Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)

Experimental Gerontology

Volumn 38, Issue 8, 2003, Pages 911-920

  Ouyang, Qin ^a,c   Wagner, Wolfgang M ^a   Voehringer, David ^b,d   Wikby, Anders ^e   Klatt, Tatjana ^a   Walter, Steffen ^a   Müller, Claudia A ^a   Pircher, Hanspeter ^b   Pawelec, Graham ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e NONE

Author keywords

Aging; Cytomegalovirus; Immunosenescence; Killer cell lectin like receptor G1; T cell; Tetramer

Indexed keywords

CD8 ANTIGEN; CELL RECEPTOR; KILLER CELL LECTIN LIKE RECEPTOR G1; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL DIVISION; CELL FUNCTION; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; HERPES VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; T LYMPHOCYTE;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; HERPES; HERPESVIRIDAE;

EID: 0042206627     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(03)00134-7     Document Type: Article

References (35)

1. Altman J.D., Moss P.A., Goulder P.J., Barouch D.H., McHeyzer-Williams M.G., Bell J.I., McMichael A.J., Davis M.M. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:1996;94-96.
2. Appay V., Dunbar P.R., Callan M., Klenerman P., Gillespie G.M., Papagno L., Ogg G.S., King A., Lechner F., Spina C.A., Little S., Havlir D.V., Richman D.D., Gruener N., Pape G., Waters A., Easterbrook P., Salio M., Cerundolo V., McMichael A.J., Rowland-Jones S.L. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8:2002;379-385.
3. Ferguson F.G., Wikby A., Maxson P., Olsson J., Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and non-survivors. J. Gerontol. A, Biol. Sci. Med. Sci. 50:1995;B378-B382.
4. Franceschi C., Bonafe M., Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine. 18:2000;1717-1720.
5. Gamadia L.E., Rentenaar R.J., Baars P.A., Remmerswaal E.B., Surachno S., Weel J.F., Toebes M., Schumacher T.N., ten Berge I.J., van Lier R.A. Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. Blood. 98:2001;754-761.
6. Gillespie G.M., Wills M.R., Appay V., O'Callaghan C., Murphy M., Smith N., Sissons P., Rowland-Jones S., Bell J.I., Moss P.A. Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors. J. Virol. 74:2000;8140-8150.
7. Gratama J.W., Naipal A.M., Oosterveer M.A., Stijnen T., Kluin-Nelemans H.C., Ginsel L.A., den Ottolander G.J., Hekker A.C., D'Amaro J., van der G.M. Effects of herpes virus carrier status on peripheral T lymphocyte subsets. Blood. 70:1987;516-523.
8. Gruener N.H., Lechner F., Jung M.C., Diepolder H., Gerlach T., Lauer G., Walker B., Sullivan J., Phillips R., Pape G.R., Klenerman P. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J. Virol. 75:2001;5550-5558.
9. Huard B., Karlsson L. KIR expression on self-reactive CD8+ T cells is controlled by T-cell receptor engagement. Nature. 403:2000;325-328.
10. Kern F., Surel I.P., Faulhaber N., Frommel C., Schneider-Mergener J., Schonemann C., Reinke P., Volk H.D. Target structures of the CD8(+)-T-cell response to human cytomegalovirus: the 72-kilodalton major immediate-early protein revisited. J. Virol. 73:1999;8179-8184.
11. Khan N., Shariff N., Cobbold M., Bruton R., Ainsworth J.A., Sinclair A.J., Nayak L., Moss P.A. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J. Immunol. 169:2002;1984-1992.
12. Lee P.P., Yee C., Savage P.A., Fong L., Brockstedt D., Weber J.S., Johnson D., Swetter S., Thompson J., Greenberg P.D., Roederer M., Davis M.M. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med. 5:1999;677-685.
13. Looney R.J., Falsey A., Campbell D., Torres A., Kolassa J., Brower C., McCann R., Menegus M., McCormick K., Frampton M., Hall W., Abraham G.N. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin. Immunol. 90:1999;213-219.
