The other side of scavenger receptors: Pattern recognition for host defense

Current Opinion in Lipidology

Volumn 8, Issue 5, 1997, Pages 275-280

  Krieger, Monty ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; CELL SURFACE RECEPTOR; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; SCAVENGER;

HOST RESISTANCE; IMMUNITY; LIPID METABOLISM; MACROPHAGE; PATTERN RECOGNITION; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0030730023     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199710000-00006     Document Type: Short Survey

References (87)

1. Goldstein JL, Ho YK, Basu SK, Brown MS: Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci U S A 1979, 76:333-337.
2. Goldstein JL, Brown MS: Familial hypercholesterolemia. In The Metabolic Basis of Inherited Disease 6th edn. Edited by Scriver CR, Beaudet AL, Sly WS, Valle D. New York: McGraw-Hill 1989:1215-1250.
3. Brown MS, Goldstein JL: Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Ann Rev Biochem 1983, 52:223-261.
4. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL: Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989, 320:915-924.
5. Krieger M: Molecular flypaper and atherosclerosis: structure of the macrophage scavenger receptor. Trends Biochem Sci 1992, 17:141-146.
6. Fogelman AM, Van LBJ, Warden C, Haberland ME, Edwards PA: Macrophage lipoprotein receptors. J Cell Sci Suppl 1988, 9:135-149.
7. Krieger M, Herz J: Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Ann Rev Biochem 1994, 63:601-637.
8. Krieger M, Acton S, Ashkenas J, Pearson A, Penman M, Hesnick D: Molecular flypaper, host defense, and atherosclerosis. Structure, binding properties, and functions of macrophage scavenger receptors. J Biol Chem 1993, 268:4569-4572.
9. Suzuki H, Kurihara Y, Takeya M, Kamada N, Kataoka M, Jishage K, Ueda O, Sakaguchi H, Higashi T, Suzuki TI et al.: A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 1997, 386:292-296. This paper describes the generation of SR-AI/II knockout mice and presents evidence for a potential role of these receptors both in atherogenesis and in host defense. These mutant mice will play a critical role in testing the hypothesis [5,7,20,37,40] that class A SRs are pattern recognition receptors for host defense.
10. Brown MS, Basu SK, Falck JR, Ho YK, Goldstein JL: The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively charged LDL by macrophages. J Supramol Struct 1980, 13:67-81.
11. Shechter I, Fogelman AM, Haberland ME, Seager J, Hokom M, Edwards PA: The metabolism of native and malondialdehyde-altered low density lipoproteins by human monocyte-macrophages. J Lipid Res 1981, 22:63-71.
12. Zhang H, Yang Y, Steinbrecher UP: Structural requirements for the binding of modified proteins to the scavenger receptor of macrophages. J Biol Chem 1993, 268:5535-5542.
13. Nishikawa K, Arai H, Inoue K: Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages. J Biol Chem 1990, 265:5226-5231.
14. Sparrow CP, Parthasarathy S, Steinberg D: A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein. J Biol Chem 1989, 264:2599-2604.
15. Arai H, Kita T, Yokode M, Narumiya S, Kawai C: Multiple receptors for modified low density lipoproteins in mouse peritoneal macrophages; different uptake mechanisms for acetylated and oxidized low density lipoproteins. Biochem Biophys Res Commun 1989, 159:1375-1382.
16. Nagelkerke JF, Barto KP, vanBerkel T: In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells. J Biol Chem 1983, 258:12221-12227.
17. VanBerkel TJ, De Rijke YB, Kruijt JK: Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells. J Biol Chem 1991, 266:2282-2289.
18. Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M: Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature 1990, 343:531-535.
19. Rohrer L, Freeman M, Kodama T, Penman M, Krieger M: Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature 1990, 343:570-572.
20. Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M: An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A 1991, 88:4931-4935.
21. Oquendo P, Hundt E, Lawler J, Seed B: CD36 directly mediates cytoadherence of Plasmodium falciparum infected erythrocytes. Cell 1989, 58:95-101.
22. Acton SL, Scherer PE, Lodish HF, Krieger M: Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem 1994, 269:21005-21009.
23. Pearson A, Lux A, Krieger M: Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster. Proc Natl Acad Sci U S A 1995, 92:4056-4060.
24. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA: CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem 1993, 268:11811-11816.
25. Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, Thesleff I, Kraal G, Tryggvason K: Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell 1995, 80:603-609.
26. Calvo D, Vega MA: Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. J Biol Chem 1993, 268:18929-18935.
27. Abumrad NA, El-Maghrabi MR, Amri E-Z, Lopez E, Grimalds PA: Cloning of a rat adipocyte membrane protein implicated in binding of transport of long-chain fatty acids that is induced during preadipocyte differentiation; homology with human CD36. J Biol Chem 1993, 268:17665-17668.
