Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 959-970

  Yang, Xuhao ^a   Stedra, Jaroslav ^a,b   Cerny, Jan ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF MATHEMATICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 NITROPHENYLACETYLHAPTEN; CD4 ANTIGEN; HAPTEN; IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

AGED; ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE ACTIVATION; HELPER CELL; IMMUNOPATHOLOGY; IMMUNOREGULATION; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SOMATIC MUTATION; T LYMPHOCYTE ACTIVATION;

AGING; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; BASE SEQUENCE; CELL AGING; CELLS, CULTURED; CODON; FLOW CYTOMETRY; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; GERMINAL CENTER; HAPTENS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTHERAPY, ADOPTIVE; MICE; MICE, INBRED C57BL; MICE, SCID; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTATION; POLYMERASE CHAIN REACTION; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES;

EID: 0029918498     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.959     Document Type: Article

References (44)

1. Makinodan, T., and M.M.B. Kay. 1980. Age influence on the immune system. Adv. Immunol. 29:287-330.
2. Wade, A.W., and M.R. Szewczuk. 1984. Aging and the mucosal associated lymphoid system. Adv. Immunol. 36:143-188.
3. Miller, R.A. 1991. Aging and immune function. Int. Rev. Cytol. 124:187-215.
4. Kishimoto, S., T. Takahama, and H. Mizumachi. 1976. In vitro immune response to the 2,4,6-trintrophenyl determinant in aged C57BL/6 mice: changes in the humoral response to avidity for the TNP determinant and responsiveness to LPS effect with aging. J. Immunol. 116:294-301.
5. Goidl, E.A., J.B. Innes, and M.E. Weksler. 1976. Immunological studies of aging. II. Loss of IgG and high avidity plaque forming cells and increased suppressor cell activity in aging mice. J. Exp. Med. 144:1037-1048.
6. Zharhary, D., Y. Segev, and H. Gershon. 1977. The affinity and spectrum of crossreactivity of antibody production in senescent mice: the IgM response. Mech. Ageing Dev. 6:385-392.
7. Doria, G., G. D'Agostaro, and A. Poretti. 1978. Age dependent variations of antibody avidity. Immunology. 35:601-611.
8. Weksler, M.E., J.B. Innes, and G. Goldstein. 1978. Immunological studies of aging. IV. The contribution of thymic involution to the immune deficiencies of aging mice. J. Exp. Med. 148:966-1006.
9. Smith, A H. 1976. The effects of age on the immune response to type III pneumococcal polysaccharide (SIII) and bacterial lipopoly saccharide (LPS) in BALB/c, SJL/J and C3H mice. J. Immunol. 116:469-474.
10. Zharhary, D., and N.R. Klinman. 1986. A selective increase in the generation of phosphorylcholine specific B cells associated with age. J. Immunol. 136:368-370.
11. Yin, J.-Z., S.R.S. Gottesman, M.K. Bell, and G.J Thorbecke. 1988. Resistance to low dose tolerance and enhanced antibody responses of aged as compared to young mice immunized with pneumococcal polysaccharides. Aging Immunol. Infect. Dis. 1:131-137.
12. Nicoletti, C., X. Yang, and J. Cerny. 1993. Repertoire diversity of antibody response to bacterial antigens in aged mice III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. J. Immunol. 150:543-549.
13. Ammann, A.J., G. Schiffman, and R. Austrian. 1980. The antibody responses to pneumococcal capsular polysaccharides in aged individuals. Proc. Soc. Exp. Biol. Med. 164:312-316.
14. H gene segment utilization in response to phosphorylcholine by aged mice. J. Immunol 143:3798-3805.
15. Nicoletti, C., and J. Cerny. 1991. The repertoire diversity and magnitude of antibody response to bacterial antigens in aged mice. I. Age-associated changes in antibody response differ according to the mouse strain. Cell Immunol. 133:72-83.
