Biomarkers of immunosenescence within an evolutionary perspective: The challenge of heterogeneity and the role of antigenic load

Experimental Gerontology

Volumn 34, Issue 8, 1999, Pages 911-921

  Franceschi, Claudio ^a,b   Valensin, Silvana ^a   Fagnoni, Francesco ^c   Barbi, Cristiana ^a   Bonafè, Massimiliano ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b INRCA   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

Aging; Centenarians; Immunosenescence; Longevity; Replicative senescence

Indexed keywords

ANTIGEN; BIOLOGICAL MARKER; CD28 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; IMMUNOGLOBULIN; INTERLEUKIN 6; MITOCHONDRIAL DNA; OXYGEN; T LYMPHOCYTE RECEPTOR;

AGING; CELL TYPE; HYPOTHESIS; IMMUNE SYSTEM; LIFESPAN; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENESCENCE; STRESS; T LYMPHOCYTE; TELOMERE;

AGING; ANTIGENS; BIOLOGICAL MARKERS; EVOLUTION; HUMANS; IMMUNE SYSTEM; VARIATION (GENETICS);

INVERTEBRATA; VERTEBRATA;

EID: 0032752273     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(99)00068-6     Document Type: Review

References (52)

1. Amadori A., Zamarchi R., De Silvestro G., Forza G., Cavatton G., Danieli G.A., Clementi M., Chieco-Bianchi L. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat Med. 1:1995;1279-1283.
2. Aspinall R., Carroll J., Jiang S. Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood. Exp Gerontol. 33:1998;581-591.
3. Baggio G., Donazzan S., Monti D., Mari D., Martini S., Gabelli C., Dalla Vestra M., Previato L., Guido M., Pigozzo S., Cortella I., Crepaldi G., Franceschi C. Lipoprotein(a) and lipoprotein profile in healthy centenarians a reappraisal of vascular risk factors . FASEB J. 12:1998;433-437.
4. Bagnara, G. P., Bonsi, L., Strippoli, P., Bonifazi, F., Tonelli, R., D'Addato, S., Paganelli, R., Scala, E., Fagiolo, U., Monti, D., Cossarizza, A., Bonafé, M., & Franceschi, C. Hemopoiesis in healthy old people and centenarians: well maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network. J. Gerontol., in press.
5. Bonafè M., Olivieri F., Mari D., Baggio D., Mattace R., Sansoni P., De Benedictis G., De Luca M., Bertolini S., Monti D., Franceschi C. p53 variants predisposing to cancer are present in healthy centenarians. Am J Hum Genet. 64:1999;292-295.
6. Cossarizza A., Ortolani C., Forti E., Montagnani G., Paganelli R., Zannotti M., Marini M., Monti D., Franceschi C. Age-related expansion of functionally inefficient cells with markers of NK activity in Down's syndrome. Blood. 77:1991;1263-1270.
7. Cossarizza A., Ortolani C., Monti D., Franceschi C. Cytometric analysis of immunosenescence. Cytometry. 27:1997;297-313.
8. Cristofalo V.J. Cell culture aging insights for cell aging in vivo? Aging Clin Exp Res. 11:1999;1-3.
9. De Benedictis G., Rose G., Carrieri G., De Luca M., Falcone E., Passarino G., Bonafe M., Monti D., Baggio G., Bertolini S., Mari D., Mattace R., Franceschi C. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J. 13:1999;1532-1536.
10. De Haan G., Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood. 93:1999;3294-3301.
11. Douek D.C., McFarland R.D., Keiser P.H., et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396:1998;690-695.
12. Ershler W.B. Interleukin-6 a cytokine for gerontologists . J Am Geriatr Soc. 41:1993;176-181.
13. Fabris N., Mocchegiani E., Amadio L., Zannotti M., Licastro F., Franceschi C. Thymic hormone deficiency in normal ageing and Down's syndrome is there a primary failure of the thymus? Lancet. 1:1984;983-986.
