Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-κB, AP-1, and Sp1 activation

Biochemical Pharmacology

Volumn 75, Issue 7, 2008, Pages 1504-1514

  Hirata, Yuki ^a   Masuda, Yutaka ^a   Kakutani, Hideki ^a   Higuchi, Toshiyuki ^a   Takada, Kimihiko ^a   Ito, Akira ^b   Nakagawa, Yoshio ^c   Ishii, Hidemi ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

AP 1; LPS; NF B; Nobiletin; Sp1; Tissue factor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NOBILETIN; NUCLEAR PROTEIN; OLIGONUCLEOTIDE; PLANT EXTRACT; SMALL INTERFERING RNA; THROMBOPLASTIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CELL LINE; CITRUS DEPRESSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; MEDICINAL PLANT; MONOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; CITRUS; FLAVONES; GENE EXPRESSION REGULATION; HUMANS; LIPOPOLYSACCHARIDES; MONOCYTES; NF-KAPPA B; PLANT EXTRACTS; RABBITS; SP1 TRANSCRIPTION FACTOR; THROMBOPLASTIN; TRANSCRIPTION FACTOR AP-1;

EID: 40649085017     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.12.019     Document Type: Article

References (39)

1. Parrillo J.E. Pathogenetic mechanisms of septic shock. N Engl J Med 328 (1993) 1471-1477
2. Thieblemont N., Thieringer R., and Wright S.D. Innate immune recognition of bacterial lipopolysaccharide: dependence on interactions with membrane lipids and endocytic movement. Immunity 8 (1998) 771-777
3. Mackman N. Regulation of the tissue factor gene. FASEB J 9 (1995) 883-889
4. Erlich J., Fearns C., Mathison J., Ulevitch R.J., and Mackman N. Lipopolysaccharide induction of tissue factor expression in rabbits. Infect Immun 67 (1999) 2540-2546
5. Cui M.Z., Parry G.C., Oeth P., Larson H., Smith M., Huang R.P., et al. Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. J Biol Chem 271 (1996) 2731-2739
6. Penn M.S., Cui M.Z., Winokur A.L., Bethea J., Hamilton T.A., DiCorleto P.E., et al. Smooth muscle cell surface tissue factor pathway activation by oxidized low-density lipoprotein requires cellular lipid peroxidation. Blood 96 (2000) 3056-3063
7. Ishii H., Takada K., Higuchi T., and Sugiyama J. Verotoxin-1 induces tissue factor expression in human umbilical vein endothelial cells through activation of NF-kappaB/Rel and AP-1. Thromb Haemost 84 (2000) 712-721
8. Drake T.A., Morrissey J.H., and Edgington T.S. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol 134 (1989) 1087-1097
9. Taylor Jr. F.B., Chang A., Ruf W., Morrissey J.H., Hinshaw L., Catlett R., et al. Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circ Shock 33 (1991) 127-134
10. Hatakeyama K., Asada Y., Marutsuka K., Sato Y., Kamikubo Y., and Sumiyoshi A. Localization and activity of tissue factor in human aortic atherosclerotic lesions. Atherosclerosis 133 (1997) 213-219
11. Hara S., Asada Y., Hatakeyama K., Marutsuka K., Sato Y., Kisanuki A., et al. Expression of tissue factor and tissue factor pathway inhibitor in rats lungs with lipopolysaccharide-induced disseminated intravascular coagulation. Lab Invest 77 (1997) 581-589
12. Ollivier V., Parry G.C., Cobb R.R., de Prost D., and Mackman N. Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells. J Biol Chem 271 (1996) 20828-20835
13. Ishii H., Horie S., Kizaki K., and Kazama M. Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 80 (1992) 2556-2562
14. Pendurthi U.R., Williams J.T., and Rao L.V. Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin. Suppression of activation of transcription factors Egr-1, AP-1, and NF-kappa B. Arterioscler Thromb Vasc Biol 17 (1997) 3406-3413
15. Bierhaus A., Zhang Y., Quehenberger P., Luther T., Haase M., Muller M., et al. The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B. Thromb Haemost 77 (1997) 772-782
16. Dackiw A.P., McGilvray I.D., Woodside M., Nathens A.B., Marshall J.C., and Rotstein O.D. Prevention of endotoxin-induced mortality by antitissue factor immunization. Arch Surg 131 (1996) 1273-1278 discussion 8-9
17. Thijs L.G. Coagulation inhibitor replacement in sepsis is a potentially useful clinical approach. Crit Care Med 28 (2000) S68-S73
18. Abraham E. Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis. Crit Care Med 28 (2000) S31-S33
19. Lin N., Sato T., Takayama Y., Mimaki Y., Sashida Y., Yano M., et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol 65 (2003) 2065-2071
20. Ishiwa J., Sato T., Mimaki Y., Sashida Y., Yano M., and Ito A. A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. J Rheumatol 27 (2000) 20-25
21. Westermarck J., and Kahari V.M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 13 (1999) 781-792
22. Subbaramaiah K., Lin D.T., Hart J.C., and Dannenberg A.J. Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300. J Biol Chem 276 (2001) 12440-12448
23. Poligone B., and Baldwin A.S. Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins. J Biol Chem 276 (2001) 38658-38664
24. Yokoo T., and Kitamura M. Dual regulation of IL-1 beta-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-kappa B and AP-1. Am J Physiol 270 (1996) F123-F130
25. Benbow U., and Brinckerhoff C.E. The AP-1 site and MMP gene regulation: what is all the fuss about?. Matrix Biol 15 (1997) 519-526
26. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 (1983) 55-63
27. Bevilacqua M.P., Pober J.S., Majeau G.R., Cotran R.S., and Gimbrone Jr. M.A. Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 160 (1984) 618-623
28. Schreiber E., Matthias P., Muller M.M., and Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17 (1989) 6419
29. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
30. Conway E.M., Bach R., Rosenberg R.D., and Konigsberg W.H. Tumor necrosis factor enhances expression of tissue factor mRNA in endothelial cells. Thromb Res 53 (1989) 231-241
31. Crossman D.C., Carr D.P., Tuddenham E.G., Pearson J.D., and McVey J.H. The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester. J Biol Chem 265 (1990) 9782-9787
32. Scarpati E.M., and Sadler J.E. Regulation of endothelial cell coagulant properties. Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor. J Biol Chem 264 (1989) 20705-20713
33. Nawroth P.P., Handley D.A., Esmon C.T., and Stern D.M. Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci U S A 83 (1986) 3460-3464
34. Mackman N., Morrissey J.H., Fowler B., and Edgington T.S. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry 28 (1989) 1755-1762
35. Oeth P., Parry G.C., and Mackman N. Regulation of the tissue factor gene in human monocytic cells. Role of AP-1, NF-kappa B/Rel, and Sp1 proteins in uninduced and lipopolysaccharide-induced expression. Arterioscler Thromb Vasc Biol 17 (1997) 365-374
36. Eguchi A., Murakami A., and Ohigashi H. Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. FEBS Lett 580 (2006) 3321-3328
37. Zhang L., Ma Y., Zhang J., Cheng J., and Du J. A new cellular signaling mechanism for angiotensin II activation of NF-kappaB: an IkappaB-independent, RSK-mediated phosphorylation of p65. Arterioscler Thromb Vasc Biol 25 (2005) 1148-1153
38. Pore N., Liu S., Shu H.K., Li B., Haas-Kogan D., Stokoe D., et al. Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell 15 (2004) 4841-4853
39. Chang W.C., and Chen B.K. Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase. Biochem Biophys Res Commun 338 (2005) 117-121