메뉴 건너뛰기




Volumn 5, Issue , 2008, Pages

Inflammaging as a prodrome to Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; CYTOKINE; DIOSMIN; EPIGALLOCATECHIN GALLATE; FLAVONOID; FLURBIPROFEN; GAMMA INTERFERON; GLUCOCORTICOID; HYDROXYCHLOROQUINE; LUTEOLIN; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; POLYPHENOL DERIVATIVE; SILIBININ; TRIFUSAL; UNCLASSIFIED DRUG;

EID: 58149499431     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-5-51     Document Type: Review
Times cited : (257)

References (229)
  • 2
    • 33747172229 scopus 로고    scopus 로고
    • Inflamm-aging, cytokines and aging: State of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
    • 10.2174/138161206777947470 16918441
    • Salvioli S Capri M Valensin S Tieri P Monti D Ottaviani E Franceschi C Inflamm-aging, cytokines and aging: State of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology Curr Pharm Des 2006, 12:3161-3171. 10.2174/138161206777947470 16918441
    • (2006) Curr Pharm Des , vol.12 , pp. 3161-3171
    • Salvioli, S.1    Capri, M.2    Valensin, S.3    Tieri, P.4    Monti, D.5    Ottaviani, E.6    Franceschi, C.7
  • 3
    • 16344376370 scopus 로고    scopus 로고
    • Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
    • 10.1016/j.febslet.2005.02.055 15811314
    • De Martinis M Franceschi C Monti D Ginaldi L Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity FEBS Lett 2005, 579:2035-2039. 10.1016/j.febslet.2005.02.055 15811314
    • (2005) FEBS Lett , vol.579 , pp. 2035-2039
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 5
    • 0028891555 scopus 로고
    • The immunology of exceptional individuals: The lesson of centenarians
    • 10.1016/0167-5699(95)80064-6 7880382
    • Franceschi C Monti D Sansoni P Cossarizza A The immunology of exceptional individuals: The lesson of centenarians Immunol Today 1995, 16:12-16. 10.1016/0167-5699(95)80064-6 7880382
    • (1995) Immunol Today , vol.16 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossarizza, A.4
  • 6
    • 0037374849 scopus 로고    scopus 로고
    • Inflammation, genetics, and longevity: Further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP
    • 1735442 12676903 10.1136/jmg.40.4.296
    • Lio D Scola L Crivello A Colonna-Romano G Candore G Bonafé M Cavallone L Marchegiani F Olivieri F Franceschi C Caruso C Inflammation, genetics, and longevity: Further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP J Med Genet 2003, 40:296-299. 1735442 12676903 10.1136/ jmg.40.4.296
    • (2003) J Med Genet , vol.40 , pp. 296-299
    • Lio, D.1    Scola, L.2    Crivello, A.3    Colonna-Romano, G.4    Candore, G.5    Bonafé, M.6    Cavallone, L.7    Marchegiani, F.8    Olivieri, F.9    Franceschi, C.10    Caruso, C.11
  • 9
    • 33845999595 scopus 로고    scopus 로고
    • Is inflammaging an auto[innate]immunity subclinical syndrome?
    • 1716179 17173699 10.1186/1742-4933-3-12
    • Giunta S Is inflammaging an auto[innate]immunity subclinical syndrome? Immun Ageing 2006, 3:12. 1716179 17173699 10.1186/1742-4933-3-12
    • (2006) Immun Ageing , vol.3 , pp. 12
    • Giunta, S.1
  • 10
    • 0033502284 scopus 로고    scopus 로고
    • Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections
    • 10.1086/314873 10395881
    • Bruunsgaard H Skinhoj P Qvist J Pedersen BK Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections J Infect Dis 1999, 180:551-554. 10.1086/314873 10395881
    • (1999) J Infect Dis , vol.180 , pp. 551-554
    • Bruunsgaard, H.1    Skinhoj, P.2    Qvist, J.3    Pedersen, B.K.4
  • 13
    • 10744223612 scopus 로고    scopus 로고
    • Marked increase with age of type 1 cytokines within memory and effector/ cytotoxic CD8+ T cells in humans: A contribution to understand the relationship between inflammation and immunosenescence
    • 10.1016/S0531-5565(03)00160-8 12954485
    • Zanni F Vescovini R Biasini C Fagnoni F Zanlari L Telera A Di Pede P Passeri G Pedrazzoni M Passeri M Franceschi C Sansoni P Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: A contribution to understand the relationship between inflammation and immunosenescence Exp Gerontol 2003, 38:981-987. 10.1016/ S0531-5565(03)00160-8 12954485
    • (2003) Exp Gerontol , vol.38 , pp. 981-987
    • Zanni, F.1    Vescovini, R.2    Biasini, C.3    Fagnoni, F.4    Zanlari, L.5    Telera, A.6    Di Pede, P.7    Passeri, G.8    Pedrazzoni, M.9    Passeri, M.10    Franceschi, C.11    Sansoni, P.12
  • 14
    • 1642462956 scopus 로고    scopus 로고
    • The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing
    • 10.1016/j.exger.2003.12.013 15050298
    • Giacconi R Cipriano C Albanese F Boccoli G Saba V Olivieri F Franceschi C Mocchegiani E The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing Exp Gerontol 2004, 39:621-628. 10.1016/j.exger.2003.12.013 15050298
    • (2004) Exp Gerontol , vol.39 , pp. 621-628
    • Giacconi, R.1    Cipriano, C.2    Albanese, F.3    Boccoli, G.4    Saba, V.5    Olivieri, F.6    Franceschi, C.7    Mocchegiani, E.8
  • 15
    • 33745451585 scopus 로고    scopus 로고
    • The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the swedish NONA immune longitudinal study of very late life functioning
    • 10.1016/j.mad.2006.04.003 16750842
    • Wikby A Nilsson BO Forsey R Thompson J Strindhall J Löfgren S Ernerudh J Pawelec G Ferguson F Johansson B The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the swedish NONA immune longitudinal study of very late life functioning Mech Ageing Dev 2006, 127:695-704. 10.1016/j.mad.2006.04.003 16750842
    • (2006) Mech Ageing Dev , vol.127 , pp. 695-704
    • Wikby, A.1    Nilsson, B.O.2    Forsey, R.3    Thompson, J.4    Strindhall, J.5    Löfgren, S.6    Ernerudh, J.7    Pawelec, G.8    Ferguson, F.9    Johansson, B.10
  • 21
    • 13544270803 scopus 로고    scopus 로고
    • The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases
    • 10.1111/j.1744-313X.2005.00490.x 15686588
    • Cipriano C Caruso C Lio D Giacconi R Malavolta M Muti E Gasparini M Franceschi C Mocchegiani E The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases Int J Immunogenet 2005, 32:13-18. 10.1111/ j.1744-313X.2005.00490.x 15686588
    • (2005) Int J Immunogenet , vol.32 , pp. 13-18
    • Cipriano, C.1    Caruso, C.2    Lio, D.3    Giacconi, R.4    Malavolta, M.5    Muti, E.6    Gasparini, M.7    Franceschi, C.8    Mocchegiani, E.9
  • 23
    • 0033985021 scopus 로고    scopus 로고
    • Immunosenescence: Potential causes and strategies for reversal
    • 10816137
    • Aspinall R Andrew D Immunosenescence: Potential causes and strategies for reversal Biochem Soc Trans 2000, 28:250-254. 10816137
    • (2000) Biochem Soc Trans , vol.28 , pp. 250-254
    • Aspinall, R.1    Andrew, D.2
  • 24
    • 0034578448 scopus 로고    scopus 로고
    • Longevity and the immune response
    • 10.1023/A:1010046532657 11707904
    • Aspinall R Longevity and the immune response Biogerontology 2000, 1:273-278. 10.1023/A:1010046532657 11707904
    • (2000) Biogerontology , vol.1 , pp. 273-278
    • Aspinall, R.1
  • 25
    • 20344374699 scopus 로고    scopus 로고
    • Intrinsic versus environmental influences on T-cell responses in aging
    • 10.1111/j.0105-2896.2005.00266.x 15882355
    • Linton PJ Li SP Zhang Y Bautista B Huynh Q Trinh T Linton PJ Intrinsic versus environmental influences on T-cell responses in aging Immunol Rev 2005, 205:207-219. 10.1111/j.0105-2896.2005.00266.x 15882355
    • (2005) Immunol Rev , vol.205 , pp. 207-219
    • Linton, P.J.1    Li, S.P.2    Zhang, Y.3    Bautista, B.4    Huynh, Q.5    Trinh, T.6    Linton, P.J.7
  • 26
    • 23944509562 scopus 로고    scopus 로고
    • B cell development and receptor diversity during aging
    • 16054808
    • Allman D Miller JP B cell development and receptor diversity during aging Curr Opin Immunol 2005, 17:463-467. 16054808
    • (2005) Curr Opin Immunol , vol.17 , pp. 463-467
    • Allman, D.1    Miller, J.P.2
  • 27
    • 20344373118 scopus 로고    scopus 로고
    • The role of CD8+ T-cell replicative senescence in human aging
    • 10.1111/j.0105-2896.2005.00259.x 15882351
    • Effros RB Dagarag M Spaulding C Man J The role of CD8+ T-cell replicative senescence in human aging Immunol Rev 2005, 205:147-157. 10.1111/j.0105-2896.2005.00259.x 15882351
    • (2005) Immunol Rev , vol.205 , pp. 147-157
    • Effros, R.B.1    Dagarag, M.2    Spaulding, C.3    Man, J.4
  • 28
    • 33644922394 scopus 로고    scopus 로고
    • When T cells get old
    • 10.1126/sageke.2005.50.pe39 16354906
    • Pawelec G When T cells get old Sci Aging Knowledge Environ 2005 2005, 50:pE39. 10.1126/sageke.2005.50.pe39 16354906
    • (2005) Sci Aging Knowledge Environ , vol.2005
    • Pawelec, G.1
  • 29
    • 20344402524 scopus 로고    scopus 로고
    • Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging
    • 10.1111/j.0105-2896.2005.00262.x 15882354
    • Fann M Chiu WK Wood WH Levine BL Becker KG Weng NP Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging Immunol Rev 2005, 205:190-206. 10.1111/ j.0105-2896.2005.00262.x 15882354
    • (2005) Immunol Rev , vol.205 , pp. 190-206
    • Fann, M.1    Chiu, W.K.2    Wood, W.H.3    Levine, B.L.4    Becker, K.G.5    Weng, N.P.6
  • 30
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: How much can the adaptive immune system adapt?
