CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: Implications for T cell memory

Mechanisms of Ageing and Development

Volumn 86, Issue 3, 1996, Pages 173-195

  Cossarizza, Andrea ^a   Ortolani, Claudio ^b   Paganelli, Roberto ^c   Barbieri, Daniela ^a   Monti, Daniela ^a   Sansoni, Paolo ^d   Fagiolo, Umberto ^e   Castellani, Gastone ^f   Bersani, Ferdinando ^f   Londei, Marco ^g   Franceschi, Claudio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Ospedale Civile SS Giovanni e Paolo   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Aging; CD45; Centenarians; Immune memory; Longevity; T lymphocytes

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; ISOPROTEIN;

ADOLESCENT; ADULT; AGED; AGING; ANTIGEN EXPRESSION; ARTICLE; CHILD; CYTOFLUOROMETRY; FEMALE; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; IMMUNOPHENOTYPING; LONGEVITY; MALE; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; SCHOOL CHILD; T LYMPHOCYTE SUBPOPULATION;

EID: 15844364600     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/0047-6374(95)01691-0     Document Type: Article

References (83)

1. E.A. Clark and J.A. Ledbetter, Leukocyte surface enzymology: CD45 (LCA, T200) is a protein tyrosine phosphatase. Immunol. Today, 10 (1989) 225-228.
2. M.L. Thomas, The leukocyte common antigen family. Annu. Rev. Immunol., 7 (1989) 339-369.
3. C. Morimoto, N.L. Letvin, A.W. Boyd, M. Hagan, H.M. Brown, M.M. Kornacki and S.F. Schlossman, The isolation and characterization of the human helper inducer T cell subset. J. Immunol., 134 (1985) 3762-3769.
4. C. Morimoto, N.L. Letvin, A. Distaso, W.R. Aldrich and S.F. Schlossman, The isolation and characterization of the human suppressor inducer T cell subset. J. Immunol., 134 (1985) 1508-1515.
5. A. Smith, M.H. Brown, D. Rowe, R.E. Callard and P.C.L. Beverley, Functional subsets of human helper-inducer cells defined by a new mAb, UCHL1. Immunology, 58 (1986) 63-70.
6. A.N. Akbar, L. Terry, P.C.L. Beverley and G. Janossy, Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J. Immunol., 140 (1988) 2171-2178.
7. M.E. Sanders, M.W. Makgoba, S.O. Sharrow, D. Stephany, T.A. Springer, H.A. Young and S. Shaw, Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2 and LFA-1) and three other molecules (UCHL-1, CDw29 and Pgp-1) and have enhanced IFN-γ production. J. Immunol., 140 (1988) 1401-1407.
8. J.C. Cerottini and H.R. MacDonald, The cellular basis of T-cell memory. Annu. Rev. Immunol., 7 (1989) 77-89.
9. P.C.L. Beverley, Human T-cell memory. In D. Gray and J. Sprent (eds.), Immunological Memory, Springer-Verlag, Berlin, 1990, pp. 111-122.
10. S.A. Brod, C.E. Rudd, M. Purvee and D.A. Hafler, Lymphokine regulation of CD45R expression on human T cell clones. J. Exp. Med., 170 (1989) 2147-2152.
11. E.B. Bell and S.M. Sparshott, Interconversion of CD45R subsets of CD4 T cells in vivo. Nature, 348 (1990) 163-166.
12. L.M. Pilarski and J.P. Deans, Selective expression of CD45 isoforms and of maturation antigens during human thymocyte differentiation: observations and hypothesis. Immunol. Lett., 21 (1989) 187-198.
13. R. Landesberg, M. Fallon and R. Insel, Alterations in helper-inducer and suppression-inducer T-cell subsets in human neonatal blood. Immunology, 65 (1988) 323-325.
14. + T cells in healthy human children. Clin. Immunol. Immunopathol., 52 (1989) 341-345.
