메뉴 건너뛰기




Volumn 5, Issue 12, 2002, Pages 1288-1293

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CD40 ANTIGEN; CD40 LIGAND; TAU PROTEIN;

EID: 0036900076     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn968     Document Type: Article
Times cited : (194)

References (35)
  • 1
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins and therapy
    • Selkoe, D. J. Alzheimer's disease: Genes, proteins and therapy. Physiol. Rev. 81, 741-766 (2001).
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 2
    • 0032146978 scopus 로고    scopus 로고
    • The importance of inflammatory mechanisms in Alzheimer disease
    • McGeer, E. G. & McGeer, P. L. The importance of inflammatory mechanisms in Alzheimer disease. Exp. Gerontol. 33, 371-378 (1998).
    • (1998) Exp. Gerontol. , vol.33 , pp. 371-378
    • McGeer, E.G.1    McGeer, P.L.2
  • 3
    • 0030250567 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease pathogenesis
    • Rogers, J. et al. Inflammation and Alzheimer's disease pathogenesis. Neurobiol. Aging 17, 681-686 (1996).
    • (1996) Neurobiol. Aging , vol.17 , pp. 681-686
    • Rogers, J.1
  • 4
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S. & Selkoe, D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol. 24, 173-182 (1989).
    • (1989) J. Neuroimmunol. , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 5
    • 0033362157 scopus 로고    scopus 로고
    • Microglia and the immune pathology of Alzheimer disease
    • Giulian, D. Microglia and the immune pathology of Alzheimer disease. Am. J. Hum. Genet. 65, 13-18 (1999).
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 13-18
    • Giulian, D.1
  • 6
    • 0030610645 scopus 로고    scopus 로고
    • Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
    • Barger, S. W. & Harmon, A. D. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388, 878-881 (1997).
    • (1997) Nature , vol.388 , pp. 878-881
    • Barger, S.W.1    Harmon, A.D.2
  • 7
    • 0028953529 scopus 로고
    • Activation of microglial cells by beta-amyloid protein and interferon-gamma
    • Meda, L. et al. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374, 647-650 (1995).
    • (1995) Nature , vol.374 , pp. 647-650
    • Meda, L.1
  • 8
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal, I. S. & Flavell, R. A. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16, 111-135 (1998).
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 9
    • 0031948066 scopus 로고    scopus 로고
    • Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta
    • Nguyen, V. T, Walker, W. S. & Benveniste, E. N. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-beta. Eur. J. Immunol. 28, 2537-2548 (1998).
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2537-2548
    • Nguyen, V.T.1    Walker, W.S.2    Benveniste, E.N.3
  • 10
    • 0033579382 scopus 로고    scopus 로고
    • Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    • Tan, J. et al. Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 286, 2352-2355 (1999).
    • (1999) Science , vol.286 , pp. 2352-2355
    • Tan, J.1
  • 11
    • 0036149449 scopus 로고    scopus 로고
    • Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury
    • Calingasan, N. Y., Erdely, H. A. & Altar, C. A. Identification of CD40 ligand in Alzheimer's disease and in animal models of Alzheimer's disease and brain injury. Neurobiol. Aging 23, 31-39 (2002).
    • (2002) Neurobiol. Aging , vol.23 , pp. 31-39
    • Calingasan, N.Y.1    Erdely, H.A.2    Altar, C.A.3
  • 12
    • 0034571241 scopus 로고    scopus 로고
    • Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases
    • Togo, T. et al. Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Res. 885, 117-121 (2000).
    • (2000) Brain Res. , vol.885 , pp. 117-121
    • Togo, T.1
  • 13
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao, K. et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102 (1996).
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1
  • 14
    • 0030612033 scopus 로고    scopus 로고
    • APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but noneuronal loss in CA1
    • Irizarry, M. C., McNamara, M., Fedorchak, K., Hsiao, K. & Hyman, B.T. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but noneuronal loss in CA1. Neuropathol. Exp. Neurol. 56, 965-973 (1997).
    • (1997) Neuropathol. Exp. Neurol. , vol.56 , pp. 965-973
    • Irizarry, M.C.1    McNamara, M.2    Fedorchak, K.3    Hsiao, K.4    Hyman, B.T.5
  • 15
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb, L. et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4, 97-100 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 97-100
    • Holcomb, L.1
  • 16
    • 0034691108 scopus 로고    scopus 로고
    • Inhibition of CD 40 signaling limits evolution of established atherosclerosis in mice
    • Schonbeck, U., Sukhova, G. K., Shimizu, K., Mach, F. & Libby, P. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice. Proc. Natl. Acad. Sci. U S A 97, 7458-7463 (2000).
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 7458-7463
    • Schonbeck, U.1    Sukhova, G.K.2    Shimizu, K.3    Mach, F.4    Libby, P.5
  • 17
    • 0025345913 scopus 로고
    • Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles
    • Schmidt, M. L., Lee, V. M. & Trojanowski, J. Q. Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. Am. J. Pathol. 136, 1069-1075 (1990).
    • (1990) Am. J. Pathol. , vol.136 , pp. 1069-1075
