Monocyte cytokine production in an elderly population: Effect of age and inflammation

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 53, Issue 1, 1998, Pages

  Roubenoff, Ronenn ^a,b   Harris, Tamara B ^a   Abad, Leslie W ^c   Wilson, Peter W E ^a   Dallal, Gerard E ^d   Dinarello, Charles A ^a  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c Epidemiol   (United States)

^d FRAMINGHAM HEART STUDY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; IL1RN PROTEIN, HUMAN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; RECOMBINANT PROTEIN; SIALOGLYCOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; AGING; ANALYSIS OF VARIANCE; ARTICLE; BIOSYNTHESIS; COHORT ANALYSIS; COMPARATIVE STUDY; DRUG ANTAGONISM; FEMALE; HUMAN; IMMUNOLOGY; INFLAMMATION; MALE; MONOCYTE; MONONUCLEAR CELL; STATISTICAL MODEL;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANALYSIS OF VARIANCE; C-REACTIVE PROTEIN; COHORT STUDIES; CYTOKINES; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; LINEAR MODELS; MALE; MONOCYTES; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; SIALOGLYCOPROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031607149     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/53a.1.m20     Document Type: Article

References (50)

1. Mooradian AD, Reed RL, Scuderi P. Serum levels of tumor necrosis factor alpha, interleukin-I alpha and beta in healthy elderly subjects. Age. 1991;14:61-64.
2. Rudd AG, Banerjee DK Interleukin-I production by human monocytes in ageing and disease. Age Ageing. 1989;18:43-6.
3. Bradley SF, Vibhagool A, Kunkel SL, Kauffman CA. Monokine secretion in aging and protein malnutrition. J Leukocyte Biol. 1989;45: 510-4.
4. Bradley SF, Vibhagool A, Fabrick S, Terpenn+ing MS, Kauffman CA. Monokine production by malnourished nursing home patients. Gerontology. 1990;36:165-70.
5. Fagiolo U, Cossarizza A, Scala E, Fanales-Belasio E, Ortolani C, Cozzi E, Monti D, Franceschi C, Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J lmmunol, 1993;23:2375-8.
6. Effros RB, Svoboda K, Walford RL. Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Cytokine Res. 1991 ;10:347-51.
7. Namizu T, Chang M-E Makinodan T. Influence of age on the production and regulation of interleukin-I in mice. Immunology. 1985;55: 447-55.
8. Tracey K J, Vlassara H, Cerami A. Cachectin/tumor necrosis factor. Lancet. 1989;i:1122-5.
9. Beutler B, Cerami A. Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response. Endocr Rev. 1988;9:57-63.
10. Kunkel SL, Remick DG. Cytokines in health and disease. New York: Marcel Dekker, Inc., 1992.
11. Dinarello CA, Wolff SM. The role of interleukin-I in disease. N Engl J Med. 1993;328:106-13.
12. Reichlin S. Neuroendocrine-immune interactions. N Engl J Med. 1993;329:1246-53.
13. Zimmerman GA, Martin SB, Tracey KJ. The neuroimmunology of turnout necrosis factor-alpha. Clin Immunother. 1994; 1:67-78,
14. Bedell SE, Bush BT. Erythrocyte sedimentation rate: from folklore to facts. Am J Med, 1985;78:1001-9.
15. Christou W, Tellado-Rodriguez J, Chartrand L, Giannas B, Kapadia B, Meakins J, Rode H, Gordon J. Estimating mortality risk in preoperative patients using immunologic, nutritional, and acute-phase response variables. Ann Surg. 1989;210:69-77.
16. Bottiger LE, Svedberg CA. Normal erythrocyte sedimentation rate and age. Br Med J. 1967;2:85-7.
17. Miller A, Green M, Robinson D. Simple rule for calculating normal erythrocyte sedimentation rate. BrMedJ. 1983;286:266.
18. Rall LC, Roubenoff R, Harris TB. Albumin as a marker of nutritional and health status. In: Rosenberg IH, ed. Nutritional assessment of elderly populations. New York: Raven Press, 1995:1-18.
19. Salive ME, Cornoni-Huntley J, Phillips CL, Guralnik JM, Cohen ILl, Ostfeld AM, Wallace RB. Serum albumin in older persons: relationship with age and health status. J Clin Epidemiol. 1992;45:213-21.
20. Liao Z, Caucino JA, Schnipper SM, Stanley ER, Small CB, Rosenstreich DL. Increased urinary cytokine levels in the elderly. Aging lmmunol lnfect Dis. 1993;4:139-53.
21. Ernst DN, Weigle WO, Noonan DJ, McQuitty DN, Hobbs MV. The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3GI 1, and MEL-14 expression. J lmmunoL 1993;151:575-87.
22. Liao Z, Tu JH, Small CB, Schnipper SM, Rosenstrich DL. Increased urine interleukin-I levels in aging. Gerontology. 1993;39:19-24.
23. Daynes RA, Araneo BA, Ershler WB, Maloney C, Li G-Z, Ryu S-Y. Altered regulation of IL-6 production with normal aging. J lmmunol. 1993; 150:5219-30.
24. Roubenoff R, Roubenoff RA, Cannon JG, Kehayias J J, Zhuang H, Dawson-Hughes B, Dinarello CA, Rosenberg IH. Rheumatoid cachexia: cytokine-driven hypermetabolism and loss of lean body mass in chronic inflammation, J Clin Invest. 1994;93:2379-86.