    • 2266981 16713964 10.1016/j.immuni.2006.05.001
    • Weng NP Aging of the immune system: How much can the adaptive immune system adapt? Immunity 2006, 24:495-499. 2266981 16713964 10.1016/ j.immuni.2006.05.001
    • (2006) Immunity , vol.24 , pp. 495-499
    • Weng, N.P.1
  • 32
    • 33646564647 scopus 로고    scopus 로고
    • Aging and innate immunity
    • 10.1016/j.immuni.2006.05.003 16713963
    • Solana R Pawelec G Tarazona R Aging and innate immunity Immunity 2006, 24:491-494. 10.1016/j.immuni.2006.05.003 16713963
    • (2006) Immunity , vol.24 , pp. 491-494
    • Solana, R.1    Pawelec, G.2    Tarazona, R.3
  • 33
    • 0035915803 scopus 로고    scopus 로고
    • Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells
    • 10.1016/S0047-6374(00)00199-8 11164462
    • Tarazona R DelaRosa O Alonso C Ostos B Espejo J Pena J Solana R Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells Mech Ageing Dev 2000, 121:77-88. 10.1016/ S0047-6374(00)00199-8 11164462
    • (2000) Mech Ageing Dev , vol.121 , pp. 77-88
    • Tarazona, R.1    DelaRosa, O.2    Alonso, C.3    Ostos, B.4    Espejo, J.5    Pena, J.6    Solana, R.7
  • 34
    • 0037103256 scopus 로고    scopus 로고
    • Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
    • 12165524
    • Khan N Shariff N Cobbold M Bruton R Ainsworth JA Sinclair AJ Nayak L Moss PA Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals J Immunol 2002, 169:1984-1992. 12165524
    • (2002) J Immunol , vol.169 , pp. 1984-1992
    • Khan, N.1    Shariff, N.2    Cobbold, M.3    Bruton, R.4    Ainsworth, J.A.5    Sinclair, A.J.6    Nayak, L.7    Moss, P.A.8
  • 35
    • 33646161724 scopus 로고    scopus 로고
    • Human cytomegalovirus infection and T cell immunosenescence: A mini review
    • 10.1016/j.mad.2006.01.011 16513159
    • Koch S Solana R Dela Rosa O Pawelec G Human cytomegalovirus infection and T cell immunosenescence: A mini review Mech Ageing Dev 2006, 127:538-543. 10.1016/j.mad.2006.01.011 16513159
    • (2006) Mech Ageing Dev , vol.127 , pp. 538-543
    • Koch, S.1    Solana, R.2    Dela Rosa, O.3    Pawelec, G.4
  • 36
    • 0042206627 scopus 로고    scopus 로고
    • Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
    • 10.1016/S0531-5565(03)00134-7 12915213
    • Ouyang Q Wagner WM Voehringer D Wikby A Klatt T Walter S Muller CA Pircher H Pawelec G Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1) Exp Gerontol 2003, 38:911-920. 10.1016/S0531-5565(03)00134-7 12915213
    • (2003) Exp Gerontol , vol.38 , pp. 911-920
    • Ouyang, Q.1    Wagner, W.M.2    Voehringer, D.3    Wikby, A.4    Klatt, T.5    Walter, S.6    Muller, C.A.7    Pircher, H.8    Pawelec, G.9
  • 38
    • 0037825764 scopus 로고    scopus 로고
    • Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old
    • 10.1023/A:1024580531705 12959217
    • Ouyang Q Wanger WM Wikby A Walter S Aubert G Dodi AI Travers P Pawelec G Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old J Clin Immunol 2003, 23:247-257. 10.1023/A:1024580531705 12959217
    • (2003) J Clin Immunol , vol.23 , pp. 247-257
    • Ouyang, Q.1    Wanger, W.M.2    Wikby, A.3    Walter, S.4    Aubert, G.5    Dodi, A.I.6    Travers, P.7    Pawelec, G.8
  • 39
    • 0032752273 scopus 로고    scopus 로고
    • Biomarkers of immunosenescence within an evolutionary perspective: The challenge of heterogeneity and the role of antigenic load
    • 10.1016/S0531-5565(99)00068-6 10673145
    • Franceschi C Valensin S Fagnoni F Barbi C Bonafe M Biomarkers of immunosenescence within an evolutionary perspective: The challenge of heterogeneity and the role of antigenic load Exp Gerontol 1999, 34:911-921. 10.1016/S0531-5565(99)00068-6 10673145
    • (1999) Exp Gerontol , vol.34 , pp. 911-921
    • Franceschi, C.1    Valensin, S.2    Fagnoni, F.3    Barbi, C.4    Bonafe, M.5
  • 40
    • 23944441502 scopus 로고    scopus 로고
    • T cell development and receptor diversity during aging
    • 16098723
    • Goronzy JJ Weyand CM T cell development and receptor diversity during aging Curr Opin Immunol 2005, 17:468-475. 16098723
    • (2005) Curr Opin Immunol , vol.17 , pp. 468-475
    • Goronzy, J.J.1    Weyand, C.M.2
  • 41
    • 23044433753 scopus 로고    scopus 로고
    • Homeostasis and the age-associated defect of CD4 T cells
    • 10.1016/j.smim.2005.05.007 15964201
    • Swain S Clise-Dwyer K Haynes L Homeostasis and the age-associated defect of CD4 T cells Semin Immunol 2005, 17:370-377. 10.1016/ j.smim.2005.05.007 15964201
    • (2005) Semin Immunol , vol.17 , pp. 370-377
    • Swain, S.1    Clise-Dwyer, K.2    Haynes, L.3
  • 42
    • 27144529078 scopus 로고    scopus 로고
    • Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells
    • 10.1093/intimm/dxh314 16141244
    • Kovaiou RD Weiskirchner I Keller M Pfister G Cioca DP Grubeck-Loebensten B Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells Int Immunol 2005, 17:1359-1366. 10.1093/intimm/dxh314 16141244
    • (2005) Int Immunol , vol.17 , pp. 1359-1366
    • Kovaiou, R.D.1    Weiskirchner, I.2    Keller, M.3    Pfister, G.4    Cioca, D.P.5    Grubeck-Loebensten, B.6
  • 43
    • 17144418549 scopus 로고    scopus 로고
    • Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen
    • 2213095 15781577 10.1084/jem.20041933
    • Haynes L Eaton SM Burns EM Randall TD Swain SL Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen J Exp Med 2005, 201:845-851. 2213095 15781577 10.1084/ jem.20041933
    • (2005) J Exp Med , vol.201 , pp. 845-851
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 44
    • 2942746461 scopus 로고    scopus 로고
    • Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine
    • 15210831
    • Kang I Hong MS Nolasco H Park SH Dan JM Choi JY Craft Kang I Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine J Immunol 2004, 173:673-681. 15210831
    • (2004) J Immunol , vol.173 , pp. 673-681
    • Kang, I.1    Hong, M.S.2    Nolasco, H.3    Park, S.H.4    Dan, J.M.5    Choi, J.Y.6    Craft Kang, I.7
  • 45
    • 14744281718 scopus 로고    scopus 로고
    • Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
    • 1075718 15731261 10.1128/JVI.79.6.3675-3683.2005
    • Almanzar G Schwaiger S Jenewein B Keller M Herndler-Brandstetter D Wurzner R Schonitzer D Grubeck-Lobenstein B Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons J Virol 2005, 79:3675-3683. 1075718 15731261 10.1128/JVI.79.6.3675-3683.2005
    • (2005) J Virol , vol.79 , pp. 3675-3683
    • Almanzar, G.1    Schwaiger, S.2    Jenewein, B.3    Keller, M.4    Herndler-Brandstetter, D.5    Wurzner, R.6    Schonitzer, D.7    Grubeck-Lobenstein, B.8
  • 46
    • 0027252136 scopus 로고
    • CD28- T lymphocytes. antigenic and functional properties
    • 8381831
    • Azuma M Phillips JH Lanier LL CD28- T lymphocytes. antigenic and functional properties J Immunol 1993, 150:1147-1159. 8381831
    • (1993) J Immunol , vol.150 , pp. 1147-1159
    • Azuma, M.1    Phillips, J.H.2    Lanier, L.L.3
  • 47
    • 20344373118 scopus 로고    scopus 로고
    • The role of CD8+ T-cell replicative senescence in human aging
    • 10.1111/j.0105-2896.2005.00259.x 15882351
    • Effros RB Dagarag M Spaulding C Man J The role of CD8+ T-cell replicative senescence in human aging Immunol Rev 2005, 205:147-157. 10.1111/j.0105-2896.2005.00259.x 15882351
    • (2005) Immunol Rev , vol.205 , pp. 147-157
    • Effros, R.B.1    Dagarag, M.2    Spaulding, C.3    Man, J.4
  • 48
    • 0035915803 scopus 로고    scopus 로고
    • Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells
    • 10.1016/S0047-6374(00)00199-8 11164462
    • Tarazona R DelaRosa O Alonso C Ostos B Espejo J Pena J Solana R Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells Mech Ageing Dev 2000, 121:77-88. 10.1016/ S0047-6374(00)00199-8 11164462
    • (2000) Mech Ageing Dev , vol.121 , pp. 77-88
    • Tarazona, R.1    DelaRosa, O.2    Alonso, C.3    Ostos, B.4    Espejo, J.5    Pena, J.6    Solana, R.7
  • 50
    • 20344402524 scopus 로고    scopus 로고
    • Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging
    • 10.1111/j.0105-2896.2005.00262.x 15882354
    • Fann M Chiu WK Wood WH 3rd Levine BL Becker KG Weng NP Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging Immunol Rev 2005, 205:190-206. 10.1111/ j.0105-2896.2005.00262.x 15882354
    • (2005) Immunol Rev , vol.205 , pp. 190-206
    • Fann, M.1    Chiu, W.K.2    Wood III, W.H.3    Levine, B.L.4    Becker, K.G.5    Weng, N.P.6
  • 51
    • 14744281718 scopus 로고    scopus 로고
    • Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
    • 1075718 15731261 10.1128/JVI.79.6.3675-3683.2005
    • Almanzar G Schwaiger S Jenewein B Keller M Herndler-Brandstetter D Wurzner R Schonitzer D Grubeck-Loebenstein B Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons J Virol 2005, 79:3675-3683. 1075718 15731261 10.1128/JVI.79.6.3675-3683.2005
    • (2005) J Virol , vol.79 , pp. 3675-3683
    • Almanzar, G.1    Schwaiger, S.2    Jenewein, B.3    Keller, M.4    Herndler-Brandstetter, D.5    Wurzner, R.6    Schonitzer, D.7    Grubeck-Loebenstein, B.8
  • 52
    • 0034069555 scopus 로고    scopus 로고
    • Age-dependent changes in B lymphocyte development in man and mouse
    • 10.1016/S0531-5565(99)00095-9 10767576
    • Ghia P Melchers F Rolink AG Age-dependent changes in B lymphocyte development in man and mouse Exp Gerontol 2000, 35:159-165. 10.1016/ S0531-5565(99)00095-9 10767576
    • (2000) Exp Gerontol , vol.35 , pp. 159-165
    • Ghia, P.1    Melchers, F.2    Rolink, A.G.3
  • 53
    • 0033050205 scopus 로고    scopus 로고
    • Age-associated defects in B lymphocyte development
    • 10.1016/S0531-5565(99)00023-6 10433397
    • Szabo P Shen S Weksler ME Age-associated defects in B lymphocyte development Exp Gerontol 1999, 34:431-434. 10.1016/S0531-5565(99)00023-6 10433397
    • (1999) Exp Gerontol , vol.34 , pp. 431-434
    • Szabo, P.1    Shen, S.2    Weksler, M.E.3
  • 54
    • 0033962638 scopus 로고    scopus 로고
    • Changes in the B-cell repertoire with age
    • 10.1016/S0264-410X(99)00497-1 10689139
