova, O.6    Reitman, M.L.7
  • 72
    • 0033594810 scopus 로고    scopus 로고
    • PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    • Marx, N., G. K. Sukhova, T. Collins, P. Libby, and J. Plutzky. 1999. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation. 99: 3125-3131.
    • (1999) Circulation , vol.99 , pp. 3125-3131
    • Marx, N.1    Sukhova, G.K.2    Collins, T.3    Libby, P.4    Plutzky, J.5
  • 74
    • 0035895326 scopus 로고    scopus 로고
    • PPARalpha activators inhibit tissue factor expression and activity in human monocytes
    • Marx, N., N. Mackman, U. Schonbeck, N. Yilmaz, V. Hombach, P. Libby, and J. Plutzky. 2001. PPARalpha activators inhibit tissue factor expression and activity in human monocytes. Circulation. 103: 213-219.
    • (2001) Circulation , vol.103 , pp. 213-219
    • Marx, N.1    Mackman, N.2    Schonbeck, U.3    Yilmaz, N.4    Hombach, V.5    Libby, P.6    Plutzky, J.7
  • 76
    • 0034614270 scopus 로고    scopus 로고
    • Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells
    • Shu, H., B. Wong, G. Zhou, Y. Li, J. Berger, J. W. Woods, S. D. Wright, and T. Q. Cai. 2000. Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells. Biochem. Biophys. Res. Commun. 267: 345-349.
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , pp. 345-349
    • Shu, H.1    Wong, B.2    Zhou, G.3    Li, Y.4    Berger, J.5    Woods, J.W.6    Wright, S.D.7    Cai, T.Q.8
  • 77
    • 0034665060 scopus 로고    scopus 로고
    • Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells
    • Lee, H., W. Shi, P. Tontonoz, S. Wang, G. Subbanagounder, C. C. Hedrick, S. Hama, C. Borromeo, R. M. Evans, J. A. Berliner, and L. Nagy. 2000. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ. Res. 87:516-521.
    • (2000) Circ. Res. , vol.87 , pp. 516-521
    • Lee, H.1    Shi, W.2    Tontonoz, P.3    Wang, S.4    Subbanagounder, G.5    Hedrick, C.C.6    Hama, S.7    Borromeo, C.8    Evans, R.M.9    Berliner, J.A.10    Nagy, L.11
  • 78
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
    • Forman, B. M., J. Chen, and R. M. Evans. 1997. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. USA. 94: 4312-4317.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 81
    • 0042669791 scopus 로고    scopus 로고
    • Insulin resistance and cardiovascular events with low HDL cholesterol. The Veterans Affairs HDL Intervention Trial (VA-HIT)
    • Robins, S. J., H. B. Rubins, F. H. Faas, E. J. Schaefer, M. B. Elam, J. W. Anderson, and D. Collins. 2003. Insulin resistance and cardiovascular events with low HDL cholesterol. The Veterans Affairs HDL Intervention Trial (VA-HIT). Diabetes Care. 26: 1513-1517.
    • (2003) Diabetes Care , vol.26 , pp. 1513-1517
    • Robins, S.J.1    Rubins, H.B.2    Faas, F.H.3    Schaefer, E.J.4    Elam, M.B.5    Anderson, J.W.6    Collins, D.7
  • 83
    • 0042568979 scopus 로고    scopus 로고
    • The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E
    • Fu, T., P. Kashireddy, and J. Borensztajn. 2003. The peroxisome- proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E. Biochem. J. 373: 941-947.
    • (2003) Biochem. J. , vol.373 , pp. 941-947
    • Fu, T.1    Kashireddy, P.2    Borensztajn, J.3
  • 88
    • 0035082586 scopus 로고    scopus 로고
    • Mouse models of atherosclerosis
    • Reardon, C. A., and G. S. Getz. 2001. Mouse models of atherosclerosis. Curr. Opin. Lipidol. 12: 167-173.
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 167-173
    • Reardon, C.A.1    Getz, G.S.2
  • 89
    • 0033395836 scopus 로고    scopus 로고
    • The PPARs and PXRs: Nuclear xenobiotic receptors that define novel hormone signaling pathways
    • Kliewer, S. A., J. M., Lehmann, M. V. Milburn, and T. M. Willson. 1999. The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways. Recent Prog. Horm. Res. 54: 345-368.
    • (1999) Recent Prog. Horm. Res. , vol.54 , pp. 345-368
    • Kliewer, S.A.1    Lehmann, J.M.2    Milburn, M.V.3    Willson, T.M.4
  • 90
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-gamma
    • Nagy, L., P. Tontonoz, J. G. A. Alvarez, H. Chen, and R. M. Evans. 1998. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-gamma. Cell. 93: 229-240.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.4    Evans, R.M.5
  • 94
    • 0028180070 scopus 로고
    • mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer
    • Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman. 1994. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8: 1224-1234.
