Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β

European Journal of Immunology

Volumn 28, Issue 8, 1998, Pages 2537-2548

  Nguyen, Vince T ^a   Walker, William S ^b   Benveniste, Etty N ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

CD40; Glial cell; Transforming growth factor

Indexed keywords

CD40 ANTIGEN; CYTOKINE; GAMMA INTERFERON; MESSENGER RNA; PROTEIN SYNTHESIS INHIBITOR; PUROMYCIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNE RESPONSE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, CD40; CELL LINE; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA, RECOMBINANT; MICE; MICROGLIA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031948066     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2537::AID-IMMU2537>3.0.CO;2-1     Document Type: Article

References (43)

1. Foy, T. M., Aruffo, A., Bajorath, J., Buhlmann, J. E. and Noelle, R. J., Immune regulation by CD40 and its ligand GP39. Annu. Rev. Immunol. 1996. 14: 591-617.
2. Iciek, L. A., Delphin, S. A. and Stavnezer, J., CD40 cross-linking induces Igε germline transcripts in B cells via activation of NF-(greek small letter script kappa)B. J. Immunol. 1997. 158: 4769-4779.
3. Wagner, D. H., Jr., Stout, R. D. and Suttles, J., Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur. J. Immunol. 1994. 24: 3148-3154.
4. Yellin, M. J., Brett, J., Baum, D., Matsushima, A., Szabolcs, M., Stern, D. and Chess, L., Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals. J. Exp. Med. 1995. 182: 1857-1864.
5. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kämpgen, E., Romani, N. and Schuler, G., High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 1996. 184: 741-746.
6. Pinchuk, L. M., Klaus, S. J., Magaletti, D. M., Pinchuk, G. V., Norsen, J. P. and Clark, E. A., Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. J. Immunol. 1996. 157: 4363-4370.
7. Kiener, P. A., Moran-Davis, P., Rankin, B. M., Wahl, A. F., Aruffo, A. and Hollenbaugh, D., Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 1995. 155: 4917-4925.
8. Yellin, M. J., Winikoff, S., Fortune, S. M., Baum, D., Crow, M. K., Lederman, S. and Chess, L., Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation. J. Leukoc. Biol. 1995. 58: 209-216.
9. Ranheim, E. A. and Kipps. T. J., Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J. Exp. Med. 1993. 177: 925-935.
10. Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M. and Delespesse, G., Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 1995. 25: 1125-1128.
11. Alderson, M. R., Armitage, R. J., Tough, T. W., Strockbine, L., Fanslow, W. C. and Spriggs, M. K., CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 1993. 178: 669-674.
12. Galy, A. H. M. and Spits, H., CD40 is functionally expressed on human thymic epithelial cells. J. Immunol. 1992. 149: 775-782.
13. Karmann, K., Hughes, C. C. W., Schechner, J., Fanslow, W. C. and Pober, J. S., CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc. Natl. Acad. Sci. USA 1995. 92: 4342-4346.
14. Benveniste, E. N., Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. 1997. 75: 165-173.
15. Gerritse, K., Laman, J. D., Noelle, R. J., Aruffo, A., Ledbetter, J. A., Boersma, W. J. A. and Claassen, E., CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. USA 1996. 93: 2499-2504.
16. Alevizopoulos, A. and Mermod, N., Transforming growth factor-β: the breaking open of a black box. Bioessays 1997. 19: 581-591.
17. Wahl, S. M., Transforming growth factor β: the good, the bad, the ugly. J. Exp. Med. 1994. 180: 1587-1590.
18. Panek, R. B., Lee, Y.-J. and Benveniste, E. N., TGF-β suppression of IFN-γ induced class M MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2 or STAT1α or modification of IFNEX expression. J. Immunol. 1995. 154: 610-619.
19. Panek, R. B. and Benveniste, E. N., Class II MHC gene expression in microglia: regulation by the cytokines IFN-γ, TNF-α and TGF-β. J. Immunol. 1995. 154: 2846-2854.