28. Ramprasad MP, Fischer W, Witztum JL, Sambrano GR, Quehenberger O, Steinberg D: The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68. Proc Natl Acad Sci U S A 1995, 92:9580-9584.
29. de Rijke YB, van Berkel TJ: Rat liver Kupffer and endothelial cells express different binding proteins for modified low density lipoproteins. Kupffer cells express a 95-kDa membrane protein as a specific binding site for oxidized low density lipoproteins. J Biol Chem 1994, 269:824-827.
30. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T: An endothelial receptor for oxidized low-density lipoprotein. Nature 1997, 386:73-77. The first molecular Identification of an endothelial SR is described in this paper.
31. Stanton LW, White RT, Bryant CM, Protter A, Endemann G: A macrophage Fc receptor for IgG is also a receptor for oxidized low density lipoprotein. J Biol Chem 1992, 267:22446-22451.
32. ••] this paper provides additional evidence for the presence of multiple, independent SRs on mammalian macrophages.
33. Schnitzer JE, Bravo J: High affinity binding, endocytosis, and degradation of conformationally modified albumins; potential role of gp30 and gp18 as novel scavenger receptors. J Biol Chem 1993, 268:7562-7570.
34. Ottnad E, Via DP, Frubis J, Sinn H, Friedrich E, Ziegler R, Dresel HA: Differentiation of binding sites on reconstituted hepatic scavenger receptors using oxidized low-density lipoprotein. Biochem J 1992, 281:745-751.
35. Emi M, Asaoka H, Matsumoto A, Itakura H, Kurihara Y, Wada Y, Kanamori H, Yazaki Y, Takahashi E, Lepert M et al.: Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene. J Biol Chem 1993, 268:2120-2125.
36. Pearson AM: Scavenger receptors in innate immunity. Curr Opin Immunol 1996, 8:20-28. This paper discusses recent developments in the SR field, in particular the potential the role of SRs in host-defence-related processes.
37. Hampton RY, Golenbock DT, Penman M, Krieger M, Raetz CRH: Recognition and plasma clearance of endotoxin by scavenger receptors. Nature 1991, 352:342-344.
38. Ashkenas J, Penman M, Vasile E, Freeman M, Krieger M: Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J Lipid Res 1993, 34:983-1000.
39. Raetz CRH: Biochemistry of endotoxins. Ann Rev Biochem 1990, 59:129-170.
40. Dunne DW, Resnick D, Greenberg J, Krieger M, Joiner KA: The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid. Proc Natl Acad Sci U S A 1994, 91:1863-1867.
41. Greenberg JW, Fischer W, Joiner KA: Influence of lipoteichoic acid structure on recognition by the macrophage scavenger receptor. Infect Immun 1996, 64:3318-3325. This study extends the finding [40] that SR-A can recognize LTA, a polyanionic, septic shock-inducing component of the surfaces of Gram-positive bacteria.
42. Resnick D, Freedman N, Xu S, Krieger M: Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos. J Biol Chem 1993, 268:3538-3545.
43. Xu X, Remold HG, Caulfield JP: Potential role for scavenger receptors of human monocytes in the killing of Schistosoma mansoni. Am J Pathol 1993, 142:685-689.
44. Zimmerli S, Edwards S, Ernst JD: Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages. Am J Respir Cell Mol Biol 1996, 15:760-770.
45. Kobzik L: Lung macrophage uptake of unopsonized environmental particulates; role of scavenger-type receptors. J Immunol 1995, 155:367-376.
46. Iyer R, Hamilton RF, Li L, Holian A: Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol Appl Pharmacol 1996, 14:84-92.
47. Acton S, Rigotti A, Landschulz K, Xu S, Hobbs HH, Krieger M: Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 1996, 271:518-520. In this study the SR, class B, type I (SR-BI) was shown to be the first molecularly well defined cell surface HDL receptor which mediates selective lipid uptake. SR-BI was shown to bind HDL with high affnity, be expressed primarily in the liver and steroidogenic tissues, and mediate selective cholesterol uptake from HDL to cells via a mechanism distinct from the classic LDL receptor pathway.
48. Landschulz KT, Pathak RP, Rigotti A, Krieger M, Hobbs HH: Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat. J Clin Invest 1996, 98:984-995.
49. Rigotti A, Edelman ER, Seifert P, Iqbal S, DeMattos RB, Temel RE, Krieger M, Williams D: Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland. J Biol Chem 1996, 271:33545-33549.
50. Xu S, Laccotripe M, Huang X, Rigotti A, Zannis VI, Krieger M: Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake. J Lipid Res 1997, 38:1289-1298.
51. Kozarsky KF, Donahee MH, Rigotti A, Iqbal SN, Edelman ER, Krieger M: Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature 1997, 387:414.
52. Rigotti A, Trigatti BL, Babitt J, Penman M, Xu S, Krieger M: Scavenger receptor B-I - a cell surface receptor for HDL. Curr Opin Lipidol 1997, 8:181-188. This recent review describes the SR-BI and its role in HDL metabolism.
53. Levine DM, Parker TS, Donnelly TM, Walsh A, Rubin AL: In vivo protection against endotoxin by plasma high density lipoprotein. Proc Natl Acad Sci U S A 1993, 90:12040-12044.
