Activation of microglial cells by the CD40 pathway: Relevance to multiple sclerosis

Journal of Neuroimmunology

Volumn 97, Issue 1-2, 1999, Pages 77-85

  Tan, Jun ^a   Town, Terrence ^a   Paris, Daniel ^a   Placzek, Andon ^a   Parker, Tim ^a   Crawford, Fiona ^a   Yu, Hua ^b   Humphrey, James ^a   Mullan, Michael ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

CD40; Interferon gamma; Microglia; Multiple sclerosis; Neuron; Tumor necrosis factor alpha

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD40; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL COMMUNICATION; CELLS, CULTURED; CEREBRAL CORTEX; FLOW CYTOMETRY; GAMMA-AMINOBUTYRIC ACID; INTERFERON TYPE II; L-LACTATE DEHYDROGENASE; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICROGLIA; MULTIPLE SCLEROSIS; NEURONS; TRITIUM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032915992     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00053-3     Document Type: Article

References (33)

1. Aloisi F., Penna G., Polazzi E., Minghetti L., Adorini L. CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostalandin E2 secretion by microglia during antigen presentation to Th1 cells. J. Immunol. 162:1999;1384-1391.
2. Armitage R.J., Fanslow W.C., Strockbine L., Sato T.A., Clifford K.N., Macduff R.M., Anderson D.M., Gimpel S.D., Davis-Smith T., Maliszewski C.R., Clark E.A., Smith C.A., Grabstein K.H., Cosman D., Spriggs M.K. Molecular and biological characterization of a murine ligand for CD40. Nature. 357:1992;80-82.
3. Balashov K.E., Smith D.R., Khoury S.J., Hafler D.A., Weiner H.L. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc. Natl. Acad. Sci. USA. 94:1997;599-603.
4. Beck J., Rondot P., Catinot L., Falcoff E., Kirchner H., Wietzerbin J. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbation? Acta. Neurol. Scand. 78:1988;318-323.
5. Blotta M.H., Marshall J.D., DeKruyff R.H., Umetsu D.T. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J. Immunol. 156:1996;3133-3140.
6. Carayanniotis G., Masters S.R., Noelle R.J. Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction. Immunology. 90:1997;421-426.
7. Carson M.J., Reilly C.R., Sutcliffe J.G., Lo D. Mature microglia resemble immature antigen-presenting cells. Glia. 22:1998;72-85.
8. Chao C.C., Hu S., Molitor T.W., Shaskan E.D., Peterson P.K. Activated microglia mediate neuronal cell injury via nitric oxide mechanism. J. Immunol. 149:1992;2736-2741.
9. Corradin S.B., Mauel J., Donini S.D., Quattrocchi E., Ricciardi-Castagnoli P. Inducible nitric oxide synthase activity of cloned murine microglial cells. Glia. 7:1993;255-262.
10. Crucian B.E., Moscinski L.C., Ballester O.F., Androlewicz M.J., Widen R., Yu H. Assessment of plasma cell intracellular TAP-1 and TAP-2 in conjunction with surface MHC class I in patients with multiple myeloma. Brit. J. Haematol. 98:1997;426-432.
11. Dowling P., Husar W., Menonna J., Donnenfeld H., Cook S., Sidhu M. Cell death and birth in multiple sclerosis brain. J. Neurol. Sci. 149:1997;1-11.
12. Foy T.M., Laman J.D., Ledbetter J.A., Aruffo A., Claassen E., Noelle R.J. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180:1994;157-163.
13. Gay F.W., Drye T.J., Dick G.W., Esiri M.M. The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion. Brain. 120:1997;1461-1483.
14. Gerritse K., Laman J.D., Noelle R.J., Aruffo A., Ledbetter J.A., Boersma W.J., Claassen E. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acd. Sci. USA. 93:1996;2499-2504.
15. Grewal I.S., Foellmer H.G., Grewal K.D., Xu J., Hardardottir F., Baron J.L., Janneway Jr., Flavell R.A. Requirement of CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science. 273:1996;1864-1867.
16. Grimaldi L.M., Martino G. Effect of interferon gamma on T lymphocytes from patients with multiple sclerosis. Mult. Scler. 1:1995;S38-S43.
17. Havenith C.E., Askew D., Walker W.S. Mouse resident microglia: isolation and characterization of immnunoregulatory properties with naïve CD4+ and CD8+ T-cells. Glia. 22:1998;348-359.
18. Issazadeh S., Navikas V., Schaub M., Sayegh M., Khoury S. Kinetics of expression costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. J. Immunol. 161:1998;1104-1112.
19. Lane P., Traunecker A., Hubele S., Inui S., Lanzavecchia A., Gray D. Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes. Eur. J. Immunol. 22:1992;2573-2578.
20. Link H. The cytokine storm in multiple sclerosis. Mult. Scler. 4:1998;12-15.
21. Mach F., Schonbeck U., Sukhova G.K., Atkinson E., Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature. 18:1998;1424-1432.
22. Martin R., McFarland H.F., McFarlin D.E. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:1992;153-187.
23. Mazzei G., Edgerton M.D., Losberger C., Lecoanet-Henchoz S., Graber P., Durandy A., Gauchat J.-F., Bernard A., Allet B., Bonnefoy J.-Y. Recombinant soluble trimeric CD40 ligand is biologically active. J. Biol. Chem. 270:1995;7025-7028.
24. Nguyen V.T., Walker W.S., Benveniste E.N. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta. Eur. J. Immunol. 28:1998;2537-2548.
25. Okuda Y., Sakoda S., Fujimura H., Yanagihara T. Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis. J. Neuroimmunol. 73:1997;107-116.
26. Peng X., Kasran A., Warmerdam P.A.M., de Boer M., Ceuppens J.L. Accessory signaling by CD40 for T cell activation: induction of Th1 and Th2 cytokines and synergy with interleukin-12 for interferon-γ production. Eur. J. Immunol. 26:1996;1621-1627.
27. Sarchielli P., Orlacchio A., Vicinanza F., Pelliccioli G.P., Tognoloni M., Saccardi C., Gallai V. Cytokine secretion and nitric oxide production by mononuclear cells of patients with multiple sclerosis. J. Neuoimmunol. 80:1997;76-86.
28. Schluesener H.J., Seid K., Kretzschmar J., Meyermann R. Leukocyte chemotactic factor, a nature ligand to CD4, is expressed by lymphocytes and microglial cells of the MS plaque. J. Neurosci. Res. 15:1996;606-611.
29. Stuber E., Strober W., Neurath M. Blocking the CD40-CD40L interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 183:1996;693-698.
30. Swaiman K.F., Neale E.A., Fitzgerald S.C., Nelson P.G. A method for large-scale production of mouse brain cortical cultures. Dev. Brain Res. 3:1982;361-369.
31. Tan J., Crucian B.E., Chang A.E., Aruga E., Aruga A., Dovhey S.E., Tanigawa K., Yu H. J. Immunother. 21:1998;48-55.
32. Xu J., Fox T.M., Laman J.D., Elliott E.A., Dunn J.J., Waldschmiodt T.J., Elsemore J., Noelle R.J., Flavell R.A. Mice deficient for the CD40 ligand. Immunity. 1:1994;423-431.
33. Vowinckel E., Reutens D., Becher B., Verge G., Evans A., Owens T., Antel J.P. PK 11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J. Neurosci. Res. 15:1997;345-353.