15. + helper/inducer lymphocyte subset of neonates. Clin. Immunol. Immunopathol., 51 (1989) 426-435.
16. + T cells. Eur. J. Immunol., 19 (1989) 771-773.
17. Y. Osugi, J. Hara, H. Kurahashi, N. Sakata, M. Inoue, K. Yumura-Yagi, K. Kawa-Ha, S. Okada and A. Tawa, Age-related changes in surface antigens on peripheral lymphocytes of healthy children. Clin. Exp. Immunol., 100 (1995) 543-548.
18. C. Franceschi, D. Monti, P. Sansoni and A. Cossarizza, The immunology of exceptional individuals: the lesson of centenarians. Immunol. Today, 16 (1995) 12-16.
19. P. Sansoni, V. Brianti, F. Fagnoni, G. Snelli, A. Marcato, G. Passeri, D. Monti, A. Cossarizza and C. Franceschi, NK cell activity and T-lymphocyte proliferation in healthy centenarians. Ann. N.Y. Acad. Sci., 663 (1992) 505-507.
20. D. Monti, L. Troiano, E. Grassilli, C. Agnesini, F. Tropea, D. Barbieri, M. Capri, S. Salvioli, I. Ronchetti, G. Bellomo, A. Cossarizza and C. Franceschi, Cell proliferation and cell death in immunosenescence. Ann. N.Y. Acad. Sci., 663 (1992) 250-261.
21. P. Sansoni, A. Cossarizza, V. Brianti, F. Fagnoni, G. Snelli, D. Monti, A. Marcato, G. Passeri, C. Ortolani, E. Forti, U. Fagiolo, M. Passeri and C. Franceschi, Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood, 80 (1993) 2767-2773.
22. S. De Paoli, S. Battistini and G.F. Santini, Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population. CHn. Immunol. Immunopathol, 48 (1988) 290-296.
23. + T cell subsets in human peripheral blood. Mech. Ageing Dev., 63 (1992) 57-68.
24. G.J. Ligthart, J.X. Corberand, C. Fournier, P. Garanaud, W. Hijmans, B. Kennes, H.K. Müller-Hermelink and G.G. Steinmann, Admission criteria for immunogerontological studies in man: the Senieur Protocol. Mech. Ageing Dev., 28 (1984) 47-55.
25. G.J. Ligthart, J.X. Corberand, H.G.M. Geertzen, A.E. Meinders, D.L. Knook and W. Hijmans, Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR Protocol. Mech. Ageing Dev., 55 (1990) 89-97.
26. A. Cossarizza, C. Ortolani, E. Forti, G. Montagnani, R. Paganelli, M. Zannotti, M. Marini, D. Monti and C. Franceschi, Age-related expansion of functionally inefficient cells with markers of NK activity in Down's syndrome. Blood, 77 (1991) 1263-1270.
27. + T cells. Implications for positive selection of T cells in man. Eur. J. Immunol., 21 (1991) 1571-1574.
28. + T lymphocytes and functional integrity of T cell repertoire during acute HIV syndrome. AIDS, 9 (1995) 547-554.
29. A. Cossarizza, C. Ortolani, C. Mussini, V. Borghi, G. Guaraldi, N. Mongiardo, E. Bellesia, M.G. Franceschini, B. De Rienzo and C. Franceschi, Massive activation of immune cells with an intact T cell repertoire in acute HIV syndrome. J. Infect. Dis., 172 (1995) 105-112.
30. L.L. Lanier, A.M. Le, J.H. Phillips, N.L. Warner and G.F. Babcock, Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J. Immunol., 131 (1983) 1789-1796.
31. +) T lymphocytes in human peripheral blood. Biochem. Biophys. Res. Commun., 191 (1993) 601-609.
32. + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura. Clin. Immunol. Immunopathol., 52 (1989) 473-485.
33. + lymphocytes in physically active adults. Eur. J. Immunol., 23 (1993) 2704-2706.
34. +) T cell populations. Clin. Exp. Immunol., 86 (1991) 500-505.
35. R. Schwinzer and K. Wonigeit, Genetically determined lack of CD45R-T cells in healthy individuals. Evidence for a regulatory polymorphism of CD45R antigen expression. J. Exp. Med., 171 (1990) 1803-1808.