54. Hubsch AP, Casas AT, Doran JE: Protective effects of reconstituted high density lipoprotein in rabbit Gram-negative bacteremia models. J Lab Clin Med 1995, 126:548-558.
55. Ulevitch RJ, Johnston AR: The modification of biophysical and endotoxic properties of bacterial lipopolysaccharides by serum. J Clin Invest 1978, 62:1313-1324.
56. Ulevitch RJ, Johnston AR, Weinstein DB: New function of high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide-high density lipoprotein complex formed in rabbit plasma. J Clin Invest 1981, 67:827-837.
57. Munford RS, Andersen JM, Dietschy JM: Sites of tissue binding and uptake in vivo of bacterial lipopolysaccharide-high density lipoprotein complexes. J Clin Invest 1981, 68:1503-1513.
58. Munford RS, Dietschy JM: Effects of specific antibodies, hormones and lipoproteins on bacterial lipopolysaccharides injected into the rat. J Infect Dis 1985, 152:177-184.
59. Sibbald WJ, Short A, Cohen MP, Wilson RF: Variations in adrenocortical responsiveness during severe bacterial infections: unrecognized adrenocortical insufficiency in severe bacterial infections. Ann Surg 1977, 186:29-33.
60. Bosworth DC: Reversible adrenocortical insufficiency in fulminant meningococcemia. Arch Intern Med 1979, 139:823-824.
61. Janeway CA: The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 1992, 13:11-16.
62. Janeway CA: Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989, 54:1-13.
63. Kappas A, Alvares AP: How the liver metabolizes foreign substances. Sci Am 1975, 232:22-31.
64. Nebert DW, Gonzalez FJ: P450 genes: structure, evolution, and regulation. Ann Rev Biochem 1987, 56:945-993.
65. Abrams JM, Lux A, Steller H, Krieger M: Macrophages in Drosophila embryos and L2 cells exhibit scavenger receptor-mediated endocytosis. Proc Natl Acad Sci U S A 1992, 89:10375-10379.
66. Resnick D, Pearson A, Krieger M: The SRCR superfamily: a family reminiscent of the Ig superfamily. Trends Biochem Sci 1994, 19:5-8.
67. Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, Aruffo A: The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site. J Biol Chem 1995, 270:18187-18190.
68. Sambrano GR, Parthasarathy S, Steinberg D: Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein. Proc Natl Acad Sci U S A 1994, 8:3265-3269.
69. Sambrano GR, Steinberg D: Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine. Proc Natl Acad Sci U S A 1995, 92:1396-1400.
70. Ottnad E, Parthasarathy S, Sambrano GR, Ramprasad MP, Quehenberger O, Kondratenko N, Green S, Steinberg D: A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells. Proc Natl Acad Sci U S A 1995, 92:1391-1395.
71. el Khoury J, Thomas CA, Loike JD, Hickman SE, Cao L, Silverstein SC: Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. J Biol Chem 1994, 269:10197-10200.
72. Araki N, Higashi T, Mori T, Shibayama R, Kawabe Y, Kodama T, Takahashi K, Shichiri M, Horiuchi S: Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction. Eur J Biochem 1995, 230:408-415.
73. Smedsrod B, Melkko J, Araki N, Sano H, Horiuchi S: Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. Biochem J 1997, 322:567-573. In conjunction with [71,72] this work raises the possibility that SRs may play a role in the processing of advanced glycation end products.
74. •].
75. •].
76. •] suggest that SRs may play a role in processing the amyloid plaques which form in Alzheimer's disease.
77. Schnitzer JE, Bravo J: High affinity binding, endocytosis, and degradation of conformationally modified albumins; potential role of gp30 and gp18 as novel scavenger receptors. J Biol Chem 1993, 268:7562-7570.
78. Savill J, Hogg N, Ren Y, Haslett C: Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest 1992, 90:1513-1522.
79. Ren Y, Silverstein RL, Allen J, Savill J: CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. J Exp Med 1995, 181:1857-1862.
80. Platt N, Suzuki H, Kurihara Y, Kodama T, Gordon S: Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc Natl Acad Sci U S A 1996, 93:12456-12460. In this work, class A SRs are shown to be able to mediate internalization of apoptotic thymocytes in vitro, thus raising the possibility that they may be able to participate in apoptotic cell clearance in vivo.
81. Fukasawa M, Adachi H, Hirota K, Tsujimoto M, Akai H, Inoue K: SR-BI, a class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells. Exp Cell Res 1996, 222:246-250.
82. Franc NC, Dimarcq J-L, Laguex M, Hoffmanm J, Ezekowitz RAB: Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity 1996, 4:431-443. This paper shows that a close structural relative to the class B SRs, croquemort, can recognize apoptotic cells.
83. •]. In addition they show that hSR-BI is expressed in monocyctes and this expression is suppressed when the monocyctes differentiate into macrophages.
84. Rigotti A, Acton S, Krieger M: The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids. J Biol Chem 1995, 270:16221-16224.
85. Savill J, Fadok V, Henson P, Haslett C: Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993, 14:131-136.
86. •].
87. •] the class B SR CD36 is shown to be an important participant in the recognition and processing of rod outer segments, probably via recognition of anionic phospholipids [84].