Inflammation, genetics, and longevity: Further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-α-308 promoter SNP [2]

Journal of Medical Genetics

Volumn 40, Issue 4, 2003, Pages 296-299

  Lio, D ^a   Scola, L ^a   Crivello, A ^a   Colonna Romano, G ^a   Candore, G ^a   Bonafe M ^b   Cavallone, L ^a,c   Marchegiani, F ^c   Olivieri, F ^c   Franceschi, C ^b,c   Caruso, C ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c INRCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA; DNA;

AGED; AGING; ALLELE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISABILITY; FEMALE; GENE FREQUENCY; GENETICS; GENOTYPE; HOMOZYGOSITY; HUMAN; INFLAMMATION; LONGEVITY; MALE; MORTALITY; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; AGE; CHEMISTRY; LETTER; MIDDLE AGED;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; DNA; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INFLAMMATION; INTERLEUKIN-10; LONGEVITY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037374849     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Bruunsgaard H, Pedersen M, Pedersen BK. Aging and proinflammatory cytokines. Curr Opin Hematol 2001;8:131-6.
2. Brod SA. Unregulated inflammation shortens human functional longevity. Inflamm Res 2000;49:561-70.
3. Pawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C, Franceschi C, Fulop T, Gupta S, Mariani E, Mocchegiani E, Solana R. T cells and aging, January 2002 update. Front Biosci 2002;7:1056-83.
4. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immunity 1999;1:3-19.
5. Lio D, Scola L, Crivello A, Bonafè M, Franceschi C, Olivieri F, Colonna-Romano G, Candore G, Caruso C. Allele frequencies of +874T→A single nucleotide polymorphism at the first intron of interferon-γ gene in a group of Italian centenarians. Exp Gerontol 2002;37:317-21.
6. Bonafe M, Olivieri F, Cavallone L, Giovagnetti S, Marchegiani F, Cardelli M, Pieri C, Marra M, Antonicelli R, Lisa R, Rizzo MR, Paolisso G, Monti D, Franceschi C. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 2001;31:2357-61.
7. Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafè M, Cavallone L, Franceschi C, Caruso C. Gender specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immunity 2002;3:30-3.
8. Franceschi C, Motta L, Valensin S, Rapisarda R, Franzone A, Berardelli M, Motta M, Monti D, Bonafe M, Ferrucci L, Deiana L, Pes GM, Carru C, Desole MS, Barbi C, Sartoni G, Gemelli C, Lescai F, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Gueresi P, Cossarizza A, Troiano L, Pini G, Sansoni P, Passeri G, Lisa R, Spazzafumo L, Amadio L, Giunta S, Stecconi R, Morresi R, Viticchi C, Mattace R, De Benedictis G, Baggio G. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging (Milano) 2000;12:77-84.
9. Deiana L, Ferrucci L, Pes GM, Carru C, Delitala G, Ganau A, Mariotti S, Nieddu A, Pettinato S, Putzu P, Franceschi C, Baggio G. AKEntAnnos. The Sardinia Study of Extreme Longevity. Aging (Milano) 1999;11:142-9.
10. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001;19:683-765.
11. Makhatadze NJ. Tumor necrosis factor locus: genetic organisation and biological implications. Hum Immunol 1998;59:571-9.
12. Candore G, Lio D, Colonna Romano G, Caruso C. Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions. Autoimmunity Rev 2002;1:29-35.
13. Lio D, Candore G, Colombo A, Colonna Romano G, Gervasi F, Marino V, Scola L, Caruso C. A genetically determined high setting of TNF-α influences immunological parameters of HLA-B8, DR3 positive subjects: implications for autoimmunity. Hum Immunol 2001;62:705-13.
14. Hutchinson IV, Pravica V, Hajeer A, Sinnott PJ. Identification of high and low responders to allografts. Rev Immunogenet 1999;1:323-33.
15. Eskdale J, Keijsers V, Huizinga T, Gallagher G. Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus. Genes Immunity 1999;1:151-5.
16. Cataldo F, Lio D, Marino V, Scola L, Crivello A, Mulè AM, Corazza GR. Cytokine genotyping (TNF and II-10) in patients with celiac disease and selective IgA deficiency. Am J Gastroenterology (in press).
17. Wilson AG, di Giovine FS, Blakemore AI, Duff GW. Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by Ncol restriction of PCR product. Hum Mol Genet 1992;1:353.
18. Westendorp RG, Langermans JA, Huizinga TW, Verweij CL, Sturk A. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349:170-3.
19. Kube D, Rieth H, Eskdale J, Kremsner PG, Gallagher G. Structural characterisation of the distal 5′ flanking region of the human interleukin-10 gene. Genes Immunity 2001;2:181-90.
20. Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P. Polymorphic haplotypes of the interleukin-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 1999;42:1101-8.
21. Turner D, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 promoter. Eur J Immunogenet 1997;24:1-8.
22. Eskdale J, Gallagher G, Verweij CL, Keijsers V, Westendorp RGJ, Huizinga TWJ. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA 1998;95:9465-70.
23. D'Alfonso S, Rampi M, Rolando V, Giordano M, Momigliano-Richiardi P. New polymorphisms in the IL-10 promoter region. Genes Immunity 2000;1:231-3.
