Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis

Archives of Pharmacal Research

Volumn 30, Issue 10, 2007, Pages 1265-1272

  Min, Kyungwon ^a,b   Yoon, Won Kee ^a   Kim, Sang Kyum ^b   Kim, Bong Hee ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

AE; Cytokines; Inflammation; Multiple sclerosis; Silibinin; T helper cells

Indexed keywords

CYTOKINE; GLYCOPROTEIN; IMMUNOSUPPRESSIVE AGENT; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35 55); MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); OLIGODENDROCYTE MYELIN GLYCOPROTEIN; OLIGODENDROCYTE-MYELIN GLYCOPROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; SILIBININ; SILYMARIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; FEMALE; HOSPITALIZATION; LYMPH NODE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PATHOLOGY; SPINAL CORD; SPLEEN; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GLYCOPROTEINS; IMMUNOSUPPRESSIVE AGENTS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYELIN-ASSOCIATED GLYCOPROTEIN; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SEVERITY OF ILLNESS INDEX; SILYMARIN; SPINAL CORD; SPLEEN; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 35649010983     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02980267     Document Type: Article

References (31)

1. Aktas, O., Prozorovski, T., Smorodchenko, A., Savaskan, N., Lauster, R., Kloetzel, P., Infante-Duarte, C., Brocke, S., and Zipp, F., Green tea epigallocatechin-3-gallate mediates T cellular NF-KB inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J. Immunol., 173, 5794-5800 (2004).
2. Bitsch, A., Schuchardt, J., Bunkowski, S., Kuhlmann, T., and Bruck, W., Acute axonal injury in multiple sclerosis. Brain, 123, 1174-1183 (2000).
3. Cudrici, C., Niculescu, T., Niculescu, F., Shin, M. L., and Rus, H., Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement. J. Rehab. Res. Devel., 43, 123-132 (2006).
4. Deep, G., Singh R. P., Agarwal, C., Kroll, D. J., and Agarwal, R., Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene, 25, 1053-1069 (2006).
5. El Behi, M., Dubucquoi, S., Lefranc, D., Zephir, H., De Seze, J., Vermersch, P., and Prin, L., New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Lett., 96, 11-26 (2005).
6. Fazilleau, N., Delarasse, C., Sweenie, C., Anderton, S., Fillatreau, S., Lemonnier, F., Pham-Dinh, D., and Kanellopoulos, J., Persistence of autoreactive myelin oligodendrocyte glycoprotein (MOG)-specific T cell repertoires in MOG-expressing mice. Eur. J. Immunol., 36, 533-543 (2006).
7. Ford, M. and Evavold, B., Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43. Cell. Immunol., 240, 53-61 (2006).
8. Friese, M. and Fugger, L., Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain, 128, 1747-1763 (2005).
9. Gay, F., Drye, T., Dick, G., and Esiri, M., The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Brain, 120, 1461-1483 (1997).
10. Goverman, J., Perchellet, A., and Huseby, E., The role of CD8+ T cells in multiple sclerosis and its animal models. Curr. Drug Targets Inflamm. Allergy, 4, 239-245 (2005).
11. Hendrikes, J., Alblas, J., van der Pol, S., van Tol, E., Dijkstra, C., and de Vries, H., Flavonoids influence monocytic GTPase activity and Are protective in experimental allergic encephalitis. J. Exp. Med., 200, 1667-1672 (2004).
12. Imitola, J., Chitnis, T., and Khoury, S., Cytokines in multiple sclerosis: from bench to bedside. Pharmacol. Therap., 106, 163-177 (2005).
13. Jacobs, B., Dennehy, C., Ramirez, G., Sapp, J., and Lawrence, V., Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am. J. Med., 113, 506-515 (2002).
14. Johnson, V., He, Q., Osuchowski, M., and Sharma, R., Physiological responses of a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice. Planta Med., 69, 44-49 (2003).
15. Kang, J. S., Jeon, Y. J., Park, S. K., Yang, K. H., and Kim, H. M., Protection against lipopolysaccharide-lnduced sepsis and inhibition of interleukin-1å and prostaglandin E2 synthesis by silymarin. Biochem. Pharmacol., 67, 175-181 (2003).
16. Kerlero de Rosbo, N. and Ben-Nun, A., T-cell responses to myelin antigens in multiple sclerosis; relevance of the predominant autoimmune reactivity to myelin oligodendrocyte glycoprotein. J. Autoimmun., 11, 287-299 (1998).
17. Khalil, M., Reindl, M., Lutterotti, A., Kuenz, B., Ehling, R., Gneiss, C., Lackner, P., Deisenhammer, F., and Berger, T., Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments. J. Neuroimmunol., 174, 147-56 (2005).
18. Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., and Iwakura, Y., IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol., 177, 566-573 (2006).
19. Kren, V. and Walterova, D., Silybin and silymarin - new effects and applications. Biomed. Papers, 149(1), 29-41 (2005).
20. Kuhlmann, T., Lingfeld, G.,. Bitsch, A., Schuchardt, J., and Bruck, W., Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain, 125, 2202-2212 (2002).
21. Lee, J., Kim, S., Kim, H., Lee, T., Jeong, Y., Lee, C., Yoon, M., Na, Y., Suh, D., Park, N., Choi, I., Kim, G., Choi, Y., Chung, H., and Park, Y., Silibinin polarized Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells. J. Cell. Physiol., (2006).
22. Mandel, M., Gurevich, M., Lavie, G., Cohen, I., and Achiron, A., Unique gene expression patterns in human T-cell lines generated from multiple sclerosis patients by stimulation with a synthetic MOG peptide. Clin. Devel. Immunol., 12(3), 203-209 (2005).
23. Muthian, G. and Bright, J., Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. J. Clin. Immunol., 24, 542-552 (2004).
24. Owens, T., The enigma of multiple sclerosis: inflammation and neurodegeneration cause heterogenous dysfunction and damage. Curr. Opin. Neurol., 16, 259-265 (2003).
25. Schumann, J., Prockl, J., Kiemer, A., Vollmar, A., Bang, R., and Tiegs, G., Silibinin protects mice from T cell-dependent liver injury. J. Hepatol., 39, 333-340 (2003).
26. Stuve, O., Youssef, S., Weber, M., Nessler, S., von Budinger, H., Hemmer, B., Prod'homme, T., Sobel, R., Steinman, L., and Zamvil, S., Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity. J. Clin. Invest., 116(4), 1037-1044 (2006).
27. Sun, D. Newman, T., Perry, V., and Weller, R., Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis. Neuropathol. Appl. Neurobiol., 30, 374-384 (2004).
28. Thelen, P., Jarry, H., Ringert, R., and Wuttke, W., Silibinin down-reglates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells. Planta Med., 70, 397-400 (2004).
29. Van den Broek, H., Damoiseaux, J., de Baets, M., and Hupperts, R., The influence of sex hormones on cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis: a review. Mult. Scier, 11, 349-359 (2005).
30. Zhang, G. X., Yu, S., Gran, B., and Rostami, A., Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response. J. Immunol., 175, 7202-7208 (2005).
31. Zhao, J. and Agarwal, R., Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase Il enzymes: implications in cancer chemoprevention. Carcinogenesis, 20(11), 2101-2108 (1999).