    • Weksler ME Changes in the B-cell repertoire with age Vaccine 2000, 18:1624-1628. 10.1016/S0264-410X(99)00497-1 10689139
    • (2000) Vaccine , vol.18 , pp. 1624-1628
    • Weksler, M.E.1
  • 55
    • 0029918498 scopus 로고    scopus 로고
    • Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice
    • 2192365 8642299 10.1084/jem.183.3.959
    • Yang X Stedra J Cerny J Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice J Exp Med 1996, 183:959-970. 2192365 8642299 10.1084/jem.183.3.959
    • (1996) J Exp Med , vol.183 , pp. 959-970
    • Yang, X.1    Stedra, J.2    Cerny, J.3
  • 56
    • 0031464890 scopus 로고    scopus 로고
    • Immunosenescence and germinal center reaction
    • 10.1111/j.1600-065X.1997.tb01028.x 9476666
    • Zheng B Han S Takahashi Y Kelsoe G Immunosenescence and germinal center reaction Immunol Rev 1997, 160:63-77. 10.1111/j.1600-065X.1997.tb01028.x 9476666
    • (1997) Immunol Rev , vol.160 , pp. 63-77
    • Zheng, B.1    Han, S.2    Takahashi, Y.3    Kelsoe, G.4
  • 57
    • 0023146592 scopus 로고
    • Satisfactory primary tetanus antitoxin responses but markedly reduced germinal centre formation in first draining lymph nodes of ageing mice
    • 1542585 3608229
    • Kraft R Bachmann M Bachmann K Buerki H Hess MW Cottier H Stoner RD Satisfactory primary tetanus antitoxin responses but markedly reduced germinal centre formation in first draining lymph nodes of ageing mice Clin Exp Immunol 1987, 67:447-453. 1542585 3608229
    • (1987) Clin Exp Immunol , vol.67 , pp. 447-453
    • Kraft, R.1    Bachmann, M.2    Bachmann, K.3    Buerki, H.4    Hess, M.W.5    Cottier, H.6    Stoner, R.D.7
  • 58
    • 0029175608 scopus 로고
    • Introduction: The reshaping of the immune system with age
    • 10.3109/08830189509056697 7595010
    • Franceschi C Cossarizza A Introduction: The reshaping of the immune system with age Int Rev Immunol 1995, 12:1-4. 10.3109/08830189509056697 7595010
    • (1995) Int Rev Immunol , vol.12 , pp. 1-4
    • Franceschi, C.1    Cossarizza, A.2
  • 59
    • 23044456776 scopus 로고    scopus 로고
    • Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans
    • 10.1016/j.smim.2005.05.005 15996480
    • Frasca D Riley RL Blomberg BB Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans Semin Immunol 2005, 17:378-384. 10.1016/ j.smim.2005.05.005 15996480
    • (2005) Semin Immunol , vol.17 , pp. 378-384
    • Frasca, D.1    Riley, R.L.2    Blomberg, B.B.3
  • 60
    • 0037198015 scopus 로고    scopus 로고
    • The frail elderly: Role of dendritic cells in the susceptibility of infection
    • 10.1016/S0047-6374(02)00033-7 12044944
    • Uyemura K Castle SC Makinodan T The frail elderly: Role of dendritic cells in the susceptibility of infection Mech Ageing Dev 2002, 123:955-962. 10.1016/S0047-6374(02)00033-7 12044944
    • (2002) Mech Ageing Dev , vol.123 , pp. 955-962
    • Uyemura, K.1    Castle, S.C.2    Makinodan, T.3
  • 61
    • 0026470167 scopus 로고
    • MHC class II-positive microglia in human brain: Association with alzheimer lesions
    • 10.1002/jnr.490330407 1484388
    • Perlmutter LS Scott SA Barron E Chui HC MHC class II-positive microglia in human brain: Association with alzheimer lesions J Neurosci Res 1992, 33:549-558. 10.1002/jnr.490330407 1484388
    • (1992) J Neurosci Res , vol.33 , pp. 549-558
    • Perlmutter, L.S.1    Scott, S.A.2    Barron, E.3    Chui, H.C.4
  • 62
    • 48949117588 scopus 로고    scopus 로고
    • Role of the innate immune system in autoimmune inflammatory demyelination
    • 10.2174/092986708784221458 18473806
    • O'Brien K Fitzgerald DC Naiken K Alugupalli KR Rostami AM Gran B Role of the innate immune system in autoimmune inflammatory demyelination Curr Med Chem 2008, 15:1105-1115. 10.2174/092986708784221458 18473806
    • (2008) Curr Med Chem , vol.15 , pp. 1105-1115
    • O'Brien, K.1    Fitzgerald, D.C.2    Naiken, K.3    Alugupalli, K.R.4    Rostami, A.M.5    Gran, B.6
  • 63
    • 45549097534 scopus 로고    scopus 로고
    • Dynamics of immune cell recruitment during west nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population
    • 18453596
    • Brehin AC Mouries J Frenkiel MP Dadaglio G Despres P Lafon M Couderc T Dynamics of immune cell recruitment during west nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population J Immunol 2008, 180:6760-6767. 18453596
    • (2008) J Immunol , vol.180 , pp. 6760-6767
    • Brehin, A.C.1    Mouries, J.2    Frenkiel, M.P.3    Dadaglio, G.4    Despres, P.5    Lafon, M.6    Couderc, T.7
  • 64
    • 0035116898 scopus 로고    scopus 로고
    • IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice
    • 199261 11181648 10.1172/JCI11696
    • Herrero C Marques L Lloberas J Celada A IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice J Clin Invest 2001, 107:485-493. 199261 11181648 10.1172/JCI11696
    • (2001) J Clin Invest , vol.107 , pp. 485-493
    • Herrero, C.1    Marques, L.2    Lloberas, J.3    Celada, A.4
  • 65
    • 13844301899 scopus 로고    scopus 로고
    • Innate immunity in aging: Impact on macrophage function
    • 10.1111/j.1474-9728.2004.00102.x 15268749
    • Plowden J Renshaw-Hoelscher M Engleman C Katz J Sambhara S Innate immunity in aging: Impact on macrophage function Aging Cell 2004, 3:161-167. 10.1111/j.1474-9728.2004.00102.x 15268749
    • (2004) Aging Cell , vol.3 , pp. 161-167
    • Plowden, J.1    Renshaw-Hoelscher, M.2    Engleman, C.3    Katz, J.4    Sambhara, S.5
  • 66
    • 0036231373 scopus 로고    scopus 로고
    • Influence of ageing on langerhans cell migration in mice: Identification of a putative deficiency of epidermal interleukin-1beta
    • 1782675 11985667 10.1046/j.1365-2567.2002.01381.x
    • Cumberbatch M Dearman RJ Kimber I Influence of ageing on langerhans cell migration in mice: Identification of a putative deficiency of epidermal interleukin-1beta Immunology 2002, 105:466-477. 1782675 11985667 10.1046/ j.1365-2567.2002.01381.x
    • (2002) Immunology , vol.105 , pp. 466-477
    • Cumberbatch, M.1    Dearman, R.J.2    Kimber, I.3
  • 68
    • 0034601309 scopus 로고    scopus 로고
    • Innate immunity
    • 10.1056/NEJM200008033430506 10922424
    • Medzhitov R Janeway C Jr Innate immunity N Engl J Med 2000, 343:338-344. 10.1056/NEJM200008033430506 10922424
    • (2000) N Engl J Med , vol.343 , pp. 338-344
    • Medzhitov, R.1    Janeway Jr., C.2
  • 69
    • 0030730023 scopus 로고    scopus 로고
    • The other side of scavenger receptors: Pattern recognition for host defense
    • 9335951
    • Krieger M The other side of scavenger receptors: Pattern recognition for host defense Curr Opin Lipidol 1997, 8:275-280. 9335951
    • (1997) Curr Opin Lipidol , vol.8 , pp. 275-280
    • Krieger, M.1
  • 70
    • 0032526861 scopus 로고    scopus 로고
    • The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    • 2212359 9625770 10.1084/jem.187.12.2097
    • Muzio M Natoli G Saccani S Levrero M Mantovani A The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6) J Exp Med 1998, 187:2097-2101. 2212359 9625770 10.1084/ jem.187.12.2097
    • (1998) J Exp Med , vol.187 , pp. 2097-2101
    • Muzio, M.1    Natoli, G.2    Saccani, S.3    Levrero, M.4    Mantovani, A.5
  • 71
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • 10.1016/S0898-6568(00)00149-2 11257452
    • Guha M Mackman N LPS induction of gene expression in human monocytes Cell Signal 2001, 13:85-94. 10.1016/S0898-6568(00)00149-2 11257452
    • (2001) Cell Signal , vol.13 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 74
    • 0028597408 scopus 로고
    • Cytokine production and aging: Overproduction of IL-8 in elderly males in response to lipopolysaccharide
    • 10.1016/0047-6374(94)90020-5 7745991
    • Clark JA Peterson TC Cytokine production and aging: Overproduction of IL-8 in elderly males in response to lipopolysaccharide Mech Ageing Dev 1994, 77:127-139. 10.1016/0047-6374(94)90020-5 7745991
    • (1994) Mech Ageing Dev , vol.77 , pp. 127-139
    • Clark, J.A.1    Peterson, T.C.2
  • 75
    • 0031878352 scopus 로고    scopus 로고
    • Quantitative intracellular cytokine measurement: Age-related changes in proinflammatory cytokine production
    • 1905038 9717970 10.1046/j.1365-2249.1998.00641.x
    • O'Mahony L Holland J Jackson J Feighery C Hennessy TP Mealy K Quantitative intracellular cytokine measurement: Age-related changes in proinflammatory cytokine production Clin Exp Immunol 1998, 113:213-219. 1905038 9717970 10.1046/j.1365-2249.1998.00641.x
    • (1998) Clin Exp Immunol , vol.113 , pp. 213-219
    • O'Mahony, L.1    Holland, J.2    Jackson, J.3    Feighery, C.4    Hennessy, T.P.5    Mealy, K.6
  • 77
    • 0032722001 scopus 로고    scopus 로고
    • Phenotypic and functional characteristics of circulating monocytes of elderly persons
    • 10.1016/S0531-5565(99)00065-0 10673149
    • Sadeghi HM Schnelle JF Thoma JK Nishanian P Fahey JL Phenotypic and functional characteristics of circulating monocytes of elderly persons Exp Gerontol 1999, 34:959-970. 10.1016/S0531-5565(99)00065-0 10673149
    • (1999) Exp Gerontol , vol.34 , pp. 959-970
    • Sadeghi, H.M.1    Schnelle, J.F.2    Thoma, J.K.3    Nishanian, P.4    Fahey, J.L.5
  • 78
    • 0033917932 scopus 로고    scopus 로고
    • Increased soluble tumor necrosis factor receptor levels in the serum of elderly people
    • 10.1159/000022157 10859456
    • Hasegawa Y Sawada M Ozaki N Inagaki T Suzumura A Increased soluble tumor necrosis factor receptor levels in the serum of elderly people Gerontology 2000, 46:185-188. 10.1159/000022157 10859456
    • (2000) Gerontology , vol.46 , pp. 185-188
    • Hasegawa, Y.1    Sawada, M.2    Ozaki, N.3    Inagaki, T.4    Suzumura, A.5
  • 79
    • 0036085174 scopus 로고    scopus 로고
    • Chemokine production by natural killer cells from nonagenarians
    • 10.1002/1521-4141(200206)32:6<1524::AID-IMMU1524>3.0.CO;2-E 12115634
    • Mariani E Meneghetti A Neri S Ravaglia G Forti P Cattini L Facchini A Chemokine production by natural killer cells from nonagenarians Eur J Immunol 2002, 32:1524-1529. 10.1002/ 1521-4141(200206)32:6<1524::AID-IMMU1524>3.0.CO;2-E 12115634