36. M. Kronenberg, G. Siu, L.E. Hood and N. Shastri, The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu. Rev. Immunol., 4 (1986) 529-591.
37. P. Marrack and J. Kappler, The T cell receptor. Science, 238 (1987) 1073-1079.
38. C. Chothia, D.R. Boswell and A.M. Lesk, The outline structure of the T-cell alpha beta receptor. EMBO J, 7 (1988) 3745-3755.
39. M.M. Davis, T cell receptor gene diversity and selection. Annu. Rev. Biochem., 59 (1990) 475-496.
40. A. Weiss, Molecular and genetic insights into T cell antigen receptor structure and function. Annu. Rev. Genet., 25 (1991) 487-510.
41. M.M. Davis and P.J. Bjorkman, T-cell antigen receptor genes and T-cell recognition. Nature, 334 (1988) 395-402.
42. G.V.J. Nossal, Negative selection of lymphocytes. Cell, 76 (1994) 229-239.
43. H. Von Boehmer, Positive selection of T lymphocytes. Cell, 76 (1994) 219-228.
44. M. Merkenschlager, L. Terry, R. Edwards and P.C.L. Beverley, Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation. Eur. J. Immunol., 18 (1988) 1653-1659.
45. A.N. Akbar, M. Salmon and G. Janossy, The sinergy between naive and memory T cells during activation. Immunol. Today, 12 (1991) 184-188.
46. F. Celada, The cellular basis of the immunologic memory. Prog. Allergy, 15 (1971) 223-267.
47. J.A. Byrne, J.L. Butler and M.D. Cooper, Differential activation requirements for virgin and memory T cells. J. Immunol., 141 (1988) 3249-3257.
48. D. Gray and P. Matzinger, T cell memory is short-lived in the absence of antigen. J. Exp. Med., 174 (1991) 969-974.
49. P.C.L. Beverley, Is T-cell memory maintained by crossreactive stimulation? Immunol. Today, 11 (1991) 203-205.
50. C.R. Mackay, T-cell memory: the connection between function, phenotype and migration pathways. Immunol. Today, 12 (1991) 189-192.
51. D.F. Tough and J. Sprent, Turnover of naive- and memory-phenotype T cells. J. Exp. Med., 179 (1994) 1127-1135.
52. C. Michie, A. McLean, C. Alcock and B. P.C.L., Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature, 360 (1992) 264-265.
53. R. Gonzalez-Quintial and A.N. Theofilopoulos, V beta gene repertoires in aging mice. J. Immunol., 149 (1992) 230-236.
54. J.E. Callahan, J.W. Kappler and P. Marrack, Unexpected expansions of CD8-bearing cells in old mice. J. Immunol., 151 (1993) 6657-6669.
55. D.N. Posnett, R. Sinha, S. Kabak and C. Russo, Clonal population of T cell in normal elderly humans: the T cell equivalent to 'benign monoclonal gammapathy'. J. Exp. Med., 179 (1994) 609-618.
56. A. Cossarizza, D. Barbieri and M. Londei, T cell repertoire usage in humans, from newborns to centenarians. Int. Rev. Immunol., 12 (1995) 41-55.
57. C. Franceschi, D. Monti, M.R. Scarfi, O. Zeni, P. Temperani, G. Emilia, P. Sansoni, M.B. Lioi, L. Troiano, C. Agnesini, S. Salvioli and A. Cossarizza, Genomic instability and aging. Studies in centenarians (successful aging) and in Down's syndrome patients (accelerated aging). Ann. N.Y. Acad. Sci., 663 (1992) 4-16.
58. C. Franceschi and A. Cossarizza, Introduction: the reshaping of immune system with age. Int. Rev. Immunol., 12 (1995) 1-3.
59. C. Franceschi, D. Monti, D. Barbieri, S.S.P. Negro, M. Capri, M. Guido, R. Azzi, S.P.R. Paganelli, U. Fagiolo, G. Baggio, S. Donazzan, S. Mariotti, S. D'Addato, A. Gaddi, C. Ortolani and A. Cossarizza, Immunosenescence in humans: deterioration or remodelling? Int. Rev. Immunol., 12 (1995) 57-74.