24. Price P, Witt C, Allcock R, Sayer D, Garlepp M, Kok CC, French M, Mallal S, Christiansen F. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol Rev 1999;167:257-74.
25. Hajeer AH, Hutchinson IV. Influence of TNFalpha gene polymorphisms on TNFalpha production and disease. Hum Immunol 2001;62:1191-9.
26. D'Alfonso S, Rampi M, Bocchio D, Colombo G, Scorza-Smeraldi R, Momigliano-Richardi P. Systemic lupus erythematosus candidate genes in the Italian population: evidence for a significant association with interleukin-10. Arthritis Rheum 2000;43:120-8.
27. Helminen M, Lahdenpohja N, Hurme M. Polymorphism of the interleukin-10 gene is associated with susceptibility to Epstein-Barr virus infection. J Infect Dis 1999 ;180:496-9.
28. Wu MS, Huang SP, Chang YT, Shun CT, Chang MC, Lin MT, Wang HP, Lin JT. Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma. J Infect Dis 2002;185:106-9.
29. Howell WM, Turner SJ, Bateman AC, Theaker JM. IL-10 promoter polymorphisms influence tumour development in cutaneous malignant melanoma. Genes Immunity 2001;2:25-31.
30. Hajeer AH, Lazarus M, Turner D, Mageed RA, Vencovsky J, Sinnott P, Hutchinson IV, Ollier WE. IL-10 gene promoter polymorphisms in rheumatoid arthritis. Scand J Rheumatol 1998;27:142-5.
31. Tagore A, Gonsalkorale WM, Pravica V, Hajeer AH, McMahon R, Whorwell PJ, Sinnott PJ, Hutchinson IV. Interleukin-10 (IL-10) genotypes in inflammatory bowel disease. Tissue Antigens 1999;54:386-90.
32. Huizinga TW, Keijsers V, Yanni G, Hall M, Ramage W, Lanchbury J, Pitzalis C, Drossaers-Bakker WK, Westendorp RG, Breedveld FC, Panayi G, Verweij CL. Are differences in interleukin 10 production associated with joint damage? Rheumatology 2000;39:1180-8.
33. Girndt M, Kaul H, Sester U, Ulrich C, Sester M, Georg T, Kohler H. Anti-inflammatory interleukin-10 genotype protects dialysis patients from cardiovascular events. Kidney Int 2002;62:949-55.
34. Shoskes DA, Albakri Q, Thomas K, Cook D. Cytokine polymorphisms in men with chronic prostatitis/chronic pelvic pain syndrome: association with diagnosis and treatment response. J Urol 2002;168:331-5.
35. Lio D, Licastro F, Scola L, Chiappelli M, Grimaldi LM, Crivello A, Coronna-Romano G, Candore G, Franceschi C, Caruso C. Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease. Genes Immunity (in press).
36. Reynard MP, Turner D, Navarrete CV. Allele frequencies of polymorphisms of the tumour necrosis factor-α, interleukin-10, interferon-γ and interleukin-2 genes in a North European Caucasoid group from the UK. Eur J Immunogenet 2000;27:241-9.
37. Witte JS, Palmer LJ, O'Connor RD, Hopkins PJ, Hall JM. Relation between tumour necrosis factor palymarphism TNFalpha-308 and risk of asthma. Eur J Hum Genet 2002;10:82-5.
38. Sakao S, Tatsumi K, Igari H, Watanabe R, Shino Y, Shirasawa H, Kuriyama T. Association of tumor necrosis factor-alpha gene promoter porymorphism with row attenuation areas on high-resolution CT in patients with COPD. Chest 2002;122:416-20.
39. Dalziel B, Gosby AK, Richman RM, Bryson JM, Caterson ID. Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesity. Obes Res 2002;10:401-7.
40. O'Keefe GE, Hybki DL, Munford RS. The G→A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-arpha promoter increases the risk for severe sepsis after trauma. J Trauma 2002;52:817-25.
41. Fernandes H, Koneru B, Fernandes N, Hameed M, Cohen MC, Raveche E, Cohen S. Investigation of promoter polymorphisms in the tumor necrosis factor-alpha and interleukin-10 genes in liver transplant patients. Transplantation 2002;73:1886-91.
42. Heijmans BT, Westendorp RG, Droog S, Kluft C, Knook DL, Slagboom PE. Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort. Genes Immunity 2002;3:225-8.
43. van Dissel JT, van Langevelde P, Westendorp RGJ, Kwappenberg K, Frolich M. Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet 1998;351:950-3.
44. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000;908:244-54.
45. Franceschi C, Valensin S, Lescai F, Olivieri F, Licastro F, Grimaldi LM, Monti D, De Benedictis G, Bonafe M. Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype. Aging 2001;13:163-70.
46. McCusker SM, Curran MD, Dynan KB, McCullagh CD, Urquhart DD, Middleton D, Patterson CC, McIlroy SP, Passmore AP. Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study. Lancet 2001;357:436-9.
47. Wang XY, Hurme M, Jylha M, Hervonen A. Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians. Mech Ageing Dev 2001;123:29-38.
48. Pes GM, Lio D, Carru C, Deiana L, Baggio G, Franceschi C, Ferrucci L, Olivieri F, Scola L, Crivello A, Candore G, Colonna-Romano G, Caruso C. Association between longevity and cytokine gene polymorphisms: a study in Sardinian centenarians. (Submitted).
49. Perneger TV. What's wrong with Bonferroni adjustments? BMJ 1998;316:1236-8.
50. Candore G, Colonna-Romano G, Lio D, Caruso C. Immunological and immunogenetic markers of successful and unsuccessful ageing. Adv Cell Aging Gerontol (in press).