    • (2002) Eur J Immunol , vol.32 , pp. 1524-1529
    • Mariani, E.1    Meneghetti, A.2    Neri, S.3    Ravaglia, G.4    Forti, P.5    Cattini, L.6    Facchini, A.7
  • 81
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • 12023394
    • Saurwein-Teissl M Lung TL Marx F Gschosser C Asch E Blasko I Parson W Bock G Schonitzer D Trannoy E Grubeck-Loebenstein B Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines J Immunol 2002, 168:5893-5899. 12023394
    • (2002) J Immunol , vol.168 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3    Gschosser, C.4    Asch, E.5    Blasko, I.6    Parson, W.7    Bock, G.8    Schonitzer, D.9    Trannoy, E.10    Grubeck-Loebenstein, B.11
  • 82
    • 0033844364 scopus 로고    scopus 로고
    • The increase of IFN-gamma production through aging correlates with the expanded CD8(+high)CD28(-)CD57(+) subpopulation
    • 10.1006/clim.2000.4894 10964541
    • Bandres E Merino J Vazquez B Inoges S Moreno C Subira ML Sanchez-Ibarrola A The increase of IFN-gamma production through aging correlates with the expanded CD8(+high)CD28(-)CD57(+) subpopulation Clin Immunol 2000, 96:230-235. 10.1006/clim.2000.4894 10964541
    • (2000) Clin Immunol , vol.96 , pp. 230-235
    • Bandres, E.1    Merino, J.2    Vazquez, B.3    Inoges, S.4    Moreno, C.5    Subira, M.L.6    Sanchez-Ibarrola, A.7
  • 83
    • 0034075938 scopus 로고    scopus 로고
    • Altered Th1/Th2 commitment in human CD4+ T cells with ageing
    • 1905644 10792375 10.1046/j.1365-2249.2000.01224.x
    • Sakata-Kaneko S Wakatsuki Y Matsunaga Y Usui T Kita T Altered Th1/Th2 commitment in human CD4+ T cells with ageing Clin Exp Immunol 2000, 120:267-273. 1905644 10792375 10.1046/j.1365-2249.2000.01224.x
    • (2000) Clin Exp Immunol , vol.120 , pp. 267-273
    • Sakata-Kaneko, S.1    Wakatsuki, Y.2    Matsunaga, Y.3    Usui, T.4    Kita, T.5
  • 84
    • 0032768847 scopus 로고    scopus 로고
    • Age-related defects in Th1 and Th2 cytokine production by human T cells can be dissociated from altered frequencies of CD45RA+ and CD45RO+ T cell subsets
    • 10.1016/S0047-6374(99)00030-5 10515660
    • Karanfilov CI Liu B Fox CC Lakshmanan RR Whisler RL Age-related defects in Th1 and Th2 cytokine production by human T cells can be dissociated from altered frequencies of CD45RA+ and CD45RO+ T cell subsets Mech Ageing Dev 1999, 109:97-112. 10.1016/S0047-6374(99)00030-5 10515660
    • (1999) Mech Ageing Dev , vol.109 , pp. 97-112
    • Karanfilov, C.I.1    Liu, B.2    Fox, C.C.3    Lakshmanan, R.R.4    Whisler, R.L.5
  • 85
    • 0030925869 scopus 로고    scopus 로고
    • Cytokines and impaired CD8+ CTL activity among elderly persons and the enhancing effect of IL-12
    • 10.1016/S0047-6374(96)01855-6 9147358
    • Mbawuike IN Acuna CL Walz KC Atmar RL Greenberg SB Couch RB Cytokines and impaired CD8+ CTL activity among elderly persons and the enhancing effect of IL-12 Mech Ageing Dev 1997, 94:25-39. 10.1016/ S0047-6374(96)01855-6 9147358
    • (1997) Mech Ageing Dev , vol.94 , pp. 25-39
    • Mbawuike, I.N.1    Acuna, C.L.2    Walz, K.C.3    Atmar, R.L.4    Greenberg, S.B.5    Couch, R.B.6
  • 86
    • 0032524973 scopus 로고    scopus 로고
    • Altered cytokine production in the elderly
    • 10.1016/S0047-6374(97)00153-X 9720652
    • Rink L Cakman I Kirchner H Altered cytokine production in the elderly Mech Ageing Dev 1998, 102:199-209. 10.1016/S0047-6374(97)00153-X 9720652
    • (1998) Mech Ageing Dev , vol.102 , pp. 199-209
    • Rink, L.1    Cakman, I.2    Kirchner, H.3
  • 87
    • 0032212474 scopus 로고    scopus 로고
    • Cytokine production after influenza vaccination in a healthy elderly population
    • 10.1016/S0264-410X(98)00140-6 9778748
    • Bernstein ED Gardner EM Abrutyn E Gross P Murasko DM Cytokine production after influenza vaccination in a healthy elderly population Vaccine 1998, 16:1722-1731. 10.1016/S0264-410X(98)00140-6 9778748
    • (1998) Vaccine , vol.16 , pp. 1722-1731
    • Bernstein, E.D.1    Gardner, E.M.2    Abrutyn, E.3    Gross, P.4    Murasko, D.M.5
  • 88
    • 0029128905 scopus 로고
    • The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature
    • 7661497
    • Gross PA Hermogenes AW Sacks HS Lau J Levandowski RA The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature Ann Intern Med 1995, 123:518-527. 7661497
    • (1995) Ann Intern Med , vol.123 , pp. 518-527
    • Gross, P.A.1    Hermogenes, A.W.2    Sacks, H.S.3    Lau, J.4    Levandowski, R.A.5
  • 89
    • 0028048820 scopus 로고
    • The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community
    • 10.1056/NEJM199409223311206 8065407
    • Nichol KL Margolis KL Wuorenma J von Sternberg T The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community N Engl J Med 1994, 331:778-784. 10.1056/ NEJM199409223311206 8065407
    • (1994) N Engl J Med , vol.331 , pp. 778-784
    • Nichol, K.L.1    Margolis, K.L.2    Wuorenma, J.3    von Sternberg, T.4
  • 90
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • 12023394
    • Saurwein-Teissl M Lung TL Marx F Gschosser C Asch E Blasko I Parson W Bock G Schonitzer D Trannoy E Grubeck-Loebenstein B Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines J Immunol 2002, 168:5893-5899. 12023394
    • (2002) J Immunol , vol.168 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3    Gschosser, C.4    Asch, E.5    Blasko, I.6    Parson, W.7    Bock, G.8    Schonitzer, D.9    Trannoy, E.10    Grubeck-Loebenstein, B.11
  • 91
    • 0029917887 scopus 로고    scopus 로고
    • Anti-inflammatory drugs in the fight against alzheimer's disease
    • 10.1111/j.1749-6632.1996.tb34421.x 8624086
    • McGeer PL McGeer EG Anti-inflammatory drugs in the fight against alzheimer's disease Ann N Y Acad Sci 1996, 777:213-220. 10.1111/ j.1749-6632.1996.tb34421.x 8624086
    • (1996) Ann N Y Acad Sci , vol.777 , pp. 213-220
    • McGeer, P.L.1    McGeer, E.G.2
  • 92
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of alzheimer and other neurodegenerative diseases
    • 10.1016/0165-0173(95)00011-9 8866675
    • McGeer PL McGeer EG The inflammatory response system of brain: Implications for therapy of alzheimer and other neurodegenerative diseases Brain Res Brain Res Rev 1995, 21:195-218. 10.1016/ 0165-0173(95)00011-9 8866675
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 93
    • 0034742698 scopus 로고    scopus 로고
    • Artherosclerosis as an infectious, inflammatory and autoimmune disease
    • 10.1016/S1471-4906(01)01922-6 11419409
    • Shoenfeld Y Sherer Y Harats D Artherosclerosis as an infectious, inflammatory and autoimmune disease Trends Immunol 2001, 22:293-295. 10.1016/S1471-4906(01)01922-6 11419409
    • (2001) Trends Immunol , vol.22 , pp. 293-295
    • Shoenfeld, Y.1    Sherer, Y.2    Harats, D.3
  • 94
    • 55549105461 scopus 로고    scopus 로고
    • Neuroprotective Effect of Sanguisorbae Radix against Oxidative Stress-Induced Brain Damage: In Vitro and in Vivo
    • 10.1248/bpb.31.2028 18981568
    • Nguyen TT Cho SO Ban JY Kim JY Ju HS Koh SB Song KS Seong YH Neuroprotective Effect of Sanguisorbae Radix against Oxidative Stress-Induced Brain Damage: In Vitro and in Vivo Biol Pharm Bull 2008, 31:2028-35. 10.1248/bpb.31.2028 18981568
    • (2008) Biol Pharm Bull , vol.31 , pp. 2028-2035
    • Nguyen, T.T.1    Cho, S.O.2    Ban, J.Y.3    Kim, J.Y.4    Ju, H.S.5    Koh, S.B.6    Song, K.S.7    Seong, Y.H.8
  • 95
    • 0028609520 scopus 로고
    • Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease
    • 7832455
    • Smith M Richey P Taneda S Kutty R Sayre L Monnier V Perry G Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease Ann N Y Acad Sci 1994, 738:447-454. 7832455
    • (1994) Ann N Y Acad Sci , vol.738 , pp. 447-454
    • Smith, M.1    Richey, P.2    Taneda, S.3    Kutty, R.4    Sayre, L.5    Monnier, V.6    Perry, G.7
  • 96
    • 0028946289 scopus 로고
    • Radical AGEing in Alzheimer's disease
    • 10.1016/0166-2236(95)93897-7 7778188
    • Smith M Sayre L Monnier V Perry G Radical AGEing in Alzheimer's disease Trends Neurosci 1995, 18:172-176. 10.1016/0166-2236(95)93897-7 7778188
    • (1995) Trends Neurosci , vol.18 , pp. 172-176
    • Smith, M.1    Sayre, L.2    Monnier, V.3    Perry, G.4
  • 97
    • 0029007478 scopus 로고
    • Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease
    • 7539057
    • Smith M Rudnicka-Nawro M Richey P Praprotnik D Mulvihill P Miller C Sayre L Perry G Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease J Neurochem 1995, 64:2660-2666. 7539057
    • (1995) J Neurochem , vol.64 , pp. 2660-2666
    • Smith, M.1    Rudnicka-Nawro, M.2    Richey, P.3    Praprotnik, D.4    Mulvihill, P.5    Miller, C.6    Sayre, L.7    Perry, G.8
  • 99
    • 0030885482 scopus 로고    scopus 로고
    • Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
    • 23283 9275217 10.1073/pnas.94.18.9866
    • Smith M Harris P Sayre L Perry G Iron accumulation in Alzheimer disease is a source of redox-generated free radicals Proc Natl Acad Sci 1997, 94:9866-9868. 23283 9275217 10.1073/pnas.94.18.9866
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 9866-9868
    • Smith, M.1    Harris, P.2    Sayre, L.3    Perry, G.4
  • 100
    • 0346386580 scopus 로고    scopus 로고
    • Widespread peroxynitrite-mediated damage in Alzheimer's disease
    • 9092586
    • Smith M Richey Harris P Sayre L Beckman J Perry G Widespread peroxynitrite-mediated damage in Alzheimer's disease J Neurosci 1997. 17(8):2653-2657. 9092586
    • (1997) J Neurosci , vol.17 , Issue.8 , pp. 2653-2657
    • Smith, M.1    Richey Harris, P.2    Sayre, L.3    Beckman, J.4    Perry, G.5
  • 102
    • 0023642584 scopus 로고
    • Production of superoxide anions by a CNS macrophage, the microglia
    • 10.1016/0014-5793(87)80305-8 2822487
    • Colton C Gilbert D Production of superoxide anions by a CNS macrophage, the microglia FEBS Lett 1987, 223:284-288. 10.1016/0014-5793(87)80305-8 2822487
    • (1987) FEBS Lett , vol.223 , pp. 284-288
    • Colton, C.1    Gilbert, D.2
  • 103