    • (1994) Genes Dev. , vol.8 , pp. 1224-1234
    • Tontonoz, P.1    Hu, E.2    Graves, R.A.3    Budavari, A.I.4    Spiegelman, B.M.5
  • 95
    • 0029102676 scopus 로고
    • Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: Alternative promoter use and different splicing yield two mPPAR gamma isoforms
    • Zhu, Y., C. Qi, J. R. Korenberg, X. N. Chen, D. Noya, M. S. Rao, and J. K. Reddy. 1995. Structural organization of mouse peroxisome proliferator- activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc. Natl. Acad. Sci. USA. 92: 7921-7925.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7921-7925
    • Zhu, Y.1    Qi, C.2    Korenberg, J.R.3    Chen, X.N.4    Noya, D.5    Rao, M.S.6    Reddy, J.K.7
  • 96
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell. 79: 1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 100
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARgamma)
    • Lehmann, J. M., L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARgamma). J. Biol. Chem. 270: 12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 101
    • 0038645828 scopus 로고    scopus 로고
    • The metabolic syndrome: Peroxisome proliferator-activated receptor gamma and its therapeutic modulation
    • Gurnell, M., D. B. Savage, V. K. Chatterjee, and S. O'Rahilly. 2003. The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation. J. Clin. Endocrinol. Metab. 88: 2412-2421.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2412-2421
    • Gurnell, M.1    Savage, D.B.2    Chatterjee, V.K.3    O'Rahilly, S.4
  • 102
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
    • He, W., Y. Barak, A. Hevener, P. Olson, D. Liao, J. Le, M. Nelson, E. Ong, J. M. Olefsky, and R. M. Evans. 2003. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. USA. 100: 15712-15717.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5    Le, J.6    Nelson, M.7    Ong, E.8    Olefsky, J.M.9    Evans, R.M.10
  • 106
    • 0031595111 scopus 로고    scopus 로고
    • PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes
    • Wu, Z., Y. Xie, R. F. Morrison, N. L. Bucher, and S. R. Farmer. 1998. PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes. J. Clin. Invest. 101: 22-32.
    • (1998) J. Clin. Invest. , vol.101 , pp. 22-32
    • Wu, Z.1    Xie, Y.2    Morrison, R.F.3    Bucher, N.L.4    Farmer, S.R.5
  • 111
    • 0348222671 scopus 로고    scopus 로고
    • Inflammation: The link between insulin resistance, obesity and diabetes
    • Dandona, P., A. Aljada, and A. Bandyopadhyay. 2004. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol. 25: 4-7.
    • (2004) Trends Immunol. , vol.25 , pp. 4-7
    • Dandona, P.1    Aljada, A.2    Bandyopadhyay, A.3
  • 112
    • 0036779687 scopus 로고    scopus 로고
    • Emerging roles of PPARs in inflammation and immunity
    • Daynes, R. A., and D. C. Jones. 2002. Emerging roles of PPARs in inflammation and immunity. Nat. Rev. Immunol. 2: 748-759.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 748-759
    • Daynes, R.A.1    Jones, D.C.2
  • 113
    • 0030885575 scopus 로고    scopus 로고
    • Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
    • Peraldi, P., M. Xu, and B. M. Spiegelman. 1997. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J. Clin. Invest. 100: 1863-1869.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1863-1869
    • Peraldi, P.1    Xu, M.2    Spiegelman, B.M.3
  • 114
    • 0037031267 scopus 로고    scopus 로고
    • Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    • Haffner, S. M., A. S. Greenberg, W. M. Weston, H. Chen, K. Williams, and M. I. Freed. 2002. Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation. 106: 679-684.
    • (2002) Circulation , vol.106 , pp. 679-684
    • Haffner, S.M.1    Greenberg, A.S.2    Weston, W.M.3    Chen, H.4    Williams, K.5    Freed, M.I.6
  • 115
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C., A. T. Ting, and B. Seed. 1998. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature. 391: 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 116
    • 1042286477 scopus 로고    scopus 로고
    • Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: Effects on lipid homeostasis, inflammation, and atherosclerosis
    • Ricote, M., A. F. Valledor, and C. K. Glass. 2004. Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24: 230-239.
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 230-239
    • Ricote, M.1    Valledor, A.F.2    Glass, C.K.3
  • 117
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla, A., Y. Barak, L. Nagy, D. Liao, P. Tontonoz, and R. M. Evans. 2001. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7: 48-52.