14. Fagiolo U., Cossarizza A., Scala E., Fanales-Belasio E., Ortolani C., Cozzi E., Monti D., Franceschi C., Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol. 23:1993;2375-2378.
15. Fagnoni F.F., Vescovini R., Mazzola M., Bologna G., Nigro E., Lavagetto G., Franceschi C., Passeri M., Sansoni P. Expansion of cytotoxic CD8+CD28- T cells in healthy ageing people, including centenarians. Immunology. 88:1996;501-507.
16. Ferguson F.G., Wikby A., Maxson P., Olsson J., Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people a comparison between survivors and nonsurvivors . J Gerontol A Biol Sci Med Sci. 50:1995;B378-B382.
17. Ferrucci L., Harris T.B., Guralnik J.M., Tracy R.P., Corti M.C., Cohen H.J., Penninx B., Pahor M., Wallace R., Havlik R.J. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc. 47:1999;639-646.
18. Franceschi C., Licastro F., Paolucci P., Masi M., Cavicchi S., Zannotti M. T and B lymphocyte subpopulations in Down's syndrome. Study on not-institutionalized subjects. J Ment Defic Res. 22:1978;179-181.
19. Franceschi C., Monti D., Barbieri D., et al. Immunosenescence in humans deterioration or remodelling? Int Rev Immunol. 12:1995;57-74.
20. Franceschi C., Monti D., Sansoni P., Cossarizza A. The immunology of exceptional individuals the lesson of centenarians . Immunol Today. 16:1995;12-16.
21. Franceschi C., Ottaviani E. Stress, inflammation and natural immunity in the aging process a new theory . Aging Clin Exp Res. 9:1997;30-31.
22. Franceschi C., Mondello C., Bonafe M., Valensin S., Sansoni P., Sorbi S. Long telomeres and well preserved proliferative vigor in cells from centenarians a contribution to longevity? Aging Clin Exp Res, 11:1999;69-72.
23. Gerli R., Paganelli R., Cossarizza A., Muscat C., Piccolo G., Barbieri D., Mariotti S., Monti D., Bistoni O., Raiola E., Venanzi F.M., & Bertotto A., Franceschi C. Long-term immunologic effects of thymectomy in patients with myasthenia gravis. J Allergy Clin Immunol. 103:1999;865-872.
24. Grassilli E., Bellesia E., Salomoni P., et al. C-fos/c-jun expression and AP-1 activation in skin fibroblasts from centenarians. Biochem Biophys Res Commun. 226:1996;517-523.
25. Harley C.B. Human ageing and telomeres. Ciba Found Symp. 211:1997;129-139.
26. Harris T.B., Ferrucci L., Tracy R.P., Corti M.C., Wacholder S., Ettinger W.H. Jr, Heimovitz H., Cohen H.J., Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 106:1999;506-512.
27. Herrera E., Samper E., Martin-Caballero J., Flores J.M., Lee H.W., Blasco M.A. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18:1999;2950-2960.
28. Hodes R.J. Telomere length, aging, somatic cell turnover. J Exp Med. 19:1999;153-156.
29. Jazwinski S.M. Molecular mechanisms of yeast longevity. Trends Microbiol. 7:1999;247-252.
30. Kapahi P., Boulton M.E., Kirkwood T.B. Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med. 26:1999;495-500.
31. Kosciolek B.A., Rowley P.T. Human lymphocyte telomerase is genetically regulated. Genes Chrom Cancer. 21:1998;124-130.
32. Lee H.W., Blasco M.A., Gottlieb G.J., Horner J.W. 2nd, Greider C.W., DePinho R.A. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:1998;569-574.
33. Maini M.K., Casorati G., Dellabona P., Wack A., Beverley P.C. T-cell clonality in immune responses. Immunol Today. 20:1999;262-266.
