Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine resistant Plasmodium falciparum

Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2002, Pages 1244-1252

  Tarnchompoo, Bongkoch ^a   Sirichaiwat, Chawanee ^a,b   Phupong, Worrapong ^b   Intaraudom, Chakapong ^a   Sirawaraporn, Worachart ^b   Kamchonwongpaisan, Sumalee ^a   Vanichtanankul, Jarunee ^a   Thebtaranonth, Yodhathai ^b   Yuthavong, Yongyuth ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; ANTIMALARIAL AGENT; ASPARAGINE; CHLORIDE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; NITROGEN; PHENYL GROUP; PYRIMETHAMINE; SERINE; TRIMETHOPRIM;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CYTOTOXICITY; DRUG BINDING; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; MALARIA; MAMMAL CELL; NONHUMAN; PLASMODIUM FALCIPARUM; STEREOSPECIFICITY;

ANIMALS; ANTIMALARIALS; BINDING, COMPETITIVE; CERCOPITHECUS AETHIOPS; FOLIC ACID ANTAGONISTS; HUMANS; KB CELLS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; POINT MUTATION; PYRIMETHAMINE; PYRIMIDINES; TETRAHYDROFOLATE DEHYDROGENASE; VERO CELLS;

EID: 0037075804     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010131q     Document Type: Article

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