    • 0029902166 scopus 로고    scopus 로고
    • Evidence of neuronal oxidative damage in Alzheimer's disease
    • 1865248 8686745
    • Good P Werner P Hsu A Olanow C Perl D Evidence of neuronal oxidative damage in Alzheimer's disease Am J Pathol 1996, 149:21-28. 1865248 8686745
    • (1996) Am J Pathol , vol.149 , pp. 21-28
    • Good, P.1    Werner, P.2    Hsu, A.3    Olanow, C.4    Perl, D.5
  • 108
    • 33646144212 scopus 로고    scopus 로고
    • Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease
    • 10.1016/j.nbd.2005.11.002 16466929
    • Butterfield A Poon H St Clair D Keller J Pierce W Klein J Markesbery W Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease Neurobiol Dis 2006, 22:223-232. 10.1016/ j.nbd.2005.11.002 16466929
    • (2006) Neurobiol Dis , vol.22 , pp. 223-232
    • Butterfield, A.1    Poon, H.2    St Clair, D.3    Keller, J.4    Pierce, W.5    Klein, J.6    Markesbery, W.7
  • 110
    • 33644987632 scopus 로고    scopus 로고
    • Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment
    • 10.1016/j.neulet.2005.12.017 16413966
    • Butterfield D Reed T Perluigi M De Marco C Coccia R Cini C Sultana R Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment Neurosci Lett 2006, 397:170-173. 10.1016/j.neulet.2005.12.017 16413966
    • (2006) Neurosci Lett , vol.397 , pp. 170-173
    • Butterfield, D.1    Reed, T.2    Perluigi, M.3    De Marco, C.4    Coccia, R.5    Cini, C.6    Sultana, R.7
  • 112
    • 0029795517 scopus 로고    scopus 로고
    • Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of alzheimer's disease neurodegeneration
    • 8858005
    • Lue LF Brachova L Civin WH Rogers J Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of alzheimer's disease neurodegeneration J Neuropathol Exp Neurol 1996, 55:1083-1088. 8858005
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 1083-1088
    • Lue, L.F.1    Brachova, L.2    Civin, W.H.3    Rogers, J.4
  • 115
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • 10.1016/j.neurobiolaging.2004.05.010 15639313
    • Mrak RE Griffin WS Glia and their cytokines in progression of neurodegeneration Neurobiol Aging 2005, 26;349-354. 10.1016/ j.neurobiolaging.2004.05.010 15639313
    • (2005) Neurobiol Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 116
    • 13844281550 scopus 로고    scopus 로고
    • How chronic inflammation can affect the brain and support the development of alzheimer's disease in old age: The role of microglia and astrocytes
    • 10.1111/j.1474-9728.2004.00101.x 15268750
    • Blasko I Stampfer-Kountchev M Robatscher P Veerhuis R Eikelenboom P Grubeck-Loebenstein B How chronic inflammation can affect the brain and support the development of alzheimer's disease in old age: The role of microglia and astrocytes Aging Cell 2004, 3:169-176. 10.1111/ j.1474-9728.2004.00101.x 15268750
    • (2004) Aging Cell , vol.3 , pp. 169-176
    • Blasko, I.1    Stampfer-Kountchev, M.2    Robatscher, P.3    Veerhuis, R.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6
  • 117
    • 0037396614 scopus 로고    scopus 로고
    • Centenarians as a model for healthy aging
    • 10.1042/BST0310457 12653662
    • Franceschi C Bonafe M Centenarians as a model for healthy aging Biochem Soc Trans 2003, 31:457-461. 10.1042/BST0310457 12653662
    • (2003) Biochem Soc Trans , vol.31 , pp. 457-461
    • Franceschi, C.1    Bonafe, M.2
  • 121
    • 23944444792 scopus 로고    scopus 로고
    • Peroxynitrite production and NOS expression in astrocytes U373MG incubated with lipoproteins from alzheimer patients
    • 10.1016/j.brainres.2005.06.025 16054114
    • Nanetti L Vignini A Moroni C Bartolini M Luzzi S Provinciali L Mazzanti L Peroxynitrite production and NOS expression in astrocytes U373MG incubated with lipoproteins from alzheimer patients Brain Res 2005, 1054:38-44. 10.1016/j.brainres.2005.06.025 16054114
    • (2005) Brain Res , vol.1054 , pp. 38-44
    • Nanetti, L.1    Vignini, A.2    Moroni, C.3    Bartolini, M.4    Luzzi, S.5    Provinciali, L.6    Mazzanti, L.7
  • 122
    • 21244461429 scopus 로고    scopus 로고
    • Age-related changes on platelet membrane: A study on elderly and centenarian monozygotic twins
    • Nanetti L Moroni C Vignini A Vannini P Franceschi C Mazzanti L Age-related changes on platelet membrane: A study on elderly and centenarian monozygotic twins Exp Gerontol 2005, 40:519-525. 10.1016/ j.exger.2005.07.002 15935592
    • (2005) Exp Gerontol , vol.40 , pp. 519-525
    • Nanetti, L.1    Moroni, C.2    Vignini, A.3    Vannini, P.4    Franceschi, C.5    Mazzanti, L.6
  • 123
    • 0027316395 scopus 로고
    • Relation between sialic acid concentrations and the haemostatic system in the elderly
    • 1678041 8324435
    • Kario K Matsuo T Relation between sialic acid concentrations and the haemostatic system in the elderly BMJ 1993, 306:1650-1651. 1678041 8324435
    • (1993) BMJ , vol.306 , pp. 1650-1651
    • Kario, K.1    Matsuo, T.2
  • 129
    • 5444275926 scopus 로고    scopus 로고
    • Neopterin in HIV-1 infection
    • 10.1016/j.molimm.2004.06.017 15488607
    • Wirleitner B Schroecksnadel K Winkler C Fuchs D Neopterin in HIV-1 infection Mol Immunol 2005, 42:183-194. 10.1016/j.molimm.2004.06.017 15488607
    • (2005) Mol Immunol , vol.42 , pp. 183-194
    • Wirleitner, B.1    Schroecksnadel, K.2    Winkler, C.3    Fuchs, D.4
  • 131
    • 0032919337 scopus 로고    scopus 로고
    • Increased serum neopterin concentrations in patients with alzheimer's disease
    • 10.1515/CCLM.1999.070 10369114
    • Leblhuber F Walli J Demel U Tilz GP Widner B Fuchs D Increased serum neopterin concentrations in patients with alzheimer's disease Clin Chem Lab Med 1999, 37:429-431. 10.1515/CCLM.1999.070 10369114
    • (1999) Clin Chem Lab Med , vol.37 , pp. 429-431
    • Leblhuber, F.1    Walli, J.2    Demel, U.3    Tilz, G.P.4    Widner, B.5    Fuchs, D.6
  • 132
    • 0033673339 scopus 로고    scopus 로고
    • Elevated plasma neopterin levels in alzheimer disease
    • 10.1097/00002093-200010000-00007 11186601
    • Hull M Pasinetti GM Aisen PS Elevated plasma neopterin levels in alzheimer disease Alzheimer Dis Assoc Disord 2000, 14:228-230. 10.1097/ 00002093-200010000-00007 11186601
    • (2000) Alzheimer Dis Assoc Disord , vol.14 , pp. 228-230
    • Hull, M.1    Pasinetti, G.M.2    Aisen, P.S.3
  • 133
    • 0025806590 scopus 로고
    • Immune system-associated antigens on the surface of peripheral blood lymphocytes in patients with alzheimer's disease
    • 10.1111/j.1600-0447.1991.tb05573.x 1679280
    • Ikeda T Yamamoto K Takahashi K Yamada M Immune system-associated antigens on the surface of peripheral blood lymphocytes in patients with alzheimer's disease Acta Psychiatr Scand 1991, 83:444-448. 10.1111/ j.1600-0447.1991.tb05573.x 1679280
    • (1991) Acta Psychiatr Scand , vol.83 , pp. 444-448
    • Ikeda, T.1    Yamamoto, K.2    Takahashi, K.3    Yamada, M.4
  • 134
    • 0028492819 scopus 로고
    • Studies of neuroimmune markers in alzheimer's disease
    • 10.1007/BF02816106 7534089
    • Singh VK Studies of neuroimmune markers in alzheimer's disease Mol Neurobiol 1994, 9:73-81. 10.1007/BF02816106 7534089
    • (1994) Mol Neurobiol , vol.9 , pp. 73-81
    • Singh, V.K.1
  • 135
    • 0022211456 scopus 로고
    • Senile dementia of alzheimer's type (SDAT): Reduced T8+-cell-mediated suppressor activity
    • 2932656
    • Skias D Bania M Reder AT Luchins D Antel JP Senile dementia of alzheimer's type (SDAT): Reduced T8+-cell-mediated suppressor activity Neurology 1985, 35:1635-1638. 2932656
    • (1985) Neurology , vol.35 , pp. 1635-1638
    • Skias, D.1    Bania, M.2    Reder, A.T.3    Luchins, D.4    Antel, J.P.5
  • 136
    • 0022869089 scopus 로고
    • Immunologic dysfunction: Simultaneous study of alzheimer's and older down's patients
    • 10.1016/0047-6374(86)90043-6
    • Singh VK Fudenberg HH Brown FR 3rd Immunologic dysfunction: Simultaneous study of alzheimer's and older down's patients Mech Ageing Dev 1986 37 257 264 10.1016/0047-6374(86)90043-6 2952844
    • (1986) Mech Ageing Dev , vol.37 , pp. 257-264
    • Singh, V.K.1    Fudenberg, H.H.2    Brown III, F.R.3
  • 137
    • 0021993332 scopus 로고
    • An analysis of T lymphocyte subpopulations in patients with alzheimer's disease
    • 3155531
    • Leffell MS Lumsden L Steiger WA An analysis of T lymphocyte subpopulations in patients with alzheimer's disease J Am Geriatr Soc 1985, 33:4-8. 3155531
    • (1985) J Am Geriatr Soc , vol.33 , pp. 4-8
    • Leffell, M.S.1    Lumsden, L.2    Steiger, W.A.3
  • 138
    • 0029053902 scopus 로고
    • T lymphocyte subpopulations and activation markers correlate with severity of alzheimer's disease
    • 10.1006/clin.1995.1078 7768042
    • Shalit F Sredni B Brodie C Kott E Huberman M T lymphocyte subpopulations and activation markers correlate with severity of alzheimer's disease Clin Immunol Immunopathol 1995, 75:246-250. 10.1006/clin.1995.1078 7768042
    • (1995) Clin Immunol Immunopathol , vol.75 , pp. 246-250
    • Shalit, F.1    Sredni, B.2    Brodie, C.3    Kott, E.4    Huberman, M.5
  • 139
    • 0029830124 scopus 로고    scopus 로고
    • APP peptides stimulate lymphocyte proliferation in normals, but not in patients with alzheimer's disease
    • 10.1016/0197-4580(96)00068-1 8832628
    • Trieb K Ransmayr G Sgonc R Lassmann H Grubeck-Loebenstein B APP peptides stimulate lymphocyte proliferation in normals, but not in patients with alzheimer's disease Neurobiol Aging 1996, 17:541-547. 10.1016/ 0197-4580(96)00068-1 8832628
    • (1996) Neurobiol Aging , vol.17 , pp. 541-547
    • Trieb, K.1    Ransmayr, G.2    Sgonc, R.3    Lassmann, H.4    Grubeck-Loebenstein, B.5
  • 140
    • 0028492819 scopus 로고
    • Studies of neuroimmune markers in alzheimer's disease
    • 10.1007/BF02816106 7534089
    • Singh VK Studies of neuroimmune markers in alzheimer's disease Mol Neurobiol 1994, 9:73-81. 10.1007/BF02816106 7534089
    • (1994) Mol Neurobiol , vol.9 , pp. 73-81
    • Singh, V.K.1
  • 141
    • 58149487275 scopus 로고    scopus 로고