34. Mondello C., Petropoulou C., Monti D., Gonos E.S., Franceschi C., Nuzzo F. Telomere length in fibroblasts and blood cells from healthy centenarians. Exp Cell Res. 248:1999;234-242.
35. Monti D., Troiano L., Grassilli E., Agnesini C., Tropea F., Capri M., Ronchetti I., Bellomo G., Cossarizza A., Franceschi C. Cell proliferation and cell death in immunosenescence. Ann NY Acad Sci. 663:1992;250-261.
36. Murasko D.M., Nelson B.J., Matour D., Goonewardene I.M., Kaye D. Heterogeneity of changes in lymphoproliferative ability with increasing age. Exp Gerontol. 26:1991;269-279.
37. Nociari M.M., Telford W., Russo C. Post-thymic development of CD28-CD8+ T cell subset age-associated expansion and shift from memory to naive phenotype . J Immunol. 162:1999;3327-3335.
38. Ottaviani E., Franceschi C. The neuroimmunology of stress from invertebrates to man. Prog Neurobiol. 48:1996;421-440.
39. Ottaviani E., Franceschi C. The invertebrate phagocytic immunocyte clues to a common evolution of immune and neuroendocrine systems . Immunol Today. 18:1997;169-174.
40. Paganelli R., Quinti I., Fagiolo U., Cossarizza A., Ortolani C., Guerra E., Sansoni P., Pucillo L.P., Scala E., Cozzi E., Franceschi C. Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin Exp Immunol. 90:1992;351-354.
41. Pawelec G., Effros R.B., Caruso C., Remarque E., Barnett Y., Solana R. T cells and aging. Front Biosci. 4:1999;D216-D269.
42. Posnett D.N., Edinger J.W., Manavalan J.S., Irwin C., Marodon G. Differentiation of human CD8 T cells implications for in vivo persistence of CD8+CD28- cytotoxic effector clones . Int Immunol. 11:1999;229-241.
43. Rodewald H.R. The thymus in the age of retirement. Nature. 396:1998;630-631.
44. Rudolph K.L., Chang S., Lee H.-W., Blasco M., Gottlieb G.J., Greider C., DePinho R.A. Longevity, stress response and cancer in aging telomerase-deficient mice. Cell. 96:1999;701-712.
45. Rufer N., Brummendorf T.H., Kolvraa S., Bischoff C., Christensen K., Wadsworth L., Schulzer M., Lansdorp P.M. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med. 190:1999;157-167.
46. Sansoni P., Fagnoni F., Vescovini R., Mazzola M., Brianti V., Bologna G., Nigro E., Lavagetto G., Cossarizza A., Monti D., Franceschi C., Passeri M. T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians. Mech Ageing Dev. 96:1997;127-136.
47. Slagboom P.E., Droog S., Boomsma D.I. Genetic determination of telomere size in humans a twin study of three age groups . Am J Hum Genet. 55:1994;876-882.
48. Tesco G., Vergelli M., Grassilli E., Salomoni P., Bellesia E., Sikora E., Radziszewska E., Barbieri D., Latorraca S., Fagiolo U., Santacaterina S., Amaducci L., Tiozzo R., Franceschi C., Sorbi S. Growth properties and growth factor responsiveness in skin fibroblasts from centenarians. Biochem Biophys Res Commun. 244:1998;912-916.
49. Vaziri H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1994). Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA, 91, 9857-9860.
50. Wack A., Cossarizza A., Heltai S., Barbieri D., D'Addato S., Franceschi C., Dellabona P., Casorati G. Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol. 10:1998;1281-1288.
51. Weng N.P., Granger L., Hodes R.J. Telomere lengthening and telomerase activation during human B cell differentiation. Proc Natl Acad Sci USA. 94:1997;10827-10832.
52. Wikby A., Maxson P., Olsson J., Johansson B., Ferguson F.G. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old the Swedish longitudinal OCTO-immune study . Mech Ageing Dev. 102:1998;187-198.