20. Lee, Y.-J., Han, Y., Lu, H.-T., Nguyen, V., Qin, H., Howe, P. H., Hocevar, B. A., Boss, J. M., Ransohoff, R. M. and Benveniste, E. N., TGF-β suppresses IFN-γ induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. J. Immunol. 1997. 158: 2065-2075.
21. Benveniste, E. N., Kwon, J. B., Chung, W. J., Sampson, J., Pandya, K. and Tang, L.-P., Differential modulation of astrocyte cytokine gene expression by TGF-β. J. Immunol. 1994. 153: 5210-5221.
22. Shrikant, P., Lee, S. J., Kalvakalanu, I., Ransohoff, R. M. and Benveniste, E. N., Stimulus-specific inhibition of ICAM-1 gene expression by TGF-β. J. Immunol. 1996. 157: 892-900.
23. Winkler, M. and Benveniste, E. N., Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes. Glia 1998. 22: 171-179.
24. Walker, W. S., Gatewood, J., Olivas, E., Askew, D. and Havenith, C. E. G., Mouse microglial cell lines differing in constitutive and interferon-γ-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells. J. Neuroimmunol. 1995. 63: 163-174.
25. Shrikant, P., Weber, E., Jilling, T. and Benveniste, E. N., ICAM-1 gene expression by glial cells: differential mechanisms of inhibition by interleukin-10 and interleukin-6. J. Immunol. 1995. 155: 1489-1501.
26. Aggarwal, B. B. and Natarajan, K., Tumor necrosis factors: development during the last decade. Eur. Cytokine Netw. 1996. 7: 93-124.
27. Levy, D. E., Kessler, D. S., Pine, R., Reich, N. and Darnell, J. E., Jr., Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev. 1988. 2: 383-393.
28. Pine, R., Decker, T., Kessler, D. S., Levy, D. E. and Darnell, J. E., Jr., Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either. Mol. Cell Biol. 1990. 10: 2448-2457.
29. Quandt, K., Frech, K., Karas, H., Wingender, E. and Werner, T., Matlnd and Matlnspector - new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 1995. 23: 4878-4884.
30. Rubio, N., Interferon-γ induces the expression of immediate early genes c-fos and c-jun in astrocytes. Immunology 1997. 91: 560-564.
31. Thomas, H. E., Dutton, R., Bartlett, P. F. and Kay, T. W. H., Interferon regulatory factor 1 is induced by interferon-γ equally in neurons and glial cells. J. Neuroimmunol. 1997. 78: 132-137.
32. Darnell, J. E., Jr., STATs and gene regulation. Science 1997. 277: 1630-1635.
33. Morrone, G., Cortese, R. and Sorrentino, V., Post-transcriptional control of negative acute phase genes by transforming growth factor beta. EMBO J. 1989. 8: 3767-3771.
34. Burd, C. G. and Dreyfuss, G., Conserved structures and diversity of functions of RNA-binding proteins. Science 1994. 265: 615-621.
35. Torres, R. M. and Clark, E. A., Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation. J. Immunol. 1992. 148: 620-626.
36. 1 responsive cytoplasmic trans-acting factor binds selectively to the 3′-untranslated region of mammalian ribonucleotide reductase R2 mRNA: role in message stability. Nucleic Acids Res. 1993. 21: 4803-4809.
37. van Kooten, C. and Banchereau, J., Functions of CD40 on B cells, dendritic cells and other cells. Curr. Opin. Cell Biol. 1997. 9: 330-337.
38. Shrikant, P. and Benveniste, E. N., The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation. J. Immunol. 1996. 157: 1819-1822.
39. Becher, B., Dodelet, V., Fedorowicz, V. and Antel, J. P., Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J. Clin. Invest. 1996. 98: 1539-1543.
40. Aloisi, F., Penna, G., Cerase, J., Iglesias, B. M. and Adorini, L., IL-12 production by central nervous system microglia is inhibited by astrocytes. J. Immunol. 1997. 159: 1604-1612.
41. Takeuchi, M., Alard, P. and Streilein, J. W., TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells. J. Immunol. 1998. 160: 1589-1597.
42. 2 and cyclic AMP-elevating agents. J. Neuroimmunol. 1997. 72: 83-93.
43. Lee, Y.-J., Panek, R. B., Huston, M. and Benveniste, E. N., Role of protein kinase C and tyrosine kinase activity in IFN-γ induced expression of the class II MHC gene. Am. J. Physiol. 1995. 268: C127-C137.