Modelling and informatics in the analysis of P. falciparum DHFR enzyme inhibitors

Current Medicinal Chemistry

Volumn 15, Issue 16, 2008, Pages 1552-1560

  Adane, Legesse ^a,b   Bharatam, Prasad V ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b JIMMA UNIVERSITY   (Ethiopia)

Author keywords

Docking; Homology modelling; P. falciparum DHFR inhibitors; Pharmacophore mapping; Quadruple mutant enzyme; Quantum medicinal chemistry and X ray crystallographic analysis

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; 4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ACETIC ACID; AMINOPTERIN; ANTIMALARIAL AGENT; CARBOLINE DERIVATIVE; CHLORCYCLOGUANIL; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; HYDRAZINE DERIVATIVE; METHOTREXATE; N [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] N' ISOPROPYLIMIDOCARBONIMIDIC DIAMIDE; PROGUANIL; PROPIONIC ACID; PYRIMETHAMINE; PYRIMETHAMINEIDOINDOLE; PYRIMIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFADIAZINE; SULFADOXINE; SULFONAMIDE; SULFONE; THIOUREA DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZINOBENZIMIDAZOLE; TRIMETHOPRIM; UNINDEXED DRUG; UREA DERIVATIVE;

BACTERIAL INFECTION; BINDING AFFINITY; BIOINFORMATICS; COMPUTER AIDED DESIGN; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME STRUCTURE; HUMAN; MALARIA; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; PROTEIN TARGETING; PROTOZOAL INFECTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM CHEMISTRY; REVIEW; STRUCTURAL HOMOLOGY; THREE DIMENSIONAL IMAGING;

ANIMALS; ANTIMALARIALS; COMPUTATIONAL BIOLOGY; FOLIC ACID ANTAGONISTS; HUMANS; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 48249149892     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986708784911551     Document Type: Review

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