    • P1-369: The impaired suppression function of peripheral blood CD4+ CD25hi regulatory T cells in patients with Alzheimer's disease
    • 10.1016/j.jalz.2008.05.951
    • Xu J Hong Y Shen W Wang L Di Q Zhang Y Sun Y Xu W Hu X P1-369: The impaired suppression function of peripheral blood CD4+ CD25hi regulatory T cells in patients with Alzheimer's disease Alz and dementia 2008, 4:T327. 10.1016/j.jalz.2008.05.951
    • (2008) Alz and Dementia , vol.4
    • Xu, J.1    Hong, Y.2    Shen, W.3    Wang, L.4    Di, Q.5    Zhang, Y.6    Sun, Y.7    Xu, W.8    Hu, X.9
  • 143
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    • 14586007
    • Sastre M Dewachter I Landreth GE Willson TM Klockgether T van Leuven F Heneka MT Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase J Neurosci 2003, 23:9796-9804. 14586007
    • (2003) J Neurosci , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3    Willson, T.M.4    Klockgether, T.5    van Leuven, F.6    Heneka, M.T.7
  • 144
    • 0032621790 scopus 로고    scopus 로고
    • TNFalpha plus IFNgamma induce the production of alzheimer beta-amyloid peptides and decrease the secretion of APPs
    • 9872930
    • Blasko I Marx F Steiner E Hartmann T Grubeck-Loebenstein B TNFalpha plus IFNgamma induce the production of alzheimer beta-amyloid peptides and decrease the secretion of APPs FASEB J 1999, 13:63-68. 9872930
    • (1999) FASEB J , vol.13 , pp. 63-68
    • Blasko, I.1    Marx, F.2    Steiner, E.3    Hartmann, T.4    Grubeck-Loebenstein, B.5
  • 145
    • 0036627214 scopus 로고    scopus 로고
    • Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to alzheimer's disease lesions
    • 10.1016/S1537-1891(02)00198-2 12529925
    • Mackic JB Bading J Ghiso J Walker L Wisniewski T Frangione B Zlokovic BV Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to alzheimer's disease lesions Vascul Pharmacol 2002, 38:303-313. 10.1016/S1537-1891(02)00198-2 12529925
    • (2002) Vascul Pharmacol , vol.38 , pp. 303-313
    • Mackic, J.B.1    Bading, J.2    Ghiso, J.3    Walker, L.4    Wisniewski, T.5    Frangione, B.6    Zlokovic, B.V.7
  • 147
    • 33947178563 scopus 로고    scopus 로고
    • Alzheimer disease, the two-hit hypothesis: An update
    • 17142016
    • Zhu X Lee HG Perry G Smith MA Alzheimer disease, the two-hit hypothesis: an update Biochim Biophys Acta 2007, 1772:494-502. 17142016
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 494-502
    • Zhu, X.1    Lee, H.G.2    Perry, G.3    Smith, M.A.4
  • 148
    • 0031043049 scopus 로고    scopus 로고
    • Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions
    • 10.1007/s004010050617
    • Nagy Z Esiri M Smith A Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions Acta Neuropathol (Berl) 1997, 93:294-300. 10.1007/ s004010050617
    • (1997) Acta Neuropathol (Berl) , vol.93 , pp. 294-300
    • Nagy, Z.1    Esiri, M.2    Smith, A.3
  • 149
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • 1858317 9176387
    • McShea A Harris P Webster K Wahl A Smith M Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease Am J Pathol 1997, 150:1933-1939. 1858317 9176387
    • (1997) Am J Pathol , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.2    Webster, K.3    Wahl, A.4    Smith, M.5
  • 150
    • 0031685160 scopus 로고    scopus 로고
    • Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease
    • 10.1016/S0197-4580(98)00071-2 9733160
    • Vincent J Zheng D Dickson D Kress Y Davies P Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease Neurobiol Aging 1998, 19:287-296. 10.1016/S0197-4580(98)00071-2 9733160
    • (1998) Neurobiol Aging , vol.19 , pp. 287-296
    • Vincent, J.1    Zheng, D.2    Dickson, D.3    Kress, Y.4    Davies, P.5
  • 151
    • 0344241479 scopus 로고    scopus 로고
    • Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    • 12684440
    • Yang Y Mufson E Herrup K Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease J Neurosci 2003, 23:2557-2563. 12684440
    • (2003) J Neurosci , vol.23 , pp. 2557-2563
    • Yang, Y.1    Mufson, E.2    Herrup, K.3
  • 152
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • 8757015
    • McGeer PL Schulzer M McGeer EG Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies Neurology 1996, 47:425-432. 8757015
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 153
    • 0028289083 scopus 로고
    • Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study
    • 8309563
    • Breitner JC Gau BA Welsh KA Inverse association of anti-inflammatory treatments and Alzheimer's disease: Initial results of a co-twin control study Neurology 1994, 44:227-232. 8309563
    • (1994) Neurology , vol.44 , pp. 227-232
    • Breitner, J.C.1    Gau, B.A.2    Welsh, K.A.3
  • 154
    • 0029160270 scopus 로고
    • Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs
    • 10.1016/0197-4580(95)00049-K
    • Breitner JCS Welsh KA Helms MJ Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs Neurobiol Aging 1995 16 523 530 10.1016/0197-4580(95)00049-K 8544901
    • (1995) Neurobiol Aging , vol.16 , pp. 523-530
    • Breitner, J.C.S.1    Welsh, K.A.2    Helms, M.J.3
  • 155
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in Alzheimer's disease
    • 8351023
    • Rogers J Kirby LC Hempelman SR Clinical trial of indomethacin in Alzheimer's disease Neurology 1993, 43:1609-1611. 8351023
    • (1993) Neurology , vol.43 , pp. 1609-1611
    • Rogers, J.1    Kirby, L.C.2    Hempelman, S.R.3
  • 156
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • 10408559
    • Scharf S Mander A Ugoni A A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease Neurology 1999, 53:197-201. 10408559
    • (1999) Neurology , vol.53 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3
  • 157
    • 0034620538 scopus 로고    scopus 로고
    • A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study
    • 10680787
    • Aisen PS Davis KL Berg JD A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study Neurology 2000, 54:588-593. 10680787
    • (2000) Neurology , vol.54 , pp. 588-593
    • Aisen, P.S.1    Davis, K.L.2    Berg, J.D.3
  • 158
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen versus placebo on Alzheimer disease progression: A randomized controlled trial
    • 10.1001/jama.289.21.2819
    • Aisen PS Schafer KA Grundman M Effects of rofecoxib or naproxen versus placebo on Alzheimer disease progression: A randomized controlled trial JAMA 2003 289 2819 2826 10.1001/jama.289.21.2819 12783912
    • (2003) JAMA , vol.289 , pp. 2819-2826
    • Aisen, P.S.1    Schafer, K.A.2    Grundman, M.3
  • 159
    • 21144447586 scopus 로고    scopus 로고
    • A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
    • 10.1038/sj.npp.1300690 15742005
    • Thal LJ Ferris SH Kirby L A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment Neuropsychopharmacology 2005, 30:1204-1215. 10.1038/sj.npp.1300690 15742005
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1204-1215
    • Thal, L.J.1    Ferris, S.H.2    Kirby, L.3
  • 160
    • 34249058674 scopus 로고    scopus 로고
    • Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
    • 10.1212/01.wnl.0000260269.93245.d2 17460158
    • Group AR Lyketsos CG Breitner JC Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial Neurology 2007, 68:1800-1808. 10.1212/01.wnl.0000260269.93245.d2 17460158
    • (2007) Neurology , vol.68 , pp. 1800-1808
    • Group, A.R.1    Lyketsos, C.G.2    Breitner, J.C.3
  • 161
    • 0035845325 scopus 로고    scopus 로고
    • Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: An 18-month randomised, double-blind, placebo- controlled study
    • 10.1016/S0140-6736(01)05623-9 11513909
    • van Gool WA Weinstein HC Scheltens PK Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: An 18-month randomised, double-blind, placebo- controlled study Lancet 2001, 358:455-460. 10.1016/S0140-6736(01)05623-9 11513909
    • (2001) Lancet , vol.358 , pp. 455-460
    • van Gool, W.A.1    Weinstein, H.C.2    Scheltens, P.K.3
  • 162
    • 21544458621 scopus 로고    scopus 로고
    • Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers
    • 10.1097/01.wnf.0000167360.27670.29 15965311
    • Siemers E Skinner M Dean R Gonzales C Satterwhite J Farlow M Ness D May P Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers Clin Neuropharmacol 2005, 28:126-132. 10.1097/01.wnf.0000167360.27670.29 15965311
    • (2005) Clin Neuropharmacol , vol.28 , pp. 126-132
    • Siemers, E.1    Skinner, M.2    Dean, R.3    Gonzales, C.4    Satterwhite, J.5    Farlow, M.6    Ness, D.7    May, P.8
  • 164
    • 33947315426 scopus 로고    scopus 로고
    • Drug evaluation: (R)-flurbiprofen-an enantiomer of flurbiprofen for the treatment of alzheimer's disease
    • 17285465
    • Geerts H Drug evaluation: (R)-flurbiprofen-an enantiomer of flurbiprofen for the treatment of alzheimer's disease IDrugs 2007, 10:121-133. 17285465
    • (2007) IDrugs , vol.10 , pp. 121-133
    • Geerts, H.1
  • 170
    • 0037424110 scopus 로고    scopus 로고
    • Reduction of beta-amyloid plaques in brain of transgenic mouse model of alzheimer's disease by EFRH-phage immunization
    • 10.1016/S0264-410X(02)00609-6 12559780
    • Frenkel D Dewachter I van Leuven F Solomon B Reduction of beta-amyloid plaques in brain of transgenic mouse model of alzheimer's disease by EFRH-phage immunization Vaccine 2003, 21:1060-1065. 10.1016/ S0264-410X(02)00609-6 12559780
    • (2003) Vaccine , vol.21 , pp. 1060-1065
    • Frenkel, D.1    Dewachter, I.2    van Leuven, F.3    Solomon, B.4
  • 172
    • 10744225891 scopus 로고    scopus 로고
    • A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of alzheimer's disease
    • 10.1016/j.nbd.2003.07.005 14678754
    • Zhang J Wu X Qin C Qi J Ma S Zhang H Kong Q Chen D Ba D He W A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of alzheimer's disease Neurobiol Dis 2003, 14:365-379. 10.1016/j.nbd.2003.07.005 14678754
    • (2003) Neurobiol Dis , vol.14 , pp. 365-379
    • Zhang, J.1    Wu, X.2    Qin, C.3    Qi, J.4    Ma, S.5    Zhang, H.6    Kong, Q.7    Chen, D.8    Ba, D.9    He, W.10
  • 175
