Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 2834-2845

  Rastelli, Giulio ^a   Pacchioni, Sara ^a   Sirawaraporn, Worachart ^b   Sirawaraporn, Rachada ^b   Parenti, Marco Daniele ^a   Ferrari, Anna Maria ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 [4 [(3,5 DICHLORO 4 PYRIDYL)OXY]PHENYL]ETHYLIDENE]HYDRAZINE 1 CARBOTHIOAMIDE; 4 (3,5 DICHLOROPHENOXY) N HYDROXY 3 NITROBENZAMIDINE; 4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; AMIDINE; ANTIMALARIAL AGENT; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE INHIBITOR; HYDRAZINE; PYRIMETHAMINE; RCL 2894 1; SULFADOXINE; SULFONAMIDE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UREA;

ARTICLE; DATA ANALYSIS; DATA BASE; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME BINDING; GENE MUTATION; MALARIA; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DATABASES, FACTUAL; DRUG DESIGN; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; MUTATION; PLASMODIUM FALCIPARUM; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0037784010     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030781p     Document Type: Article

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