    • Schmidt, M.L.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 18
    • 84920237810 scopus 로고
    • A new definition of Alzheimer's disease: A hippocampal dementia
    • Ball, M. J. et al. A new definition of Alzheimer's disease: A hippocampal dementia. Lancet 1, 14-16 (1985).
    • (1985) Lancet , vol.1 , pp. 14-16
    • Ball, M.J.1
  • 19
    • 0035116273 scopus 로고    scopus 로고
    • Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
    • Luo, Y. et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat. Neurosci. 4, 231-232 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 231-232
    • Luo, Y.1
  • 20
    • 18244397199 scopus 로고    scopus 로고
    • CD40 is expressed and functional on neuronal cells
    • Tan, J. et al. CD40 is expressed and functional on neuronal cells. EMBO J. 21, 643-652 (2002).
    • (2002) EMBO J. , vol.21 , pp. 643-652
    • Tan, J.1
  • 21
    • 0029942495 scopus 로고    scopus 로고
    • Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus
    • Thinakaran, G., Teplow, D.B., Siman, R., Greenberg, B. & Sisodia, S.S. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus. J. Biol. Chem. 271, 9390-9397 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 9390-9397
    • Thinakaran, G.1    Teplow, D.B.2    Siman, R.3    Greenberg, B.4    Sisodia, S.S.5
  • 22
    • 1842406550 scopus 로고    scopus 로고
    • Ligation of CD40 activates interleukin-1beta-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1beta
    • Schonbeck, U. et al. Ligation of CD40 activates interleukin-1beta-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1beta. J. Biol. Chem. 272, 19569-19574 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 19569-19574
    • Schonbeck, U.1
  • 23
    • 0031049711 scopus 로고    scopus 로고
    • Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD 40 ligand signaling in atherosclerosis
    • Mach, F. et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. Proc. Natl. Acad. Sci. U S A 94, 1931-1936 (1997).
    • (1997) Proc. Natl. Acad. Sci. U S A , vol.94 , pp. 1931-1936
    • Mach, F.1
  • 24
    • 0034880236 scopus 로고    scopus 로고
    • Role of CD40-CD 40L in mouse severe malaria
    • Piguet, P. F. et al. Role of CD40-CD40L in mouse severe malaria. Am. J. Pathol. 159, 733-742 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 733-742
    • Piguet, P.F.1
  • 25
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B. et al. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U S A 98, 8850-8855 (2001).
    • (2001) Proc. Natl. Acad. Sci. U S A , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1
  • 26
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M. & Holtzman, D. M. Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295, 2264-2267 (2002).
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 27
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D. et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1
  • 28
    • 0035544150 scopus 로고    scopus 로고
    • Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels
    • Wilcock, D. M. et al. Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. DNA Cell Biol. 20, 731-736 (2001).
    • (2001) DNA Cell Biol. , vol.20 , pp. 731-736
    • Wilcock, D.M.1
  • 29
    • 0035696328 scopus 로고    scopus 로고
    • Intrahippocampal LPS injections reduce Abeta load in APP+PS 1 transgenic mice
    • DiCarlo G. et al. Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice. Neurobiol. Aging 22, 1007-1012 (2001).
    • (2001) Neurobiol. Aging , vol.22 , pp. 1007-1012
    • DiCarlo, G.1
  • 30
    • 0035726544 scopus 로고    scopus 로고
    • Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse
    • Qiao, X., Cummins, D. J. & Paul, S. M. Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse. Eur. J. Neurosci. 14, 474-482 (2001).
    • (2001) Eur. J. Neurosci. , vol.14 , pp. 474-482
    • Qiao, X.1    Cummins, D.J.2    Paul, S.M.3
  • 31
    • 0034254924 scopus 로고    scopus 로고
    • Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
    • Lim, G. P. et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J. Neurosci. 20, 5709-5714 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 5709-5714
    • Lim, G.P.1
  • 32
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim, G. P. et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 21, 8370-8377 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 8370-8377
    • Lim, G.P.1
  • 33
    • 0037088914 scopus 로고    scopus 로고
    • Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenitin-1 transgenic mice
    • Jantzen, P. T. et al. Microglial activation and beta-amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenitin-1 transgenic mice. J. Neurosci. 22, 2246-2256 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 2246-2256
    • Jantzen, P.T.1
  • 34
    • 0028486131 scopus 로고
    • Mice deficient for the CD40 ligand
    • Xu, J. et al. Mice deficient for the CD40 ligand. Immunity 1, 423-431 (1994).
    • (1994) Immunity , vol.1 , pp. 423-431
    • Xu, J.1
  • 35
    • 0031020909 scopus 로고    scopus 로고
    • Amyloid precursor protein processing and A beta 42 deposition in a transgenic mouse model of Alzheimer disease
    • Johnson-Wood, K. et al. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 1550-1555 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1550-1555
    • Johnson-Wood, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.