16. Goidl, E A., X. Chen, and D.H. Schulze. 1990. B cell function in the immune response of the aged. Aging Immunol. Infect. Dis. 2:135-138.
17. Perlmutter, R.M., S.T. Crews, R.E. Douglas, G. Sorensen, N. Johnson, N. Nivera, P.J. Gerahart, and L. Hood. 1984. The generation of diversity in phosphorylcholine-binding antibodies. Adv. Immunol. 35:1-37.
18. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centers. Nature (Lond.). 354:389-392.
19. Berek, C., A. Berger, and M. Apel. 1991. Maturation of the immune response in germinal centers. Cell. 67:1121-1129.
20. Miller, C., and G. Kelsoe. 1995. Somatic hypermutation is absent in the germinal centers of aged mice. J. Immunol. 155: 3377-3384.
21. Jacobson, E.B., L.H. Corporale, and G.J. Thorbecke. 1974. Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymus less) mice. Cell. Immunol. 13:416-430.
22. Gastkemper, N.A., A.S. Wubbena, F.J.H. Gimbrere, A. DeGraff, and P. Nieuwenhuis. 1981. Germinal centers and the B-cell system. V. Presence of germinal center precursor cells among lymphocytes of the thoracic duct in the rat. Cell Tissue Res. 219:281-289.
23. + cells limit germinal center formation? Immunology. 69:487-489.
24. H genes. J. Exp. Med. 181:1319-1331.
25. Maizels, N., and A. Bothwell. 1985. The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes. Cell. 43:715-720.
26. Cumano, A., and K. Rajewsky. 1986. Clonal recruitment and somatic mutation in the generation of immunologic memory to the hapten NP. EMBO (Eur. Mol. Biol. Organ.) J. 5:2459-2468.
27. b family of antibodies: somatic mutation evident in a γ 2a variable region. Cell. 24:625-637.
28. Bothwell, A.L M., M. Paskind, M. Reth, T. Inianishi-Kari, K. Rajewsky, and D. Baltimore. 1982. Somatic variants of murine immunoglobulin lambda light chains. Nature (Lond.). 298:380-382.
29. H genes during the primary immune response. J. Exp. Med. 169:2007-2019.
30. Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. III. The kinetics of V-region mutation and selection in germinal centers B cells. J. Exp. Med. 178: 1293-1307.
31. McHeyzer-Williams, M.G., M.J. McLean, P.A. Lalor, and G.J.V. Nossal. 1993. Antigen driven B cell differentiation in vivo. J. Exp. Med. 178:295-307.
32. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165-1175.
33. Jacob, J., and G. Kelsoe. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. II. A common clonal origin for periateriolar lymphoid sheath - associated foci and germinal centers. J. Exp. Med. 176:679-687.
34. Stedra, J., and J. Cerny. 1994. Distinct pathways of B cell differentiation. I. Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody. J. Immunol. 152:1718-1726.
35. Gu, H., D. Tarlinton, W. Muller, K. Rajewsky, and I. Forster. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173:1357-1371.
36. H gene. Eur. J. Immunol. 19:1847-1854.
37. H element reading frames. Cell. 65:47-54.
38. Kocks, C., and K. Rajewsky. 1989. Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. Annu. Rev. Immunol. 7:537-559.
39. Tao, W., F. Hardardottin, and A.L.M. Bothwell. 1993. Extensive somatic mutation in the Ig heavy chain V genes in a late primary anti-hapten immune response. Mol. Immunol. 30: 593-602.
40. Tew, J.G., R.P. Phipps, and T.E. Mandel. 1980. The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol. Rev. 53:175-201.
41. hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur. J. Immunol. 19:977-982.
42. + cells from young and aged mice. J. Immunol 145:1295-1302.
43. Hawklins, R.E., and G. Winter. 1992. Cell selection strategies for making antibodies from variable gene libraries: trapping the memory pool. Eur. J. Immunol. 22:867-870.
44. McHeyzer-Willaim, G.C., G.J. Nossal, and P.A. Lalor. 1991. Molecular characterization of single memory B cells. Nature (Lond.). 350:502-505.