    • 0036850612 scopus 로고    scopus 로고
    • Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42). Reduced Th1 and enhanced Th2 immunity
    • 10.1016/S0165-5728(02)00307-7 12417433
    • Town T Vendrame M Patel A Poetter D DelleDonne A Mori T Smeed R Crawford F Klein T Tan J Mullan M Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42). Reduced Th1 and enhanced Th2 immunity J Neuroimmunol 2002, 132:49-59. 10.1016/ S0165-5728(02)00307-7 12417433
    • (2002) J Neuroimmunol , vol.132 , pp. 49-59
    • Town, T.1    Vendrame, M.2    Patel, A.3    Poetter, D.4    DelleDonne, A.5    Mori, T.6    Smeed, R.7    Crawford, F.8    Klein, T.9    Tan, J.10    Mullan, M.11
  • 176
    • 0035854603 scopus 로고    scopus 로고
    • Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42
    • 10.1016/S0304-3940(01)01951-6
    • Town T Tan J Sansone N Obregon D Klein T Mullan M Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42 Neurosci Lett 2002, 307:101-104. 10.1016/S0304-3940(01)01951-6
    • (2002) Neurosci Lett , vol.307 , pp. 101-104
    • Town, T.1    Tan, J.2    Sansone, N.3    Obregon, D.4    Klein, T.5    Mullan, M.6
  • 177
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • 10.1126/science.1067568 11910111
    • DeMattos RB Bales KR Cummins DJ Paul SM Holtzman DM Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease Science 2002, 295:2264-2267. 10.1126/ science.1067568 11910111
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 178
    • 28844439301 scopus 로고    scopus 로고
    • Anti-inflammatory effects of human cord blood cells in a rat model of stroke
    • 10.1089/scd.2005.14.595 16305344
    • Vendrame M Anti-inflammatory effects of human cord blood cells in a rat model of stroke Stem Cells Dev 2005, 14:595-604. 10.1089/scd.2005.14.595 16305344
    • (2005) Stem Cells Dev , vol.14 , pp. 595-604
    • Vendrame, M.1
  • 179
    • 4744341332 scopus 로고    scopus 로고
    • Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume
    • 10.1161/01.STR.0000141681.06735.9b 15322304
    • Vendrame M Cassady J Newcomb J Butler T Pennypacker KR Zigova T Sanberg CD Sanberg PR Willing AE Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume Stroke 2004, 35:2390-2395. 10.1161/ 01.STR.0000141681.06735.9b 15322304
    • (2004) Stroke , vol.35 , pp. 2390-2395
    • Vendrame, M.1    Cassady, J.2    Newcomb, J.3    Butler, T.4    Pennypacker, K.R.5    Zigova, T.6    Sanberg, C.D.7    Sanberg, P.R.8    Willing, A.E.9
  • 184
    • 0032915992 scopus 로고    scopus 로고
    • Activation of microglial cells by the CD40 pathway: Relevance to multiple sclerosis
    • 10.1016/S0165-5728(99)00053-3 10408982
    • Tan J Town T Paris D Placzek A Parker T Crawford F Yu H Humphrey J Mullan M Activation of microglial cells by the CD40 pathway: Relevance to multiple sclerosis J Neuroimmunol 1999, 97:77-85. 10.1016/ S0165-5728(99)00053-3 10408982
    • (1999) J Neuroimmunol , vol.97 , pp. 77-85
    • Tan, J.1    Town, T.2    Paris, D.3    Placzek, A.4    Parker, T.5    Crawford, F.6    Yu, H.7    Humphrey, J.8    Mullan, M.9
  • 185
    • 0032756061 scopus 로고    scopus 로고
    • Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10
    • 10586056
    • Tan J Town T Saxe M Paris D Wu Y Mullan M Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10 J Immunol 1999, 163:6614-6621. 10586056
    • (1999) J Immunol , vol.163 , pp. 6614-6621
    • Tan, J.1    Town, T.2    Saxe, M.3    Paris, D.4    Wu, Y.5    Mullan, M.6
  • 186
    • 0033579382 scopus 로고    scopus 로고
    • Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    • 10.1126/science.286.5448.2352 10600748
    • Tan J Town T Paris D Mori T Suo Z Crawford F Mattson MP Flavell RA Mullan M Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation Science 1999, 286:2352-2355. 10.1126/ science.286.5448.2352 10600748
    • (1999) Science , vol.286 , pp. 2352-2355
    • Tan, J.1    Town, T.2    Paris, D.3    Mori, T.4    Suo, Z.5    Crawford, F.6    Mattson, M.P.7    Flavell, R.A.8    Mullan, M.9
  • 187
    • 0031948066 scopus 로고    scopus 로고
    • Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta
    • 10.1002/(SICI)1521-4141(199808)28:08<2537::AID-IMMU2537>3.0.CO;2-1 9710231
    • Nguyen VT Walker WS Benveniste EN Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta Eur J Immunol 1998, 28:2537-2548. 10.1002/ (SICI)1521-4141(199808)28:08<2537::AID-IMMU2537>3.0.CO;2-1 9710231
    • (1998) Eur J Immunol , vol.28 , pp. 2537-2548
    • Nguyen, V.T.1    Walker, W.S.2    Benveniste, E.N.3
  • 188
    • 0031985336 scopus 로고    scopus 로고
    • Mature microglia resemble immature antigen-presenting cells
    • 10.1002/(SICI)1098-1136(199801)22:1<72::AID-GLIA7>3.0.CO;2-A 9436789
    • Carson MJ Reilly CR Sutcliffe JG Lo D Mature microglia resemble immature antigen-presenting cells Glia 1998, 22:72-85. 10.1002/ (SICI)1098-1136(199801)22:1<72::AID-GLIA7>3.0.CO;2-A 9436789
    • (1998) Glia , vol.22 , pp. 72-85
    • Carson, M.J.1    Reilly, C.R.2    Sutcliffe, J.G.3    Lo, D.4
  • 189
    • 0029978178 scopus 로고    scopus 로고
    • CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis
    • 39826 8637903 10.1073/pnas.93.6.2499
    • Gerritse K Laman JD Noelle RJ Aruffo A Ledbetter JA Boersma WJ Claassen E CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis Proc Natl Acad Sci USA 1996, 93:2499-2504. 39826 8637903 10.1073/pnas.93.6.2499
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2499-2504
    • Gerritse, K.1    Laman, J.D.2    Noelle, R.J.3    Aruffo, A.4    Ledbetter, J.A.5    Boersma, W.J.6    Claassen, E.7
  • 191
    • 27844497059 scopus 로고    scopus 로고
    • Resveratrol promotes clearance of alzheimer's disease amyloid-beta peptides
    • 10.1074/jbc.M508246200 16162502
    • Marambaud P Zhao H Davies P Resveratrol promotes clearance of alzheimer's disease amyloid-beta peptides J Biol Chem 2005, 280:37377-37382. 10.1074/jbc.M508246200 16162502
    • (2005) J Biol Chem , vol.280 , pp. 37377-37382
    • Marambaud, P.1    Zhao, H.2    Davies, P.3
  • 192
    • 25444500410 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in alzheimer transgenic mice
    • 10.1523/JNEUROSCI.1521-05.2005 16177050
    • Rezai-Zadeh K Shytle D Sun N Mori T Hou H Jeanniton D Ehrhart J Townsend K Zeng J Morgan D Hardy J Town T Tan J Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in alzheimer transgenic mice J Neurosci 2005, 25:8807-8814. 10.1523/JNEUROSCI.1521-05.2005 16177050
    • (2005) J Neurosci , vol.25 , pp. 8807-8814
    • Rezai-Zadeh, K.1    Shytle, D.2    Sun, N.3    Mori, T.4    Hou, H.5    Jeanniton, D.6    Ehrhart, J.7    Townsend, K.8    Zeng, J.9    Morgan, D.10    Hardy, J.11    Town, T.12    Tan, J.13
  • 193
    • 33745209915 scopus 로고    scopus 로고
    • ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein
    • 10.1074/jbc.M600617200 16624814
    • Obregon DF Rezai-Zadeh K Bai Y Sun N Hou H Ehrhart J Zeng J Mori T Arendash GW Shytle D Town T Tan J ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein J Biol Chem 2006, 281:16419-16427. 10.1074/jbc.M600617200 16624814
    • (2006) J Biol Chem , vol.281 , pp. 16419-16427
    • Obregon, D.F.1    Rezai-Zadeh, K.2    Bai, Y.3    Sun, N.4    Hou, H.5    Ehrhart, J.6    Zeng, J.7    Mori, T.8    Arendash, G.W.9    Shytle, D.10    Town, T.11    Tan, J.12
  • 194
    • 33751260100 scopus 로고    scopus 로고
    • EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and tat in the presence of IFN-gamma: Role of JAK/STAT1 signaling and implications for HIV-associated dementia
    • 10.1016/j.brainres.2006.09.057 17078933
    • Giunta B Obregon D Hou H Zeng J Sun N Nikolic V Ehrhart J Shytle D Fernandez F Tan J EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and tat in the presence of IFN-gamma: Role of JAK/STAT1 signaling and implications for HIV-associated dementia Brain Res 2006, 1123:216-225. 10.1016/j.brainres.2006.09.057 17078933
    • (2006) Brain Res , vol.1123 , pp. 216-225
    • Giunta, B.1    Obregon, D.2    Hou, H.3    Zeng, J.4    Sun, N.5    Nikolic, V.6    Ehrhart, J.7    Shytle, D.8    Fernandez, F.9    Tan, J.10
  • 196
    • 0141863402 scopus 로고    scopus 로고
    • Overview of dietary flavonoids: Nomenclature, occurrence and intake
    • 14519822
    • Beecher GR Overview of dietary flavonoids: Nomenclature, occurrence and intake J Nutr 2003, 133:3248S-3254S. 14519822
    • (2003) J Nutr , vol.133
    • Beecher, G.R.1
  • 198
    • 0023555979 scopus 로고
    • Radical scavenging by flavonoid antioxidants
    • 10.3109/10715768709065294 3504810
    • Bors W Saran M Radical scavenging by flavonoid antioxidants Free Radic Res Commun 1987, 2:289-294. 10.3109/10715768709065294 3504810
    • (1987) Free Radic Res Commun , vol.2 , pp. 289-294
    • Bors, W.1    Saran, M.2
  • 199
    • 39149120805 scopus 로고    scopus 로고
    • Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    • 10.1016/j.intimp.2007.12.012 18279803
    • Zheng LT Ock J Kwon BM Suk K Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity Int Immunopharmacol 2008, 8:484-494. 10.1016/j.intimp.2007.12.012 18279803
    • (2008) Int Immunopharmacol , vol.8 , pp. 484-494
    • Zheng, L.T.1    Ock, J.2    Kwon, B.M.3    Suk, K.4
  • 200
    • 39149120805 scopus 로고    scopus 로고
    • Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    • 10.1016/j.intimp.2007.12.012 18279803
    • Zheng LT Ock J Kwon BM Suk K Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity Int Immunopharmacol 2008, 8:484-494. 10.1016/j.intimp.2007.12.012 18279803
    • (2008) Int Immunopharmacol , vol.8 , pp. 484-494
    • Zheng, L.T.1    Ock, J.2    Kwon, B.M.3    Suk, K.4
  • 201
    • 21244441184 scopus 로고    scopus 로고
    • The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells
    • 1782165 15946255 10.1111/j.1365-2567.2005.02156.x
    • Kim JS Jobin C The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells Immunology 2005, 115:375-387. 1782165 15946255 10.1111/j.1365-2567.2005.02156.x
    • (2005) Immunology , vol.115 , pp. 375-387
    • Kim, J.S.1    Jobin, C.2
  • 202
