A complete model of the Plasmodium falciparum bifunctional enzyme dihydrofolate reductase-thymidylate synthase. A model to design new antimalarials

Journal of the Brazilian Chemical Society

Volumn 15, Issue 3, 2004, Pages 450-454

  França, Tanos C C ^a   De Medeiros, André L R ^a   Dos Santos, Edison C P ^a   Santos Filho, Osvaldo A ^a   Figueroa Villar, José D ^a  

^a MILITARY INSTITUTE OF ENGINEERING   (Brazil)

Author keywords

DHFR TS; Homology modeling; Malaria; Optimized substrate transport; Plasmodium falciparum

Indexed keywords

AMINO ACID; ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; ENZYME; THYMIDINE PHOSPHATE;

ARTICLE; CALCULATION; CRYSTALLOGRAPHY; DRUG DESIGN; ELECTRIC POTENTIAL; PLASMODIUM FALCIPARUM; SURFACE PROPERTY; THEORETICAL MODEL; TRANSPORT KINETICS;

EID: 4143051396     PISSN: 01035053     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0103-50532004000300019     Document Type: Article

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