14. Mayer S., Scheibenbogen C., Lee K.H., Keilholz W., Stevanovic S., Rammensee H.G., Keilholz U. A sensitive proliferation assay to determine the specific T cell response against HLA-A2.1-binding peptides. J. Immunol. Meth. 197:1996;131-137.
15. Mingari M.C., Schiavetti F., Ponte M., Vitale C., Maggi E., Romagnani S., Demarest J., Pantaleo G., Fauci A.S., Moretta L. Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc. Natl Acad. Sci. USA. 93:1996;12433-12438.
16. Nilsson B.O., Ernerudh J., Johansson B., Evrin P.E., Lofgren S., Ferguson F.G., Wikby A. Morbidity does not influence the T cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols. Mech. Ageing Dev. 124:2003;469-476.
17. Olsson J., Wikby A., Johansson B., Lofgren S., Nilsson B.O., Ferguson F.G. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 121:2000;187-201.
18. Ouyang Q., Wagner W.M., Walter S., Muller C.A., Wikby A., Aubert G., Klatt T., Stevanovic S., Dodi T., Pawelec G. Age-related increase in CD8+ T cells carrying receptors for an immunodominant Epstein-Barr Virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Mech. Ageing Dev. 124:2003;477-485.
19. Pawelec G., Ferguson F.G., Wikby A. The SENIEUR protocol after 16 years. Mech. Ageing Dev. 122:2001;132-134.
20. Pawelec G., Barnett Y., Forsey R., Frasca D., Globerson A., McLeod J., Caruso C., Franceschi C., Fulop T., Gupta S., Mariani E., Mocchegiani E., Solana R. T cells and aging, January 2002 update. Front. Biosci. 7:2002;d1056-d1183.
21. Pawelec G., Ouyang Q., Colonna-Romano G., Candore G., Lio D., Caruso C. Is human immunosenescence clinically relevant? Looking for immunological risk phenotypes. Trends Immunol. 23:2002;330-332.
22. Posnett D.N., Sinha R., Kabak S., Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to benign monoclonal gammapathy. J. Exp. Med. 179:1994;609-618.
23. Raulet D.H., Vance R.E., McMahon C.W. Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 19:2001;291-330.
24. *0201-restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus. J. Immunol. 163:1999;5512-5518.
25. Solana R., Mariani E. NK and NK/T cells in human senescence. Vaccine. 18:2000;1613-1620.
26. Spaulding C., Guo W., Effros R.B. Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp. Gerontol. 34:1999;633-644.
27. van Baarle D., Hovenkamp E., Callan M.F., Wolthers K.C., Kostense S., Tan L.C., Niesters H.G., Osterhaus A.D., McMichael A.J., van Oers M.H., Miedema F. Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma. Blood. 98:2001;146-155.
28. Voehringer D., Blaser C., Brawand P., Raulet D.H., Hanke T., Pircher H. Viral infections induce abundant numbers of senescent CD8 T cells. J. Immunol. 167:2001;4838-4843.
29. Voehringer D., Kaufmann M., Pircher H. Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA. Immunogenetics. 52:2001;206-211.
30. Voehringer D., Koschella M., Pircher H. Lack of proliferative capacity of human effector and memory T cells expressing Killer cell lectin-like receptor G1 (KLRG1). Blood. 100:2002;3698-3702.
31. Wack A., Cossarizza A., Heltai S., Barbieri D., D'Addato S., Fransceschi C., Dellabona P., Casorati G. Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int. Immunol. 10:1998;1281-1288.
32. Wikby A., Maxson P., Olsson J., Johansson B., Ferguson F.G. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech. Ageing Dev. 102:1998;187-198.
33. Wikby A., Johansson B., Olsson J., Lofgren S., Nilsson B.O., Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 37:2002;445-453.
34. Wills M.R., Carmichael A.J., Mynard K., Jin X., Weekes M.P., Plachter B., Sissons J.G. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Virol. 70:1996;7569-7579.
35. Zhou T., Edwards C.K. III, Mountz J.D. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J. Exp. Med. 182:1995;129-137.