25. Roubenoff R, Rall LC. Humoral mediation of changing body composition during aging and chronic inflammation. Nutr Rev. 1993;51: 1-11.
26. Roubenoff R, Kehayias JJ. The meaning and measurement of lean body mass, Nutr Rev. 1991 ;46:163-75.
27. Tzankoff SE Norris AH. Longitudinal changes in basal metabolism in man. J Appl Physiol. 1978;45:536-9.
28. Frontera WR, Hughes VA, Lutz KJ, Evans WJ. A cross-sectional study of muscle strength and mass in 45-to 78-yr-old men and women. J Appl Physiol. 1991 ;71:644-50.
29. Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330:1769-75.
30. Tsujinaka T, Fujita J, Ebisui C, Yano M, Kominami E, Suzuki K, Tanaka K, Katsume A, Ohsugi Y, Shiozaki H, Monden M. Interleukin 6 receptor antibody inhibits muscle atrophy and modulates proteolytic systems in interleukin 6 transgenic mice. J Clin Invest. 1996; 97:244-9.
31. Poll V, Balena R, Fattori E, Markatos A, Yamamoto M, Tanaka H, Ciliberto G, Rodan GA, Constantini F. lnterleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J, 1994; 13:1189-96.
32. Kania DM, Binkley N, Checovich M, Havighurst T, Schilling M, Ershler WB. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density, J Am Geriatr Soc. 1995;43:236-9.
33. McKane WR, Khosla S, Peterson JM, Egan K, Riggs BL. Circulating levels of cytokines that modulate bone resorption: effects of age and menopause in women. J Bone Min Res. 1994;9:1313-8.
34. Dinarello CA, Cannon JG, Mancilla J, Bishai l, Lees J, Coceani E Interleukin-6 as an endogenous pyrogen: induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Brain Res. 1991;562:191-203.
35. Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood. 1994;83:113-8.
36. Hauptmann B, Van Damme J, Dayer JM. Modulation of 1L-1 inflammatory and immunomodulatory properties by IL-6. Eur Cytokine Netw. 1991 ;2:39.
37. Aderka D, Le JM, Vilcek J. IL-6 inhibits lipopolysaccahride-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. J lmmunol. 1989;143:3517-22.
38. Fattori E, Cappelletti M, Costa P, Sellitto C, Cantoni L, Carelli M, Faggioni R, Fantuzzi G, Ghezzi P, Poll V. Defective inflammatory response in interleukin-6 deficient mice. J Exp Med. 1994;180:1243-50.
39. van de Loo FAJ, Arntz OJ, van den Berg WB. Role of IL-6 in IL-1 induced cartilage insult in mice. Arthritus Rheum. 1995;38(Suppl 9):S160.
40. Steel DM, Whitehead AS. The major acute phase proteins: C-reactive protein, serum amyloid P component, and serum amyloid A protein. lmmunol Today. 1994;15:81-8,
41. Pottratz ST, Bellido T, Mocharla H, Crabb D, Manologas SC. 17Beta-estradiol inhibits expression of human interleukin-6 promoterreporter constructs by a receptor-dependent mechanism. J Clin Invest. 1994;93:944-50.
42. Lapp CA, Thomas ME, Lewis JB. Modulation by progesterone of interleukin-6 production by gingival fibroblasts. J Periodontol. 1995; 66:27-84.
43. Granowitz EV, Porat R, Mier JW, Pribble JR Stiles DM, Bloedow DC, Catalano MA, Wolff SM, Dinarello CA. Pharmacokinetics, safety, and immunomodulatory effects of human recombinant interleukin-I receptor antagonist in healthy humans. Cytokine. 1992;4:353-60.
44. Arend WE lnterleukin-I receptor antagonist. Adv Immunol. 1993;54: 167-93.
45. Endres S, Cannon JG, Ghorbani R, Dempsey RA, Sisson SD, Lonnemann G, van der Meer JWM, Wolff SM, Dinarello CA. In vitro production of IL-Iβ, IL-1α, TNF, and IL-2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation. Eur J lmmunol. 1989;19:2327-33.
46. Schindler R, Clark BD, Dinarello CA. Dissociation between interleukin-l[3 mRNA and protein synthesis in human peripheral blood mononuclear cells. J Biol Chem. 1990;265:10232-7.
47. Dinarello CA, Lonnemann G, Maxwell R, Shaldon S. Ultrafiltration to reject human interleukin-l-inducing substances derived from bacterial cultures. J Clin Microbiol. 1987;25:1233-8.
48. van der Meer JWM, Endres S, Lonnemann G, Cannon JG, Ikejima T, Okusawa S, Gelfand JA, Dinarello CA. Concentrations of immunoreactive human tumor necrosis factor-a produced by human mononuclear cells in vitro. JLeukocyte Biol. 1988; 43:216-23.
49. Cannon JG, van der Meer JWM, Kwiatkowski D, Endres S, Lonnemann G, Burke JF, Dinarello CA. Interleukin-l[3 in human plasma: optimization of blood collection, plasma extraction, and radioimmunoassay methods. Lymphokine Res. 1988;7:457-467.
50. Poutsiaka DD, Clark BD, Vannier E, Dinarello CA. Production of interleukin-1 receptor antagonist and interleukin-lbeta by peripheral blood mononuclear cells is differentially regulated. Blood. 1991;78: 1275-81.