    • (2001) Nat. Med. , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 119
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
    • Rossi, A., P. Kapahi, G. Natoli, T. Takahashi, Y. Chen, M. Karin, and M. G. Santoro. 2000. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 403: 103-108.
    • (2000) Nature , vol.403 , pp. 103-108
    • Rossi, A.1    Kapahi, P.2    Natoli, G.3    Takahashi, T.4    Chen, Y.5    Karin, M.6    Santoro, M.G.7
  • 120
    • 0038460253 scopus 로고    scopus 로고
    • PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
    • Welch, J. S., M. Ricote, T. E. Akiyama, F. J. Gonzalez, and C. K. Glass. 2003. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc. Natl. Acad. Sci. USA. 100: 6712-6717.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6712-6717
    • Welch, J.S.1    Ricote, M.2    Akiyama, T.E.3    Gonzalez, F.J.4    Glass, C.K.5
  • 121
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • Wellen, K. E., and G. S. Hotamisligil. 2003. Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest. 112: 1785-1788.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 123
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz, P., L. Nagy, J. G. A. Alvarez, V. A. Thomazy, and R. M. Evans. 1998. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 93: 241-252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.A.3    Thomazy, V.A.4    Evans, R.M.5
  • 124
    • 0034833822 scopus 로고    scopus 로고
    • CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
    • Febbraio, M., D. P. Hajjar, and R. L. Silverstein. 2001. CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J. Can. Invest. 108: 785-791.
    • (2001) J. Can. Invest. , vol.108 , pp. 785-791
    • Febbraio, M.1    Hajjar, D.P.2    Silverstein, R.L.3
  • 128
    • 0031724132 scopus 로고    scopus 로고
    • Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes
    • Minamikawa, J., S. Tanaka, M. Yamauchi, D. Inoue, and H. Koshiyama. 1998. Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J. Clin. Endocrinol. Metab. 83: 1818-1820.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1818-1820
    • Minamikawa, J.1    Tanaka, S.2    Yamauchi, M.3    Inoue, D.4    Koshiyama, H.5
  • 130
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • Li, A., K. Brown, M. Silvestre, T. Willson, W. Palinski, and C. Glass. 2000. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 106: 523-531.
    • (2000) J. Clin. Invest. , vol.106 , pp. 523-531
    • Li, A.1    Brown, K.2    Silvestre, M.3    Willson, T.4    Palinski, W.5    Glass, C.6
  • 135
    • 0035967492 scopus 로고    scopus 로고
    • Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice
    • Kusunoki, J., D. K. Hansoty, K. Aragane, J. T. Fallon, J. J. Badimon, and E. A. Fisher. 2001. Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 103: 2604-2609.
    • (2001) Circulation , vol.103 , pp. 2604-2609
    • Kusunoki, J.1    Hansoty, D.K.2    Aragane, K.3    Fallon, J.T.4    Badimon, J.J.5    Fisher, E.A.6
  • 138
    • 0035999532 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice
    • Zuckerman, S. H., R. F. Kauffman, and G. F. Evans. 2002. Peroxisome proliferator-activated receptor alpha,gamma coagonist LY465608 inhibits macrophage activation and atherosclerosis in apolipoprotein E knockout mice. Lipids. 37: 487-494.
    • (2002) Lipids , vol.37 , pp. 487-494
    • Zuckerman, S.H.1    Kauffman, R.F.2    Evans, G.F.3
  • 139
    • 0028321529 scopus 로고
    • Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
    • Kliewer, S. A., B. M. Forman, B. Blumberg, E. S. Ong, U. Borgmeyer, D. J. Mangelsdorf, K. Umesono, and R. M. Evans. 1994. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA. 91: 7355-7359.
    • (1994) Proc. Natl. Acad. Sci. USA. , vol.91 , pp. 7355-7359
    • Kliewer, S.A.1    Forman, B.M.2    Blumberg, B.3    Ong, E.S.4    Borgmeyer, U.5    Mangelsdorf6
  • 140
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
    • Wang, Y. X., C. H. Lee, S. Tiep, R. T. Yu, J. Ham, H. Kang, and R. M. Evans. 2003. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 113: 159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5    Kang, H.6    Evans, R.M.7
  • 147
    • 0142116239 scopus 로고    scopus 로고
    • Transcriptional repression of atherogenic inflammation: Modulation by PPARdelta
    • Lee, C. H., A. Chawla, N. Urbiztondo, D. Liao, W. A. Boisvert, and R. M. Evans. 2003. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 302: 453-457.
    • (2003) Science , vol.302 , pp. 453-457
    • Lee, C.H.1    Chawla, A.2    Urbiztondo, N.3    Liao, D.4    Boisvert, W.A.5    Evans, R.M.6


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