Target Guided Synthesis of 5-Benzyl-2,4-diamonopyrimidines: Their Antimalarial Activities and Binding Affinities to Wild Type and Mutant Dihydrofolate Reductases from Plasmodium falciparum

Journal of Medicinal Chemistry

Volumn 47, Issue 2, 2004, Pages 345-354

  Sirichaiwat, Chawanee ^a,b   Intaraudom, Chakapong ^a   Kamchonwongpaisan, Sumalee ^a   Vanichtanankul, Jarunee ^a   Thebtaranonth, Yodhathai ^a,b   Yuthavong, Yongyuth ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 BENZYLPYRIMIDINE; 4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ANTIMALARIAL AGENT; ASPARAGINE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; SERINE; TRIMETHOPRIM;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM; STEREOCHEMISTRY;

ANIMALS; ANTIMALARIALS; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; MUTATION; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

EID: 0346333092     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0303352     Document Type: Article

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