    • 34047160496 scopus 로고    scopus 로고
    • Tea polyphenol inhibits allostimulation in mixed lymphocyte culture
    • 10.3727/000000007783472381 17436857
    • Kim JY Kina T Iwanaga Y Noguchi H Matsumura K Hyon SH Tea polyphenol inhibits allostimulation in mixed lymphocyte culture Cell Transplant 2007, 16:75-83. 10.3727/000000007783472381 17436857
    • (2007) Cell Transplant , vol.16 , pp. 75-83
    • Kim, J.Y.1    Kina, T.2    Iwanaga, Y.3    Noguchi, H.4    Matsumura, K.5    Hyon, S.H.6
  • 203
    • 27544437494 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors
    • 10.1562/2005-04-11-RA-487 15938647
    • Mantena SK Roy AM Katiyar SK Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors Photochem Photobiol 2005, 81:1174-1179. 10.1562/2005-04-11-RA-487 15938647
    • (2005) Photochem Photobiol , vol.81 , pp. 1174-1179
    • Mantena, S.K.1    Roy, A.M.2    Katiyar, S.K.3
  • 205
    • 35649010983 scopus 로고    scopus 로고
    • Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis
    • 10.1007/BF02977779 18038905
    • Min K Yoon WK Kim SK Kim BH Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis Arch Pharm Res 2007, 30:1265-1272. 10.1007/BF02977779 18038905
    • (2007) Arch Pharm Res , vol.30 , pp. 1265-1272
    • Min, K.1    Yoon, W.K.2    Kim, S.K.3    Kim, B.H.4
  • 206
    • 7044253578 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4
    • 10.1152/ajpgi.00302.2003 15231486
    • Watson JL Ansari S Cameron H Wang A Akhtar M McKay DM Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4 Am J Physiol Gastrointest Liver Physiol 2004, 287:G954-961. 10.1152/ajpgi.00302.2003 15231486
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Watson, J.L.1    Ansari, S.2    Cameron, H.3    Wang, A.4    Akhtar, M.5    McKay, D.M.6
  • 207
    • 41749111341 scopus 로고    scopus 로고
    • Epigallocatechin-3-O-gallate inhibits TNFalpha-induced monocyte chemotactic protein-1 production from vascular endothelial cells
    • 10.1016/j.lfs.2008.02.018 18397796
    • Ahn HY Xu Y Davidge ST Epigallocatechin-3-O-gallate inhibits TNFalpha-induced monocyte chemotactic protein-1 production from vascular endothelial cells Life Sci 2008, 82:964-968. 10.1016/j.lfs.2008.02.018 18397796
    • (2008) Life Sci , vol.82 , pp. 964-968
    • Ahn, H.Y.1    Xu, Y.2    Davidge, S.T.3
  • 208
    • 33750718502 scopus 로고    scopus 로고
    • Neuroprotective effects of (-)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis
    • 10.1007/s11064-006-9166-z 17021948
    • Xu Z Chen S Li X Luo G Li L Le W Neuroprotective effects of (-)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis Neurochem Res 2006, 31:1263-1269. 10.1007/ s11064-006-9166-z 17021948
    • (2006) Neurochem Res , vol.31 , pp. 1263-1269
    • Xu, Z.1    Chen, S.2    Li, X.3    Luo, G.4    Li, L.5    Le, W.6
  • 209
    • 34548416749 scopus 로고    scopus 로고
    • Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols
    • 10.1189/jlb.0207125 17540733
    • Graff JC Jutila MA Differential regulation of CD11b on gammadelta T cells and monocytes in response to unripe apple polyphenols J Leukoc Biol 2007, 82:603-607. 10.1189/jlb.0207125 17540733
    • (2007) J Leukoc Biol , vol.82 , pp. 603-607
    • Graff, J.C.1    Jutila, M.A.2
  • 211
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, abeta elevation, and amyloid plaques in transgenic mice
    • 10.1126/science.274.5284.99 8810256
    • Hsiao K Chapman P Nilsen S Eckman C Harigaya Y Younkin S Yang F Cole G Correlative memory deficits, abeta elevation, and amyloid plaques in transgenic mice Science 1996, 274:99-102. 10.1126/science.274.5284.99 8810256
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 213
    • 33846037755 scopus 로고    scopus 로고
    • In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from gingko biloba yellow leaves
    • 10.1007/BF02969294 17225453
    • Hyun SK Jung HA Chung HY Choi JS In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from gingko biloba yellow leaves Arch Pharm Res 2006, 29:1074-1079. 10.1007/ BF02969294 17225453
    • (2006) Arch Pharm Res , vol.29 , pp. 1074-1079
    • Hyun, S.K.1    Jung, H.A.2    Chung, H.Y.3    Choi, J.S.4
  • 214
    • 8444250342 scopus 로고    scopus 로고
    • Determination of free radical scavenging activity of quercetin, rutin, luteolin and apigenin in H2O2-treated human ML cells K562
    • 15640946
    • Horvathova K Novotny L Tothova D Vachalkova A Determination of free radical scavenging activity of quercetin, rutin, luteolin and apigenin in H2O2-treated human ML cells K562 Neoplasma 2004, 51:395-399. 15640946
    • (2004) Neoplasma , vol.51 , pp. 395-399
    • Horvathova, K.1    Novotny, L.2    Tothova, D.3    Vachalkova, A.4
  • 215
    • 13844299448 scopus 로고    scopus 로고
    • Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages
    • 10.1016/j.bcp.2004.10.002 15627476
    • Hougee S Sanders A Faber J Graus YM Berg van den WB Garssen J Smit HF Hoijer MA Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/ macrophages Biochem Pharmacol 2005, 69:241-248. 10.1016/ j.bcp.2004.10.002 15627476
    • (2005) Biochem Pharmacol , vol.69 , pp. 241-248
    • Hougee, S.1    Sanders, A.2    Faber, J.3    Graus, Y.M.4    Berg, W.B.5    Garssen, J.6    Smit, H.F.7    Hoijer, M.A.8
  • 216
    • 3242720446 scopus 로고    scopus 로고
    • The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells
    • 10.1016/j.bcp.2004.05.012 15276069
    • Verbeek R Plomp AC van Tol EA van Noort JM The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells Biochem Pharmacol 2004, 68:621-629. 10.1016/j.bcp.2004.05.012 15276069
    • (2004) Biochem Pharmacol , vol.68 , pp. 621-629
    • Verbeek, R.1    Plomp, A.C.2    van Tol, E.A.3    van Noort, J.M.4
  • 218
    • 2642580606 scopus 로고    scopus 로고
    • Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils
    • 10.1159/000078498 15153793
    • Hirano T Higa S Arimitsu J Naka T Shima Y Ohshima S Fujimoto M Yamadori T Kawase I Tanaka T Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils Int Arch Allergy Immunol 2004, 134:135-140. 10.1159/000078498 15153793
    • (2004) Int Arch Allergy Immunol , vol.134 , pp. 135-140
    • Hirano, T.1    Higa, S.2    Arimitsu, J.3    Naka, T.4    Shima, Y.5    Ohshima, S.6    Fujimoto, M.7    Yamadori, T.8    Kawase, I.9    Tanaka, T.10
  • 219
    • 40649085017 scopus 로고    scopus 로고
    • Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation
    • 10.1016/j.bcp.2007.12.019 18261712
    • Hirata Y Masuda Y Kakutani H Higuchi T Takada K Ito A Nakagawa Y Ishii H Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation Biochem Pharmacol 2008, 75:1504-1514. 10.1016/j.bcp.2007.12.019 18261712
    • (2008) Biochem Pharmacol , vol.75 , pp. 1504-1514
    • Hirata, Y.1    Masuda, Y.2    Kakutani, H.3    Higuchi, T.4    Takada, K.5    Ito, A.6    Nakagawa, Y.7    Ishii, H.8
  • 220
    • 39149120805 scopus 로고    scopus 로고
    • Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    • 10.1016/j.intimp.2007.12.012 18279803
    • Zheng LT Ock J Kwon BM Suk K Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity Int Immunopharmacol 2008, 8:484-494. 10.1016/j.intimp.2007.12.012 18279803
    • (2008) Int Immunopharmacol , vol.8 , pp. 484-494
    • Zheng, L.T.1    Ock, J.2    Kwon, B.M.3    Suk, K.4
  • 221
    • 21244441184 scopus 로고    scopus 로고
    • The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells
    • 1782165 15946255 10.1111/j.1365-2567.2005.02156.x
    • Kim JS Jobin C The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells Immunology 2005, 115:375-387. 1782165 15946255 10.1111/j.1365-2567.2005.02156.x
    • (2005) Immunology , vol.115 , pp. 375-387
    • Kim, J.S.1    Jobin, C.2
  • 223
    • 0037736704 scopus 로고    scopus 로고
    • Blueberry supplementation enhances signaling and prevents behavioral deficits in an alzheimer disease model
    • 10.1080/1028415031000111282 12793519
    • Joseph JA Denisova NA Arendash G Gordon M Diamond D Shukitt-Hale B Morgan D Blueberry supplementation enhances signaling and prevents behavioral deficits in an alzheimer disease model Nutr Neurosci 2003, 6:153-162. 10.1080/1028415031000111282 12793519
    • (2003) Nutr Neurosci , vol.6 , pp. 153-162
    • Joseph, J.A.1    Denisova, N.A.2    Arendash, G.3    Gordon, M.4    Diamond, D.5    Shukitt-Hale, B.6    Morgan, D.7
  • 224
    • 33745209915 scopus 로고    scopus 로고
    • ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein
    • 10.1074/jbc.M600617200 16624814
    • Obregon DF Rezai-Zadeh K Bai Y Sun N Hou H Ehrhart J Zeng J Mori T Arendash GW Shytle D Town T Tan J ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein J Biol Chem 2006, 281:16419-16427. 10.1074/jbc.M600617200 16624814
    • (2006) J Biol Chem , vol.281 , pp. 16419-16427
    • Obregon, D.F.1    Rezai-Zadeh, K.2    Bai, Y.3    Sun, N.4    Hou, H.5    Ehrhart, J.6    Zeng, J.7    Mori, T.8    Arendash, G.W.9    Shytle, D.10    Town, T.11    Tan, J.12
  • 225
    • 0033568849 scopus 로고    scopus 로고
    • Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
    • 10479711
    • Joseph JA Shukitt-Hale B Denisova NA Bielinski D Martin A McEwen JJ Bickford PC Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation J Neurosci 1999, 19:8114-8121. 10479711
    • (1999) J Neurosci , vol.19 , pp. 8114-8121
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Bielinski, D.4    Martin, A.5    McEwen, J.J.6    Bickford, P.C.7
  • 226
    • 2342608923 scopus 로고    scopus 로고
    • Midlife dietary intake of antioxidants and risk of late-life incident dementia: The honolulu-asia aging study
    • 10.1093/aje/kwh124 15128608
    • Laurin D Masaki KH Foley DJ White LR Launer LJ Midlife dietary intake of antioxidants and risk of late-life incident dementia: The honolulu-asia aging study Am J Epidemiol 2004, 159:959-967. 10.1093/aje/kwh124 15128608
    • (2004) Am J Epidemiol , vol.159 , pp. 959-967
    • Laurin, D.1    Masaki, K.H.2    Foley, D.J.3    White, L.R.4    Launer, L.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.