60. G.G. Steinmann, B. Klaus and H.-K. Mueller-Hermelink, The involution of the ageing human thymic epithelium is independent of puberty. Scand. J. Immunol., 22 (1985) 563-575.
61. M. Hartwig and G. Steinmann, On a causal mechanism of chronic thymic involution in man. Mech. Ageing Dev., 75 (1994) 151-156.
62. C.R. Mackay, W.L. Marston and L. Dudler, Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med., 171 (1990) 801-817.
63. + T cell line. J. Immunol., 146 (1991) 1175-1183.
64. + T cell clones. J. Immunol., 143 (1989) 907-912.
65. F. Bettens, C. Walker, J.-F. Gauchat, D. Gauchat, T. Wyss and W.J. Pichler, Lymphokine gene expression related to CD4 T cell subset (CD45R/CDw29) phenotype conversion. Eur. J. Immunol., 19 (1989) 1569-1574.
66. T.R. Mosmann and R.L. Coffman, Heterogeneity of cytokine secretion patterns and helper T cells. Adv. Immunol., 46 (1989) 111-147.
67. N. Fabris, E. Mocchegiani, L. Amadio, M. Zannotti, F. Licastro and C. Franceschi, Thymic hormone deficiency in normal ageing and in Down's syndrome: is there a primary failure of the thymus? Lancet, i (1984) 983-986.
68. D. Gray, Immunological memory. Annu. Rev. Immunol., 11 (1993) 49-77.
69. E. Vörös, C. Robert and A.M. Robert, Age-related changes of the human skin surface microrelief. Gerontology, 36 (1990) 276-285.
70. J.R. Carey, P. Liedo, D. Orozco and J.W. Vaupel, Slowing of mortality rates at older ages in large medfly cohorts. Science, 238 (1992) 457-461.
71. J.W. Curtsinger, H.H. Fukui, D.R. Townsend and J.W. Vaupel, Demography of genotypes: failure of the limited life-span paradigm in Drosophila melanogaster. Science, 258 (1992) 461-463.
72. C. Doyle and J.L. Strominger, Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature, 330 (1987) 256-259.
73. J.R. Parnes, Molecular biology and function of CD4 and CD8. Adv. Immunol., 44 (1989) 265-311.
74. M.T. Sweetser, L.A. Morrison, V.L. Braciale and T.J. Braciale, Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells. Nature, 342 (1989) 180-182.
75. + T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon-γ can be definited by the Leu-18 and UCHL1 monoclonal antibodies. Eur. J. Immunol., 18 (1988) 1173-1178.
76. - lymphocytes. Clin. Exp. Immunol., 81 (1991) 149-155.
77. high T cell population. Eur. J. Immunol., 23 (1993) 1057-1063.
78. + T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression, a phenotype of primed T cells. J. Immunol., 150 (1993) 429-437.
79. D. Unutmaz, P. Pileri and S. Abrignani, Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med., 180 (1994) 1159-1164.
80. A.N. Akbar, N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J.E. Grundy and G. Janossy, The significance of low bcl-2 expression by CD45R0 T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J. Exp. Med., 178 (1993) 427-438.
81. A.N. Akbar, M. Salmon, J. Savill and G. Janossy, A possible role for bcl-2 in regulating T-cell memory - a 'balancing act' between cell death and survival. Immunol. Today, 14 (1993) 526-535.
82. M. Salmon, D. Pilling, N.J. Borthwick, N. Viner, G. Janossy, P.A. Bacon and A.N. Akbar, The progressive differentiation of primed T cells is associated with an increased susceptibility to apoptosis. Eur. J. Immunol., 24 (1994) 892-899.
83. G. Nuñez, R. Merino, D. Grillot and M. Gonzales-Garcia, Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. Immunol. Today, 15 (1994) 582-588.